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Q5SLI9 (Q5SLI9_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] PIRNR PIRNR000094
EC=1.3.1.9 PIRNR PIRNR000094
Gene names
Ordered Locus Names:TTHA0304
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. PIRNR PIRNR000094

Pathway

Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000094

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. PIRNR PIRNR000094

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding15 – 173NAD PDB 2WYV PDB 2WYW
Nucleotide binding21 – 222NAD PDB 2WYV PDB 2WYW
Nucleotide binding21 – 222NADP PDB 2YW9
Nucleotide binding66 – 672NAD PDB 2WYV PDB 2WYW
Nucleotide binding193 – 1975NAD PDB 2WYV PDB 2WYW

Sites

Active site1571Proton acceptor By similarity PIRSR PIRSR000094-1
Binding site171NADP PDB 2YW9
Binding site421NAD PDB 2WYV PDB 2WYW
Binding site421NADP PDB 2YW9
Binding site671NADP; via amide nitrogen PDB 2YW9
Binding site951NAD; via amide nitrogen PDB 2WYV
Binding site1641NAD PDB 2WYV PDB 2WYW
Binding site1641NADP PDB 2YW9
Binding site1931NADP; via amide nitrogen PDB 2YW9

Sequences

Sequence LengthMass (Da)Tools
Q5SLI9 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 49A63C766929DE99

FASTA26128,110
        10         20         30         40         50         60 
MLTVDLSGKK ALVMGVTNQR SLGFAIAAKL KEAGAEVALS YQAERLRPEA EKLAEALGGA 

        70         80         90        100        110        120 
LLFRADVTQD EELDALFAGV KEAFGGLDYL VHAIAFAPRE AMEGRYIDTR RQDWLLALEV 

       130        140        150        160        170        180 
SAYSLVAVAR RAEPLLREGG GIVTLTYYAS EKVVPKYNVM AIAKAALEAS VRYLAYELGP 

       190        200        210        220        230        240 
KGVRVNAISA GPVRTVAARS IPGFTKMYDR VAQTAPLRRN ITQEEVGNLG LFLLSPLASG 

       250        260 
ITGEVVYVDA GYHIMGMELE G

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Crystal structure of tt0143 from Thermus thermophilus HB8."
Ago H., Hamada K., Ida K., Kanda H., Sugahara M., Yamamoto M., Nodake Y., Kuramitsu S., Yokoyama S., Miyano M.
Submitted (SEP-2003) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[3]"Crystal structure of TT0143 from Thermus thermophilus HB8."
Ago H., Hamada K., Ida K., Kanda H., Sugahara M., Yamamoto M., Nodake Y., Kuramitsu S., Yokoyama S., Miyano M.
Submitted (APR-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH NADP.
[4]"High Resolution Structures of Thermus Thermophilus Enoyl-Acyl Carrier Protein Reductase Apo-Form, in Complex with Nad, and with Nad and Triclosan."
Otero J.M., Noel A.J., Guardado-Calvo P., Llamas-Saiz A.L., Van Raaij M.J.
Submitted (NOV-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD70127.1.
RefSeqYP_143570.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ULUX-ray2.00A/B/C/D1-261[»]
2WYUX-ray1.50A/B/C/D1-261[»]
2WYVX-ray1.86A/B/C/D1-261[»]
2WYWX-ray1.90A/B/C/D1-261[»]
2YW9X-ray2.50A/B/C/D/E/F/G/H1-261[»]
ProteinModelPortalQ5SLI9.
SMRQ5SLI9. Positions 1-257.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5SLI9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3168609.
GenomeReviewsGene locus TTHA0304 in contig AP008226_GR.
KEGGttj:TTHA0304.
NMPDRfig|300852.3.peg.335.
PATRIC23955563. VBITheThe93045_0304.

Phylogenomic databases

eggNOGCOG0623.
HOGENOMHBG750976.
OMAMGVANNR.
PhylomeDBQ5SLI9.
ProtClustDBCLSK445334.

Enzyme and pathway databases

BioCycTTHE300852:TTHA0304-MONOMER.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00208.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameQ5SLI9_THET8
AccessionPrimary (citable) accession number: Q5SLI9
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info