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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH]

Gene

TTHA0304

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei17NADPCombined sources1
Binding sitei42NADCombined sources1
Binding sitei42NADPCombined sources1
Binding sitei67NADP; via amide nitrogenCombined sources1
Binding sitei95NAD; via amide nitrogenCombined sources1
Binding sitei97Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation1
Active sitei147Proton acceptorUniRule annotation1
Active sitei157Proton acceptorUniRule annotation1
Binding sitei164NADCombined sources1
Binding sitei164NADPCombined sources1
Binding sitei193NADP; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 17NADCombined sources3
Nucleotide bindingi21 – 22NADCombined sources2
Nucleotide bindingi21 – 22NADPCombined sources2
Nucleotide bindingi66 – 67NADCombined sources2
Nucleotide bindingi193 – 197NADCombined sources5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADUniRule annotationCombined sources, NADPCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-316-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH]UniRule annotation (EC:1.3.1.9UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0304Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0304.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ULUX-ray2.00A/B/C/D1-261[»]
2WYUX-ray1.50A/B/C/D1-261[»]
2WYVX-ray1.86A/B/C/D1-261[»]
2WYWX-ray1.90A/B/C/D1-261[»]
2YW9X-ray2.50A/B/C/D/E/F/G/H1-261[»]
ProteinModelPortaliQ5SLI9.
SMRiQ5SLI9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SLI9.

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSJ. Bacteria.
COG0623. LUCA.
KOiK00208.
OMAiDILIHCL.
PhylomeDBiQ5SLI9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF317. PTHR24322:SF317. 2 hits.
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SLI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVDLSGKK ALVMGVTNQR SLGFAIAAKL KEAGAEVALS YQAERLRPEA
60 70 80 90 100
EKLAEALGGA LLFRADVTQD EELDALFAGV KEAFGGLDYL VHAIAFAPRE
110 120 130 140 150
AMEGRYIDTR RQDWLLALEV SAYSLVAVAR RAEPLLREGG GIVTLTYYAS
160 170 180 190 200
EKVVPKYNVM AIAKAALEAS VRYLAYELGP KGVRVNAISA GPVRTVAARS
210 220 230 240 250
IPGFTKMYDR VAQTAPLRRN ITQEEVGNLG LFLLSPLASG ITGEVVYVDA
260
GYHIMGMELE G
Length:261
Mass (Da):28,110
Last modified:December 21, 2004 - v1
Checksum:i49A63C766929DE99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70127.1.
RefSeqiWP_011227843.1. NC_006461.1.
YP_143570.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70127; BAD70127; BAD70127.
GeneIDi3168609.
KEGGittj:TTHA0304.
PATRICi23955563. VBITheThe93045_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70127.1.
RefSeqiWP_011227843.1. NC_006461.1.
YP_143570.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ULUX-ray2.00A/B/C/D1-261[»]
2WYUX-ray1.50A/B/C/D1-261[»]
2WYVX-ray1.86A/B/C/D1-261[»]
2WYWX-ray1.90A/B/C/D1-261[»]
2YW9X-ray2.50A/B/C/D/E/F/G/H1-261[»]
ProteinModelPortaliQ5SLI9.
SMRiQ5SLI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70127; BAD70127; BAD70127.
GeneIDi3168609.
KEGGittj:TTHA0304.
PATRICi23955563. VBITheThe93045_0304.

Phylogenomic databases

eggNOGiENOG4105CSJ. Bacteria.
COG0623. LUCA.
KOiK00208.
OMAiDILIHCL.
PhylomeDBiQ5SLI9.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciTTHE300852:GH8R-316-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SLI9.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF317. PTHR24322:SF317. 2 hits.
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SLI9_THET8
AccessioniPrimary (citable) accession number: Q5SLI9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.