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Q5SLE7

- Q5SLE7_THET8

UniProt

Q5SLE7 - Q5SLE7_THET8

Protein

Peptidyl-prolyl cis-trans isomerase

Gene

TTHA0346

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621Succinate; via carbonyl oxygenImported
    Metal bindingi145 – 1451Nickel; via pros nitrogen
    Metal bindingi145 – 1451Zinc; via pros nitrogenImported
    Metal bindingi147 – 1471Nickel; via tele nitrogen
    Metal bindingi147 – 1471Zinc; via tele nitrogenImported
    Metal bindingi149 – 1491Nickel; via tele nitrogen
    Metal bindingi149 – 1491Zinc; via tele nitrogenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, RotamaseUniRule annotation

    Keywords - Ligandi

    Metal-bindingImported, ZincImported

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-363-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
    Gene namesi
    Ordered Locus Names:TTHA0346Imported
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA0346.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CGMX-ray2.41A1-149[»]
    3CGNX-ray2.70A1-149[»]
    3LUOX-ray2.55A1-149[»]
    ProteinModelPortaliQ5SLE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SLE7.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1047.
    HOGENOMiHOG000154889.
    KOiK03775.
    OMAiHMLAGQT.
    OrthoDBiEOG6Q8J79.
    PhylomeDBiQ5SLE7.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SLE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVGQDKVVT IRYTLQVEGE VLDQGELSYL HGHRNLIPGL EEALEGREEG    50
    EAFQAHVPAE KAYGPHDPEG VQVVPLSAFP EDAEVVPGAQ FYAQDMEGNP 100
    MPLTVVAVEG EEVTVDFNHP LAGKDLDFQV EVVKVREATP EELLHGHAH 149
    Length:149
    Mass (Da):16,313
    Last modified:December 21, 2004 - v1
    Checksum:iFE9ABD7980C37C76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70169.1.
    RefSeqiYP_143612.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70169; BAD70169; BAD70169.
    GeneIDi3168679.
    KEGGittj:TTHA0346.
    PATRICi23955654. VBITheThe93045_0346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70169.1 .
    RefSeqi YP_143612.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CGM X-ray 2.41 A 1-149 [» ]
    3CGN X-ray 2.70 A 1-149 [» ]
    3LUO X-ray 2.55 A 1-149 [» ]
    ProteinModelPortali Q5SLE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70169 ; BAD70169 ; BAD70169 .
    GeneIDi 3168679.
    KEGGi ttj:TTHA0346.
    PATRICi 23955654. VBITheThe93045_0346.

    Phylogenomic databases

    eggNOGi COG1047.
    HOGENOMi HOG000154889.
    KOi K03775.
    OMAi HMLAGQT.
    OrthoDBi EOG6Q8J79.
    PhylomeDBi Q5SLE7.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-363-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SLE7.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579Imported.
    2. "Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus."
      Low C., Neumann P., Tidow H., Weininger U., Haupt C., Friedrich-Epler B., Scholz C., Stubbs M.T., Balbach J.
      J. Mol. Biol. 398:375-390(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) IN COMPLEX WITH SUCCINATE AND ZINC.

    Entry informationi

    Entry nameiQ5SLE7_THET8
    AccessioniPrimary (citable) accession number: Q5SLE7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3