Uncharacterized protein - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Uncharacterized protein EMBL BAD70490.1

Gene names

Ordered Locus Names:

TTHA0667 EMBL BAD70490.1

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP] EMBL BAD70490.1

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the precorrin methyltransferase family. RuleBase RU003960

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine SAAS SAAS003043
Molecular function	Methyltransferase SAAS SAAS003043 RuleBase RU003960 Transferase
Technical term	3D-structure PDB 1V9A PDB 1VA0 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW precorrin-2 dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Region

84 – 90

7

S-adenosyl-L-homocysteine binding PDB 1V9A

Region

114 – 115

2

S-adenosyl-L-homocysteine binding PDB 1V9A

Region

214 – 215

2

S-adenosyl-L-homocysteine binding PDB 1V9A

Sites

Binding site

11

1

S-adenosyl-L-homocysteine; via carbonyl oxygen PDB 1V9A

Binding site

160

1

S-adenosyl-L-homocysteine; via amide nitrogen PDB 1V9A

Binding site

189

1

S-adenosyl-L-homocysteine; via amide nitrogen and carbonyl oxygen PDB 1V9A

Sequences

Sequence

Length

Mass (Da)

Tools

Q5SKH6 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 0FA4E4E186F7B73F
Show »

FASTA

240

26,234

        10         20         30         40         50         60 
MGRVYLVGAG PGDPELLTLK AYRLLKEAPV VLYDRLVDER VLALAPGEKV YVGKEEGESE 

        70         80         90        100        110        120 
KQEEIHRLLL RHARAHPFVV RLKGGDPMVF GRGGEEVLFL LRHGVPVEVV PGVTSLLASG 

       130        140        150        160        170        180 
LPLTHRGLAH GFAAVSGVLE GGGYPDLRPF ARVPTLVVLM GVGRRVWIAK ELLRLGRDPR 

       190        200        210        220        230        240 
EPTLFVERAS TPKERRVHAR LEEVAEGKVE VRPPALWILG EVVRVFAEKE APVDALALGG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Structure of a closed-form uroporphyrinogen-III C-methyltransferase from Thermus thermophilus." Rehse P.H., Kitao T., Tahirov T.H. Acta Crystallogr. D 61:913-919(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2-240 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008226 Genomic DNA. Translation: BAD70490.1.

RefSeq

YP_143933.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V9A	X-ray	2.00	A/B	2-240	[»]
1VA0	X-ray	1.97	A/B	2-240	[»]

ProteinModelPortal

Q5SKH6.

SMR

Q5SKH6. Positions 2-238.

ModBase

Search...

Protein-protein interaction databases

STRING

300852.TTHA0667.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

BAD70490; BAD70490; BAD70490.

GeneID

3168431.

KEGG

ttj:TTHA0667.

PATRIC

23956311. VBITheThe93045_0661.

Phylogenomic databases

eggNOG

COG0007.

HOGENOM

HOG000290519.

KO

K02303.

OMA

ERASTPK.

ProtClustDB

CLSK738406.

Family and domain databases

Gene3D

3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.

InterPro

IPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]

Pfam

PF00590. TP_methylase. 1 hit.
[Graphical view]

SUPFAM

SSF53790. Cor/por_Metransf. 1 hit.

TIGRFAMs

TIGR01469. cobA_cysG_Cterm. 1 hit.

PROSITE

PS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q5SKH6.

Entry information

Entry name

Q5SKH6_THET8

Accession

Primary (citable) accession number: Q5SKH6

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)