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Q5SJS8

- Q5SJS8_THET8

UniProt

Q5SJS8 - Q5SJS8_THET8

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported, TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Purine biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-961-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:TTHA0930Imported
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA0930.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SJS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.
    PhylomeDBiQ5SJS8.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SJS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSMWALLSV ADKRGIVDFA RGLAELGFRL LATGGTYRAL REAGLPVTYI    50
    SDFTGFPEIL EGRVKTLHPK VHAALLARPD QEEELKALGL ERIGVLAVNL 100
    YPFRETVARG ASFAEALEQI DIGGPAMLRA AAKNHQAVLP VCDPEDYPRV 150
    LEALKAGPSP DFRQKLARKA FAHTALYDAA IAEWLSGEKF PEEKLLALRR 200
    EASLRYGENP HQEAALYRVV GERGPLLEAQ VLQGKAMSFN NYLDAEAAWN 250
    LVSEFAEPAC VAVKHQNPCG VALGETPLEA YRKAYEADPV SIFGGIVAFN 300
    RPLDGPTAEA LAEVFLEVVL APSFSPEARA VLARKKNLRL LQVPFPAQGP 350
    YLDLRRLRGG VLLQDADTED PAEPKVVTER APTPEEWPDL RFAWKVVKHV 400
    RSNAIVVAKG GMTLGIGVGQ TNRLAAARHA LEAAGERAKG AVLASDAFFP 450
    FDDVVRLAAS YGIAAIIQPG GSVRDQDSIR AAEEAGIAMV FTGVRHFRH 499
    Length:499
    Mass (Da):54,200
    Last modified:December 21, 2004 - v1
    Checksum:iE6E08A406B79432D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70753.1.
    RefSeqiWP_011173006.1. NC_006461.1.
    YP_144196.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70753; BAD70753; BAD70753.
    GeneIDi3169136.
    KEGGittj:TTHA0930.
    PATRICi23956824. VBITheThe93045_0913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70753.1 .
    RefSeqi WP_011173006.1. NC_006461.1.
    YP_144196.1. NC_006461.1.

    3D structure databases

    ProteinModelPortali Q5SJS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA0930.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70753 ; BAD70753 ; BAD70753 .
    GeneIDi 3169136.
    KEGGi ttj:TTHA0930.
    PATRICi 23956824. VBITheThe93045_0913.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.
    PhylomeDBi Q5SJS8.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci TTHE300852:GH8R-961-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579Imported.

    Entry informationi

    Entry nameiQ5SJS8_THET8
    AccessioniPrimary (citable) accession number: Q5SJS8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3