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Q5SJ80 (COX2_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene names
Name:cbaB
Synonyms:ctaC
Ordered Locus Names:TTHA1134
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell membrane; Single-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 168168Cytochrome c oxidase subunit 2
PRO_0000183722

Regions

Topological domain1 – 33Cytoplasmic
Transmembrane4 – 3835Helical
Topological domain39 – 168130Periplasmic

Sites

Metal binding1141Copper A
Metal binding1491Copper A
Metal binding1531Copper A
Metal binding1571Copper A

Secondary structure

................................. 168
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SJ80 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: FE5689FB7672CF05

FASTA16818,563
        10         20         30         40         50         60 
MVDEHKAHKA ILAYEKGWLA FSLAMLFVFI ALIAYTLATH TAGVIPAGKL ERVDPTTVRQ 

        70         80         90        100        110        120 
EGPWADPAQA VVQTGPNQYT VYVLAFAFGY QPNPIEVPQG AEIVFKITSP DVIHGFHVEG 

       130        140        150        160 
TNINVEVLPG EVSTVRYTFK RPGEYRIICN QYCGLGHQNM FGTIVVKE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-30.
[2]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[3]"Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.
PIRT52480.
RefSeqYP_144400.1. NC_006461.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40B1-168[»]
2QPDX-ray3.25B1-168[»]
2QPEX-ray2.90B1-168[»]
3BVDX-ray3.37B1-168[»]
3EH3X-ray3.10B3-168[»]
3EH4X-ray2.90B3-168[»]
3EH5X-ray2.80B3-168[»]
3QJQX-ray2.90B1-168[»]
3QJRX-ray3.20B1-168[»]
3QJSX-ray2.80B1-168[»]
3QJTX-ray2.95B1-168[»]
3QJUX-ray2.90B1-168[»]
3QJVX-ray2.80B1-168[»]
3S33X-ray4.45B3-168[»]
3S38X-ray4.20B3-168[»]
3S39X-ray4.80B3-168[»]
3S3AX-ray4.25B3-168[»]
3S3BX-ray3.30B3-168[»]
3S3CX-ray4.00B3-168[»]
3S3DX-ray3.75B3-168[»]
3S8FX-ray1.80B1-168[»]
3S8GX-ray1.80B1-168[»]
4FA7X-ray2.50B1-168[»]
4FAAX-ray2.80B1-168[»]
4G70X-ray2.60B1-168[»]
4G71X-ray2.90B1-168[»]
4G72X-ray3.19B1-168[»]
4G7QX-ray2.60B1-168[»]
4G7RX-ray3.05B1-168[»]
4G7SX-ray2.00B1-168[»]
4GP4X-ray2.80B1-168[»]
4GP5X-ray2.70B1-168[»]
4GP8X-ray2.80B1-168[»]
ProteinModelPortalQ5SJ80.
SMRQ5SJ80. Positions 3-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA1134.

Protein family/group databases

TCDB3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70957; BAD70957; BAD70957.
GeneID3169672.
KEGGttj:TTHA1134.
PATRIC23957227. VBITheThe93045_1113.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000249469.
KOK02275.
OMACHEFCGF.
OrthoDBEOG6TFCQV.
PhylomeDBQ5SJ80.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1166-MONOMER.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5SJ80.

Entry information

Entry nameCOX2_THET8
AccessionPrimary (citable) accession number: Q5SJ80
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references