Cytochrome c oxidase subunit 2 - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

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Q5SJ80 (COX2_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c ba(3) subunit II
Cytochrome c oxidase polypeptide II
Cytochrome cba3 subunit 2

Gene names

Name:	cbaB
Synonyms:	ctaC
Ordered Locus Names:	TTHA1134

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Subcellular location	Cell membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 168

168

Cytochrome c oxidase subunit 2

PRO_0000183722

Regions

Topological domain

1 – 3

Cytoplasmic

Transmembrane

4 – 38

Helical

Topological domain

39 – 168

130

Periplasmic

Sites

Metal binding

114

Copper A

Metal binding

149

Copper A

Metal binding

153

Copper A

Metal binding

157

Copper A

Secondary structure

168

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q5SJ80 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: FE5689FB7672CF05
Show »

FASTA

168

18,563

        10         20         30         40         50         60 
MVDEHKAHKA ILAYEKGWLA FSLAMLFVFI ALIAYTLATH TAGVIPAGKL ERVDPTTVRQ 

        70         80         90        100        110        120 
EGPWADPAQA VVQTGPNQYT VYVLAFAFGY QPNPIEVPQG AEIVFKITSP DVIHGFHVEG 

       130        140        150        160 
TNINVEVLPG EVSTVRYTFK RPGEYRIICN QYCGLGHQNM FGTIVVKE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8." Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A. J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-30.
[2]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[3]	"Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus." Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E. EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L09121 Genomic DNA. Translation: AAB00369.1.
AP008226 Genomic DNA. Translation: BAD70957.1.

PIR

T52480.

RefSeq

YP_144400.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EHK	X-ray	2.40	B	1-168	[»]
2QPD	X-ray	3.25	B	1-168	[»]
2QPE	X-ray	2.90	B	1-168	[»]
3BVD	X-ray	3.37	B	1-168	[»]
3EH3	X-ray	3.10	B	5-168	[»]
3EH4	X-ray	2.90	B	5-168	[»]
3EH5	X-ray	2.80	B	5-168	[»]
3QJQ	X-ray	2.90	B	1-168	[»]
3QJR	X-ray	3.20	B	1-168	[»]
3QJS	X-ray	2.80	B	1-168	[»]
3QJT	X-ray	2.95	B	1-168	[»]
3QJU	X-ray	2.90	B	1-168	[»]
3QJV	X-ray	2.80	B	1-168	[»]
3S33	X-ray	4.45	B	3-168	[»]
3S38	X-ray	4.20	B	3-168	[»]
3S39	X-ray	4.80	B	3-168	[»]
3S3A	X-ray	4.25	B	3-168	[»]
3S3B	X-ray	3.30	B	3-168	[»]
3S3C	X-ray	4.00	B	3-168	[»]
3S3D	X-ray	3.75	B	3-168	[»]
3S8F	X-ray	1.80	B	1-168	[»]
3S8G	X-ray	1.80	B	1-168	[»]
4FA7	X-ray	2.50	B	1-168	[»]
4FAA	X-ray	2.80	B	1-168	[»]
4GP4	X-ray	2.80	B	1-168	[»]
4GP5	X-ray	2.70	B	1-168	[»]
4GP8	X-ray	2.80	B	1-168	[»]

ProteinModelPortal

Q5SJ80.

SMR

Q5SJ80. Positions 3-168.

ModBase

Search...

Protein-protein interaction databases

STRING

300852.TTHA1134.

Protein family/group databases

TCDB

3.D.4.2.1. proton-translocating cytochrome oxidase (COX) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

BAD70957; BAD70957; BAD70957.

GeneID

3169672.

KEGG

ttj:TTHA1134.

PATRIC

23957227. VBITheThe93045_1113.

Phylogenomic databases

eggNOG

COG1622.

HOGENOM

HOG000249469.

K02275.

OMA

DTNINTM.

ProtClustDB

CLSK738612.

Family and domain databases

Gene3D

2.60.40.420. 1 hit.

InterPro

IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR015209. Cyt_c_oxidase_su2a_TM_dom.
[Graphical view]

Pfam

PF00116. COX2. 1 hit.
PF09125. COX2-transmemb. 1 hit.
[Graphical view]

SUPFAM

SSF49503. Cupredoxin. 1 hit.
SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.

PROSITE

PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q5SJ80.

Entry information

Entry name

COX2_THET8

Accession

Primary (citable) accession number: Q5SJ80

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents