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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. In contrast to pyr attenuation in Bacillus, PyrR from Thermus could act as a translational repressor: the binding of PyrR at its proposed recognition site in the transcript would prevent initiation of translation of the leader peptide, resulting in terminator formation and reduced expression of downstream genes (By similarity). Also displays uracil phosphoribosyltransferase activity (By similarity).By similarity

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate; shared with dimeric partnerBy similarity
Binding sitei86 – 861SubstrateBy similarity
Binding sitei136 – 1361SubstrateBy similarity
Binding sitei160 – 1601SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-814-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrR
Including the following 2 domains:
Pyrimidine operon regulatory protein
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Short name:
UPRTase
Gene namesi
Name:pyrR
Ordered Locus Names:TTHA0783
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Bifunctional protein PyrRPRO_0000294122Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0783.

Structurei

Secondary structure

1
181
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Helixi10 – 2819Combined sources
Beta strandi34 – 396Combined sources
Turni40 – 423Combined sources
Helixi43 – 5816Combined sources
Beta strandi64 – 707Combined sources
Beta strandi84 – 907Combined sources
Beta strandi98 – 10912Combined sources
Helixi110 – 12213Combined sources
Beta strandi126 – 13510Combined sources
Beta strandi140 – 1434Combined sources
Beta strandi146 – 1516Combined sources
Beta strandi159 – 1635Combined sources
Helixi165 – 1684Combined sources
Beta strandi172 – 1765Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFRX-ray2.60A/B/C/D1-181[»]
ProteinModelPortaliQ5SK65.
SMRiQ5SK65. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SK65.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 422Substrate-bindingBy similarity
Regioni103 – 1119Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 11113PRPP-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
PhylomeDBiQ5SK65.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SK65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFKAELMNA PEMRRALYRI AHEIVEANKG TEGLALVGIH TRGIPLAHRI
60 70 80 90 100
ARFIAEFEGK EVPVGVLDIT LYRDDLTEIG YRPQVRETRI PFDLTGKAIV
110 120 130 140 150
LVDDVLYTGR TARAALDALI DLGRPRRIYL AVLVDRGHRE LPIRADFVGK
160 170 180
NVPTSRSEVV KVKVEEVDGE DRVELWEREG A
Length:181
Mass (Da):20,467
Last modified:December 21, 2004 - v1
Checksum:i87FDF462E6E6D3C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70606.1.
RefSeqiWP_011172875.1. NC_006461.1.
YP_144049.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70606; BAD70606; BAD70606.
GeneIDi3169141.
KEGGittj:TTHA0783.
PATRICi23956543. VBITheThe93045_0776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70606.1.
RefSeqiWP_011172875.1. NC_006461.1.
YP_144049.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFRX-ray2.60A/B/C/D1-181[»]
ProteinModelPortaliQ5SK65.
SMRiQ5SK65. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70606; BAD70606; BAD70606.
GeneIDi3169141.
KEGGittj:TTHA0783.
PATRICi23956543. VBITheThe93045_0776.

Phylogenomic databases

eggNOGiENOG4108UK1. Bacteria.
COG2065. LUCA.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
PhylomeDBiQ5SK65.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-814-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SK65.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPYRR_THET8
AccessioniPrimary (citable) accession number: Q5SK65
Secondary accession number(s): P83822
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.