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Q5SKC1 (HISX_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:TTHA0722
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135871

Sites

Active site3111Proton acceptor By similarity
Active site3121Proton acceptor By similarity
Metal binding2441Zinc By similarity
Metal binding2471Zinc By similarity
Metal binding3451Zinc By similarity
Metal binding4041Zinc By similarity
Binding site1181NAD By similarity
Binding site1761NAD By similarity
Binding site1991NAD By similarity
Binding site2221Substrate By similarity
Binding site2441Substrate By similarity
Binding site2471Substrate By similarity
Binding site3121Substrate By similarity
Binding site3451Substrate By similarity
Binding site3991Substrate By similarity
Binding site4041Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5SKC1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 4A4BBDC4F9027A3E

FASTA41244,123
        10         20         30         40         50         60 
MIYAAEEVRA RFARRGLSFD PTVEEIVRGI LEAVREEGDE ALDRFSRDLD GYPVEEVPKR 

        70         80         90        100        110        120 
AWREAYEDLD EDLRDALETA RERIEAFYRE EARGGFLRAE GGGVLAQLVR PLERVGVYVP 

       130        140        150        160        170        180 
GGSAPLLSTL LMTVVPAKVA GVREVIVASP PKVHPGVLAA AWVAGADRLF AMGGAQAIAA 

       190        200        210        220        230        240 
LAYGTGRVPR VDKIVGPGNR YVVAAKRLVY GTVGIDGLAG PTETMIIADG SASPRLLAAD 

       250        260        270        280        290        300 
LLAQAEHGPD SEPWLLSPDR ALLERVEAEL SWQLQDLPRA EVARQALEKG GLVLTKDLEE 

       310        320        330        340        350        360 
AFALANLYAP EHLSLALSDP LPWLEKVQNA GGVFLGEGSP EALGDYIAGP SHVMPTSGTA 

       370        380        390        400        410 
RFQGGLAVRD FLKVIPVVGL SEGAARELAK KGALLARAEG LEGHARSLDL RR 

« Hide

References

[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD70545.1.
RefSeqYP_143988.1. NC_006461.1.

3D structure databases

ProteinModelPortalQ5SKC1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA0722.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70545; BAD70545; BAD70545.
GeneID3170022.
KEGGttj:TTHA0722.
PATRIC23956419. VBITheThe93045_0715.

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-752-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_THET8
AccessionPrimary (citable) accession number: Q5SKC1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways