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Q5SLI2

- Q5SLI2_THET8

UniProt

Q5SLI2 - Q5SLI2_THET8

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Protein

Cytochrome c oxidase subunit 2

Gene

TTHA0311

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi162 – 1621Copper A; via pros nitrogenCombined sources
Metal bindingi197 – 1971Copper ACombined sources
Metal bindingi199 – 1991Copper A; via carbonyl oxygenCombined sources
Metal bindingi201 – 2011Copper ACombined sources
Metal bindingi205 – 2051Copper A; via pros nitrogenCombined sources
Metal bindingi208 – 2081Copper ACombined sources
Binding sitei247 – 2471Heme (covalent)Combined sources
Binding sitei250 – 2501Heme (covalent)Combined sources
Metal bindingi251 – 2511Iron (heme axial ligand); via tele nitrogenCombined sources
Metal bindingi303 – 3031Iron (heme axial ligand)Combined sources

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotation, HemeCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-325-MONOMER.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0311Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-59902N.
STRINGi300852.TTHA0311.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortaliQ5SLI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiCOG2857.
HOGENOMiHOG000268576.
KOiK02275.
OMAiKMTGTYP.
OrthoDBiEOG6S52JN.
PhylomeDBiQ5SLI2.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF
60 70 80 90 100
LVVAGSLAYV TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG
110 120 130 140 150
LTAKALIQVN RPIPGAMKVE VTGYQFWWDF HYPELGLRNS NELVLPAGVP
160 170 180 190 200
VELEITSKDV IHSFWVPGLA GKRDAIPGQT TRISFEPKEP GLYYGFCAEL
210 220 230 240 250
CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ QVFQQNCAAC
260 270 280 290 300
HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG
310 320 330
VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF
Length:337
Mass (Da):37,351
Last modified:December 21, 2004 - v1
Checksum:iF97FF0A8FB9B5819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70134.1.
RefSeqiYP_143577.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70134; BAD70134; BAD70134.
GeneIDi3169690.
KEGGittj:TTHA0311.
PATRICi23955578. VBITheThe93045_0311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70134.1 .
RefSeqi YP_143577.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YEV X-ray 2.36 B/E 1-337 [» ]
ProteinModelPortali Q5SLI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59902N.
STRINGi 300852.TTHA0311.

Protein family/group databases

TCDBi 3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70134 ; BAD70134 ; BAD70134 .
GeneIDi 3169690.
KEGGi ttj:TTHA0311.
PATRICi 23955578. VBITheThe93045_0311.

Phylogenomic databases

eggNOGi COG2857.
HOGENOMi HOG000268576.
KOi K02275.
OMAi KMTGTYP.
OrthoDBi EOG6S52JN.
PhylomeDBi Q5SLI2.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-325-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view ]
SUPFAMi SSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  2. "Structural insights into electron transfer in caa3-type cytochrome oxidase."
    Lyons J.A., Aragao D., Slattery O., Pisliakov A.V., Soulimane T., Caffrey M.
    Nature 487:514-518(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) IN COMPLEX WITH COPPER A AND HEME.

Entry informationi

Entry nameiQ5SLI2_THET8
AccessioniPrimary (citable) accession number: Q5SLI2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.