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Q5SJ79

- COX1_THET8

UniProt

Q5SJ79 - COX1_THET8

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Protein

Cytochrome c oxidase subunit 1

Gene

cbaA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • hemeBy similarityNote: Binds 2 heme groups.By similarity
  • Cu cationBy similarityNote: Binds a copper B center.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi72 – 721Iron (heme A axial ligand)Curated
Metal bindingi233 – 2331Copper B
Metal bindingi237 – 2371Copper B
Metal bindingi282 – 2821Copper BCurated
Metal bindingi283 – 2831Copper BCurated
Metal bindingi384 – 3841Iron (heme A3 axial ligand)Curated
Metal bindingi386 – 3861Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1002-MONOMER.
TTHE300852:GH8R-1167-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit I
Cytochrome c oxidase polypeptide I
Cytochrome cba3 subunit 1
Gene namesi
Name:cbaA
Ordered Locus Names:TTHA1135
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei300 – 32021HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence AnalysisAdd
BLAST
Transmembranei471 – 49121HelicalSequence AnalysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Cytochrome c oxidase subunit 1PRO_0000183462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki233 ↔ 2371'-histidyl-3'-tyrosine (His-Tyr)

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1135.

Structurei

Secondary structure

1
562
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 145Combined sources
Helixi16 – 3621Combined sources
Helixi38 – 458Combined sources
Turni46 – 483Combined sources
Helixi52 – 587Combined sources
Helixi65 – 7713Combined sources
Helixi79 – 9719Combined sources
Helixi103 – 12523Combined sources
Turni132 – 1354Combined sources
Beta strandi137 – 1393Combined sources
Helixi143 – 17331Combined sources
Helixi181 – 20626Combined sources
Helixi208 – 2136Combined sources
Beta strandi215 – 2195Combined sources
Helixi221 – 23212Combined sources
Helixi234 – 24916Combined sources
Helixi251 – 2544Combined sources
Helixi262 – 27514Combined sources
Helixi280 – 2834Combined sources
Turni284 – 2863Combined sources
Beta strandi288 – 2903Combined sources
Helixi292 – 32635Combined sources
Beta strandi331 – 3333Combined sources
Helixi334 – 3374Combined sources
Helixi344 – 36623Combined sources
Helixi369 – 3713Combined sources
Helixi372 – 3754Combined sources
Beta strandi376 – 3783Combined sources
Helixi380 – 3889Combined sources
Turni389 – 3913Combined sources
Helixi392 – 3998Combined sources
Turni400 – 4034Combined sources
Helixi404 – 4096Combined sources
Helixi415 – 44430Combined sources
Beta strandi448 – 4503Combined sources
Helixi453 – 4553Combined sources
Helixi457 – 4593Combined sources
Helixi461 – 4633Combined sources
Helixi464 – 49229Combined sources
Beta strandi493 – 4953Combined sources
Helixi499 – 5035Combined sources
Helixi520 – 5245Combined sources
Helixi527 – 55024Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40A1-562[»]
2QPDX-ray3.25A2-562[»]
2QPEX-ray2.90A2-562[»]
3BVDX-ray3.37A2-562[»]
3EH3X-ray3.10A2-562[»]
3EH4X-ray2.90A2-562[»]
3EH5X-ray2.80A2-562[»]
3QJQX-ray2.90A2-562[»]
3QJRX-ray3.20A2-562[»]
3QJSX-ray2.80A2-562[»]
3QJTX-ray2.95A2-562[»]
3QJUX-ray2.90A2-562[»]
3QJVX-ray2.80A2-562[»]
3S33X-ray4.45A2-562[»]
3S38X-ray4.20A2-562[»]
3S39X-ray4.80A2-562[»]
3S3AX-ray4.25A2-562[»]
3S3BX-ray3.30A2-562[»]
3S3CX-ray4.00A2-562[»]
3S3DX-ray3.75A2-562[»]
3S8FX-ray1.80A2-562[»]
3S8GX-ray1.80A2-562[»]
4FA7X-ray2.50A2-562[»]
4FAAX-ray2.80A2-562[»]
4G70X-ray2.60A2-562[»]
4G71X-ray2.90A2-562[»]
4G72X-ray3.19A2-562[»]
4G7QX-ray2.60A2-562[»]
4G7RX-ray3.05A2-562[»]
4G7SX-ray2.00A2-562[»]
4GP4X-ray2.80A2-562[»]
4GP5X-ray2.70A2-562[»]
4GP8X-ray2.80A2-562[»]
4N4YX-ray2.90A2-562[»]
ProteinModelPortaliQ5SJ79.
SMRiQ5SJ79. Positions 6-562.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJ79.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000249472.
