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Q5SLI2 (Q5SLI2_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2 RuleBase RU004024

EC=1.9.3.1 RuleBase RU004024
Gene names
Ordered Locus Names:TTHA0311 EMBL BAD70134.1
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP] EMBL BAD70134.1
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity RuleBase RU000456.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family. RuleBase RU000456

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1621Copper A; via pros nitrogen PDB 2YEV
Metal binding1971Copper A PDB 2YEV
Metal binding1991Copper A; via carbonyl oxygen PDB 2YEV
Metal binding2011Copper A PDB 2YEV
Metal binding2051Copper A; via pros nitrogen PDB 2YEV
Metal binding2081Copper A PDB 2YEV
Metal binding2511Iron (heme axial ligand); via tele nitrogen PDB 2YEV
Metal binding3031Iron (heme axial ligand) PDB 2YEV
Binding site2471Heme (covalent) PDB 2YEV
Binding site2501Heme (covalent) PDB 2YEV

Sequences

Sequence LengthMass (Da)Tools
Q5SLI2 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: F97FF0A8FB9B5819

FASTA33737,351
        10         20         30         40         50         60 
MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF LVVAGSLAYV 

        70         80         90        100        110        120 
TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG LTAKALIQVN RPIPGAMKVE 

       130        140        150        160        170        180 
VTGYQFWWDF HYPELGLRNS NELVLPAGVP VELEITSKDV IHSFWVPGLA GKRDAIPGQT 

       190        200        210        220        230        240 
TRISFEPKEP GLYYGFCAEL CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ 

       250        260        270        280        290        300 
QVFQQNCAAC HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG 

       310        320        330 
VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Structural insights into electron transfer in caa3-type cytochrome oxidase."
Lyons J.A., Aragao D., Slattery O., Pisliakov A.V., Soulimane T., Caffrey M.
Nature 487:514-518(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) IN COMPLEX WITH COPPER A AND HEME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD70134.1.
RefSeqYP_143577.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortalQ5SLI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59902N.
STRING300852.TTHA0311.

Protein family/group databases

TCDB3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70134; BAD70134; BAD70134.
GeneID3169690.
KEGGttj:TTHA0311.
PATRIC23955578. VBITheThe93045_0311.

Phylogenomic databases

eggNOGCOG2857.
HOGENOMHOG000268576.
KOK02275.
OMAKMTGTYP.
OrthoDBEOG6S52JN.
ProtClustDBCLSK738613.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-325-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
SUPFAMSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5SLI2_THET8
AccessionPrimary (citable) accession number: Q5SLI2
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)