Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 2

Gene

TTHA0311

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi162Copper ACombined sources1
Metal bindingi197Copper ACombined sources1
Metal bindingi199Copper A; via carbonyl oxygenCombined sources1
Metal bindingi201Copper ACombined sources1
Metal bindingi208Copper ACombined sources1
Binding sitei247Heme (covalent)Combined sources1
Binding sitei250Heme (covalent)Combined sources1
Metal bindingi251Iron (heme axial ligand); via tele nitrogenCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotationCombined sources, HemePROSITE-ProRule annotationCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-321-MONOMER.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0311Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 62HelicalSequence analysisAdd BLAST26
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-59902N.
STRINGi300852.TTHA0311.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortaliQ5SLI2.
SMRiQ5SLI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 113COX2_TMInterPro annotationAdd BLAST98
Domaini114 – 226COX2_CUAInterPro annotationAdd BLAST113
Domaini234 – 325Cytochrome cInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
KOiK02275.
OMAiKMTGTYP.
PhylomeDBiQ5SLI2.

Family and domain databases

CDDicd04213. CuRO_CcO_Caa3_II. 1 hit.
Gene3Di1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR034236. CuRO_CcO_Caa3_II.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SLI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF
60 70 80 90 100
LVVAGSLAYV TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG
110 120 130 140 150
LTAKALIQVN RPIPGAMKVE VTGYQFWWDF HYPELGLRNS NELVLPAGVP
160 170 180 190 200
VELEITSKDV IHSFWVPGLA GKRDAIPGQT TRISFEPKEP GLYYGFCAEL
210 220 230 240 250
CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ QVFQQNCAAC
260 270 280 290 300
HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG
310 320 330
VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF
Length:337
Mass (Da):37,351
Last modified:December 21, 2004 - v1
Checksum:iF97FF0A8FB9B5819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70134.1.
RefSeqiWP_011227850.1. NC_006461.1.
YP_143577.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70134; BAD70134; BAD70134.
GeneIDi3169690.
KEGGittj:TTHA0311.
PATRICifig|300852.9.peg.311.

Similar proteinsi

Entry informationi

Entry nameiQ5SLI2_THET8
AccessioniPrimary (citable) accession number: Q5SLI2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported