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Q5SJS8 (Q5SJS8_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
Gene names
Name:purH HAMAP-Rule MF_00139
Ordered Locus Names:TTHA0930 EMBL BAD70753.1
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP] EMBL BAD70753.1
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139 SAAS SAAS024051

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139 SAAS SAAS024051

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139 SAAS SAAS024051

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. HAMAP-Rule MF_00139 SAAS SAAS024051

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family. HAMAP-Rule MF_00139

Sequences

Sequence LengthMass (Da)Tools
Q5SJS8 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: E6E08A406B79432D

FASTA49954,200
        10         20         30         40         50         60 
MRSMWALLSV ADKRGIVDFA RGLAELGFRL LATGGTYRAL REAGLPVTYI SDFTGFPEIL 

        70         80         90        100        110        120 
EGRVKTLHPK VHAALLARPD QEEELKALGL ERIGVLAVNL YPFRETVARG ASFAEALEQI 

       130        140        150        160        170        180 
DIGGPAMLRA AAKNHQAVLP VCDPEDYPRV LEALKAGPSP DFRQKLARKA FAHTALYDAA 

       190        200        210        220        230        240 
IAEWLSGEKF PEEKLLALRR EASLRYGENP HQEAALYRVV GERGPLLEAQ VLQGKAMSFN 

       250        260        270        280        290        300 
NYLDAEAAWN LVSEFAEPAC VAVKHQNPCG VALGETPLEA YRKAYEADPV SIFGGIVAFN 

       310        320        330        340        350        360 
RPLDGPTAEA LAEVFLEVVL APSFSPEARA VLARKKNLRL LQVPFPAQGP YLDLRRLRGG 

       370        380        390        400        410        420 
VLLQDADTED PAEPKVVTER APTPEEWPDL RFAWKVVKHV RSNAIVVAKG GMTLGIGVGQ 

       430        440        450        460        470        480 
TNRLAAARHA LEAAGERAKG AVLASDAFFP FDDVVRLAAS YGIAAIIQPG GSVRDQDSIR 

       490 
AAEEAGIAMV FTGVRHFRH

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References

[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD70753.1.
RefSeqYP_144196.1. NC_006461.1.

3D structure databases

ProteinModelPortalQ5SJS8.
ModBaseSearch...

Protein-protein interaction databases

STRING300852.TTHA0930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70753; BAD70753; BAD70753.
GeneID3169136.
KEGGttj:TTHA0930.
PATRIC23956824. VBITheThe93045_0913.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
ProtClustDBPRK00881.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF52335. MGS-like_dom. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5SJS8_THET8
AccessionPrimary (citable) accession number: Q5SJS8
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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