Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5SLL6 (G6PI_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:TTHA0277
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_0000180759

Sites

Active site2671Proton donor By similarity
Active site2931 By similarity
Active site4061 By similarity

Secondary structure

1 ........................................................................ 415
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SLL6 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: A8C23A5C2E3EFC56

FASTA41546,081
        10         20         30         40         50         60 
MLRLDTRFLP GFPEALSRHG PLLEEARRRL LAKRGEPGSM LGWMDLPEDT ETLREVRRYR 

        70         80         90        100        110        120 
EANPWVEDFV LIGIGGSALG PKALEAAFNE SGVRFHYLDH VEPEPILRLL RTLDPRKTLV 

       130        140        150        160        170        180 
NAVSKSGSTA ETLAGLAVFL KWLKAHLGED WRRHLVVTTD PKEGPLRAFA EREGLKAFAI 

       190        200        210        220        230        240 
PKEVGGRFSA LSPVGLLPLA FAGADLDALL MGARKANETA LAPLEESLPL KTALLLHLHR 

       250        260        270        280        290        300 
HLPVHVFMVY SERLSHLPSW FVQLHDESLG KVDRQGQRVG TTAVPALGPK DQHAQVQLFR 

       310        320        330        340        350        360 
EGPLDKLLAL VIPEAPLEDV EIPEVEGLEA ASYLFGKTLF QLLKAEAEAT YEALAEAGQR 

       370        380        390        400        410 
VYALFLPEVS PYAVGWLMQH LMWQTAFLGE LWEVNAFDQP GVELGKVLTR KRLAG

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Crystal structure of hypothetical protein TT0277 from Thermus thermophilus HB8."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD70100.1.
RefSeqYP_143543.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZGX-ray1.95A/B1-415[»]
ProteinModelPortalQ5SLL6.
SMRQ5SLL6. Positions 1-415.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5SLL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3168044.
GenomeReviewsGene locus TTHA0277 in contig AP008226_GR.
KEGGttj:TTHA0277.
NMPDRfig|300852.3.peg.308.
PATRIC23955509. VBITheThe93045_0277.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHBG615843.
OMADNLDGLN.
ProtClustDBCLSK738916.

Enzyme and pathway databases

BioCycTTHE300852:TTHA0277-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. False negative.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_THET8
AccessionPrimary (citable) accession number: Q5SLL6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents