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Q5SLL6

- G6PI_THET8

UniProt

Q5SLL6 - G6PI_THET8

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei267 – 2671Proton donorUniRule annotation
    Active sitei293 – 2931UniRule annotation
    Active sitei406 – 4061UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-291-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:TTHA0277
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Glucose-6-phosphate isomerasePRO_0000180759Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA0277.

    Structurei

    Secondary structure

    1
    415
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Helixi12 – 187
    Helixi20 – 3213
    Beta strandi34 – 363
    Helixi42 – 443
    Helixi46 – 483
    Helixi52 – 6110
    Beta strandi67 – 726
    Helixi75 – 773
    Helixi79 – 8810
    Beta strandi94 – 985
    Helixi103 – 11210
    Helixi115 – 1173
    Beta strandi118 – 12710
    Helixi130 – 14718
    Helixi148 – 1547
    Beta strandi155 – 1595
    Beta strandi161 – 1644
    Helixi165 – 1739
    Beta strandi176 – 1794
    Helixi186 – 1883
    Helixi193 – 2019
    Helixi206 – 22116
    Helixi224 – 2263
    Helixi228 – 23811
    Turni239 – 2413
    Beta strandi242 – 2498
    Turni253 – 2564
    Helixi257 – 26913
    Beta strandi270 – 2723
    Beta strandi282 – 2876
    Helixi290 – 2923
    Turni293 – 2953
    Helixi296 – 3016
    Beta strandi306 – 3149
    Helixi329 – 3313
    Turni332 – 3365
    Helixi339 – 35618
    Beta strandi360 – 37011
    Helixi371 – 39121
    Helixi400 – 4023
    Helixi403 – 41412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZZGX-ray1.95A/B1-415[»]
    ProteinModelPortaliQ5SLL6.
    SMRiQ5SLL6. Positions 1-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SLL6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000100402.
    KOiK01810.
    OMAiQVIFIGN.
    OrthoDBiEOG64R61J.
    PhylomeDBiQ5SLL6.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SLL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRLDTRFLP GFPEALSRHG PLLEEARRRL LAKRGEPGSM LGWMDLPEDT    50
    ETLREVRRYR EANPWVEDFV LIGIGGSALG PKALEAAFNE SGVRFHYLDH 100
    VEPEPILRLL RTLDPRKTLV NAVSKSGSTA ETLAGLAVFL KWLKAHLGED 150
    WRRHLVVTTD PKEGPLRAFA EREGLKAFAI PKEVGGRFSA LSPVGLLPLA 200
    FAGADLDALL MGARKANETA LAPLEESLPL KTALLLHLHR HLPVHVFMVY 250
    SERLSHLPSW FVQLHDESLG KVDRQGQRVG TTAVPALGPK DQHAQVQLFR 300
    EGPLDKLLAL VIPEAPLEDV EIPEVEGLEA ASYLFGKTLF QLLKAEAEAT 350
    YEALAEAGQR VYALFLPEVS PYAVGWLMQH LMWQTAFLGE LWEVNAFDQP 400
    GVELGKVLTR KRLAG 415
    Length:415
    Mass (Da):46,081
    Last modified:December 21, 2004 - v1
    Checksum:iA8C23A5C2E3EFC56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70100.1.
    RefSeqiWP_011227825.1. NC_006461.1.
    YP_143543.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70100; BAD70100; BAD70100.
    GeneIDi3168044.
    KEGGittj:TTHA0277.
    PATRICi23955509. VBITheThe93045_0277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70100.1 .
    RefSeqi WP_011227825.1. NC_006461.1.
    YP_143543.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZZG X-ray 1.95 A/B 1-415 [» ]
    ProteinModelPortali Q5SLL6.
    SMRi Q5SLL6. Positions 1-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70100 ; BAD70100 ; BAD70100 .
    GeneIDi 3168044.
    KEGGi ttj:TTHA0277.
    PATRICi 23955509. VBITheThe93045_0277.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000100402.
    KOi K01810.
    OMAi QVIFIGN.
    OrthoDBi EOG64R61J.
    PhylomeDBi Q5SLL6.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci TTHE300852:GH8R-291-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SLL6.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    2. "Crystal structure of hypothetical protein TT0277 from Thermus thermophilus HB8."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

    Entry informationi

    Entry nameiG6PI_THET8
    AccessioniPrimary (citable) accession number: Q5SLL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3