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Q5SKP3 (Q5SKP3_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP-Rule MF_00323
EC=4.99.1.1 HAMAP-Rule MF_00323
Alternative name(s):
Heme synthase HAMAP-Rule MF_00323
Protoheme ferro-lyase HAMAP-Rule MF_00323
Gene names
Name:hemH HAMAP-Rule MF_00323
Ordered Locus Names:TTHA0600 EMBL BAD70423.1
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP] EMBL BAD70423.1
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP-Rule MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP-Rule MF_00323 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP-Rule MF_00323 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP-Rule MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1911Iron By similarity HAMAP-Rule MF_00323
Metal binding2711Iron By similarity HAMAP-Rule MF_00323

Sequences

Sequence LengthMass (Da)Tools
Q5SKP3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 3B12E53D6E535773

FASTA31735,651
        10         20         30         40         50         60 
MNVLLMAYGT PYAPEEVEPY YTDIRRGRRP SEELLKELAE RYEAIGKSPL NEITLAQAVR 

        70         80         90        100        110        120 
LQALLNLEAP PYPKRLLSPF PPRAPHGPAR VYVGTKHWHP SIGEAVAAMH EDGVRRAVAI 

       130        140        150        160        170        180 
VAAPHYSLRS VAEYREKVDS ALKALPEPID FVWVESYEAH PGLIAAYARR LEEVIWRLKN 

       190        200        210        220        230        240 
PGKAAYVFTA HSIPLSAVEK GDPYPRQVEK TAELIAKKLA LPRFHVAYQS AGRTPEPWLG 

       250        260        270        280        290        300 
PDINELLRTL KEEGYEEVAV QAVGFPADHL EVFYDLDLEA QATARELGLR LLRARSLNAD 

       310 
LDYIQVLKDL VEAAWPR

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References

[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD70423.1.
RefSeqYP_143866.1. NC_006461.1.

3D structure databases

ProteinModelPortalQ5SKP3.
ModBaseSearch...

Protein-protein interaction databases

STRING300852.TTHA0600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70423; BAD70423; BAD70423.
GeneID3168511.
KEGGttj:TTHA0600.
PATRIC23956175. VBITheThe93045_0598.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHOG000060729.
KOK01772.
OMAPDICDHL.
ProtClustDBPRK00035.

Enzyme and pathway databases

UniPathwayUPA00252; UER00325.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
InterProIPR001015. Ferrochelatase.
[Graphical view]
PANTHERPTHR11108. PTHR11108. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5SKP3_THET8
AccessionPrimary (citable) accession number: Q5SKP3
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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