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Q5SKU2

- IF3_THET8

UniProt

Q5SKU2 - IF3_THET8

Protein

Translation initiation factor IF-3

Gene

infC

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.

    GO - Molecular functioni

    1. translation initiation factor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-576-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-3UniRule annotation
    Gene namesi
    Name:infCUniRule annotation
    Ordered Locus Names:TTHA0551
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Translation initiation factor IF-3PRO_0000280033Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer. Binds to proteins S7, S11 and S18 of the small ribosomal subunit.

    Protein-protein interaction databases

    STRINGi300852.TTHA0551.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1I96X-ray4.20V83-171[»]
    ProteinModelPortaliQ5SKU2.
    SMRiQ5SKU2. Positions 2-77.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SKU2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IF-3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0290.
    HOGENOMiHOG000035157.
    KOiK02520.
    OMAiPRYNEFI.
    OrthoDBiEOG63JRGJ.

    Family and domain databases

    Gene3Di3.10.20.80. 1 hit.
    3.30.110.10. 1 hit.
    HAMAPiMF_00080. IF_3.
    InterProiIPR001288. Translation_initiation_fac_3.
    IPR019815. Translation_initiation_fac_3_C.
    IPR019814. Translation_initiation_fac_3_N.
    [Graphical view]
    PANTHERiPTHR10938. PTHR10938. 1 hit.
    PfamiPF00707. IF3_C. 1 hit.
    PF05198. IF3_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54364. SSF54364. 1 hit.
    SSF55200. SSF55200. 1 hit.
    TIGRFAMsiTIGR00168. infC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SKU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEYLTNERI RAKQVRVVGP DGKQLGIMDT REALRLAQEM DLDLVLVGPN    50
    ADPPVARIMD YSKWRYEQQM AEKEARKKAK RTEVKSIKFR VKIDEHDYQT 100
    KLGHIKRFLQ EGHKVKVTIM FRGREVAHPE LGERILNRVT EDLKDLAVVE 150
    MKPEMLGRDM NMLLAPVKVS A 171
    Length:171
    Mass (Da):19,866
    Last modified:March 6, 2007 - v2
    Checksum:i55954FFC1E365E29
    GO

    Sequence cautioni

    The sequence BAD70374.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70374.1. Different initiation.
    RefSeqiYP_143817.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70374; BAD70374; BAD70374.
    GeneIDi3168619.
    KEGGittj:TTHA0551.
    PATRICi23956079. VBITheThe93045_0550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70374.1 . Different initiation.
    RefSeqi YP_143817.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1I96 X-ray 4.20 V 83-171 [» ]
    ProteinModelPortali Q5SKU2.
    SMRi Q5SKU2. Positions 2-77.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70374 ; BAD70374 ; BAD70374 .
    GeneIDi 3168619.
    KEGGi ttj:TTHA0551.
    PATRICi 23956079. VBITheThe93045_0550.

    Phylogenomic databases

    eggNOGi COG0290.
    HOGENOMi HOG000035157.
    KOi K02520.
    OMAi PRYNEFI.
    OrthoDBi EOG63JRGJ.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-576-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SKU2.

    Family and domain databases

    Gene3Di 3.10.20.80. 1 hit.
    3.30.110.10. 1 hit.
    HAMAPi MF_00080. IF_3.
    InterProi IPR001288. Translation_initiation_fac_3.
    IPR019815. Translation_initiation_fac_3_C.
    IPR019814. Translation_initiation_fac_3_N.
    [Graphical view ]
    PANTHERi PTHR10938. PTHR10938. 1 hit.
    Pfami PF00707. IF3_C. 1 hit.
    PF05198. IF3_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54364. SSF54364. 1 hit.
    SSF55200. SSF55200. 1 hit.
    TIGRFAMsi TIGR00168. infC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    2. "Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3."
      Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H., Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A., Franceschi F.
      EMBO J. 20:1829-1839(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 83-171 WITH THE 30S RIBOSOMAL SUBUNIT.

    Entry informationi

    Entry nameiIF3_THET8
    AccessioniPrimary (citable) accession number: Q5SKU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Translation initiation factors
      List of translation initiation factor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3