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Q5SI18

- KGUA_THET8

UniProt

Q5SI18 - KGUA_THET8

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Protein
Guanylate kinase
Gene
gmk, TTHA1562
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1601-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:TTHA1562
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Guanylate kinaseUniRule annotation
PRO_0000266428Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1562.

Structurei

3D structure databases

ProteinModelPortaliQ5SI18.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 183178Guanylate kinase-like
Add
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037639.
KOiK00942.
OMAiDAVFSIS.
OrthoDBiEOG6CP410.
PhylomeDBiQ5SI18.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SI18-1 [UniParc]FASTAAdd to Basket

« Hide

MKGMRGRLFV MTGASGVGKG TVRAKVLERT RLFYSISMTT RPPRPGEVDG    50
VDYYFVDRPT FEALVREDGF LEYAEYVGHL YGTPRAPVER ALSRGEDVLL 100
EIEVQGALQV KRAVPEAVLI FLLPPSLSEL KRRLVYRGKD SPEKIQKRLE 150
QAEWEIRNAH LFDYVVVNDV LEEAVADFLA ILTAERRRSG RMGEALEMAL 200
RRDLALEAEL DEILRRRYGG TGH 223
Length:223
Mass (Da):25,338
Last modified:December 21, 2004 - v1
Checksum:i903093C51D0757AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71385.1.
RefSeqiWP_011228765.1. NC_006461.1.
YP_144828.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71385; BAD71385; BAD71385.
GeneIDi3169695.
KEGGittj:TTHA1562.
PATRICi23958081. VBITheThe93045_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71385.1 .
RefSeqi WP_011228765.1. NC_006461.1.
YP_144828.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SI18.
ModBasei Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71385 ; BAD71385 ; BAD71385 .
GeneIDi 3169695.
KEGGi ttj:TTHA1562.
PATRICi 23958081. VBITheThe93045_1533.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037639.
KOi K00942.
OMAi DAVFSIS.
OrthoDBi EOG6CP410.
PhylomeDBi Q5SI18.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1601-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiKGUA_THET8
AccessioniPrimary (citable) accession number: Q5SI18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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