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Q5SLL6

- G6PI_THET8

UniProt

Q5SLL6 - G6PI_THET8

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Protein

Glucose-6-phosphate isomerase

Gene
pgi, TTHA0277
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei267 – 2671Proton donor By similarity
Active sitei293 – 2931 By similarity
Active sitei406 – 4061 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-291-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:TTHA0277
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Glucose-6-phosphate isomeraseUniRule annotationPRO_0000180759Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0277.

Structurei

Secondary structure

1
415
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53
Helixi12 – 187
Helixi20 – 3213
Beta strandi34 – 363
Helixi42 – 443
Helixi46 – 483
Helixi52 – 6110
Beta strandi67 – 726
Helixi75 – 773
Helixi79 – 8810
Beta strandi94 – 985
Helixi103 – 11210
Helixi115 – 1173
Beta strandi118 – 12710
Helixi130 – 14718
Helixi148 – 1547
Beta strandi155 – 1595
Beta strandi161 – 1644
Helixi165 – 1739
Beta strandi176 – 1794
Helixi186 – 1883
Helixi193 – 2019
Helixi206 – 22116
Helixi224 – 2263
Helixi228 – 23811
Turni239 – 2413
Beta strandi242 – 2498
Turni253 – 2564
Helixi257 – 26913
Beta strandi270 – 2723
Beta strandi282 – 2876
Helixi290 – 2923
Turni293 – 2953
Helixi296 – 3016
Beta strandi306 – 3149
Helixi329 – 3313
Turni332 – 3365
Helixi339 – 35618
Beta strandi360 – 37011
Helixi371 – 39121
Helixi400 – 4023
Helixi403 – 41412

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZGX-ray1.95A/B1-415[»]
ProteinModelPortaliQ5SLL6.
SMRiQ5SLL6. Positions 1-415.

Miscellaneous databases

EvolutionaryTraceiQ5SLL6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100402.
KOiK01810.
OMAiQVIFIGN.
OrthoDBiEOG64R61J.
PhylomeDBiQ5SLL6.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLL6-1 [UniParc]FASTAAdd to Basket

« Hide

MLRLDTRFLP GFPEALSRHG PLLEEARRRL LAKRGEPGSM LGWMDLPEDT    50
ETLREVRRYR EANPWVEDFV LIGIGGSALG PKALEAAFNE SGVRFHYLDH 100
VEPEPILRLL RTLDPRKTLV NAVSKSGSTA ETLAGLAVFL KWLKAHLGED 150
WRRHLVVTTD PKEGPLRAFA EREGLKAFAI PKEVGGRFSA LSPVGLLPLA 200
FAGADLDALL MGARKANETA LAPLEESLPL KTALLLHLHR HLPVHVFMVY 250
SERLSHLPSW FVQLHDESLG KVDRQGQRVG TTAVPALGPK DQHAQVQLFR 300
EGPLDKLLAL VIPEAPLEDV EIPEVEGLEA ASYLFGKTLF QLLKAEAEAT 350
YEALAEAGQR VYALFLPEVS PYAVGWLMQH LMWQTAFLGE LWEVNAFDQP 400
GVELGKVLTR KRLAG 415
Length:415
Mass (Da):46,081
Last modified:December 21, 2004 - v1
Checksum:iA8C23A5C2E3EFC56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70100.1.
RefSeqiWP_011227825.1. NC_006461.1.
YP_143543.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70100; BAD70100; BAD70100.
GeneIDi3168044.
KEGGittj:TTHA0277.
PATRICi23955509. VBITheThe93045_0277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70100.1 .
RefSeqi WP_011227825.1. NC_006461.1.
YP_143543.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZZG X-ray 1.95 A/B 1-415 [» ]
ProteinModelPortali Q5SLL6.
SMRi Q5SLL6. Positions 1-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70100 ; BAD70100 ; BAD70100 .
GeneIDi 3168044.
KEGGi ttj:TTHA0277.
PATRICi 23955509. VBITheThe93045_0277.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100402.
KOi K01810.
OMAi QVIFIGN.
OrthoDBi EOG64R61J.
PhylomeDBi Q5SLL6.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci TTHE300852:GH8R-291-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SLL6.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Crystal structure of hypothetical protein TT0277 from Thermus thermophilus HB8."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Entry informationi

Entry nameiG6PI_THET8
AccessioniPrimary (citable) accession number: Q5SLL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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