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Protein

Thymidylate kinase

Gene

tmk

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1613-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:TTHA1607
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553611 – 198Thymidylate kinaseAdd BLAST198

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1607

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X7JX-ray1.84A/B1-198[»]
5X86X-ray1.19A/B1-198[»]
5X8AX-ray2.51A/B1-198[»]
5X8BX-ray1.39A/B1-198[»]
5X8CX-ray2.07A/B1-198[»]
5X8DX-ray2.26A/B1-198[»]
5X8JX-ray1.80A/B1-198[»]
5X8KX-ray1.67A/B1-198[»]
5X8VX-ray1.66A/B1-198[»]
5X98X-ray1.76A/B1-198[»]
5X99X-ray1.73A/B1-198[»]
5XAKX-ray1.50A/B1-198[»]
5XALX-ray1.84A/B1-198[»]
ProteinModelPortaliQ5SHX3
SMRiQ5SHX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229077
KOiK00943
OMAiFLYTADH
PhylomeDBiQ5SHX3

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SHX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGLFLTLEG LDGSGKTTQA RRLAAFLEAQ GRPVLLTREP GGGLPEVRSL
60 70 80 90 100
LLTQELSPEA EYLLFSADRA EHVRKVILPG LAAGKVVISD RYLDSSLAYQ
110 120 130 140 150
GYGRGLPLPW LREVAREATR GLKPRLTFLL DLPPEAALRR VRRPDRLEGL
160 170 180 190
GLEFFRRVRE GYLALARAEP GRFVVLDATL PEEEIARAIQ AHLRPLLP
Length:198
Mass (Da):21,979
Last modified:December 21, 2004 - v1
Checksum:iD2D908A11DC07F55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71430.1
RefSeqiWP_011173647.1, NC_006461.1
YP_144873.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71430; BAD71430; BAD71430
GeneIDi3169786
KEGGittj:TTHA1607
PATRICifig|300852.9.peg.1577

Similar proteinsi

Entry informationi

Entry nameiKTHY_THET8
AccessioniPrimary (citable) accession number: Q5SHX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health