Q5SLE6 (Q5SLE6_THET8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cysteine synthase RuleBase RU003985
EC=2.5.1.47 RuleBase RU003985

Gene names

Ordered Locus Names:

TTHA0347

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	O(3)-acetyl-L-serine + H2S = L-cysteine + acetate. RuleBase RU003985
Sequence similarities	Belongs to the cysteine synthase/cystathionine beta-synthase family. RuleBase RU003985

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis RuleBase RU003985
Ligand	Pyridoxal phosphate PDB 1VE1 PDB 2ECO PDB 2ECQ PDB 2EFY
Molecular function	Lyase EMBL BAD70170.1 Transferase RuleBase RU003985
Technical term	3D-structure PDB 1VE1 PDB 2ECO PDB 2ECQ PDB 2EFY Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cysteine biosynthetic process from serine Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	40	1	Pyridoxal phosphate PDB 1VE1 PDB 2ECO PDB 2ECQ PDB 2EFY

Sequences

	Sequence		Length	Mass (Da)
	Q5SLE6 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: AF36091F5AE76360	FASTA	304	33,025
	10 20 30 40 50 60 MRVEGAIGKT PVVRLAKVVE PDMAEVWVKL EGLNPGGSIK DRPAWYMIKD AEERGILRPG 70 80 90 100 110 120 SGQVIVEPTS GNTGIGLAMI AASRGYRLIL TMPAQMSEER KRVLKAFGAE LVLTDPERRM 130 140 150 160 170 180 LAAREEALRL KEELGAFMPD QFKNPANVRA HYETTGPELY EALEGRIDAF VYGSGTGGTI 190 200 210 220 230 240 TGVGRYLKER IPHVKVIAVE PARSNVLSGG KMGQHGFQGM GPGFIPENLD LSLLDGVIQV 250 260 270 280 290 300 WEEDAFPLAR RLAREEGLFL GMSSGGIVWA ALQVARELGP GKRVACISPD GGWKYLSTPL YAEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Crystal Structure of T.th. HB8 O-acetylserine sulfhydrylase." Goto M. Submitted (MAR-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-40.
[3]	"Crystal Structure of T.th. HB8 O-acetylserine sulfhydrylase Complexed with 4-methylvalerate." Goto M. Submitted (FEB-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-40.
[4]	"Crystal Structure of T.th. HB8 O-acetylserine sulfhydrylase Complexed with 3-Hydroxylactate." Goto M. Submitted (FEB-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-40.
[5]	"Crystal Structure of T.th. HB8 O-acetylserine sulfhydrylase Complexed with 4-Acetylbutyric acid." Goto M. Submitted (FEB-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-40.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008226 Genomic DNA. Translation: BAD70170.1.

RefSeq

YP_143613.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VE1	X-ray	1.45	A	1-304	[»]
2ECO	X-ray	1.90	A	1-304	[»]
2ECQ	X-ray	1.90	A	1-304	[»]
2EFY	X-ray	2.35	A/B	1-304	[»]

ProteinModelPortal

Q5SLE6.

SMR

Q5SLE6. Positions 1-302.

ModBase

Search...

Protein-protein interaction databases

STRING

Q5SLE6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3168884.

GenomeReviews

Gene locus TTHA0347 in contig AP008226_GR.

KEGG

ttj:TTHA0347.

NMPDR

fig|300852.3.peg.378.

PATRIC

23955656. VBITheThe93045_0347.

Phylogenomic databases

eggNOG

COG0031.

HOGENOM

HBG748215.

OMA

PERRMLA.

PhylomeDB

Q5SLE6.

ProtClustDB

CLSK444716.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA0347-MONOMER.

Family and domain databases

InterPro

IPR001216. Cys_synth_BS.
IPR005856. Cys_synthKM.
IPR005859. CysK.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]

KO

K01738.

Pfam

PF00291. PALP. 1 hit.
[Graphical view]

SUPFAM

SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.

TIGRFAMs

TIGR01139. CysK. 1 hit.
TIGR01136. CysKM. 1 hit.

PROSITE

PS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q5SLE6_THET8

Accession

Primary (citable) accession number: Q5SLE6

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)