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Q5SJ79

- COX1_THET8

UniProt

Q5SJ79 - COX1_THET8

Protein

Cytochrome c oxidase subunit 1

Gene

cbaA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 2 heme groups.By similarity
    Copper B.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi72 – 721Iron (heme A axial ligand)Curated
    Metal bindingi233 – 2331Copper B
    Metal bindingi237 – 2371Copper B
    Metal bindingi282 – 2821Copper BCurated
    Metal bindingi283 – 2831Copper BCurated
    Metal bindingi384 – 3841Iron (heme A3 axial ligand)Curated
    Metal bindingi386 – 3861Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-1002-MONOMER.
    TTHE300852:GH8R-1167-MONOMER.
    UniPathwayiUPA00705.

    Protein family/group databases

    TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c ba(3) subunit I
    Cytochrome c oxidase polypeptide I
    Cytochrome cba3 subunit 1
    Gene namesi
    Name:cbaA
    Ordered Locus Names:TTHA1135
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Cytochrome c oxidase subunit 1PRO_0000183462Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki233 ↔ 2371'-histidyl-3'-tyrosine (His-Tyr)

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA1135.

    Structurei

    Secondary structure

    1
    562
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 145
    Helixi16 – 3621
    Helixi38 – 458
    Turni46 – 483
    Helixi52 – 587
    Helixi65 – 7713
    Helixi79 – 9719
    Helixi103 – 12523
    Turni132 – 1354
    Beta strandi137 – 1393
    Helixi143 – 17331
    Helixi181 – 20626
    Helixi208 – 2136
    Beta strandi215 – 2195
    Helixi221 – 23212
    Helixi234 – 24916
    Helixi251 – 2544
    Helixi262 – 27514
    Helixi280 – 2834
    Turni284 – 2863
    Beta strandi288 – 2903
    Helixi292 – 32635
    Beta strandi331 – 3333
    Helixi334 – 3374
    Helixi344 – 36623
    Helixi369 – 3713
    Helixi372 – 3754
    Beta strandi376 – 3783
    Helixi380 – 3889
    Turni389 – 3913
    Helixi392 – 3998
    Turni400 – 4034
    Helixi404 – 4096
    Helixi415 – 44430
    Beta strandi448 – 4503
    Helixi453 – 4553
    Helixi457 – 4593
    Helixi461 – 4633
    Helixi464 – 49229
    Beta strandi493 – 4953
    Helixi499 – 5035
    Helixi520 – 5245
    Helixi527 – 55024

