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Protein

Probable transaldolase

Gene

tal

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Schiff-base intermediate with substrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1098-MONOMER.
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transaldolaseUniRule annotation (EC:2.2.1.2UniRule annotation)
Gene namesi
Name:talUniRule annotation
Ordered Locus Names:TTHA1066
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Probable transaldolasePRO_1000126370Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1066.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi10 – 1910Combined sources
Beta strandi24 – 263Combined sources
Helixi29 – 3911Combined sources
Helixi45 – 5915Combined sources
Beta strandi63 – 664Combined sources
Helixi72 – 8514Combined sources
Beta strandi89 – 968Combined sources
Helixi97 – 10812Combined sources
Beta strandi113 – 1186Combined sources
Helixi121 – 1299Combined sources
Beta strandi133 – 1386Combined sources
Helixi139 – 1446Combined sources
Helixi149 – 16214Combined sources
Beta strandi168 – 1725Combined sources
Helixi177 – 1859Combined sources
Beta strandi189 – 1935Combined sources
Helixi195 – 2017Combined sources
Helixi205 – 2106Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WX0X-ray2.27A/B/C/D/E/F/G/H/I/J1-223[»]
ProteinModelPortaliQ5SJE8.
SMRiQ5SJE8. Positions 1-211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJE8.

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000226073.
KOiK00616.
OMAiVRHPMHV.
PhylomeDBiQ5SJE8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SJE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELYLDTASL EEIREIAAWG VLSGVTTNPT LVAKAFAAKG EALTEEAFAA
60 70 80 90 100
HLRAICETVG GPVSAEVTAL EAEAMVAEGR RLAAIHPNIV VKLPTTEEGL
110 120 130 140 150
KACKRLSAEG IKVNMTLIFS ANQALLAARA GASYVSPFLG RVDDISWDGG
160 170 180 190 200
ELLREIVEMI QVQDLPVKVI AASIRHPRHV TEAALLGADI ATMPHAVFKQ
210 220
LLKHPLTDIG LKRFLEDWEK VKP
Length:223
Mass (Da):24,023
Last modified:December 21, 2004 - v1
Checksum:iF5C9D213FB1E2E47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70889.1.
RefSeqiWP_011228415.1. NC_006461.1.
YP_144332.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70889; BAD70889; BAD70889.
GeneIDi3168258.
KEGGittj:TTHA1066.
PATRICi23957092. VBITheThe93045_1046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70889.1.
RefSeqiWP_011228415.1. NC_006461.1.
YP_144332.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WX0X-ray2.27A/B/C/D/E/F/G/H/I/J1-223[»]
ProteinModelPortaliQ5SJE8.
SMRiQ5SJE8. Positions 1-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70889; BAD70889; BAD70889.
GeneIDi3168258.
KEGGittj:TTHA1066.
PATRICi23957092. VBITheThe93045_1046.

Phylogenomic databases

eggNOGiENOG4105CW3. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000226073.
KOiK00616.
OMAiVRHPMHV.
PhylomeDBiQ5SJE8.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
BioCyciTTHE300852:GH8R-1098-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SJE8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_THET8
AccessioniPrimary (citable) accession number: Q5SJE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.