5'-nucleotidase - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Preferred order of sections

Names and origin

Protein names

Submitted name:
5'-nucleotidase EMBL BAD71151.1

Gene names

Ordered Locus Names:

TTHA1328

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the 5'-nucleotidase family. RuleBase RU003467

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU004470 PDB 2Z1A Nucleotide-binding RuleBase RU004470 Zinc PDB 2Z1A
Technical term	3D-structure PDB 2Z1A Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

37

1

Zinc 1 PDB 2Z1A

Metal binding

39

1

Zinc 1; via tele nitrogen PDB 2Z1A

Metal binding

83

1

Zinc 1 PDB 2Z1A

Metal binding

83

1

Zinc 2 PDB 2Z1A

Metal binding

115

1

Zinc 2 PDB 2Z1A

Metal binding

215

1

Zinc 2; via tele nitrogen PDB 2Z1A

Metal binding

238

1

Zinc 2; via pros nitrogen PDB 2Z1A

Metal binding

240

1

Zinc 1; via tele nitrogen PDB 2Z1A

Sequences

Sequence

Length

Mass (Da)

Tools

Q5SIP1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 0030AF05053DF3ED
Show »

FASTA

552

59,970

        10         20         30         40         50         60 
MKRREVLQAG MALGGLAGLG RALAQGGFTL TLVHTNDTHA HLEPVELTLS GEKTPVGGVA 

        70         80         90        100        110        120 
RRVALFDRVW ARAKNPLFLD AGDVFQGTLY FNQYRGLADR YFMHRLRYRA MALGNHEFDL 

       130        140        150        160        170        180 
GPGPLADFLK GARFKVVSAN VDASREPRLK GLFAPYAVVV VGGERVGIIG LTTPDTREIS 

       190        200        210        220        230        240 
NPGPTVAFLD PYESAQKAVY ELLAKGVNKI VVLSHLGYGE DLKLARRLVG VQVIVGGHSH 

       250        260        270        280        290        300 
TLLGSFPHKE LSPAGPYPTV VKNPEGKDVL VVQAWEWGKV VGLLEVTFDA KGELLAYKGE 

       310        320        330        340        350        360 
ALLMTPEAAP EDFFAKEALL AYAQPVMALM QQVIAEAKVD LVGERAVVRR RESNLGNLIT 

       370        380        390        400        410        420 
DGMLWKTRNA GTQIALQNGG GIRASIPKGP ITVGKVYEVL PFGNTLVVMD LKGKEILAAL 

       430        440        450        460        470        480 
ENGVSQWENT AGRFLQVSGL RYAFDLSRPA GSRVVRVEVK TEKGYVPLDL EATYRVVVNN 

       490        500        510        520        530        540 
FIANGGDGFT VLKEAQGYRV DTGFSDAESF MDYLKELKVV EAGLEGRIEV LNEPKGERPA 

       550 
YFAYRVPGLV GV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
[2]	"Crystal structure of 5'-nucleotidase precursor from Thermus thermophilus HB8." Nakakaga N., Kishishita S., Yokoyama S., Kuramitsu S. Submitted (MAY-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AP008226 Genomic DNA. Translation: BAD71151.1.

RefSeq

YP_144594.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2Z1A	X-ray	1.75	A	1-552	[»]

ProteinModelPortal

Q5SIP1.

SMR

Q5SIP1. Positions 28-534.

ModBase

Search...

Protein-protein interaction databases

STRING

Q5SIP1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

3167981.

GenomeReviews

Gene locus TTHA1328 in contig AP008226_GR.

KEGG

ttj:TTHA1328.

NMPDR

fig|300852.3.peg.1581.

PATRIC

23957617. VBITheThe93045_1306.

Phylogenomic databases

eggNOG

COG0737.

HOGENOM

HBG534106.

OMA

FQGSLFY.

ProtClustDB

CLSK539103.

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA1328-MONOMER.

Family and domain databases

InterPro

IPR008334. 5'-Nucleotdase_C.
IPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Metallo_PEstase_dom.
[Graphical view]

Gene3D

G3DSA:3.90.780.10. 5'-Nucleotdase_C. 1 hit.

KO

K01081.

PANTHER

PTHR11575. 5_nucleotidase. 1 hit.

Pfam

PF02872. 5_nucleotid_C. 1 hit.
PF00149. Metallophos. 1 hit.
[Graphical view]

PRINTS

PR01607. APYRASEFAMLY.

SUPFAM

SSF55816. 5'-Nucleotdase_C. 1 hit.

PROSITE

PS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q5SIP1_THET8

Accession

Primary (citable) accession number: Q5SIP1

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)