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Q5SJ80

- COX2_THET8

UniProt

Q5SJ80 - COX2_THET8

Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi114 – 1141Copper A
    Metal bindingi149 – 1491Copper A
    Metal bindingi153 – 1531Copper A
    Metal bindingi157 – 1571Copper A

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1166-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c ba(3) subunit II
    Cytochrome c oxidase polypeptide II
    Cytochrome cba3 subunit 2
    Gene namesi
    Name:cbaB
    Synonyms:ctaC
    Ordered Locus Names:TTHA1134
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Cytochrome c oxidase subunit 2PRO_0000183722Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA1134.

    Structurei

    Secondary structure

    1
    168
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 3633
    Helixi40 – 445
    Turni55 – 606
    Turni63 – 653
    Helixi67 – 693
    Beta strandi71 – 755
    Beta strandi78 – 869
    Beta strandi89 – 9810
    Beta strandi101 – 1088
    Beta strandi110 – 1123
    Beta strandi114 – 1185
    Beta strandi124 – 1274
    Beta strandi133 – 1386
    Beta strandi143 – 1486
    Helixi157 – 1593
    Beta strandi161 – 1677

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EHKX-ray2.40B1-168[»]
    2QPDX-ray3.25B1-168[»]
    2QPEX-ray2.90B1-168[»]
    3BVDX-ray3.37B1-168[»]
    3EH3X-ray3.10B3-168[»]
    3EH4X-ray2.90B3-168[»]
    3EH5X-ray2.80B3-168[»]
    3QJQX-ray2.90B1-168[»]
    3QJRX-ray3.20B1-168[»]
    3QJSX-ray2.80B1-168[»]
    3QJTX-ray2.95B1-168[»]
    3QJUX-ray2.90B1-168[»]
    3QJVX-ray2.80B1-168[»]
    3S33X-ray4.45B3-168[»]
    3S38X-ray4.20B3-168[»]
    3S39X-ray4.80B3-168[»]
    3S3AX-ray4.25B3-168[»]
    3S3BX-ray3.30B3-168[»]
    3S3CX-ray4.00B3-168[»]
    3S3DX-ray3.75B3-168[»]
    3S8FX-ray1.80B1-168[»]
    3S8GX-ray1.80B1-168[»]
    4FA7X-ray2.50B1-168[»]
    4FAAX-ray2.80B1-168[»]
    4G70X-ray2.60B1-168[»]
    4G71X-ray2.90B1-168[»]
    4G72X-ray3.19B1-168[»]
    4G7QX-ray2.60B1-168[»]
    4G7RX-ray3.05B1-168[»]
    4G7SX-ray2.00B1-168[»]
    4GP4X-ray2.80B1-168[»]
    4GP5X-ray2.70B1-168[»]
    4GP8X-ray2.80B1-168[»]
    ProteinModelPortaliQ5SJ80.
    SMRiQ5SJ80. Positions 3-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SJ80.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33Cytoplasmic
    Topological domaini39 – 168130PeriplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 3835HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    HOGENOMiHOG000249469.
    KOiK02275.
    OMAiCHEFCGF.
    OrthoDBiEOG6TFCQV.
    PhylomeDBiQ5SJ80.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    IPR015209. Cyt_c_oxidase_su2a_TM_dom.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF09125. COX2-transmemb. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SJ80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDEHKAHKA ILAYEKGWLA FSLAMLFVFI ALIAYTLATH TAGVIPAGKL    50
    ERVDPTTVRQ EGPWADPAQA VVQTGPNQYT VYVLAFAFGY QPNPIEVPQG 100
    AEIVFKITSP DVIHGFHVEG TNINVEVLPG EVSTVRYTFK RPGEYRIICN 150
    QYCGLGHQNM FGTIVVKE 168
    Length:168
    Mass (Da):18,563
    Last modified:December 21, 2004 - v1
    Checksum:iFE5689FB7672CF05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09121 Genomic DNA. Translation: AAB00369.1.
    AP008226 Genomic DNA. Translation: BAD70957.1.
    PIRiT52480.
    RefSeqiWP_011173203.1. NC_006461.1.
    YP_144400.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70957; BAD70957; BAD70957.
    GeneIDi3169672.
    KEGGittj:TTHA1134.
    PATRICi23957227. VBITheThe93045_1113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09121 Genomic DNA. Translation: AAB00369.1 .
    AP008226 Genomic DNA. Translation: BAD70957.1 .
    PIRi T52480.
    RefSeqi WP_011173203.1. NC_006461.1.
    YP_144400.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EHK X-ray 2.40 B 1-168 [» ]
    2QPD X-ray 3.25 B 1-168 [» ]
    2QPE X-ray 2.90 B 1-168 [» ]
    3BVD X-ray 3.37 B 1-168 [» ]
    3EH3 X-ray 3.10 B 3-168 [» ]
    3EH4 X-ray 2.90 B 3-168 [» ]
    3EH5 X-ray 2.80 B 3-168 [» ]
    3QJQ X-ray 2.90 B 1-168 [» ]
    3QJR X-ray 3.20 B 1-168 [» ]
    3QJS X-ray 2.80 B 1-168 [» ]
    3QJT X-ray 2.95 B 1-168 [» ]
    3QJU X-ray 2.90 B 1-168 [» ]
    3QJV X-ray 2.80 B 1-168 [» ]
    3S33 X-ray 4.45 B 3-168 [» ]
    3S38 X-ray 4.20 B 3-168 [» ]
    3S39 X-ray 4.80 B 3-168 [» ]
    3S3A X-ray 4.25 B 3-168 [» ]
    3S3B X-ray 3.30 B 3-168 [» ]
    3S3C X-ray 4.00 B 3-168 [» ]
    3S3D X-ray 3.75 B 3-168 [» ]
    3S8F X-ray 1.80 B 1-168 [» ]
    3S8G X-ray 1.80 B 1-168 [» ]
    4FA7 X-ray 2.50 B 1-168 [» ]
    4FAA X-ray 2.80 B 1-168 [» ]
    4G70 X-ray 2.60 B 1-168 [» ]
    4G71 X-ray 2.90 B 1-168 [» ]
    4G72 X-ray 3.19 B 1-168 [» ]
    4G7Q X-ray 2.60 B 1-168 [» ]
    4G7R X-ray 3.05 B 1-168 [» ]
    4G7S X-ray 2.00 B 1-168 [» ]
    4GP4 X-ray 2.80 B 1-168 [» ]
    4GP5 X-ray 2.70 B 1-168 [» ]
    4GP8 X-ray 2.80 B 1-168 [» ]
    ProteinModelPortali Q5SJ80.
    SMRi Q5SJ80. Positions 3-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1134.

    Protein family/group databases

    TCDBi 3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70957 ; BAD70957 ; BAD70957 .
    GeneIDi 3169672.
    KEGGi ttj:TTHA1134.
    PATRICi 23957227. VBITheThe93045_1113.

    Phylogenomic databases

    eggNOGi COG1622.
    HOGENOMi HOG000249469.
    KOi K02275.
    OMAi CHEFCGF.
    OrthoDBi EOG6TFCQV.
    PhylomeDBi Q5SJ80.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-1166-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SJ80.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    IPR015209. Cyt_c_oxidase_su2a_TM_dom.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF09125. COX2-transmemb. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
      Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
      J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-30.
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    3. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
      Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
      EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

    Entry informationi

    Entry nameiCOX2_THET8
    AccessioniPrimary (citable) accession number: Q5SJ80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3