Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Uncharacterized protein

Gene

TTHA1280

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei202 – 2021S-adenosyl-L-homocysteineCombined sources
Binding sitei217 – 2171S-adenosyl-L-homocysteineCombined sources
Binding sitei238 – 2381S-adenosyl-L-homocysteineCombined sources
Binding sitei286 – 2861S-adenosyl-L-homocysteineCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseSAAS annotation, Transferase

Keywords - Biological processi

rRNA processingSAAS annotation

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1314-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:TTHA1280Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1280.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WXWX-ray2.55A/B/C/D1-382[»]
1WXXX-ray1.80A/B/C/D1-382[»]
2CWWX-ray2.60A/B1-382[»]
ProteinModelPortaliQ5SIT4.
SMRiQ5SIT4. Positions 1-382.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SIT4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 342178Methyltrans_SAMInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2662S-adenosyl-L-homocysteine bindingCombined sources

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmI family.SAAS annotation
Contains PUA domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105DR4. Bacteria.
COG1092. LUCA.
HOGENOMiHOG000266008.
KOiK06969.
OMAiDCFCHTG.
OrthoDBiEOG6DG2T1.
PhylomeDBiQ5SIT4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR015947. PUA-like_domain.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
SSF88697. SSF88697. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SIT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIQVNAKGA ARLLSRHLWV FRRDVVSGPE TPGLYPVYWG RRFLALALYN
60 70 80 90 100
PHTDLAVRAY RFAPAEDPVA ALLENLAQAL ARREAVLRQD PEGGYRLVHA
110 120 130 140 150
EGDLLPGLVV DYYAGHAVVQ ATAHAWEGLL PQVAEALRPH VQSVLAKNDA
160 170 180 190 200
RTRELEGLPL YVRPLLGEVP ERVQVQEGRV RYLVDLRAGQ KTGAYLDQRE
210 220 230 240 250
NRLYMERFRG ERALDVFSYA GGFALHLALG FREVVAVDSS AEALRRAEEN
260 270 280 290 300
ARLNGLGNVR VLEANAFDLL RRLEKEGERF DLVVLDPPAF AKGKKDVERA
310 320 330 340 350
YRAYKEVNLR AIKLLKEGGI LATASCSHHM TEPLFYAMVA EAAQDAHRLL
360 370 380
RVVEKRGQPF DHPVLLNHPE THYLKFAVFQ VL
Length:382
Mass (Da):43,000
Last modified:December 21, 2004 - v1
Checksum:iA9535E02207F9C1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71103.1.
RefSeqiWP_011228566.1. NC_006461.1.
YP_144546.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71103; BAD71103; BAD71103.
GeneIDi3168447.
KEGGittj:TTHA1280.
PATRICi23957523. VBITheThe93045_1259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71103.1.
RefSeqiWP_011228566.1. NC_006461.1.
YP_144546.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WXWX-ray2.55A/B/C/D1-382[»]
1WXXX-ray1.80A/B/C/D1-382[»]
2CWWX-ray2.60A/B1-382[»]
ProteinModelPortaliQ5SIT4.
SMRiQ5SIT4. Positions 1-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71103; BAD71103; BAD71103.
GeneIDi3168447.
KEGGittj:TTHA1280.
PATRICi23957523. VBITheThe93045_1259.

Phylogenomic databases

eggNOGiENOG4105DR4. Bacteria.
COG1092. LUCA.
HOGENOMiHOG000266008.
KOiK06969.
OMAiDCFCHTG.
OrthoDBiEOG6DG2T1.
PhylomeDBiQ5SIT4.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1314-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SIT4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR015947. PUA-like_domain.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
SSF88697. SSF88697. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  2. "Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine."
    Pioszak A.A., Murayama K., Nakagawa N., Ebihara A., Kuramitsu S., Shirouzu M., Yokoyama S.
    Acta Crystallogr. F 61:867-874(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE.

Entry informationi

Entry nameiQ5SIT4_THET8
AccessioniPrimary (citable) accession number: Q5SIT4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.