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Protein

Cytochrome c oxidase subunit 2

Gene

TTHA0311

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi162Copper A; via pros nitrogenCombined sources1
Metal bindingi197Copper ACombined sources1
Metal bindingi199Copper A; via carbonyl oxygenCombined sources1
Metal bindingi201Copper ACombined sources1
Metal bindingi205Copper A; via pros nitrogenCombined sources1
Metal bindingi208Copper ACombined sources1
Binding sitei247Heme (covalent)Combined sources1
Binding sitei250Heme (covalent)Combined sources1
Metal bindingi251Iron (heme axial ligand); via tele nitrogenCombined sources1
Metal bindingi303Iron (heme axial ligand)Combined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotationCombined sources, HemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-321-MONOMER.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0311Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 62HelicalSequence analysisAdd BLAST26
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-59902N.
STRINGi300852.TTHA0311.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortaliQ5SLI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 113COX2_TMInterPro annotationAdd BLAST98
Domaini114 – 226COX2_CUAInterPro annotationAdd BLAST113
Domaini234 – 325Cytochrome cInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
KOiK02275.
OMAiKMTGTYP.
PhylomeDBiQ5SLI2.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF
60 70 80 90 100
LVVAGSLAYV TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG
110 120 130 140 150
LTAKALIQVN RPIPGAMKVE VTGYQFWWDF HYPELGLRNS NELVLPAGVP
160 170 180 190 200
VELEITSKDV IHSFWVPGLA GKRDAIPGQT TRISFEPKEP GLYYGFCAEL
210 220 230 240 250
CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ QVFQQNCAAC
260 270 280 290 300
HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG
310 320 330
VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF
Length:337
Mass (Da):37,351
Last modified:December 21, 2004 - v1
Checksum:iF97FF0A8FB9B5819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70134.1.
RefSeqiWP_011227850.1. NC_006461.1.
YP_143577.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70134; BAD70134; BAD70134.
GeneIDi3169690.
KEGGittj:TTHA0311.
PATRICi23955578. VBITheThe93045_0311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70134.1.
RefSeqiWP_011227850.1. NC_006461.1.
YP_143577.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortaliQ5SLI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59902N.
STRINGi300852.TTHA0311.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70134; BAD70134; BAD70134.
GeneIDi3169690.
KEGGittj:TTHA0311.
PATRICi23955578. VBITheThe93045_0311.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
KOiK02275.
OMAiKMTGTYP.
PhylomeDBiQ5SLI2.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-321-MONOMER.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SLI2_THET8
AccessioniPrimary (citable) accession number: Q5SLI2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.