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Q5SJ80

- COX2_THET8

UniProt

Q5SJ80 - COX2_THET8

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Protein

Cytochrome c oxidase subunit 2

Gene

cbaB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Copper A
Metal bindingi149 – 1491Copper A
Metal bindingi153 – 1531Copper A
Metal bindingi157 – 1571Copper A

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1166-MONOMER.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2
Gene namesi
Name:cbaB
Synonyms:ctaC
Ordered Locus Names:TTHA1134
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33Cytoplasmic
Transmembranei4 – 3835HelicalAdd
BLAST
Topological domaini39 – 168130PeriplasmicAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Cytochrome c oxidase subunit 2PRO_0000183722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1134.

Structurei

Secondary structure

1
168
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 3633Combined sources
Helixi40 – 445Combined sources
Turni55 – 606Combined sources
Turni63 – 653Combined sources
Helixi67 – 693Combined sources
Beta strandi71 – 755Combined sources
Beta strandi78 – 869Combined sources
Beta strandi89 – 9810Combined sources
Beta strandi101 – 1088Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi114 – 1185Combined sources
Beta strandi124 – 1274Combined sources
Beta strandi133 – 1386Combined sources
Beta strandi143 – 1486Combined sources
Helixi157 – 1593Combined sources
Beta strandi161 – 1677Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40B1-168[»]
2QPDX-ray3.25B1-168[»]
2QPEX-ray2.90B1-168[»]
3BVDX-ray3.37B1-168[»]
3EH3X-ray3.10B3-168[»]
3EH4X-ray2.90B3-168[»]
3EH5X-ray2.80B3-168[»]
3QJQX-ray2.90B1-168[»]
3QJRX-ray3.20B1-168[»]
3QJSX-ray2.80B1-168[»]
3QJTX-ray2.95B1-168[»]
3QJUX-ray2.90B1-168[»]
3QJVX-ray2.80B1-168[»]
3S33X-ray4.45B3-168[»]
3S38X-ray4.20B3-168[»]
3S39X-ray4.80B3-168[»]
3S3AX-ray4.25B3-168[»]
3S3BX-ray3.30B3-168[»]
3S3CX-ray4.00B3-168[»]
3S3DX-ray3.75B3-168[»]
3S8FX-ray1.80B1-168[»]
3S8GX-ray1.80B1-168[»]
4FA7X-ray2.50B1-168[»]
4FAAX-ray2.80B1-168[»]
4G70X-ray2.60B1-168[»]
4G71X-ray2.90B1-168[»]
4G72X-ray3.19B1-168[»]
4G7QX-ray2.60B1-168[»]
4G7RX-ray3.05B1-168[»]
4G7SX-ray2.00B1-168[»]
4GP4X-ray2.80B1-168[»]
4GP5X-ray2.70B1-168[»]
4GP8X-ray2.80B1-168[»]
4N4YX-ray2.90B1-168[»]
ProteinModelPortaliQ5SJ80.
SMRiQ5SJ80. Positions 3-168.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJ80.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
HOGENOMiHOG000249469.
KOiK02275.
OMAiCHEFCGF.
OrthoDBiEOG6TFCQV.
PhylomeDBiQ5SJ80.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SJ80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDEHKAHKA ILAYEKGWLA FSLAMLFVFI ALIAYTLATH TAGVIPAGKL
60 70 80 90 100
ERVDPTTVRQ EGPWADPAQA VVQTGPNQYT VYVLAFAFGY QPNPIEVPQG
110 120 130 140 150
AEIVFKITSP DVIHGFHVEG TNINVEVLPG EVSTVRYTFK RPGEYRIICN
160
QYCGLGHQNM FGTIVVKE
Length:168
Mass (Da):18,563
Last modified:December 21, 2004 - v1
Checksum:iFE5689FB7672CF05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.
PIRiT52480.
RefSeqiWP_011173203.1. NC_006461.1.
YP_144400.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70957; BAD70957; BAD70957.
GeneIDi3169672.
KEGGittj:TTHA1134.
PATRICi23957227. VBITheThe93045_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00369.1 .
AP008226 Genomic DNA. Translation: BAD70957.1 .
PIRi T52480.
RefSeqi WP_011173203.1. NC_006461.1.
YP_144400.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EHK X-ray 2.40 B 1-168 [» ]
2QPD X-ray 3.25 B 1-168 [» ]
2QPE X-ray 2.90 B 1-168 [» ]
3BVD X-ray 3.37 B 1-168 [» ]
3EH3 X-ray 3.10 B 3-168 [» ]
3EH4 X-ray 2.90 B 3-168 [» ]
3EH5 X-ray 2.80 B 3-168 [» ]
3QJQ X-ray 2.90 B 1-168 [» ]
3QJR X-ray 3.20 B 1-168 [» ]
3QJS X-ray 2.80 B 1-168 [» ]
3QJT X-ray 2.95 B 1-168 [» ]
3QJU X-ray 2.90 B 1-168 [» ]
3QJV X-ray 2.80 B 1-168 [» ]
3S33 X-ray 4.45 B 3-168 [» ]
3S38 X-ray 4.20 B 3-168 [» ]
3S39 X-ray 4.80 B 3-168 [» ]
3S3A X-ray 4.25 B 3-168 [» ]
3S3B X-ray 3.30 B 3-168 [» ]
3S3C X-ray 4.00 B 3-168 [» ]
3S3D X-ray 3.75 B 3-168 [» ]
3S8F X-ray 1.80 B 1-168 [» ]
3S8G X-ray 1.80 B 1-168 [» ]
4FA7 X-ray 2.50 B 1-168 [» ]
4FAA X-ray 2.80 B 1-168 [» ]
4G70 X-ray 2.60 B 1-168 [» ]
4G71 X-ray 2.90 B 1-168 [» ]
4G72 X-ray 3.19 B 1-168 [» ]
4G7Q X-ray 2.60 B 1-168 [» ]
4G7R X-ray 3.05 B 1-168 [» ]
4G7S X-ray 2.00 B 1-168 [» ]
4GP4 X-ray 2.80 B 1-168 [» ]
4GP5 X-ray 2.70 B 1-168 [» ]
4GP8 X-ray 2.80 B 1-168 [» ]
4N4Y X-ray 2.90 B 1-168 [» ]
ProteinModelPortali Q5SJ80.
SMRi Q5SJ80. Positions 3-168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1134.

Protein family/group databases

TCDBi 3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70957 ; BAD70957 ; BAD70957 .
GeneIDi 3169672.
KEGGi ttj:TTHA1134.
PATRICi 23957227. VBITheThe93045_1113.

Phylogenomic databases

eggNOGi COG1622.
HOGENOMi HOG000249469.
KOi K02275.
OMAi CHEFCGF.
OrthoDBi EOG6TFCQV.
PhylomeDBi Q5SJ80.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1166-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SJ80.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
    Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
    J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-30.
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  3. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
    Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
    EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiCOX2_THET8
AccessioniPrimary (citable) accession number: Q5SJ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3