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Q5SLI2

- Q5SLI2_THET8

UniProt

Q5SLI2 - Q5SLI2_THET8

Protein

Cytochrome c oxidase subunit 2

Gene

TTHA0311

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).UniRule annotation
    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

    Cofactori

    Copper A.UniRule annotation
    Copper A By similarity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi162 – 1621Copper A; via pros nitrogenImported
    Metal bindingi197 – 1971Copper AImported
    Metal bindingi199 – 1991Copper A; via carbonyl oxygenImported
    Metal bindingi201 – 2011Copper AImported
    Metal bindingi205 – 2051Copper A; via pros nitrogenImported
    Metal bindingi208 – 2081Copper AImported
    Binding sitei247 – 2471Heme (covalent)Imported
    Binding sitei250 – 2501Heme (covalent)Imported
    Metal bindingi251 – 2511Iron (heme axial ligand); via tele nitrogenImported
    Metal bindingi303 – 3031Iron (heme axial ligand)Imported

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Electron transport, Respiratory chainUniRule annotation, Transport

    Keywords - Ligandi

    CopperUniRule annotation, HemeImported, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-325-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:TTHA0311Imported
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59902N.
    STRINGi300852.TTHA0311.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YEVX-ray2.36B/E1-337[»]
    ProteinModelPortaliQ5SLI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2857.
    HOGENOMiHOG000268576.
    KOiK02275.
    OMAiFWIPSVG.
    OrthoDBiEOG6S52JN.
    PhylomeDBiQ5SLI2.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    1.10.760.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR009056. Cyt_c-like_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    PF13442. Cytochrome_CBB3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46626. SSF46626. 1 hit.
    SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    PS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SLI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF    50
    LVVAGSLAYV TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG 100
    LTAKALIQVN RPIPGAMKVE VTGYQFWWDF HYPELGLRNS NELVLPAGVP 150
    VELEITSKDV IHSFWVPGLA GKRDAIPGQT TRISFEPKEP GLYYGFCAEL 200
    CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ QVFQQNCAAC 250
    HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG 300
    VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF 337
    Length:337
    Mass (Da):37,351
    Last modified:December 21, 2004 - v1
    Checksum:iF97FF0A8FB9B5819
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70134.1.
    RefSeqiWP_011227850.1. NC_006461.1.
    YP_143577.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70134; BAD70134; BAD70134.
    GeneIDi3169690.
    KEGGittj:TTHA0311.
    PATRICi23955578. VBITheThe93045_0311.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70134.1 .
    RefSeqi WP_011227850.1. NC_006461.1.
    YP_143577.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YEV X-ray 2.36 B/E 1-337 [» ]
    ProteinModelPortali Q5SLI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59902N.
    STRINGi 300852.TTHA0311.

    Protein family/group databases

    TCDBi 3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70134 ; BAD70134 ; BAD70134 .
    GeneIDi 3169690.
    KEGGi ttj:TTHA0311.
    PATRICi 23955578. VBITheThe93045_0311.

    Phylogenomic databases

    eggNOGi COG2857.
    HOGENOMi HOG000268576.
    KOi K02275.
    OMAi FWIPSVG.
    OrthoDBi EOG6S52JN.
    PhylomeDBi Q5SLI2.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-325-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    1.10.760.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR009056. Cyt_c-like_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    PF13442. Cytochrome_CBB3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46626. SSF46626. 1 hit.
    SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579Imported.
    2. "Structural insights into electron transfer in caa3-type cytochrome oxidase."
      Lyons J.A., Aragao D., Slattery O., Pisliakov A.V., Soulimane T., Caffrey M.
      Nature 487:514-518(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) IN COMPLEX WITH COPPER A AND HEME.

    Entry informationi

    Entry nameiQ5SLI2_THET8
    AccessioniPrimary (citable) accession number: Q5SLI2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3