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Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Copper A1
Metal bindingi149Copper A1
Metal bindingi153Copper A1
Metal bindingi157Copper A1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BRENDAi1.9.3.1. 2305.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene namesi
Name:cbaB
Synonyms:ctaC
Ordered Locus Names:TTHA1134
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3Cytoplasmic3
Transmembranei4 – 38HelicalAdd BLAST35
Topological domaini39 – 168PeriplasmicAdd BLAST130

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837221 – 168Cytochrome c oxidase subunit 2Add BLAST168

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1134.

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 36Combined sources33
Helixi40 – 44Combined sources5
Turni55 – 60Combined sources6
Turni63 – 65Combined sources3
Helixi67 – 69Combined sources3
Beta strandi71 – 75Combined sources5
Beta strandi78 – 86Combined sources9
Beta strandi89 – 98Combined sources10
Beta strandi101 – 108Combined sources8
Beta strandi110 – 112Combined sources3
Beta strandi114 – 118Combined sources5
Beta strandi124 – 127Combined sources4
Beta strandi133 – 138Combined sources6
Beta strandi143 – 148Combined sources6
Helixi157 – 159Combined sources3
Beta strandi161 – 167Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40B1-168[»]
2QPDX-ray3.25B1-168[»]
2QPEX-ray2.90B1-168[»]
3BVDX-ray3.37B1-168[»]
3EH3X-ray3.10B3-168[»]
3EH4X-ray2.90B3-168[»]
3EH5X-ray2.80B3-168[»]
3QJQX-ray2.90B1-168[»]
3QJRX-ray3.20B1-168[»]
3QJSX-ray2.80B1-168[»]
3QJTX-ray2.95B1-168[»]
3QJUX-ray2.90B1-168[»]
3QJVX-ray2.80B1-168[»]
3S33X-ray4.45B3-168[»]
3S38X-ray4.20B3-168[»]
3S39X-ray4.80B3-168[»]
3S3AX-ray4.25B3-168[»]
3S3BX-ray3.30B3-168[»]
3S3CX-ray4.00B3-168[»]
3S3DX-ray3.75B3-168[»]
3S8FX-ray1.80B1-168[»]
3S8GX-ray1.80B1-168[»]
4FA7X-ray2.50B1-168[»]
4FAAX-ray2.80B1-168[»]
4G70X-ray2.60B1-168[»]
4G71X-ray2.90B1-168[»]
4G72X-ray3.19B1-168[»]
4G7QX-ray2.60B1-168[»]
4G7RX-ray3.05B1-168[»]
4G7SX-ray2.00B1-168[»]
4GP4X-ray2.80B1-168[»]
4GP5X-ray2.70B1-168[»]
4GP8X-ray2.80B1-168[»]
4N4YX-ray2.90B1-168[»]
ProteinModelPortaliQ5SJ80.
SMRiQ5SJ80.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJ80.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105NAA. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000249469.
KOiK02275.
OMAiNMMVVPG.
PhylomeDBiQ5SJ80.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SJ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDEHKAHKA ILAYEKGWLA FSLAMLFVFI ALIAYTLATH TAGVIPAGKL
60 70 80 90 100
ERVDPTTVRQ EGPWADPAQA VVQTGPNQYT VYVLAFAFGY QPNPIEVPQG
110 120 130 140 150
AEIVFKITSP DVIHGFHVEG TNINVEVLPG EVSTVRYTFK RPGEYRIICN
160
QYCGLGHQNM FGTIVVKE
Length:168
Mass (Da):18,563
Last modified:December 21, 2004 - v1
Checksum:iFE5689FB7672CF05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.
PIRiT52480.
RefSeqiWP_011173203.1. NC_006461.1.
YP_144400.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70957; BAD70957; BAD70957.
GeneIDi3169672.
KEGGittj:TTHA1134.
PATRICi23957227. VBITheThe93045_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.
PIRiT52480.
RefSeqiWP_011173203.1. NC_006461.1.
YP_144400.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40B1-168[»]
2QPDX-ray3.25B1-168[»]
2QPEX-ray2.90B1-168[»]
3BVDX-ray3.37B1-168[»]
3EH3X-ray3.10B3-168[»]
3EH4X-ray2.90B3-168[»]
3EH5X-ray2.80B3-168[»]
3QJQX-ray2.90B1-168[»]
3QJRX-ray3.20B1-168[»]
3QJSX-ray2.80B1-168[»]
3QJTX-ray2.95B1-168[»]
3QJUX-ray2.90B1-168[»]
3QJVX-ray2.80B1-168[»]
3S33X-ray4.45B3-168[»]
3S38X-ray4.20B3-168[»]
3S39X-ray4.80B3-168[»]
3S3AX-ray4.25B3-168[»]
3S3BX-ray3.30B3-168[»]
3S3CX-ray4.00B3-168[»]
3S3DX-ray3.75B3-168[»]
3S8FX-ray1.80B1-168[»]
3S8GX-ray1.80B1-168[»]
4FA7X-ray2.50B1-168[»]
4FAAX-ray2.80B1-168[»]
4G70X-ray2.60B1-168[»]
4G71X-ray2.90B1-168[»]
4G72X-ray3.19B1-168[»]
4G7QX-ray2.60B1-168[»]
4G7RX-ray3.05B1-168[»]
4G7SX-ray2.00B1-168[»]
4GP4X-ray2.80B1-168[»]
4GP5X-ray2.70B1-168[»]
4GP8X-ray2.80B1-168[»]
4N4YX-ray2.90B1-168[»]
ProteinModelPortaliQ5SJ80.
SMRiQ5SJ80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1134.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70957; BAD70957; BAD70957.
GeneIDi3169672.
KEGGittj:TTHA1134.
PATRICi23957227. VBITheThe93045_1113.

Phylogenomic databases

eggNOGiENOG4105NAA. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000249469.
KOiK02275.
OMAiNMMVVPG.
PhylomeDBiQ5SJ80.

Enzyme and pathway databases

BRENDAi1.9.3.1. 2305.

Miscellaneous databases

EvolutionaryTraceiQ5SJ80.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_THET8
AccessioniPrimary (citable) accession number: Q5SJ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.