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Protein

Ribosome hibernation promoting factor

Gene

hpf

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.UniRule annotation

GO - Biological processi

Keywordsi

Biological processTranslation regulationUniRule annotation

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1298-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome hibernation promoting factorUniRule annotation
Short name:
HPFUniRule annotation
Gene namesi
Name:hpfUniRule annotation
Ordered Locus Names:TTHA1294Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts with 100S ribosomes.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA1294

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YWQX-ray2.64A/B/C/D1-105[»]
ProteinModelPortaliQ5SIS0
SMRiQ5SIS0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SIS0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 182Ribosom_S30AE_CInterPro annotationAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 97Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105MS2 Bacteria
COG1544 LUCA
HOGENOMiHOG000074927
KOiK05808
OMAiHGGYGVI
PhylomeDBiQ5SIS0

Family and domain databases

CDDicd00552 RaiA, 1 hit
Gene3Di3.30.160.1001 hit
3.30.505.501 hit
HAMAPiMF_00839 HPF, 1 hit
InterProiView protein in InterPro
IPR034694 HPF_long/plastid
IPR036567 RHF-like
IPR003489 RHF/RaiA
IPR032528 Ribosom_S30AE_C
IPR038416 Ribosom_S30AE_C_sf
PfamiView protein in Pfam
PF16321 Ribosom_S30AE_C, 1 hit
PF02482 Ribosomal_S30AE, 1 hit
SUPFAMiSSF69754 SSF69754, 1 hit
TIGRFAMsiTIGR00741 yfiA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SIS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIYKLIGRN LEITDAIRDY VEKKLARLDR YQDGELMAKV VLSLAGSPHV
60 70 80 90 100
EKKARAEIQV DLPGGLVRVE EEDADLYAAI DRAVDRLETQ VKRFRERRYV
110 120 130 140 150
GKRHSYQGPP PPEVRDLEAL RKPEEEEGPR IVRVKRFEMK PMDPEEAAFQ
160 170 180
MEALGHSFFV FRNAKTDEIN VIYRRKDGNY GLIEPA
Length:186
Mass (Da):21,569
Last modified:December 21, 2004 - v1
Checksum:i106561264DA68439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71117.1
RefSeqiWP_008632742.1, NC_006461.1
YP_144560.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71117; BAD71117; BAD71117
GeneIDi3168424
KEGGittj:TTHA1294
PATRICifig|300852.9.peg.1272

Similar proteinsi

Entry informationi

Entry nameiQ5SIS0_THET8
AccessioniPrimary (citable) accession number: Q5SIS0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported