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Q5SHW1

- TRMB_THET8

UniProt

Q5SHW1 - TRMB_THET8

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281S-adenosyl-L-methionineUniRule annotation
    Binding sitei53 – 531S-adenosyl-L-methionineUniRule annotation
    Active sitei103 – 1031By similarity
    Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
    Binding sitei107 – 1071SubstrateUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1658-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:TTHA1619
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311tRNA (guanine-N(7)-)-methyltransferasePRO_0000229205Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi300852.TTHA1619.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SHW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000099573.
    KOiK03439.
    OMAiTKYALKW.
    OrthoDBiEOG6K6VBC.
    PhylomeDBiQ5SHW1.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5SHW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVVPARLHR WPPEVQDLFG REGPLVLEIG FGDGRFTAEL ARSRPDWLVL    50
    GAEVSAASVL RALRRMRREG LANVRLYHGQ GPFALRNLVL PGTLDQVIVN 100
    FPDPWPKKRH QERRLLREAF FRRLSTRLKP GGSLLLTTDH EEYFRFALEE 150
    AERTGLYRVE VRPPPEAHLR TKYALKWKEA GRAFFHAAFI KLREDPAPWP 200
    PLRRYDVAHA LLSGELPQDL ALEKTPVRLK EGVAVFLEVA RGKEGFYVLT 250
    HVEEEDLTQD LLLEVRKSAR GVYAGVSRFG SPLITEAVKG AVRALVDRLE 300
    AHGLEVVQDH T 311
    Length:311
    Mass (Da):35,375
    Last modified:December 21, 2004 - v1
    Checksum:i46161AC2A5DA32D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71442.1.
    RefSeqiYP_144885.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD71442; BAD71442; BAD71442.
    GeneIDi3168435.
    KEGGittj:TTHA1619.
    PATRICi23958193. VBITheThe93045_1589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71442.1 .
    RefSeqi YP_144885.1. NC_006461.1.

    3D structure databases

    ProteinModelPortali Q5SHW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD71442 ; BAD71442 ; BAD71442 .
    GeneIDi 3168435.
    KEGGi ttj:TTHA1619.
    PATRICi 23958193. VBITheThe93045_1589.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000099573.
    KOi K03439.
    OMAi TKYALKW.
    OrthoDBi EOG6K6VBC.
    PhylomeDBi Q5SHW1.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci TTHE300852:GH8R-1658-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.

    Entry informationi

    Entry nameiTRMB_THET8
    AccessioniPrimary (citable) accession number: Q5SHW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3