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Protein

Uridine kinase

Gene

udk

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + uridine = ADP + UMP.UniRule annotation
ATP + cytidine = ADP + CMP.UniRule annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-603-MONOMER.
BRENDAi2.7.1.48. 2305.
UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotation (EC:2.7.1.48UniRule annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udkUniRule annotation
Ordered Locus Names:TTHA0578
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Uridine kinasePRO_1000081978Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0578.

Structurei

Secondary structure

1
211
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 148Combined sources
Helixi19 – 3012Combined sources
Helixi31 – 333Combined sources
Beta strandi34 – 385Combined sources
Helixi39 – 413Combined sources
Helixi51 – 566Combined sources
Helixi62 – 643Combined sources
Helixi67 – 7812Combined sources
Beta strandi83 – 897Combined sources
Turni90 – 934Combined sources
Beta strandi94 – 1029Combined sources
Beta strandi106 – 1127Combined sources
Turni113 – 1164Combined sources
Helixi119 – 1224Combined sources
Beta strandi126 – 1327Combined sources
Helixi135 – 14915Combined sources
Helixi154 – 16310Combined sources
Helixi165 – 1717Combined sources
Helixi174 – 1796Combined sources
Beta strandi181 – 1866Combined sources
Helixi191 – 20919Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASYX-ray2.40A/B1-211[»]
3ASZX-ray2.25A/B1-211[»]
3W34X-ray1.91A/B1-211[»]
3W8RX-ray2.50A/B1-211[»]
ProteinModelPortaliQ5SKR5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SKR5.

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DBI. Bacteria.
COG0572. LUCA.
HOGENOMiHOG000262756.
KOiK00876.
OMAiHPSAFEW.
PhylomeDBiQ5SKR5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SKR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPKPFVIG IAGGTASGKT TLAQALARTL GERVALLPMD HYYKDLGHLP
60 70 80 90 100
LEERLRVNYD HPDAFDLALY LEHAQALLRG LPVEMPVYDF RAYTRSPRRT
110 120 130 140 150
PVRPAPVVIL EGILVLYPKE LRDLMDLKVF VDADADERFI RRLKRDVLER
160 170 180 190 200
GRSLEGVVAQ YLEQVKPMHL HFVEPTKRYA DVIVPRGGQN PVALEMLAAK
210
ALARLARMGA A
Length:211
Mass (Da):23,674
Last modified:December 21, 2004 - v1
Checksum:i8A64A64FF033E6B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70401.1.
RefSeqiWP_011172663.1. NC_006461.1.
YP_143844.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70401; BAD70401; BAD70401.
GeneIDi3168643.
KEGGittj:TTHA0578.
PATRICi23956133. VBITheThe93045_0577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70401.1.
RefSeqiWP_011172663.1. NC_006461.1.
YP_143844.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ASYX-ray2.40A/B1-211[»]
3ASZX-ray2.25A/B1-211[»]
3W34X-ray1.91A/B1-211[»]
3W8RX-ray2.50A/B1-211[»]
ProteinModelPortaliQ5SKR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70401; BAD70401; BAD70401.
GeneIDi3168643.
KEGGittj:TTHA0578.
PATRICi23956133. VBITheThe93045_0577.

Phylogenomic databases

eggNOGiENOG4105DBI. Bacteria.
COG0572. LUCA.
HOGENOMiHOG000262756.
KOiK00876.
OMAiHPSAFEW.
PhylomeDBiQ5SKR5.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.
BioCyciTTHE300852:GH8R-603-MONOMER.
BRENDAi2.7.1.48. 2305.

Miscellaneous databases

EvolutionaryTraceiQ5SKR5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
[Graphical view]
PfamiPF00485. PRK. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiURK_THET8
AccessioniPrimary (citable) accession number: Q5SKR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.