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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei199 – 1991NADUniRule annotation
Binding sitei222 – 2221SubstrateUniRule annotation
Metal bindingi244 – 2441ZincUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Metal bindingi247 – 2471ZincUniRule annotation
Binding sitei247 – 2471SubstrateUniRule annotation
Active sitei311 – 3111Proton acceptorUniRule annotation
Active sitei312 – 3121Proton acceptorUniRule annotation
Binding sitei312 – 3121SubstrateUniRule annotation
Metal bindingi345 – 3451ZincUniRule annotation
Binding sitei345 – 3451SubstrateUniRule annotation
Binding sitei399 – 3991SubstrateUniRule annotation
Metal bindingi404 – 4041ZincUniRule annotation
Binding sitei404 – 4041SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-752-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:TTHA0722
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Histidinol dehydrogenasePRO_0000135871Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0722.

Structurei

3D structure databases

ProteinModelPortaliQ5SKC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ5SKC1.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SKC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYAAEEVRA RFARRGLSFD PTVEEIVRGI LEAVREEGDE ALDRFSRDLD
60 70 80 90 100
GYPVEEVPKR AWREAYEDLD EDLRDALETA RERIEAFYRE EARGGFLRAE
110 120 130 140 150
GGGVLAQLVR PLERVGVYVP GGSAPLLSTL LMTVVPAKVA GVREVIVASP
160 170 180 190 200
PKVHPGVLAA AWVAGADRLF AMGGAQAIAA LAYGTGRVPR VDKIVGPGNR
210 220 230 240 250
YVVAAKRLVY GTVGIDGLAG PTETMIIADG SASPRLLAAD LLAQAEHGPD
260 270 280 290 300
SEPWLLSPDR ALLERVEAEL SWQLQDLPRA EVARQALEKG GLVLTKDLEE
310 320 330 340 350
AFALANLYAP EHLSLALSDP LPWLEKVQNA GGVFLGEGSP EALGDYIAGP
360 370 380 390 400
SHVMPTSGTA RFQGGLAVRD FLKVIPVVGL SEGAARELAK KGALLARAEG
410
LEGHARSLDL RR
Length:412
Mass (Da):44,123
Last modified:December 21, 2004 - v1
Checksum:i4A4BBDC4F9027A3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70545.1.
RefSeqiWP_011228145.1. NC_006461.1.
YP_143988.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70545; BAD70545; BAD70545.
GeneIDi3170022.
KEGGittj:TTHA0722.
PATRICi23956419. VBITheThe93045_0715.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70545.1.
RefSeqiWP_011228145.1. NC_006461.1.
YP_143988.1. NC_006461.1.

3D structure databases

ProteinModelPortaliQ5SKC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70545; BAD70545; BAD70545.
GeneIDi3170022.
KEGGittj:TTHA0722.
PATRICi23956419. VBITheThe93045_0715.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ5SKC1.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciTTHE300852:GH8R-752-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiHISX_THET8
AccessioniPrimary (citable) accession number: Q5SKC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 21, 2004
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.