KOiK02274.
OMAiFYPPLQA.
OrthoDBiEOG64FKC6.
PhylomeDBiQ5SJ79.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SJ79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVRASEISR VYEAYPEKKA TLYFLVLGFL ALIVGSLFGP FQALNYGNVD
60 70 80 90 100
AYPLLKRLLP FVQSYYQGLT LHGVLNAIVF TQLFAQAIMV YLPARELNMR
110 120 130 140 150
PNMGLMWLSW WMAFIGLVVA ALPLLANEAT VLYTFYPPLK GHWAFYLGAS
160 170 180 190 200
VFVLSTWVSI YIVLDLWRRW KAANPGKVTP LVTYMAVVFW LMWFLASLGL
210 220 230 240 250
VLEAVLFLLP WSFGLVEGVD PLVARTLFWW TGHPIVYFWL LPAYAIIYTI
260 270 280 290 300
LPKQAGGKLV SDPMARLAFL LFLLLSTPVG FHHQFADPGI DPTWKMIHSV
310 320 330 340 350
LTLFVAVPSL MTAFTVAASL EFAGRLRGGR GLFGWIRALP WDNPAFVAPV
360 370 380 390 400
LGLLGFIPGG AGGIVNASFT LDYVVHNTAW VPGHFHLQVA SLVTLTAMGS
410 420 430 440 450
LYWLLPNLTG KPISDAQRRL GLAVVWLWFL GMMIMAVGLH WAGLLNVPRR
460 470 480 490 500
AYIAQVPDAY PHAAVPMVFN VLAGIVLLVA LLLFIYGLFS VLLSRERKPE
510 520 530 540 550
LAEAPLPFAE VISGPEDRRL VLAMDRIGFW FAVAAILVVL AYGPTLVQLF
560
GHLNPVPGWR LW
Length:562
Mass (Da):62,528
Last modified:December 21, 2004 - v1
Checksum:i769B9E2F2033617B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00370.1.
AP008226 Genomic DNA. Translation: BAD70958.1.
RefSeqiYP_144401.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70958; BAD70958; BAD70958.
GeneIDi3168993.
KEGGittj:TTHA1135.
PATRICi23957229. VBITheThe93045_1114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09121 Genomic DNA. Translation: AAB00370.1 .
AP008226 Genomic DNA. Translation: BAD70958.1 .
RefSeqi YP_144401.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EHK X-ray 2.40 A 1-562 [» ]
2QPD X-ray 3.25 A 2-562 [» ]
2QPE X-ray 2.90 A 2-562 [» ]
3BVD X-ray 3.37 A 2-562 [» ]
3EH3 X-ray 3.10 A 2-562 [» ]
3EH4 X-ray 2.90 A 2-562 [» ]
3EH5 X-ray 2.80 A 2-562 [» ]
3QJQ X-ray 2.90 A 2-562 [» ]
3QJR X-ray 3.20 A 2-562 [» ]
3QJS X-ray 2.80 A 2-562 [» ]
3QJT X-ray 2.95 A 2-562 [» ]
3QJU X-ray 2.90 A 2-562 [» ]
3QJV X-ray 2.80 A 2-562 [» ]
3S33 X-ray 4.45 A 2-562 [» ]
3S38 X-ray 4.20 A 2-562 [» ]
3S39 X-ray 4.80 A 2-562 [» ]
3S3A X-ray 4.25 A 2-562 [» ]
3S3B X-ray 3.30 A 2-562 [» ]
3S3C X-ray 4.00 A 2-562 [» ]
3S3D X-ray 3.75 A 2-562 [» ]
3S8F X-ray 1.80 A 2-562 [» ]
3S8G X-ray 1.80 A 2-562 [» ]
4FA7 X-ray 2.50 A 2-562 [» ]
4FAA X-ray 2.80 A 2-562 [» ]
4G70 X-ray 2.60 A 2-562 [» ]
4G71 X-ray 2.90 A 2-562 [» ]
4G72 X-ray 3.19 A 2-562 [» ]
4G7Q X-ray 2.60 A 2-562 [» ]
4G7R X-ray 3.05 A 2-562 [» ]
4G7S X-ray 2.00 A 2-562 [» ]
4GP4 X-ray 2.80 A 2-562 [» ]
4GP5 X-ray 2.70 A 2-562 [» ]
4GP8 X-ray 2.80 A 2-562 [» ]
4N4Y X-ray 2.90 A 2-562 [» ]
ProteinModelPortali Q5SJ79.
SMRi Q5SJ79. Positions 6-562.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1135.

Protein family/group databases

TCDBi 3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70958 ; BAD70958 ; BAD70958 .
GeneIDi 3168993.
KEGGi ttj:TTHA1135.
PATRICi 23957229. VBITheThe93045_1114.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000249472.
KOi K02274.
OMAi FYPPLQA.
OrthoDBi EOG64FKC6.
PhylomeDBi Q5SJ79.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci RETL1328306-WGS:GSTH-1002-MONOMER.
TTHE300852:GH8R-1167-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SJ79.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
    Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
    J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  3. "Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase."
    Buse G., Soulimane T., Dewor M., Meyer H.E., Blueggel M.
    Protein Sci. 8:985-990(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: COVALENT BOND.
  4. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
    Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
    EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiCOX1_THET8
AccessioniPrimary (citable) accession number: Q5SJ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3