Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Copper A
Metal bindingi149 – 1491Copper A
Metal bindingi153 – 1531Copper A
Metal bindingi157 – 1571Copper A

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1166-MONOMER.
BRENDAi1.9.3.1. 2305.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene namesi
Name:cbaB
Synonyms:ctaC
Ordered Locus Names:TTHA1134
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Cytoplasmic
Transmembranei4 – 3835HelicalAdd
BLAST
Topological domaini39 – 168130PeriplasmicAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Cytochrome c oxidase subunit 2PRO_0000183722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1134.

Structurei

Secondary structure

1
168
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 3633Combined sources
Helixi40 – 445Combined sources
Turni55 – 606Combined sources
Turni63 – 653Combined sources
Helixi67 – 693Combined sources
Beta strandi71 – 755Combined sources
Beta strandi78 – 869Combined sources
Beta strandi89 – 9810Combined sources
Beta strandi101 – 1088Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi114 – 1185Combined sources
Beta strandi124 – 1274Combined sources
Beta strandi133 – 1386Combined sources
Beta strandi143 – 1486Combined sources
Helixi157 – 1593Combined sources
Beta strandi161 – 1677Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40B1-168[»]
2QPDX-ray3.25B1-168[»]
2QPEX-ray2.90B1-168[»]
3BVDX-ray3.37B1-168[»]
3EH3X-ray3.10B3-168[»]
3EH4X-ray2.90B3-168[»]
3EH5X-ray2.80B3-168[»]
3QJQX-ray2.90B1-168[»]
3QJRX-ray3.20B1-168[»]
3QJSX-ray2.80B1-168[»]
3QJTX-ray2.95B1-168[»]
3QJUX-ray2.90B1-168[»]
3QJVX-ray2.80B1-168[»]
3S33X-ray4.45B3-168[»]
3S38X-ray4.20B3-168[»]
3S39X-ray4.80B3-168[»]
3S3AX-ray4.25B3-168[»]
3S3BX-ray3.30B3-168[»]
3S3CX-ray4.00B3-168[»]
3S3DX-ray3.75B3-168[»]
3S8FX-ray1.80B1-168[»]
3S8GX-ray1.80B1-168[»]
4FA7X-ray2.50B1-168[»]
4FAAX-ray2.80B1-168[»]
4G70X-ray2.60B1-168[»]
4G71X-ray2.90B1-168[»]
4G72X-ray3.19B1-168[»]
4G7QX-ray2.60B1-168[»]
4G7RX-ray3.05B1-168[»]
4G7SX-ray2.00B1-168[»]
4GP4X-ray2.80B1-168[»]
4GP5X-ray2.70B1-168[»]
4GP8X-ray2.80B1-168[»]
4N4YX-ray2.90B1-168[»]
ProteinModelPortaliQ5SJ80.
SMRiQ5SJ80. Positions 3-168.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJ80.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000249469.
KOiK02275.
OMAiAGTNVNM.
OrthoDBiEOG6TFCQV.
PhylomeDBiQ5SJ80.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SJ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDEHKAHKA ILAYEKGWLA FSLAMLFVFI ALIAYTLATH TAGVIPAGKL
60 70 80 90 100
ERVDPTTVRQ EGPWADPAQA VVQTGPNQYT VYVLAFAFGY QPNPIEVPQG
110 120 130 140 150
AEIVFKITSP DVIHGFHVEG TNINVEVLPG EVSTVRYTFK RPGEYRIICN
160
QYCGLGHQNM FGTIVVKE
Length:168
Mass (Da):18,563
Last modified:December 21, 2004 - v1
Checksum:iFE5689FB7672CF05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.
PIRiT52480.
RefSeqiWP_011173203.1. NC_006461.1.
YP_144400.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70957; BAD70957; BAD70957.
GeneIDi3169672.
KEGGittj:TTHA1134.
PATRICi23957227. VBITheThe93045_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.
PIRiT52480.
RefSeqiWP_011173203.1. NC_006461.1.
YP_144400.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40B1-168[»]
2QPDX-ray3.25B1-168[»]
2QPEX-ray2.90B1-168[»]
3BVDX-ray3.37B1-168[»]
3EH3X-ray3.10B3-168[»]
3EH4X-ray2.90B3-168[»]
3EH5X-ray2.80B3-168[»]
3QJQX-ray2.90B1-168[»]
3QJRX-ray3.20B1-168[»]
3QJSX-ray2.80B1-168[»]
3QJTX-ray2.95B1-168[»]
3QJUX-ray2.90B1-168[»]
3QJVX-ray2.80B1-168[»]
3S33X-ray4.45B3-168[»]
3S38X-ray4.20B3-168[»]
3S39X-ray4.80B3-168[»]
3S3AX-ray4.25B3-168[»]
3S3BX-ray3.30B3-168[»]
3S3CX-ray4.00B3-168[»]
3S3DX-ray3.75B3-168[»]
3S8FX-ray1.80B1-168[»]
3S8GX-ray1.80B1-168[»]
4FA7X-ray2.50B1-168[»]
4FAAX-ray2.80B1-168[»]
4G70X-ray2.60B1-168[»]
4G71X-ray2.90B1-168[»]
4G72X-ray3.19B1-168[»]
4G7QX-ray2.60B1-168[»]
4G7RX-ray3.05B1-168[»]
4G7SX-ray2.00B1-168[»]
4GP4X-ray2.80B1-168[»]
4GP5X-ray2.70B1-168[»]
4GP8X-ray2.80B1-168[»]
4N4YX-ray2.90B1-168[»]
ProteinModelPortaliQ5SJ80.
SMRiQ5SJ80. Positions 3-168.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1134.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70957; BAD70957; BAD70957.
GeneIDi3169672.
KEGGittj:TTHA1134.
PATRICi23957227. VBITheThe93045_1113.

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000249469.
KOiK02275.
OMAiAGTNVNM.
OrthoDBiEOG6TFCQV.
PhylomeDBiQ5SJ80.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1166-MONOMER.
BRENDAi1.9.3.1. 2305.

Miscellaneous databases

EvolutionaryTraceiQ5SJ80.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
    Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
    J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-30.
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  3. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
    Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
    EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiCOX2_THET8
AccessioniPrimary (citable) accession number: Q5SJ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: December 21, 2004
Last modified: April 1, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.