Q5SIY7 (Q5SIY7_THET8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tryptophanyl-tRNA synthetase EMBL BAD71050.1

Gene names

Ordered Locus Names:

TTHA1227

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). SAAS SAAS024109
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family. RuleBase RU003489

Ontologies

Keywords
Biological process	Protein biosynthesis RuleBase RU003489 SAAS SAAS024109
Ligand	ATP-binding RuleBase RU003489 SAAS SAAS024109 Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase RuleBase RU003489 SAAS SAAS024109 EMBL BAD71050.1 Ligase
Technical term	3D-structure PDB 2EL7 Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophanyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tryptophan-tRNA ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5SIY7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 2242BCDEC1C0D908	FASTA	337	37,988
	10 20 30 40 50 60 MKRVLSGIQP SGEIHIGNYL GAIKQWVAIG EKLGRDAFFC IVDYHALTNP LAYDPSTLAQ 70 80 90 100 110 120 RTFEAALVNI AAGLDPEKVT LFVQSHVPEH TELSWVFTTL TPLGDLTRMT QFKDKASKQE 130 140 150 160 170 180 TVWSGLLMYP VLQAADILIY KADTVPVGED QVQHIELTRE IARRFNHLFG ETFPEPQALL 190 200 210 220 230 240 NPEAPRVPGI DGKAKMSKSL GNTIGLLEPE ESIWQKIQHL PDDPQRIRLS DPGDPERTIL 250 260 270 280 290 300 FTYLSYFAPK DLVEALKEEY RKAGVGTYVV KRILFDHLME ALRPIRERAE ALKKDPDYVM 310 320 330 DALLEGAKRA RAVAQATMEE VREKVGLLLP RKRPVLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Crystal structure of Tryptophanyl-tRNA synthetase from Thermus thermophilus." Yanagisawa T., Sumida T., Ishii R., Sakamoto K., Shirouzu M., Sekine S., Shinkai A., Kuramitsu S., Yokoyama S. Submitted (MAR-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008226 Genomic DNA. Translation: BAD71050.1.

RefSeq

YP_144493.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EL7	X-ray	2.50	A/B	1-337	[»]

ProteinModelPortal

Q5SIY7.

SMR

Q5SIY7. Positions 1-331.

ModBase

Search...

Protein-protein interaction databases

STRING

Q5SIY7.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3168998.

GenomeReviews

Gene locus TTHA1227 in contig AP008226_GR.

KEGG

ttj:TTHA1227.

PATRIC

23957415. VBITheThe93045_1206.

Phylogenomic databases

eggNOG

COG0180.

HOGENOM

HBG293263.

OMA

KENIYEM.

PhylomeDB

Q5SIY7.

ProtClustDB

PRK00927.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA1227-MONOMER.

Family and domain databases

HAMAP

MF_00140_B. Trp_tRNA_synth_B.
[Tree]

InterPro

IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-synth.
IPR024109. Trp-tRNA-synth_bac-type.
[Graphical view]

Gene3D

G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.

KO

K01867.

PANTHER

PTHR10055. Trp_tRNA-synt_1b. 1 hit.

Pfam

PF00579. tRNA-synt_1b. 1 hit.
[Graphical view]

PRINTS

PR01039. TRNASYNTHTRP.

TIGRFAMs

TIGR00233. TrpS. 1 hit.

PROSITE

PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q5SIY7_THET8

Accession

Primary (citable) accession number: Q5SIY7

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)