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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase 2 (pfkA2), ATP-dependent 6-phosphofructokinase 1 (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei267Proton donorUniRule annotation1
Active sitei293UniRule annotation1
Active sitei406UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:TTHA0277
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807591 – 415Glucose-6-phosphate isomeraseAdd BLAST415

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0277.

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi12 – 18Combined sources7
Helixi20 – 32Combined sources13
Beta strandi34 – 36Combined sources3
Helixi42 – 44Combined sources3
Helixi46 – 48Combined sources3
Helixi52 – 61Combined sources10
Beta strandi67 – 72Combined sources6
Helixi75 – 77Combined sources3
Helixi79 – 88Combined sources10
Beta strandi94 – 98Combined sources5
Helixi103 – 112Combined sources10
Helixi115 – 117Combined sources3
Beta strandi118 – 127Combined sources10
Helixi130 – 147Combined sources18
Helixi148 – 154Combined sources7
Beta strandi155 – 159Combined sources5
Beta strandi161 – 164Combined sources4
Helixi165 – 173Combined sources9
Beta strandi176 – 179Combined sources4
Helixi186 – 188Combined sources3
Helixi193 – 201Combined sources9
Helixi206 – 221Combined sources16
Helixi224 – 226Combined sources3
Helixi228 – 238Combined sources11
Turni239 – 241Combined sources3
Beta strandi242 – 249Combined sources8
Turni253 – 256Combined sources4
Helixi257 – 269Combined sources13
Beta strandi270 – 272Combined sources3
Beta strandi282 – 287Combined sources6
Helixi290 – 292Combined sources3
Turni293 – 295Combined sources3
Helixi296 – 301Combined sources6
Beta strandi306 – 314Combined sources9
Helixi329 – 331Combined sources3
Turni332 – 336Combined sources5
Helixi339 – 356Combined sources18
Beta strandi360 – 370Combined sources11
Helixi371 – 391Combined sources21
Helixi400 – 402Combined sources3
Helixi403 – 414Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZZGX-ray1.95A/B1-415[»]
ProteinModelPortaliQ5SLL6.
SMRiQ5SLL6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLL6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100402.
KOiK01810.
OMAiSFIIPDD.
PhylomeDBiQ5SLL6.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLDTRFLP GFPEALSRHG PLLEEARRRL LAKRGEPGSM LGWMDLPEDT
60 70 80 90 100
ETLREVRRYR EANPWVEDFV LIGIGGSALG PKALEAAFNE SGVRFHYLDH
110 120 130 140 150
VEPEPILRLL RTLDPRKTLV NAVSKSGSTA ETLAGLAVFL KWLKAHLGED
160 170 180 190 200
WRRHLVVTTD PKEGPLRAFA EREGLKAFAI PKEVGGRFSA LSPVGLLPLA
210 220 230 240 250
FAGADLDALL MGARKANETA LAPLEESLPL KTALLLHLHR HLPVHVFMVY
260 270 280 290 300
SERLSHLPSW FVQLHDESLG KVDRQGQRVG TTAVPALGPK DQHAQVQLFR
310 320 330 340 350
EGPLDKLLAL VIPEAPLEDV EIPEVEGLEA ASYLFGKTLF QLLKAEAEAT
360 370 380 390 400
YEALAEAGQR VYALFLPEVS PYAVGWLMQH LMWQTAFLGE LWEVNAFDQP
410
GVELGKVLTR KRLAG
Length:415
Mass (Da):46,081
Last modified:December 21, 2004 - v1
Checksum:iA8C23A5C2E3EFC56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70100.1.
RefSeqiWP_011227825.1. NC_006461.1.
YP_143543.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70100; BAD70100; BAD70100.
GeneIDi3168044.
KEGGittj:TTHA0277.
PATRICi23955509. VBITheThe93045_0277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70100.1.
RefSeqiWP_011227825.1. NC_006461.1.
YP_143543.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZZGX-ray1.95A/B1-415[»]
ProteinModelPortaliQ5SLL6.
SMRiQ5SLL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70100; BAD70100; BAD70100.
GeneIDi3168044.
KEGGittj:TTHA0277.
PATRICi23955509. VBITheThe93045_0277.

Phylogenomic databases

eggNOGiENOG4105C89. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100402.
KOiK01810.
OMAiSFIIPDD.
PhylomeDBiQ5SLL6.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Miscellaneous databases

EvolutionaryTraceiQ5SLL6.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_THET8
AccessioniPrimary (citable) accession number: Q5SLL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.