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Protein

Cytochrome c oxidase subunit 2

Gene

TTHA0311

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi162Copper ACombined sources1
Metal bindingi197Copper ACombined sources1
Metal bindingi199Copper A; via carbonyl oxygenCombined sources1
Metal bindingi201Copper ACombined sources1
Metal bindingi208Copper ACombined sources1
Binding sitei247Heme (covalent)Combined sources1
Binding sitei250Heme (covalent)Combined sources1
Metal bindingi251Iron (heme axial ligand); via tele nitrogenCombined sources1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotationCombined sources, HemePROSITE-ProRule annotationCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-322-MONOMER

Protein family/group databases

TCDBi3.D.4.4.3 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0311Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 62HelicalSequence analysisAdd BLAST26
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-59902N
IntActiQ5SLI2, 1 interactor
STRINGi300852.TTHA0311

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortaliQ5SLI2
SMRiQ5SLI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 113COX2_TMInterPro annotationAdd BLAST98
Domaini114 – 226COX2_CUAInterPro annotationAdd BLAST113
Domaini234 – 325Cytochrome cInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA
COG2857 LUCA
HOGENOMiHOG000268576
KOiK02275
OMAiKMTGTYP
PhylomeDBiQ5SLI2

Family and domain databases

CDDicd04213 CuRO_CcO_Caa3_II, 1 hit
Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR034236 CuRO_CcO_Caa3_II
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
PF00034 Cytochrom_C, 1 hit
SUPFAMiSSF46626 SSF46626, 1 hit
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SLI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF
60 70 80 90 100
LVVAGSLAYV TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG
110 120 130 140 150
LTAKALIQVN RPIPGAMKVE VTGYQFWWDF HYPELGLRNS NELVLPAGVP
160 170 180 190 200
VELEITSKDV IHSFWVPGLA GKRDAIPGQT TRISFEPKEP GLYYGFCAEL
210 220 230 240 250
CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ QVFQQNCAAC
260 270 280 290 300
HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG
310 320 330
VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF
Length:337
Mass (Da):37,351
Last modified:December 21, 2004 - v1
Checksum:iF97FF0A8FB9B5819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70134.1
RefSeqiWP_011227850.1, NC_006461.1
YP_143577.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70134; BAD70134; BAD70134
GeneIDi3169690
KEGGittj:TTHA0311
PATRICifig|300852.9.peg.311

Similar proteinsi

Entry informationi

Entry nameiQ5SLI2_THET8
AccessioniPrimary (citable) accession number: Q5SLI2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health