Q5SIW2 (GCP_THET8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein

Gene names

Name:	gcp
Ordered Locus Names:	TTHA1252

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity. HAMAP MF_01445
Subcellular location	Cytoplasm Potential HAMAP MF_01445.
Sequence similarities	Belongs to the KAE1 / YgjD family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp HAMAP MF_01445		PRO_0000303597

Sequences

	Sequence		Length	Mass (Da)
	Q5SIW2 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 28046FA6A0FD79A1	FASTA	326	34,727
	10 20 30 40 50 60 MRAVWVLGID TSCDDTGVGL VRDGKVVVNL VASQVRLHEA FGGVVPELAS REHLKALPLL 70 80 90 100 110 120 VERALAEAGL RPKDLDLVAA TRGPGLIGAL LVGYTFAKGM AFALDRPFYA VHHLEGHIAA 130 140 150 160 170 180 AWPEGLPPPF LALVASGGHT HLYEVLDLGR YRLLGATRDD AAGEAFDKVA RLLGLGFPGG 190 200 210 220 230 240 PEVERLAEEA EEAIPFPVPL RGQEGYDFSF SGLKTKALHL VEKGLPKAAL AKGFQEAAIA 250 260 270 280 290 300 HLAEVVLKAA KDTGHRVLLV AGGVAANRAL QERFKEAGLE VHFPPRGLSQ DNGAMIALAA 310 320 WRRHQRGFPP SPLSLGATAY WPLEEA

References

[1]

"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008226 Genomic DNA. Translation: BAD71075.1.
RefSeq	YP_144518.2. NC_006461.1.
3D structure databases
ProteinModelPortal	Q5SIW2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5SIW2.
Protein family/group databases
MEROPS	M22.A01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3169345.
GenomeReviews	Gene locus TTHA1252 in contig AP008226_GR.
KEGG	ttj:TTHA1252.
PATRIC	23957467. VBITheThe93045_1231.
Phylogenomic databases
eggNOG	COG0533.
HOGENOM	HBG304663.
OMA	MEVIGQT.
PhylomeDB	Q5SIW2.
ProtClustDB	PRK09604.
Enzyme and pathway databases
BioCyc	TTHE300852:TTHA1252-MONOMER.
Family and domain databases
HAMAP	MF_01445. gcp. [Tree]
InterPro	IPR022450. Pept_M22_O-sialoglycopept. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
KO	K01409.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR03723. Bact_gcp. 1 hit. TIGR00329. Gcp_kae1. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_THET8

Accession

Primary (citable) accession number: Q5SIW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program