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Protein

Glycine cleavage system H protein

Gene

gcvH

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.UniRule annotation

Cofactori

(R)-lipoateUniRule annotation1 PublicationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation1 Publication

GO - Biological processi

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-541-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine cleavage system H proteinUniRule annotation
Gene namesi
Name:gcvHUniRule annotation
Ordered Locus Names:TTHA0524
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003024581 – 128Glycine cleavage system H proteinAdd BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-lipoyllysineUniRule annotation1 Publication1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity). Monomer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA0524

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Beta strandi13 – 19Combined sources7
Beta strandi22 – 27Combined sources6
Helixi29 – 35Combined sources7
Beta strandi37 – 42Combined sources6
Beta strandi55 – 69Combined sources15
Beta strandi71 – 79Combined sources9
Helixi82 – 85Combined sources4
Helixi89 – 92Combined sources4
Turni94 – 98Combined sources5
Beta strandi101 – 106Combined sources6
Helixi108 – 113Combined sources6
Helixi117 – 126Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ONLX-ray2.50A/B/C1-128[»]
ProteinModelPortaliQ5SKW9
SMRiQ5SKW9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SKW9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 104Lipoyl-bindingPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the GcvH family.UniRule annotation

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiENOG4105KE9 Bacteria
COG0509 LUCA
HOGENOMiHOG000239392
KOiK02437
OMAiIVYVEVE
PhylomeDBiQ5SKW9

Family and domain databases

CDDicd06848 GCS_H, 1 hit
HAMAPiMF_00272 GcvH, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR000089 Biotin_lipoyl
IPR002930 GCV_H
IPR033753 GCV_H/Fam206
IPR017453 GCV_H_sub
IPR011053 Single_hybrid_motif
PANTHERiPTHR11715 PTHR11715, 1 hit
PfamiView protein in Pfam
PF01597 GCV_H, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR00527 gcvH, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SKW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIPKDRFYT KTHEWALPEG DTVLVGITDY AQDALGDVVY VELPEVGRVV
60 70 80 90 100
EKGEAVAVVE SVKTASDIYA PVAGEIVEVN LALEKTPELV NQDPYGEGWI
110 120
FRLKPRDMGD LDELLDAGGY QEVLESEA
Length:128
Mass (Da):14,083
Last modified:December 21, 2004 - v1
Checksum:i9A93A6CA42B4DD4E
GO

Mass spectrometryi

Molecular mass is 14083 Da from positions 1 - 128. Determined by MALDI. Unlipoylated protein.1 Publication
Molecular mass is 14273 Da from positions 1 - 128. Determined by MALDI. Lipoylated protein.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD70347.1
RefSeqiWP_011228002.1, NC_006461.1
YP_143790.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD70347; BAD70347; BAD70347
GeneIDi3169107
KEGGittj:TTHA0524
PATRICifig|300852.9.peg.522

Similar proteinsi

Entry informationi

Entry nameiGCSH_THET8
AccessioniPrimary (citable) accession number: Q5SKW9
Secondary accession number(s): P83697
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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