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Q5SL28 (FENR_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferredoxin--NADP reductase

Short name=FNR
Short name=Fd-NADP(+) reductase
EC=1.18.1.2
Gene names
Ordered Locus Names:TTHA0465
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP-Rule MF_01685

Cofactor

Binds 1 FAD per subunit. Ref.2

Subunit structure

Homodimer. Ref.2

Sequence similarities

Belongs to the ferredoxin--NADP reductase type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Ferredoxin--NADP reductase HAMAP-Rule MF_01685
PRO_0000364981

Sites

Binding site161FAD
Binding site351FAD
Binding site431FAD
Binding site481FAD
Binding site881FAD; via amide nitrogen and carbonyl oxygen
Binding site1221FAD; via amide nitrogen
Binding site2871FAD
Binding site3281FAD

Secondary structure

............................................................... 335
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SL28 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: F0C4631F805520C0

FASTA33536,207
        10         20         30         40         50         60 
MAADHTDVLI VGAGPTGLFA GFYVGMRGLS FRFVDPLPEP GGQLTALYPE KYIYDVAGFP 

        70         80         90        100        110        120 
KVYAKDLVKG LVEQVAPFNP VYSLGERAET LEREGDLFKV TTSQGNAYTA KAVIIAAGVG 

       130        140        150        160        170        180 
AFEPRRIGAP GEREFEGRGV YYAVKSKAEF QGKRVLIVGG GDSAVDWALN LLDTARRITL 

       190        200        210        220        230        240 
IHRRPQFRAH EASVKELMKA HEEGRLEVLT PYELRRVEGD ERVRWAVVFH NQTQEELALE 

       250        260        270        280        290        300 
VDAVLILAGY ITKLGPLANW GLALEKNKIK VDTTMATSIP GVYACGDIVT YPGKLPLIVL 

       310        320        330 
GFGEAAIAAN HAAAYANPAL KVNPGHSSEK AAPGT 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Crystal structure of thioredoxin reductase-like protein from Thermus thermophilus HB8."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH FAD, COFACTOR, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD70288.1.
RefSeqYP_143731.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZBWX-ray2.10A/B1-335[»]
ProteinModelPortalQ5SL28.
SMRQ5SL28. Positions 2-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA0465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70288; BAD70288; BAD70288.
GeneID3169949.
KEGGttj:TTHA0465.
PATRIC23955901. VBITheThe93045_0464.

Phylogenomic databases

eggNOGCOG0492.
HOGENOMHOG000072909.
KOK00384.
OMAESMPQLG.
OrthoDBEOG661H9M.
ProtClustDBCLSK738278.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-487-MONOMER.

Family and domain databases

HAMAPMF_01685. FENR2.
InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNetSearch...

Other

EvolutionaryTraceQ5SL28.

Entry information

Entry nameFENR_THET8
AccessionPrimary (citable) accession number: Q5SL28
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references