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Q5SLL6

- G6PI_THET8

UniProt

Q5SLL6 - G6PI_THET8

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei267 – 2671Proton donorUniRule annotation
Active sitei293 – 2931UniRule annotation
Active sitei406 – 4061UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-291-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:TTHA0277
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Glucose-6-phosphate isomerasePRO_0000180759Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0277.

Structurei

Secondary structure

1
415
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Helixi12 – 187Combined sources
Helixi20 – 3213Combined sources
Beta strandi34 – 363Combined sources
Helixi42 – 443Combined sources
Helixi46 – 483Combined sources
Helixi52 – 6110Combined sources
Beta strandi67 – 726Combined sources
Helixi75 – 773Combined sources
Helixi79 – 8810Combined sources
Beta strandi94 – 985Combined sources
Helixi103 – 11210Combined sources
Helixi115 – 1173Combined sources
Beta strandi118 – 12710Combined sources
Helixi130 – 14718Combined sources
Helixi148 – 1547Combined sources
Beta strandi155 – 1595Combined sources
Beta strandi161 – 1644Combined sources
Helixi165 – 1739Combined sources
Beta strandi176 – 1794Combined sources
Helixi186 – 1883Combined sources
Helixi193 – 2019Combined sources
Helixi206 – 22116Combined sources
Helixi224 – 2263Combined sources
Helixi228 – 23811Combined sources
Turni239 – 2413Combined sources
Beta strandi242 – 2498Combined sources
Turni253 – 2564Combined sources
Helixi257 – 26913Combined sources
Beta strandi270 – 2723Combined sources
Beta strandi282 – 2876Combined sources
Helixi290 – 2923Combined sources
Turni293 – 2953Combined sources
Helixi296 – 3016Combined sources
Beta strandi306 – 3149Combined sources
Helixi329 – 3313Combined sources
Turni332 – 3365Combined sources
Helixi339 – 35618Combined sources
Beta strandi360 – 37011Combined sources
Helixi371 – 39121Combined sources
Helixi400 – 4023Combined sources
Helixi403 – 41412Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZZGX-ray1.95A/B1-415[»]
ProteinModelPortaliQ5SLL6.
SMRiQ5SLL6. Positions 1-415.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLL6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100402.
KOiK01810.
OMAiQVIFIGN.
OrthoDBiEOG64R61J.
PhylomeDBiQ5SLL6.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRLDTRFLP GFPEALSRHG PLLEEARRRL LAKRGEPGSM LGWMDLPEDT
60 70 80 90 100
ETLREVRRYR EANPWVEDFV LIGIGGSALG PKALEAAFNE SGVRFHYLDH
110 120 130 140 150
VEPEPILRLL RTLDPRKTLV NAVSKSGSTA ETLAGLAVFL KWLKAHLGED
160 170 180 190 200
WRRHLVVTTD PKEGPLRAFA EREGLKAFAI PKEVGGRFSA LSPVGLLPLA
210 220 230 240 250
FAGADLDALL MGARKANETA LAPLEESLPL KTALLLHLHR HLPVHVFMVY
260 270 280 290 300
SERLSHLPSW FVQLHDESLG KVDRQGQRVG TTAVPALGPK DQHAQVQLFR
310 320 330 340 350
EGPLDKLLAL VIPEAPLEDV EIPEVEGLEA ASYLFGKTLF QLLKAEAEAT
360 370 380 390 400
YEALAEAGQR VYALFLPEVS PYAVGWLMQH LMWQTAFLGE LWEVNAFDQP
410
GVELGKVLTR KRLAG
Length:415
Mass (Da):46,081
Last modified:December 21, 2004 - v1
Checksum:iA8C23A5C2E3EFC56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70100.1.
RefSeqiWP_011227825.1. NC_006461.1.
YP_143543.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70100; BAD70100; BAD70100.
GeneIDi3168044.
KEGGittj:TTHA0277.
PATRICi23955509. VBITheThe93045_0277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70100.1 .
RefSeqi WP_011227825.1. NC_006461.1.
YP_143543.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZZG X-ray 1.95 A/B 1-415 [» ]
ProteinModelPortali Q5SLL6.
SMRi Q5SLL6. Positions 1-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70100 ; BAD70100 ; BAD70100 .
GeneIDi 3168044.
KEGGi ttj:TTHA0277.
PATRICi 23955509. VBITheThe93045_0277.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000100402.
KOi K01810.
OMAi QVIFIGN.
OrthoDBi EOG64R61J.
PhylomeDBi Q5SLL6.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci TTHE300852:GH8R-291-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SLL6.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Crystal structure of hypothetical protein TT0277 from Thermus thermophilus HB8."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Entry informationi

Entry nameiG6PI_THET8
AccessioniPrimary (citable) accession number: Q5SLL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3