TTHA0533

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	8	S-adenosyl-L-homocysteineCombined sources	1
Binding siteⁱ	207	S-adenosyl-L-homocysteineCombined sources	1
Metal bindingⁱ	216	Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources	1
Binding siteⁱ	216	S-adenosyl-L-homocysteineCombined sources	1
Metal bindingⁱ	241	Iron-sulfur (4Fe-4S-S-AdoMet); via carbonyl oxygenCombined sources	1
Binding siteⁱ	241	S-adenosyl-L-homocysteine; via carbonyl oxygenCombined sources	1
Metal bindingⁱ	262	Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources	1
Metal bindingⁱ	288	Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources	1
Metal bindingⁱ	289	Iron-sulfur (4Fe-4S-S-AdoMet); via amide nitrogenCombined sources	1
Binding siteⁱ	307	S-adenosyl-L-homocysteineCombined sources	1

GO - Molecular functionⁱ

4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro
rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	MethyltransferaseSAAS annotationImported, Transferase
Biological process	rRNA processingSAAS annotation
Ligand	4Fe-4SCombined sources, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCycⁱ	TTHE300852:GH8R-546-MONOMER.

BioCycⁱ

TTHE300852:GH8R-546-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Probable ribosomal RNA small subunit methyltransferaseImported
Gene namesⁱ	Ordered Locus Names:TTHA0533Imported
Organismⁱ	Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifierⁱ	300852 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › Thermus thermophilus
Proteomesⁱ	UP000000532 Componentⁱ: Chromosome

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	300852.TTHA0533.

STRINGⁱ

300852.TTHA0533.

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZUL	X-ray	1.80	A	1-375	[»]
	2ZWV	X-ray	2.00	A	1-375	[»]
	3DMF	X-ray	1.58	A	1-375	[»]
	3DMG	X-ray	1.55	A	1-375	[»]
	3DMH	X-ray	1.55	A	1-375	[»]
ProteinModelPortalⁱ	Q5SKW0.
SMRⁱ	Q5SKW0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q5SKW0.

EvolutionaryTraceⁱ

Q5SKW0.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	197 – 368	MTSInterPro annotationAdd BLAST		172

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	262 – 263	S-adenosyl-L-homocysteine bindingCombined sources		2
Regionⁱ	288 – 289	S-adenosyl-L-homocysteine bindingCombined sources		2

Phylogenomic databases

eggNOGⁱ	ENOG4107S8D. Bacteria. COG2813. LUCA.
HOGENOMⁱ	HOG000099293.
KEGG Orthology (KO) More...KOⁱ	K00564.
OMAⁱ	TNPPFHV.
PhylomeDBⁱ	Q5SKW0.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002052. DNA_methylase_N6_adenine_CS. IPR020596. rRNA_Ade_Mease_Trfase_CS. IPR029063. SAM-dependent_MTases. IPR007848. Small_mtfrase_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05175. MTS. 1 hit.
SUPFAMⁱ	SSF53335. SSF53335. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00092. N6_MTASE. 1 hit. PS01131. RRNA_A_DIMETH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5SKW0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLTREAYHR LTPLPHPGGR LFIKPGARGY RDPVHDLLQK TVEPFGERAL 
        60         70         80         90        100
DLNPGVGWGS LPLEGRMAVE RLETSRAAFR CLTASGLQAR LALPWEAAAG 
       110        120        130        140        150
AYDLVVLALP AGRGTAYVQA SLVAAARALR MGGRLYLAGD KNKGFERYFK 
       160        170        180        190        200
EARALLGYGV VVRREGPYRV ALLEKEKEAP PLPSLWRAFS ARILGAEYTF 
       210        220        230        240        250
HHLPGVFSAG KVDPASLLLL EALQERLGPE GVRGRQVLDL GAGYGALTLP 
       260        270        280        290        300
LARMGAEVVG VEDDLASVLS LQKGLEANAL KAQALHSDVD EALTEEARFD 
       310        320        330        340        350
IIVTNPPFHV GGAVILDVAQ AFVNVAAARL RPGGVFFLVS NPFLKYEPLL 
       360        370 
EEKFGAFQTL KVAEYKVLFA EKRGR

Length:375

Mass (Da):40,656

Last modified:December 21, 2004 - v1

Checksum:ⁱ7EF362A795A93C55

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP008226 Genomic DNA. Translation: BAD70356.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011228006.1. NC_006461.1. YP_143799.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaⁱ	BAD70356; BAD70356; BAD70356.
GeneIDⁱ	3169440.
KEGGⁱ	ttj:TTHA0533.
PATRICⁱ	fig\|300852.9.peg.532.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP008226 Genomic DNA. Translation: BAD70356.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011228006.1. NC_006461.1. YP_143799.1. NC_006461.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZUL	X-ray	1.80	A	1-375	[»]
	2ZWV	X-ray	2.00	A	1-375	[»]
	3DMF	X-ray	1.58	A	1-375	[»]
	3DMG	X-ray	1.55	A	1-375	[»]
	3DMH	X-ray	1.55	A	1-375	[»]
ProteinModelPortalⁱ	Q5SKW0.
SMRⁱ	Q5SKW0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	300852.TTHA0533.

STRINGⁱ

300852.TTHA0533.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAD70356; BAD70356; BAD70356.
GeneIDⁱ	3169440.
KEGGⁱ	ttj:TTHA0533.
PATRICⁱ	fig\|300852.9.peg.532.

Phylogenomic databases

eggNOGⁱ	ENOG4107S8D. Bacteria. COG2813. LUCA.
HOGENOMⁱ	HOG000099293.
KEGG Orthology (KO) More...KOⁱ	K00564.
OMAⁱ	TNPPFHV.
PhylomeDBⁱ	Q5SKW0.

Enzyme and pathway databases

BioCycⁱ	TTHE300852:GH8R-546-MONOMER.

BioCycⁱ

TTHE300852:GH8R-546-MONOMER.

Miscellaneous databases

EvolutionaryTraceⁱ	Q5SKW0.

EvolutionaryTraceⁱ

Q5SKW0.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002052. DNA_methylase_N6_adenine_CS. IPR020596. rRNA_Ade_Mease_Trfase_CS. IPR029063. SAM-dependent_MTases. IPR007848. Small_mtfrase_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05175. MTS. 1 hit.
SUPFAMⁱ	SSF53335. SSF53335. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00092. N6_MTASE. 1 hit. PS01131. RRNA_A_DIMETH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SKW0_THET8
Accessionⁱ	Q5SKW0Primary (citable) accession number: Q5SKW0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	July 5, 2017
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB - Q5SKW0 (Q5SKW0_THET8)

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Probable ribosomal RNA small subunit methyltransferase

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Functionⁱ

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Miscellaneous databases

Family & Domainsⁱ

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5SKW0 (Q5SKW0_THET8)

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Probable ribosomal RNA small subunit methyltransferase

TTHA0533

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