Q5SLI2 (Q5SLI2_THET8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2 RuleBase RU004024
EC=1.9.3.1 RuleBase RU004024

Gene names

Ordered Locus Names:

TTHA0311 EMBL BAD70134.1

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP] EMBL BAD70134.1

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › Thermus thermophilus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU000456.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family. RuleBase RU000456

Ontologies

Keywords
Biological process	Electron transport Respiratory chain RuleBase RU000456 RuleBase RU003381 Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000456 RuleBase RU003381
Ligand	Copper RuleBase RU004024 Metal-binding RuleBase RU004024
Molecular function	Oxidoreductase RuleBase RU000456
Technical term	3D-structure PDB 2YEV Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5SLI2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: F97FF0A8FB9B5819	FASTA	337	37,351
	10 20 30 40 50 60 MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF LVVAGSLAYV 70 80 90 100 110 120 TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG LTAKALIQVN RPIPGAMKVE 130 140 150 160 170 180 VTGYQFWWDF HYPELGLRNS NELVLPAGVP VELEITSKDV IHSFWVPGLA GKRDAIPGQT 190 200 210 220 230 240 TRISFEPKEP GLYYGFCAEL CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ 250 260 270 280 290 300 QVFQQNCAAC HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG 310 320 330 VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Structural insights into electron transfer in caa3-type cytochrome oxidase." Lyons J.A., Aragao D., Slattery O., Pisliakov A.V., Soulimane T., Caffrey M. Nature 487:514-518(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008226 Genomic DNA. Translation: BAD70134.1.

RefSeq

YP_143577.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YEV	X-ray	2.36	B/E	1-337	[»]

ProteinModelPortal

Q5SLI2.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59902N.

STRING

300852.TTHA0311.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

BAD70134; BAD70134; BAD70134.

GeneID

3169690.

KEGG

ttj:TTHA0311.

PATRIC

23955578. VBITheThe93045_0311.

Phylogenomic databases

eggNOG

COG2857.

HOGENOM

HOG000268576.

KO

K02275.

OMA

FYGKCAE.

ProtClustDB

CLSK738613.

Family and domain databases

Gene3D

1.10.287.90. 1 hit.
2.60.40.420. 1 hit.

InterPro

IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]

Pfam

PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]

SUPFAM

SSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.

TIGRFAMs

TIGR02866. CoxB. 1 hit.

PROSITE

PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q5SLI2_THET8

Accession

Primary (citable) accession number: Q5SLI2

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)