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EHKX-ray2.40A1-562[»]
    2QPDX-ray3.25A2-562[»]
    2QPEX-ray2.90A2-562[»]
    3BVDX-ray3.37A2-562[»]
    3EH3X-ray3.10A2-562[»]
    3EH4X-ray2.90A2-562[»]
    3EH5X-ray2.80A2-562[»]
    3QJQX-ray2.90A2-562[»]
    3QJRX-ray3.20A2-562[»]
    3QJSX-ray2.80A2-562[»]
    3QJTX-ray2.95A2-562[»]
    3QJUX-ray2.90A2-562[»]
    3QJVX-ray2.80A2-562[»]
    3S33X-ray4.45A2-562[»]
    3S38X-ray4.20A2-562[»]
    3S39X-ray4.80A2-562[»]
    3S3AX-ray4.25A2-562[»]
    3S3BX-ray3.30A2-562[»]
    3S3CX-ray4.00A2-562[»]
    3S3DX-ray3.75A2-562[»]
    3S8FX-ray1.80A2-562[»]
    3S8GX-ray1.80A2-562[»]
    4FA7X-ray2.50A2-562[»]
    4FAAX-ray2.80A2-562[»]
    4G70X-ray2.60A2-562[»]
    4G71X-ray2.90A2-562[»]
    4G72X-ray3.19A2-562[»]
    4G7QX-ray2.60A2-562[»]
    4G7RX-ray3.05A2-562[»]
    4G7SX-ray2.00A2-562[»]
    4GP4X-ray2.80A2-562[»]
    4GP5X-ray2.70A2-562[»]
    4GP8X-ray2.80A2-562[»]
    ProteinModelPortaliQ5SJ79.
    SMRiQ5SJ79. Positions 6-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SJ79.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei300 – 32021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei471 – 49121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000249472.
    KOiK02274.
    OMAiFYPPLQA.
    OrthoDBiEOG64FKC6.
    PhylomeDBiQ5SJ79.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SJ79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRASEISR VYEAYPEKKA TLYFLVLGFL ALIVGSLFGP FQALNYGNVD    50
    AYPLLKRLLP FVQSYYQGLT LHGVLNAIVF TQLFAQAIMV YLPARELNMR 100
    PNMGLMWLSW WMAFIGLVVA ALPLLANEAT VLYTFYPPLK GHWAFYLGAS 150
    VFVLSTWVSI YIVLDLWRRW KAANPGKVTP LVTYMAVVFW LMWFLASLGL 200
    VLEAVLFLLP WSFGLVEGVD PLVARTLFWW TGHPIVYFWL LPAYAIIYTI 250
    LPKQAGGKLV SDPMARLAFL LFLLLSTPVG FHHQFADPGI DPTWKMIHSV 300
    LTLFVAVPSL MTAFTVAASL EFAGRLRGGR GLFGWIRALP WDNPAFVAPV 350
    LGLLGFIPGG AGGIVNASFT LDYVVHNTAW VPGHFHLQVA SLVTLTAMGS 400
    LYWLLPNLTG KPISDAQRRL GLAVVWLWFL GMMIMAVGLH WAGLLNVPRR 450
    AYIAQVPDAY PHAAVPMVFN VLAGIVLLVA LLLFIYGLFS VLLSRERKPE 500
    LAEAPLPFAE VISGPEDRRL VLAMDRIGFW FAVAAILVVL AYGPTLVQLF 550
    GHLNPVPGWR LW 562
    Length:562
    Mass (Da):62,528
    Last modified:December 21, 2004 - v1
    Checksum:i769B9E2F2033617B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09121 Genomic DNA. Translation: AAB00370.1.
    AP008226 Genomic DNA. Translation: BAD70958.1.
    RefSeqiYP_144401.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70958; BAD70958; BAD70958.
    GeneIDi3168993.
    KEGGittj:TTHA1135.
    PATRICi23957229. VBITheThe93045_1114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09121 Genomic DNA. Translation: AAB00370.1 .
    AP008226 Genomic DNA. Translation: BAD70958.1 .
    RefSeqi YP_144401.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EHK X-ray 2.40 A 1-562 [» ]
    2QPD X-ray 3.25 A 2-562 [» ]
    2QPE X-ray 2.90 A 2-562 [» ]
    3BVD X-ray 3.37 A 2-562 [» ]
    3EH3 X-ray 3.10 A 2-562 [» ]
    3EH4 X-ray 2.90 A 2-562 [» ]
    3EH5 X-ray 2.80 A 2-562 [» ]
    3QJQ X-ray 2.90 A 2-562 [» ]
    3QJR X-ray 3.20 A 2-562 [» ]
    3QJS X-ray 2.80 A 2-562 [» ]
    3QJT X-ray 2.95 A 2-562 [» ]
    3QJU X-ray 2.90 A 2-562 [» ]
    3QJV X-ray 2.80 A 2-562 [» ]
    3S33 X-ray 4.45 A 2-562 [» ]
    3S38 X-ray 4.20 A 2-562 [» ]
    3S39 X-ray 4.80 A 2-562 [» ]
    3S3A X-ray 4.25 A 2-562 [» ]
    3S3B X-ray 3.30 A 2-562 [» ]
    3S3C X-ray 4.00 A 2-562 [» ]
    3S3D X-ray 3.75 A 2-562 [» ]
    3S8F X-ray 1.80 A 2-562 [» ]
    3S8G X-ray 1.80 A 2-562 [» ]
    4FA7 X-ray 2.50 A 2-562 [» ]
    4FAA X-ray 2.80 A 2-562 [» ]
    4G70 X-ray 2.60 A 2-562 [» ]
    4G71 X-ray 2.90 A 2-562 [» ]
    4G72 X-ray 3.19 A 2-562 [» ]
    4G7Q X-ray 2.60 A 2-562 [» ]
    4G7R X-ray 3.05 A 2-562 [» ]
    4G7S X-ray 2.00 A 2-562 [» ]
    4GP4 X-ray 2.80 A 2-562 [» ]
    4GP5 X-ray 2.70 A 2-562 [» ]
    4GP8 X-ray 2.80 A 2-562 [» ]
    ProteinModelPortali Q5SJ79.
    SMRi Q5SJ79. Positions 6-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1135.

    Protein family/group databases

    TCDBi 3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70958 ; BAD70958 ; BAD70958 .
    GeneIDi 3168993.
    KEGGi ttj:TTHA1135.
    PATRICi 23957229. VBITheThe93045_1114.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000249472.
    KOi K02274.
    OMAi FYPPLQA.
    OrthoDBi EOG64FKC6.
    PhylomeDBi Q5SJ79.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci RETL1328306-WGS:GSTH-1002-MONOMER.
    TTHE300852:GH8R-1167-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SJ79.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8."
      Keightley J.A., Zimmermann B.H., Mather M.W., Springer P., Pastuszyn A., Lawrence D.M., Fee J.A.
      J. Biol. Chem. 270:20345-20358(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    3. "Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase."
      Buse G., Soulimane T., Dewor M., Meyer H.E., Blueggel M.
      Protein Sci. 8:985-990(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: COVALENT BOND.
    4. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
      Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
      EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

    Entry informationi

    Entry nameiCOX1_THET8
    AccessioniPrimary (citable) accession number: Q5SJ79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3