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Q5SJ79 (COX1_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1
Alternative name(s):
Cytochrome c ba(3) subunit I
Cytochrome c oxidase polypeptide I
Cytochrome cba3 subunit 1
Gene names
Name:cbaA
Ordered Locus Names:TTHA1135
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 2 heme groups By similarity.

Copper B By similarity.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Cytochrome c oxidase subunit 1
PRO_0000183462

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane267 – 28721Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane385 – 40521Helical; Potential
Transmembrane420 – 44021Helical; Potential
Transmembrane471 – 49121Helical; Potential
Transmembrane527 – 54721Helical; Potential

Sites

Metal binding721Iron (heme A axial ligand) Probable
Metal binding2331Copper B
Metal binding2371Copper B
Metal binding2821Copper B Probable
Metal binding2831Copper B Probable
Metal binding3841Iron (heme A3 axial ligand) Probable
Metal binding3861Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link233 ↔ 2371'-histidyl-3'-tyrosine (His-Tyr)

Secondary structure

1 ........................................................................... 562
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SJ79 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 769B9E2F2033617B

FASTA56262,528
        10         20         30         40         50         60 
MAVRASEISR VYEAYPEKKA TLYFLVLGFL ALIVGSLFGP FQALNYGNVD AYPLLKRLLP 

        70         80         90        100        110        120 
FVQSYYQGLT LHGVLNAIVF TQLFAQAIMV YLPARELNMR PNMGLMWLSW WMAFIGLVVA 

       130        140        150        160        170        180 
ALPLLANEAT VLYTFYPPLK GHWAFYLGAS VFVLSTWVSI YIVLDLWRRW KAANPGKVTP 

       190        200        210        220        230        240 
LVTYMAVVFW LMWFLASLGL VLEAVLFLLP WSFGLVEGVD PLVARTLFWW TGHPIVYFWL 

       250        260        270        280        290        300 
LPAYAIIYTI LPKQAGGKLV SDPMARLAFL LFLLLSTPVG FHHQFADPGI DPTWKMIHSV 

       310        320        330        340        350        360 
LTLFVAVPSL MTAFTVAASL EFAGRLRGGR GLFGWIRALP WDNPAFVAPV LGLLGFIPGG 

       370        380        390        400        410        420 
AGGIVNASFT LDYVVHNTAW VPGHFHLQVA SLVTLTAMGS LYWLLPNLTG KPISDAQRRL 

       430        440        450        460        470        480 
GLAVVWLWFL GMMIMAVGLH WAGLLNVPRR AYIAQVPDAY PHAAVPMVFN VLAGIVLLVA 

       490        500        510        520        530        540 
LLLFIYGLFS VLLSRERKPE LAEAPLPFAE VISGPEDRRL VLAMDRIGFW FAVAAILVVL 

       550        560 
AYGPTLVQLF GHLNPVPGWR LW

« Hide

References

« Hide 'large scale' references
[1]"Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[3]"Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase."
Buse G., Soulimane T., Dewor M., Meyer H.E., Blueggel M.
Protein Sci. 8:985-990(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: COVALENT BOND.
[4]"Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L09121 Genomic DNA. Translation: AAB00370.1.
AP008226 Genomic DNA. Translation: BAD70958.1.
RefSeqYP_144401.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40A1-562[»]
2QPDX-ray3.25A2-562[»]
2QPEX-ray2.90A2-562[»]
3BVDX-ray3.37A2-562[»]
3EH3X-ray3.10A2-562[»]
3EH4X-ray2.90A2-562[»]
3EH5X-ray2.80A2-562[»]
3QJQX-ray2.90A2-562[»]
3QJRX-ray3.20A2-562[»]
3QJSX-ray2.80A2-562[»]
3QJTX-ray2.95A2-562[»]
3QJUX-ray2.90A2-562[»]
3QJVX-ray2.80A2-562[»]
3S33X-ray4.45A2-562[»]
3S38X-ray4.20A2-562[»]
3S39X-ray4.80A2-562[»]
3S3AX-ray4.25A2-562[»]
3S3BX-ray3.30A2-562[»]
3S3CX-ray4.00A2-562[»]
3S3DX-ray3.75A2-562[»]
3S8FX-ray1.80A2-562[»]
3S8GX-ray1.80A2-562[»]
4FA7X-ray2.50A2-562[»]
4FAAX-ray2.80A2-562[»]
4GP4X-ray2.80A2-562[»]
4GP5X-ray2.70A2-562[»]
4GP8X-ray2.80A2-562[»]
ProteinModelPortalQ5SJ79.
SMRQ5SJ79. Positions 6-562.
ModBaseSearch...

Protein-protein interaction databases

STRING300852.TTHA1135.

Protein family/group databases

TCDB3.D.4.2.1. proton-translocating cytochrome oxidase (COX) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70958; BAD70958; BAD70958.
GeneID3168993.
KEGGttj:TTHA1135.
PATRIC23957229. VBITheThe93045_1114.

Phylogenomic databases

eggNOGCOG0843.
HOGENOMHOG000249472.
KOK02274.
OMATLFWYFG.
ProtClustDBCLSK2761931.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. COX1. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5SJ79.

Entry information

Entry nameCOX1_THET8
AccessionPrimary (citable) accession number: Q5SJ79
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents