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Protein

Ribosomal RNA small subunit methyltransferase H

Gene

rsmH

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511S-adenosyl-L-methionineUniRule annotation1 Publication
Binding sitei75 – 751S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1 Publication
Binding sitei96 – 961S-adenosyl-L-methionineUniRule annotation1 Publication
Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1108-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase HUniRule annotation (EC:2.1.1.199UniRule annotation)
Alternative name(s):
16S rRNA m(4)C1402 methyltransferaseUniRule annotation
rRNA (cytosine-N(4)-)-methyltransferase RsmHUniRule annotation
Gene namesi
Name:rsmHUniRule annotation
Synonyms:mraW
Ordered Locus Names:TTHA1076
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Ribosomal RNA small subunit methyltransferase HPRO_0000108734Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1076.

Structurei

Secondary structure

1
285
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 188Combined sources
Beta strandi25 – 284Combined sources
Helixi35 – 428Combined sources
Beta strandi46 – 527Combined sources
Helixi54 – 629Combined sources
Beta strandi68 – 736Combined sources
Helixi75 – 773Combined sources
Helixi78 – 847Combined sources
Beta strandi90 – 967Combined sources
Helixi101 – 1055Combined sources
Helixi107 – 1093Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi123 – 1253Combined sources
Helixi130 – 1367Combined sources
Helixi139 – 15012Combined sources
Helixi155 – 16814Combined sources
Helixi174 – 18512Combined sources
Beta strandi189 – 1913Combined sources
Helixi195 – 20511Combined sources
Helixi208 – 22215Combined sources
Beta strandi223 – 23311Combined sources
Helixi236 – 24914Combined sources
Beta strandi251 – 2544Combined sources
Helixi263 – 2686Combined sources
Helixi270 – 2745Combined sources
Beta strandi276 – 2816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG8X-ray2.00A/B1-285[»]
ProteinModelPortaliQ5SJD8.
SMRiQ5SJD8. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJD8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 363S-adenosyl-L-methionine binding

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049777.
KOiK03438.
OMAiNKKIHPA.
PhylomeDBiQ5SJD8.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SJD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPMTHVPVL YQEALDLLAV RPGGVYVDAT LGGAGHARGI LERGGRVIGL
60 70 80 90 100
DQDPEAVARA KGLHLPGLTV VQGNFRHLKR HLAALGVERV DGILADLGVS
110 120 130 140 150
SFHLDDPSRG FSYQKEGPLD MRMGLEGPTA KEVVNRLPLE ALARLLRELG
160 170 180 190 200
EEPQAYRIAR AIVAAREKAP IETTTQLAEI VRKAVGFRRA GHPARKTFQA
210 220 230 240 250
LRIYVNDELN ALKEFLEQAA EVLAPGGRLV VIAFHSLEDR VVKRFLRESG
260 270 280
LKVLTKKPLV PSEKEAAQNP RARSAKLRAA EKEAP
Length:285
Mass (Da):31,171
Last modified:December 21, 2004 - v1
Checksum:iE1EE6E83A286ABB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70899.1.
RefSeqiWP_011228422.1. NC_006461.1.
YP_144342.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70899; BAD70899; BAD70899.
GeneIDi3168225.
KEGGittj:TTHA1076.
PATRICi23957112. VBITheThe93045_1056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD70899.1.
RefSeqiWP_011228422.1. NC_006461.1.
YP_144342.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WG8X-ray2.00A/B1-285[»]
ProteinModelPortaliQ5SJD8.
SMRiQ5SJD8. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1076.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70899; BAD70899; BAD70899.
GeneIDi3168225.
KEGGittj:TTHA1076.
PATRICi23957112. VBITheThe93045_1056.

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049777.
KOiK03438.
OMAiNKKIHPA.
PhylomeDBiQ5SJD8.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1108-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SJD8.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSMH_THET8
AccessioniPrimary (citable) accession number: Q5SJD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.