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Q5SJS8

- Q5SJS8_THET8

UniProt

Q5SJS8 - Q5SJS8_THET8

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, TTHA0930
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotations
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationsImported, TransferaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-961-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:TTHA0930Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0930.

Structurei

3D structure databases

ProteinModelPortaliQ5SJS8.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ5SJS8.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SJS8-1 [UniParc]FASTAAdd to Basket

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MRSMWALLSV ADKRGIVDFA RGLAELGFRL LATGGTYRAL REAGLPVTYI    50
SDFTGFPEIL EGRVKTLHPK VHAALLARPD QEEELKALGL ERIGVLAVNL 100
YPFRETVARG ASFAEALEQI DIGGPAMLRA AAKNHQAVLP VCDPEDYPRV 150
LEALKAGPSP DFRQKLARKA FAHTALYDAA IAEWLSGEKF PEEKLLALRR 200
EASLRYGENP HQEAALYRVV GERGPLLEAQ VLQGKAMSFN NYLDAEAAWN 250
LVSEFAEPAC VAVKHQNPCG VALGETPLEA YRKAYEADPV SIFGGIVAFN 300
RPLDGPTAEA LAEVFLEVVL APSFSPEARA VLARKKNLRL LQVPFPAQGP 350
YLDLRRLRGG VLLQDADTED PAEPKVVTER APTPEEWPDL RFAWKVVKHV 400
RSNAIVVAKG GMTLGIGVGQ TNRLAAARHA LEAAGERAKG AVLASDAFFP 450
FDDVVRLAAS YGIAAIIQPG GSVRDQDSIR AAEEAGIAMV FTGVRHFRH 499
Length:499
Mass (Da):54,200
Last modified:December 21, 2004 - v1
Checksum:iE6E08A406B79432D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70753.1.
RefSeqiWP_011173006.1. NC_006461.1.
YP_144196.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70753; BAD70753; BAD70753.
GeneIDi3169136.
KEGGittj:TTHA0930.
PATRICi23956824. VBITheThe93045_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70753.1 .
RefSeqi WP_011173006.1. NC_006461.1.
YP_144196.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SJS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70753 ; BAD70753 ; BAD70753 .
GeneIDi 3169136.
KEGGi ttj:TTHA0930.
PATRICi 23956824. VBITheThe93045_0913.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.
PhylomeDBi Q5SJS8.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci TTHE300852:GH8R-961-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiQ5SJS8_THET8
AccessioniPrimary (citable) accession number: Q5SJS8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotations, Reference proteome

External Data

Dasty 3

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