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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151Schiff-base intermediate with acetaldehyde1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:TTHA1186
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315721 – 220Deoxyribose-phosphate aldolaseAdd BLAST220

Interactioni

Subunit structurei

Homotetramer, in solution and in the crystal structure.1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA1186.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Beta strandi7 – 10Combined sources4
Helixi18 – 31Combined sources14
Beta strandi34 – 37Combined sources4
Helixi40 – 42Combined sources3
Helixi43 – 49Combined sources7
Beta strandi54 – 62Combined sources9
Turni63 – 65Combined sources3
Helixi70 – 82Combined sources13
Beta strandi86 – 91Combined sources6
Helixi94 – 98Combined sources5
Helixi102 – 115Combined sources14
Beta strandi119 – 124Combined sources6
Helixi127 – 129Combined sources3
Helixi132 – 145Combined sources14
Beta strandi148 – 151Combined sources4
Beta strandi155 – 158Combined sources4
Helixi163 – 173Combined sources11
Beta strandi176 – 184Combined sources9
Helixi188 – 196Combined sources9
Beta strandi200 – 204Combined sources5
Helixi207 – 211Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J2WX-ray1.50A/B/C/D1-220[»]
1UB3X-ray1.40A/B/C/D1-220[»]
ProteinModelPortaliQ5SJ28.
SMRiQ5SJ28.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SJ28.

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241645.
KOiK01619.
OMAiFFSVCVN.
PhylomeDBiQ5SJ28.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SJ28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLAAHIDHT LLKPTATLEE VAKAAEEALE YGFYGLCIPP SYVAWVRARY
60 70 80 90 100
PHAPFRLVTV VGFPLGYQEK EVKALEAALA CARGADEVDM VLHLGRAKAG
110 120 130 140 150
DLDYLEAEVR AVREAVPQAV LKVILETGYF SPEEIARLAE AAIRGGADFL
160 170 180 190 200
KTSTGFGPRG ASLEDVALLV RVAQGRAQVK AAGGIRDRET ALRMLKAGAS
210 220
RLGTSSGVAL VAGEGGTLGY
Length:220
Mass (Da):23,307
Last modified:December 21, 2004 - v1
Checksum:iF8E933B08155AF53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71009.1.
RefSeqiWP_011228499.1. NC_006461.1.
YP_144452.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71009; BAD71009; BAD71009.
GeneIDi3169004.
KEGGittj:TTHA1186.
PATRICi23957337. VBITheThe93045_1167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71009.1.
RefSeqiWP_011228499.1. NC_006461.1.
YP_144452.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J2WX-ray1.50A/B/C/D1-220[»]
1UB3X-ray1.40A/B/C/D1-220[»]
ProteinModelPortaliQ5SJ28.
SMRiQ5SJ28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71009; BAD71009; BAD71009.
GeneIDi3169004.
KEGGittj:TTHA1186.
PATRICi23957337. VBITheThe93045_1167.

Phylogenomic databases

eggNOGiENOG4105FCI. Bacteria.
COG0274. LUCA.
HOGENOMiHOG000241645.
KOiK01619.
OMAiFFSVCVN.
PhylomeDBiQ5SJ28.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Miscellaneous databases

EvolutionaryTraceiQ5SJ28.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00126. deoC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDEOC_THET8
AccessioniPrimary (citable) accession number: Q5SJ28
Secondary accession number(s): Q7SIC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.