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Protein
Submitted name:

Elongation factor G (EF-G-2)

Gene

TTHA1498

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361GTPCombined sources
Binding sitei76 – 761GTP; via amide nitrogenCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176GTPCombined sources
Nucleotide bindingi53 – 542GTPCombined sources
Nucleotide bindingi128 – 1303GTPCombined sources
Nucleotide bindingi247 – 2493GTPCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factorImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1535-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Elongation factor G (EF-G-2)Imported
Gene namesi
Ordered Locus Names:TTHA1498Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1498.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WDTX-ray2.20A1-658[»]
2DY1X-ray1.60A1-658[»]
ProteinModelPortaliQ5SI76.
SMRiQ5SI76. Positions 1-658.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SI76.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 269269Tr-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
HOGENOMiHOG000231587.
KOiK02355.
OMAiHLIPVCF.
OrthoDBiEOG6FJNNN.
PhylomeDBiQ5SI76.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
[Graphical view]
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SI76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRTVALVGH AGSGKTTLTE ALLYKTGAKE RRGRVEEGTT TTDYTPEAKL
60 70 80 90 100
HRTTVRTGVA PLLFRGHRVF LLDAPGYGDF VGEIRGALEA ADAALVAVSA
110 120 130 140 150
EAGVQVGTER AWTVAERLGL PRMVVVTKLD KGGDYYALLE DLRSTLGPIL
160 170 180 190 200
PIDLPLYEGG KWVGLIDVFH GKAYRYENGE EREAEVPPEE RERVQRFRQE
210 220 230 240 250
VLEAIVETDE GLLEKYLEGE EVTGEALEKA FHEAVRRGLL YPVALASGER
260 270 280 290 300
EIGVLPLLEL ILEALPSPTE RFGDGPPLAK VFKVQVDPFM GQVAYLRLYR
310 320 330 340 350
GRLKPGDSLQ SEAGQVRLPH LYVPMGKDLL EVEEAEAGFV LGVPKAEGLH
360 370 380 390 400
RGMVLWQGEK PESEEVPFAR LPDPNVPVAL HPKGRTDEAR LGEALRKLLE
410 420 430 440 450
EDPSLKLERQ EETGELLLWG HGELHLATAK ERLQDYGVEV EFSVPKVPYR
460 470 480 490 500
ETIKKVAEGQ GKYKKQTGGH GQYGDVWLRL EPASEYGFEW RITGGVIPSK
510 520 530 540 550
YQEAIEEGIK EAAKKGVLAG FPVMGFKAIV YNGSYHEVDS SDLAFQIAAS
560 570 580 590 600
LAFKKVMAEA HPVLLEPIYR LKVLAPQERV GDVLSDLQAR RGRILGMEQE
610 620 630 640 650
GALSVVHAEV PLAEVLEYYK ALPGLTGGAG AYTLEFSHYA EVPPHLAQRI

VQERAQEG
Length:658
Mass (Da):72,534
Last modified:December 21, 2004 - v1
Checksum:i2946C1AC7F069FFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71321.1.
RefSeqiWP_011228719.1. NC_006461.1.
YP_144764.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71321; BAD71321; BAD71321.
GeneIDi3169428.
KEGGittj:TTHA1498.
PATRICi23957957. VBITheThe93045_1473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71321.1.
RefSeqiWP_011228719.1. NC_006461.1.
YP_144764.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WDTX-ray2.20A1-658[»]
2DY1X-ray1.60A1-658[»]
ProteinModelPortaliQ5SI76.
SMRiQ5SI76. Positions 1-658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1498.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71321; BAD71321; BAD71321.
GeneIDi3169428.
KEGGittj:TTHA1498.
PATRICi23957957. VBITheThe93045_1473.

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
HOGENOMiHOG000231587.
KOiK02355.
OMAiHLIPVCF.
OrthoDBiEOG6FJNNN.
PhylomeDBiQ5SI76.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1535-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SI76.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
[Graphical view]
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Crystal structure of ttk003000868 from Thermus thermophilus HB8."
    Wang H., Takemoto-Hori C., Murayama K., Sekine S., Terada T., Shirouzu M., Kuramitsu S., Yokoyama S.
    Submitted (MAY-2004) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH GTP.
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  3. "Crystal structure of EF-G-2 from Thermus thermophilus."
    Wang H., Takemoto C., Murayama K., Terada T., Chen L., Liu Z.J., Wang B.C., Shirouzu M., Yokoyama S.
    Submitted (SEP-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH GTP.

Entry informationi

Entry nameiQ5SI76_THET8
AccessioniPrimary (citable) accession number: Q5SI76
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 16, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.