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Protein

Ribonuclease TTHA0252

Gene

TTHA0252

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has endoribonuclease activity towards 23S and 16S rRNA (in vitro).1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 2 Zn2+ ions.1 Publication

Enzyme regulationi

Inhibited by cadmium, cobalt, manganese, magnesium, calcium and nickel ions.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Zinc 11
Metal bindingi61Zinc 11
Metal bindingi63Zinc 21
Metal bindingi64Zinc 21
Metal bindingi141Zinc 11
Metal bindingi162Zinc 11
Metal bindingi162Zinc 21
Metal bindingi400Zinc 21

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease TTHA0252 (EC:3.1.-.-)
Gene namesi
Ordered Locus Names:TTHA0252
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003193221 – 431Ribonuclease TTHA0252Add BLAST431

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA0252.

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 5Combined sources4
Beta strandi9 – 13Combined sources5
Beta strandi17 – 21Combined sources5
Beta strandi24 – 28Combined sources5
Helixi35 – 42Combined sources8
Helixi49 – 51Combined sources3
Beta strandi54 – 56Combined sources3
Helixi62 – 65Combined sources4
Helixi68 – 73Combined sources6
Beta strandi80 – 82Combined sources3
Helixi84 – 100Combined sources17
Helixi108 – 116Combined sources9
Beta strandi118 – 120Combined sources3
Beta strandi127 – 129Combined sources3
Beta strandi132 – 138Combined sources7
Beta strandi146 – 152Combined sources7
Beta strandi155 – 159Combined sources5
Beta strandi168 – 171Combined sources4
Beta strandi181 – 186Combined sources6
Turni188 – 191Combined sources4
Helixi197 – 213Combined sources17
Beta strandi217 – 221Combined sources5
Turni224 – 226Combined sources3
Helixi227 – 238Combined sources12
Helixi239 – 241Combined sources3
Beta strandi247 – 250Combined sources4
Helixi252 – 260Combined sources9
Helixi261 – 267Combined sources7
Helixi270 – 277Combined sources8
Beta strandi288 – 290Combined sources3
Helixi294 – 302Combined sources9
Beta strandi305 – 312Combined sources8
Beta strandi316 – 319Combined sources4
Helixi320 – 328Combined sources9
Beta strandi335 – 338Combined sources4
Helixi347 – 352Combined sources6
Beta strandi356 – 360Combined sources5
Beta strandi363 – 366Combined sources4
Beta strandi369 – 373Combined sources5
Helixi375 – 377Combined sources3
Helixi383 – 390Combined sources8
Beta strandi394 – 401Combined sources8
Helixi403 – 415Combined sources13
Beta strandi419 – 422Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKFX-ray2.80A/B/C/D1-431[»]
3A4YX-ray2.50A/B/C/D1-431[»]
3IDZX-ray2.50A/B/C/D1-431[»]
3IE0X-ray2.73A/B/C/D1-431[»]
3IE1X-ray2.85A/B/C/D1-431[»]
3IE2X-ray2.80A/B/C/D1-431[»]
3IEKX-ray2.05A/B/C/D1-431[»]
3IELX-ray2.35A/B/C/D1-431[»]
3IEMX-ray2.50A/B/C/D1-431[»]
ProteinModelPortaliQ5SLP1.
SMRiQ5SLP1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLP1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CY0. Bacteria.
COG1236. LUCA.
HOGENOMiHOG000244774.
KOiK07576.
OMAiNLRLRNW.
PhylomeDBiQ5SLP1.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR022712. Beta_Casp.
IPR001279. Metallo-B-lactamas.
IPR011108. RMMBL.
[Graphical view]
PfamiPF10996. Beta-Casp. 1 hit.
PF00753. Lactamase_B. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SLP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVPFGAAR EVTGSAHLLL AGGRRVLLDC GMFQGKEEAR NHAPFGFDPK
60 70 80 90 100
EVDAVLLTHA HLDHVGRLPK LFREGYRGPV YATRATVLLM EIVLEDALKV
110 120 130 140 150
MDEPFFGPED VEEALGHLRP LEYGEWLRLG ALSLAFGQAG HLPGSAFVVA
160 170 180 190 200
QGEGRTLVYS GDLGNREKDV LPDPSLPPLA DLVLAEGTYG DRPHRPYRET
210 220 230 240 250
VREFLEILEK TLSQGGKVLI PTFAVERAQE ILYVLYTHGH RLPRAPIYLD
260 270 280 290 300
SPMAGRVLSL YPRLVRYFSE EVQAHFLQGK NPFRPAGLEV VEHTEASKAL
310 320 330 340 350
NRAPGPMVVL AGSGMLAGGR ILHHLKHGLS DPRNALVFVG YQPQGGLGAE
360 370 380 390 400
IIARPPAVRI LGEEVPLRAS VHTLGGFSGH AGQDELLDWL QGEPRVVLVH
410 420 430
GEEEKLLALG KLLALRGQEV SLARFGEGVP V
Length:431
Mass (Da):47,055
Last modified:December 21, 2004 - v1
Checksum:i89BB88D1F61D4BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70075.1.
RefSeqiWP_011227806.1. NC_006461.1.
YP_143518.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70075; BAD70075; BAD70075.
GeneIDi3170139.
KEGGittj:TTHA0252.
PATRICi23955459. VBITheThe93045_0252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70075.1.
RefSeqiWP_011227806.1. NC_006461.1.
YP_143518.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKFX-ray2.80A/B/C/D1-431[»]
3A4YX-ray2.50A/B/C/D1-431[»]
3IDZX-ray2.50A/B/C/D1-431[»]
3IE0X-ray2.73A/B/C/D1-431[»]
3IE1X-ray2.85A/B/C/D1-431[»]
3IE2X-ray2.80A/B/C/D1-431[»]
3IEKX-ray2.05A/B/C/D1-431[»]
3IELX-ray2.35A/B/C/D1-431[»]
3IEMX-ray2.50A/B/C/D1-431[»]
ProteinModelPortaliQ5SLP1.
SMRiQ5SLP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70075; BAD70075; BAD70075.
GeneIDi3170139.
KEGGittj:TTHA0252.
PATRICi23955459. VBITheThe93045_0252.

Phylogenomic databases

eggNOGiENOG4105CY0. Bacteria.
COG1236. LUCA.
HOGENOMiHOG000244774.
KOiK07576.
OMAiNLRLRNW.
PhylomeDBiQ5SLP1.

Miscellaneous databases

EvolutionaryTraceiQ5SLP1.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR022712. Beta_Casp.
IPR001279. Metallo-B-lactamas.
IPR011108. RMMBL.
[Graphical view]
PfamiPF10996. Beta-Casp. 1 hit.
PF00753. Lactamase_B. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNSE_THET8
AccessioniPrimary (citable) accession number: Q5SLP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.