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Protein

Guanylate kinase

Gene

gmk

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1568-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:TTHA1562
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002664281 – 223Guanylate kinaseAdd BLAST223

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1562

Structurei

3D structure databases

ProteinModelPortaliQ5SI18
SMRiQ5SI18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 183Guanylate kinase-likeUniRule annotationAdd BLAST178

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT
PhylomeDBiQ5SI18

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SI18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGMRGRLFV MTGASGVGKG TVRAKVLERT RLFYSISMTT RPPRPGEVDG
60 70 80 90 100
VDYYFVDRPT FEALVREDGF LEYAEYVGHL YGTPRAPVER ALSRGEDVLL
110 120 130 140 150
EIEVQGALQV KRAVPEAVLI FLLPPSLSEL KRRLVYRGKD SPEKIQKRLE
160 170 180 190 200
QAEWEIRNAH LFDYVVVNDV LEEAVADFLA ILTAERRRSG RMGEALEMAL
210 220
RRDLALEAEL DEILRRRYGG TGH
Length:223
Mass (Da):25,338
Last modified:December 21, 2004 - v1
Checksum:i903093C51D0757AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71385.1
RefSeqiWP_011228765.1, NC_006461.1
YP_144828.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71385; BAD71385; BAD71385
GeneIDi3169695
KEGGittj:TTHA1562
PATRICifig|300852.9.peg.1533

Similar proteinsi

Entry informationi

Entry nameiKGUA_THET8
AccessioniPrimary (citable) accession number: Q5SI18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health