Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methyltransferase

Gene

TTHA0409

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi29 – 291Iron-sulfur (4Fe-4S-S-AdoMet); via amide nitrogenCombined sources
Metal bindingi47 – 471Iron-sulfur (4Fe-4S-S-AdoMet); via carbonyl oxygenCombined sources
Metal bindingi219 – 2191Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi220 – 2201Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi243 – 2431Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi244 – 2441Iron-sulfur (4Fe-4S-S-AdoMet); via carbonyl oxygenCombined sources
Metal bindingi245 – 2451Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi246 – 2461Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi248 – 2481Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources
Metal bindingi264 – 2641Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, Transferase

Keywords - Ligandi

4Fe-4SCombined sources, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-430-MONOMER.

Protein family/group databases

REBASEi10545. M.TthHB8ORF409P.

Names & Taxonomyi

Protein namesi
Recommended name:
MethyltransferaseUniRule annotation (EC:2.1.1.-UniRule annotation)
Gene namesi
Ordered Locus Names:TTHA0409Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0409.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZIEX-ray2.50A/B1-297[»]
2ZIFX-ray2.40A/B1-297[»]
2ZIGX-ray2.10A/B1-297[»]
ProteinModelPortaliQ5SL84.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SL84.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 275235N6_N4_MtaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108M6F. Bacteria.
COG0863. LUCA.
HOGENOMiHOG000004191.
OMAiVWNEGNI.
OrthoDBiEOG6GXTTS.
PhylomeDBiQ5SL84.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SL84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSFPKAKEA FSEGEKVSFG VHRLHVGDAR EVLASFPEAS VHLVVTSPPY
60 70 80 90 100
WTLKRYEDTP GQLGHIEDYE AFLDELDRVW REVFRLLVPG GRLVIVVGDV
110 120 130 140 150
AVARRRFGRH LVFPLHADIQ VRCRKLGFDN LNPIIWHKHT NASLEVEGRG
160 170 180 190 200
VFLGKPYEPG AIIKTEIEYI LMQRKPGGYR KPTQEQREKS RLPKEDFHRF
210 220 230 240 250
FRQIWDDIPG ESTKDHPAPF PLELAERLVR MFSFVGDVVL DPFAGTGTTL
260 270 280 290
IAAARWGRRA LGVELVPRYA QLAKERFARE VPGFSLEVLD GATHPRR
Length:297
Mass (Da):33,968
Last modified:December 21, 2004 - v1
Checksum:iC21FA15EF9C87F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70232.1.
RefSeqiWP_011227916.1. NC_006461.1.
YP_143675.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70232; BAD70232; BAD70232.
GeneIDi3168950.
KEGGittj:TTHA0409.
PATRICi23955789. VBITheThe93045_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70232.1.
RefSeqiWP_011227916.1. NC_006461.1.
YP_143675.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZIEX-ray2.50A/B1-297[»]
2ZIFX-ray2.40A/B1-297[»]
2ZIGX-ray2.10A/B1-297[»]
ProteinModelPortaliQ5SL84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0409.

Protein family/group databases

REBASEi10545. M.TthHB8ORF409P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70232; BAD70232; BAD70232.
GeneIDi3168950.
KEGGittj:TTHA0409.
PATRICi23955789. VBITheThe93045_0409.

Phylogenomic databases

eggNOGiENOG4108M6F. Bacteria.
COG0863. LUCA.
HOGENOMiHOG000004191.
OMAiVWNEGNI.
OrthoDBiEOG6GXTTS.
PhylomeDBiQ5SL84.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-430-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SL84.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR017985. MeTrfase_CN4_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00093. N4_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  2. "Crystal structure of a putative DNA methylase TTHA0409 from Thermus thermophilus HB8."
    Morita R., Ishikawa H., Nakagawa N., Kuramitsu S., Masui R.
    Proteins 73:259-264(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S-S-ADOMET).

Entry informationi

Entry nameiQ5SL84_THET8
AccessioniPrimary (citable) accession number: Q5SL84
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.