Q5SKS6 (ACYP_THET8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acylphosphatase
EC=3.6.1.7

Alternative name(s):
Acylphosphate phosphohydrolase

Gene names

Name:	acyP
Ordered Locus Names:	TTHA0567

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	88 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate. HAMAP MF_01450
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 88

88

Acylphosphatase HAMAP MF_01450

PRO_0000326836

Regions

Domain

3 – 88

86

Acylphosphatase-like

Sites

Active site

18

1

By similarity

Active site

36

1

By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

88

Helix Strand Turn

Details...

Beta strand

4 – 9

6

Helix

18 – 27

10

Beta strand

33 – 36

4

Beta strand

42 – 47

6

Helix

50 – 61

12

Beta strand

71 – 75

5

Sequences

	Sequence		Length	Mass (Da)
	Q5SKS6 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: DFBD2365517774C7	FASTA	88	9,679
	10 20 30 40 50 60 MPRLVALVKG RVQGVGYRAF AQKKALELGL SGYAENLPDG RVEVVAEGPK EALELFLHHL 70 80 KQGPRLARVE AVEVQWGEEA GLKGFHVY

References

[1]

"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008226 Genomic DNA. Translation: BAD70390.1.

RefSeq

YP_143833.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ULR	X-ray	1.30	A	1-88	[»]

ProteinModelPortal

Q5SKS6.

SMR

Q5SKS6. Positions 2-88.

ModBase

Search...

Protein-protein interaction databases

STRING

Q5SKS6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3170007.

GenomeReviews

Gene locus TTHA0567 in contig AP008226_GR.

KEGG

ttj:TTHA0567.

PATRIC

23956111. VBITheThe93045_0566.

Phylogenomic databases

eggNOG

COG1254.

HOGENOM

HBG750266.

OMA

ALIGWAH.

PhylomeDB

Q5SKS6.

ProtClustDB

PRK14433.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA0567-MONOMER.

Family and domain databases

HAMAP

MF_01450. Acylphosphatase.
[Tree]

InterPro

IPR001792. Acylphosphatase-like.
[Graphical view]

KO

K01512.

Pfam

PF00708. Acylphosphatase. 1 hit.
[Graphical view]

SUPFAM

SSF54975. Acylphosphatase. 1 hit.

PROSITE

PS00150. ACYLPHOSPHATASE_1. False negative.
PS00151. ACYLPHOSPHATASE_2. False negative.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

ACYP_THET8

Accession

Primary (citable) accession number: Q5SKS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program