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Protein

Cytidylate kinase

Gene

cmk

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-479-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:cmkUniRule annotation
Ordered Locus Names:TTHA0458
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Cytidylate kinasePRO_1000048310Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0458.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi15 – 2612Combined sources
Beta strandi30 – 323Combined sources
Helixi33 – 4715Combined sources
Helixi54 – 6310Combined sources
Beta strandi67 – 693Combined sources
Beta strandi76 – 794Combined sources
Helixi85 – 873Combined sources
Beta strandi88 – 903Combined sources
Helixi91 – 10111Combined sources
Helixi104 – 11613Combined sources
Beta strandi121 – 1277Combined sources
Helixi128 – 1325Combined sources
Beta strandi137 – 1437Combined sources
Helixi146 – 15510Combined sources
Beta strandi157 – 1593Combined sources
Helixi161 – 17313Combined sources
Helixi176 – 1783Combined sources
Beta strandi186 – 1894Combined sources
Turni190 – 1923Combined sources
Helixi195 – 20713Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AKCX-ray1.65A1-208[»]
3AKDX-ray1.60A1-208[»]
3AKEX-ray1.50A1-208[»]
3W8NX-ray2.20A1-208[»]
3W90X-ray1.65A1-208[»]
ProteinModelPortaliQ5SL35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
HOGENOMiHOG000242849.
KOiK00945.
OMAiLKIFMTA.
OrthoDBiEOG6WDSMP.
PhylomeDBiQ5SL35.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SL35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGIVTIDGP SASGKSSVAR RVAAALGVPY LSSGLLYRAA AFLALRAGVD
60 70 80 90 100
PGDEEGLLAL LEGLGVRLLA QAEGNRVLAD GEDLTSFLHT PEVDRVVSAV
110 120 130 140 150
ARLPGVRAWV NRRLKEVPPP FVAEGRDMGT AVFPEAAHKF YLTASPEVRA
160 170 180 190 200
WRRARERPQA YEEVLRDLLR RDERDKAQSA PAPDALVLDT GGMTLDEVVA

WVLAHIRR
Length:208
Mass (Da):22,554
Last modified:December 21, 2004 - v1
Checksum:i9D3B0F6BB95E0B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70281.1.
RefSeqiWP_011227951.1. NC_006461.1.
YP_143724.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70281; BAD70281; BAD70281.
GeneIDi3170130.
KEGGittj:TTHA0458.
PATRICi23955885. VBITheThe93045_0457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70281.1.
RefSeqiWP_011227951.1. NC_006461.1.
YP_143724.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AKCX-ray1.65A1-208[»]
3AKDX-ray1.60A1-208[»]
3AKEX-ray1.50A1-208[»]
3W8NX-ray2.20A1-208[»]
3W90X-ray1.65A1-208[»]
ProteinModelPortaliQ5SL35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70281; BAD70281; BAD70281.
GeneIDi3170130.
KEGGittj:TTHA0458.
PATRICi23955885. VBITheThe93045_0457.

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
HOGENOMiHOG000242849.
KOiK00945.
OMAiLKIFMTA.
OrthoDBiEOG6WDSMP.
PhylomeDBiQ5SL35.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-479-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiKCY_THET8
AccessioniPrimary (citable) accession number: Q5SL35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.