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Q5SHW1

- TRMB_THET8

UniProt

Q5SHW1 - TRMB_THET8

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, TTHA1619
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281S-adenosyl-L-methionine By similarity
Binding sitei53 – 531S-adenosyl-L-methionine By similarity
Active sitei103 – 1031 By similarity
Binding sitei103 – 1031S-adenosyl-L-methionine By similarity
Binding sitei107 – 1071Substrate By similarity
Binding sitei139 – 1391Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1658-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:TTHA1619
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000229205Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1619.

Structurei

3D structure databases

ProteinModelPortaliQ5SHW1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000099573.
KOiK03439.
OMAiTKYALKW.
OrthoDBiEOG6K6VBC.
PhylomeDBiQ5SHW1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHW1-1 [UniParc]FASTAAdd to Basket

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MLVVPARLHR WPPEVQDLFG REGPLVLEIG FGDGRFTAEL ARSRPDWLVL    50
GAEVSAASVL RALRRMRREG LANVRLYHGQ GPFALRNLVL PGTLDQVIVN 100
FPDPWPKKRH QERRLLREAF FRRLSTRLKP GGSLLLTTDH EEYFRFALEE 150
AERTGLYRVE VRPPPEAHLR TKYALKWKEA GRAFFHAAFI KLREDPAPWP 200
PLRRYDVAHA LLSGELPQDL ALEKTPVRLK EGVAVFLEVA RGKEGFYVLT 250
HVEEEDLTQD LLLEVRKSAR GVYAGVSRFG SPLITEAVKG AVRALVDRLE 300
AHGLEVVQDH T 311
Length:311
Mass (Da):35,375
Last modified:December 21, 2004 - v1
Checksum:i46161AC2A5DA32D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71442.1.
RefSeqiYP_144885.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71442; BAD71442; BAD71442.
GeneIDi3168435.
KEGGittj:TTHA1619.
PATRICi23958193. VBITheThe93045_1589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71442.1 .
RefSeqi YP_144885.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SHW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71442 ; BAD71442 ; BAD71442 .
GeneIDi 3168435.
KEGGi ttj:TTHA1619.
PATRICi 23958193. VBITheThe93045_1589.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000099573.
KOi K03439.
OMAi TKYALKW.
OrthoDBi EOG6K6VBC.
PhylomeDBi Q5SHW1.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci TTHE300852:GH8R-1658-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiTRMB_THET8
AccessioniPrimary (citable) accession number: Q5SHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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