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Q5SLI2

- Q5SLI2_THET8

UniProt

Q5SLI2 - Q5SLI2_THET8

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Protein
Cytochrome c oxidase subunit 2
Gene
TTHA0311
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi162 – 1621Copper A; via pros nitrogenImported
Metal bindingi197 – 1971Copper AImported
Metal bindingi199 – 1991Copper A; via carbonyl oxygenImported
Metal bindingi201 – 2011Copper AImported
Metal bindingi205 – 2051Copper A; via pros nitrogenImported
Metal bindingi208 – 2081Copper AImported
Binding sitei247 – 2471Heme (covalent)Imported
Binding sitei250 – 2501Heme (covalent)Imported
Metal bindingi251 – 2511Iron (heme axial ligand); via tele nitrogenImported
Metal bindingi303 – 3031Iron (heme axial ligand)Imported

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CopperUniRule annotationImported, HemeImported, Iron, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-325-MONOMER.

Protein family/group databases

TCDBi3.D.4.4.3. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0311Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-59902N.
STRINGi300852.TTHA0311.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YEVX-ray2.36B/E1-337[»]
ProteinModelPortaliQ5SLI2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiCOG2857.
HOGENOMiHOG000268576.
KOiK02275.
OMAiFWIPSVG.
OrthoDBiEOG6S52JN.
PhylomeDBiQ5SLI2.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SLI2-1 [UniParc]FASTAAdd to Basket

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MQRSFAALGL WGLSLAQEAH RVAITHPGGS FNQEVAFLFP WVYFFSFLIF    50
LVVAGSLAYV TWKFRARPED QEEPPQIHGN DRLEVVWTLI PLAIVFVLFG 100
LTAKALIQVN RPIPGAMKVE VTGYQFWWDF HYPELGLRNS NELVLPAGVP 150
VELEITSKDV IHSFWVPGLA GKRDAIPGQT TRISFEPKEP GLYYGFCAEL 200
CGASHARMLF RVVVLPKEEF DRFVEAAKAS PAPVADERGQ QVFQQNCAAC 250
HGVARSMPPA VIGPELGLWG NRTSLGAGIV ENTPENLKAW IRDPAGMKPG 300
VKMPGFPQLS EEDLDALVRY LEGLKVEGFD FGALPKF 337
Length:337
Mass (Da):37,351
Last modified:December 21, 2004 - v1
Checksum:iF97FF0A8FB9B5819
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70134.1.
RefSeqiWP_011227850.1. NC_006461.1.
YP_143577.1. NC_006461.1.