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Protein

Ribosome hibernation promoting factor

Gene

hpf

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.UniRule annotation

GO - Biological processi

Keywordsi

Biological processTranslation regulationUniRule annotation

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome hibernation promoting factorUniRule annotation
Short name:
HPFUniRule annotation
Gene namesi
Name:hpfUniRule annotation
Ordered Locus Names:TTHA1294Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts with 100S ribosomes.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA1294.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YWQX-ray2.64A/B/C/D1-105[»]
ProteinModelPortaliQ5SIS0.
SMRiQ5SIS0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SIS0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 182Ribosom_S30AE_CInterPro annotationAdd BLAST56

Sequence similaritiesi

Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105MS2. Bacteria.
COG1544. LUCA.
HOGENOMiHOG000074927.
KOiK05808.
OMAiHGGYGVI.
PhylomeDBiQ5SIS0.

Family and domain databases

CDDicd00552. RaiA. 1 hit.
Gene3Di3.30.160.100. 1 hit.
HAMAPiMF_00839. HPF. 1 hit.
InterProiView protein in InterPro
IPR034694. HPF_long/plastid.
IPR032528. Ribosom_S30AE_C.
IPR003489. Ribosomal_S30Ae/sigma54_mod.
PfamiView protein in Pfam
PF16321. Ribosom_S30AE_C. 1 hit.
PF02482. Ribosomal_S30AE. 1 hit.
SUPFAMiSSF69754. SSF69754. 1 hit.
TIGRFAMsiTIGR00741. yfiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SIS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIYKLIGRN LEITDAIRDY VEKKLARLDR YQDGELMAKV VLSLAGSPHV
60 70 80 90 100
EKKARAEIQV DLPGGLVRVE EEDADLYAAI DRAVDRLETQ VKRFRERRYV
110 120 130 140 150
GKRHSYQGPP PPEVRDLEAL RKPEEEEGPR IVRVKRFEMK PMDPEEAAFQ
160 170 180
MEALGHSFFV FRNAKTDEIN VIYRRKDGNY GLIEPA
Length:186
Mass (Da):21,569
Last modified:December 21, 2004 - v1
Checksum:i106561264DA68439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71117.1.
RefSeqiWP_008632742.1. NC_006461.1.
YP_144560.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71117; BAD71117; BAD71117.
GeneIDi3168424.
KEGGittj:TTHA1294.
PATRICifig|300852.9.peg.1272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71117.1.
RefSeqiWP_008632742.1. NC_006461.1.
YP_144560.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YWQX-ray2.64A/B/C/D1-105[»]
ProteinModelPortaliQ5SIS0.
SMRiQ5SIS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1294.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71117; BAD71117; BAD71117.
GeneIDi3168424.
KEGGittj:TTHA1294.
PATRICifig|300852.9.peg.1272.

Phylogenomic databases

eggNOGiENOG4105MS2. Bacteria.
COG1544. LUCA.
HOGENOMiHOG000074927.
KOiK05808.
OMAiHGGYGVI.
PhylomeDBiQ5SIS0.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1285-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SIS0.

Family and domain databases

CDDicd00552. RaiA. 1 hit.
Gene3Di3.30.160.100. 1 hit.
HAMAPiMF_00839. HPF. 1 hit.
InterProiView protein in InterPro
IPR034694. HPF_long/plastid.
IPR032528. Ribosom_S30AE_C.
IPR003489. Ribosomal_S30Ae/sigma54_mod.
PfamiView protein in Pfam
PF16321. Ribosom_S30AE_C. 1 hit.
PF02482. Ribosomal_S30AE. 1 hit.
SUPFAMiSSF69754. SSF69754. 1 hit.
TIGRFAMsiTIGR00741. yfiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SIS0_THET8
AccessioniPrimary (citable) accession number: Q5SIS0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 7, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.