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Q5SJS8

- Q5SJS8_THET8

UniProt

Q5SJS8 - Q5SJS8_THET8

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-961-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotationSAAS annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:TTHA0930Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA0930.

Structurei

3D structure databases

ProteinModelPortaliQ5SJS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ5SJS8.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SJS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSMWALLSV ADKRGIVDFA RGLAELGFRL LATGGTYRAL REAGLPVTYI
60 70 80 90 100
SDFTGFPEIL EGRVKTLHPK VHAALLARPD QEEELKALGL ERIGVLAVNL
110 120 130 140 150
YPFRETVARG ASFAEALEQI DIGGPAMLRA AAKNHQAVLP VCDPEDYPRV
160 170 180 190 200
LEALKAGPSP DFRQKLARKA FAHTALYDAA IAEWLSGEKF PEEKLLALRR
210 220 230 240 250
EASLRYGENP HQEAALYRVV GERGPLLEAQ VLQGKAMSFN NYLDAEAAWN
260 270 280 290 300
LVSEFAEPAC VAVKHQNPCG VALGETPLEA YRKAYEADPV SIFGGIVAFN
310 320 330 340 350
RPLDGPTAEA LAEVFLEVVL APSFSPEARA VLARKKNLRL LQVPFPAQGP
360 370 380 390 400
YLDLRRLRGG VLLQDADTED PAEPKVVTER APTPEEWPDL RFAWKVVKHV
410 420 430 440 450
RSNAIVVAKG GMTLGIGVGQ TNRLAAARHA LEAAGERAKG AVLASDAFFP
460 470 480 490
FDDVVRLAAS YGIAAIIQPG GSVRDQDSIR AAEEAGIAMV FTGVRHFRH
Length:499
Mass (Da):54,200
Last modified:December 21, 2004 - v1
Checksum:iE6E08A406B79432D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70753.1.
RefSeqiWP_011173006.1. NC_006461.1.
YP_144196.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70753; BAD70753; BAD70753.
GeneIDi3169136.
KEGGittj:TTHA0930.
PATRICi23956824. VBITheThe93045_0913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70753.1 .
RefSeqi WP_011173006.1. NC_006461.1.
YP_144196.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SJS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA0930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70753 ; BAD70753 ; BAD70753 .
GeneIDi 3169136.
KEGGi ttj:TTHA0930.
PATRICi 23956824. VBITheThe93045_0913.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.
PhylomeDBi Q5SJS8.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci TTHE300852:GH8R-961-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.

Entry informationi

Entry nameiQ5SJS8_THET8
AccessioniPrimary (citable) accession number: Q5SJS8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

External Data

Dasty 3