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Protein

Endonuclease V

Gene

nfi

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi42MagnesiumUniRule annotation1
Metal bindingi110MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1350-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:TTHA1347
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596761 – 226Endonuclease VAdd BLAST226

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei80Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi300852.TTHA1347

Structurei

3D structure databases

ProteinModelPortaliQ5SIM2
SMRiQ5SIM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X Bacteria
COG1515 LUCA
HOGENOMiHOG000229135
KOiK05982
OMAiCKYRVPE
PhylomeDBiQ5SIM2

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SIM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPPFPKPA HPEEALALQR ALAKKVRLAG SLEGVRRIAA LDASHKRGRP
60 70 80 90 100
LVAVALLYDL EKGPLHVATA LLPEEALFPY VPGLLSFREA PAYLEALAAL
110 120 130 140 150
PEAPEALLVD GQGVAHPRGL GIASHLGVHL DLPSVGVAKR LLYGRPEAPL
160 170 180 190 200
PEEKGAAVRL LAPDGRPLGY VYRSRTGVKP LYVSPGHRVG LEEALRFVRR
210 220
LPTRFRLPEP LRLAHLEAGR ALKALD
Length:226
Mass (Da):24,431
Last modified:December 21, 2004 - v1
Checksum:i64E55AC96B507DCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71170.1
RefSeqiWP_011173403.1, NC_006461.1
YP_144613.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71170; BAD71170; BAD71170
GeneIDi3168384
KEGGittj:TTHA1347
PATRICifig|300852.9.peg.1324

Similar proteinsi

Entry informationi

Entry nameiNFI_THET8
AccessioniPrimary (citable) accession number: Q5SIM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health