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Q5SHW1

- TRMB_THET8

UniProt

Q5SHW1 - TRMB_THET8

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281S-adenosyl-L-methionineUniRule annotation
Binding sitei53 – 531S-adenosyl-L-methionineUniRule annotation
Active sitei103 – 1031By similarity
Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
Binding sitei107 – 1071SubstrateUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1658-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:TTHA1619
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311tRNA (guanine-N(7)-)-methyltransferasePRO_0000229205Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1619.

Structurei

3D structure databases

ProteinModelPortaliQ5SHW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000099573.
KOiK03439.
OMAiTKYALKW.
OrthoDBiEOG6K6VBC.
PhylomeDBiQ5SHW1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVVPARLHR WPPEVQDLFG REGPLVLEIG FGDGRFTAEL ARSRPDWLVL
60 70 80 90 100
GAEVSAASVL RALRRMRREG LANVRLYHGQ GPFALRNLVL PGTLDQVIVN
110 120 130 140 150
FPDPWPKKRH QERRLLREAF FRRLSTRLKP GGSLLLTTDH EEYFRFALEE
160 170 180 190 200
AERTGLYRVE VRPPPEAHLR TKYALKWKEA GRAFFHAAFI KLREDPAPWP
210 220 230 240 250
PLRRYDVAHA LLSGELPQDL ALEKTPVRLK EGVAVFLEVA RGKEGFYVLT
260 270 280 290 300
HVEEEDLTQD LLLEVRKSAR GVYAGVSRFG SPLITEAVKG AVRALVDRLE
310
AHGLEVVQDH T
Length:311
Mass (Da):35,375
Last modified:December 21, 2004 - v1
Checksum:i46161AC2A5DA32D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71442.1.
RefSeqiWP_011228808.1. NC_006461.1.
YP_144885.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71442; BAD71442; BAD71442.
GeneIDi3168435.
KEGGittj:TTHA1619.
PATRICi23958193. VBITheThe93045_1589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71442.1 .
RefSeqi WP_011228808.1. NC_006461.1.
YP_144885.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SHW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71442 ; BAD71442 ; BAD71442 .
GeneIDi 3168435.
KEGGi ttj:TTHA1619.
PATRICi 23958193. VBITheThe93045_1589.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000099573.
KOi K03439.
OMAi TKYALKW.
OrthoDBi EOG6K6VBC.
PhylomeDBi Q5SHW1.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci TTHE300852:GH8R-1658-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiTRMB_THET8
AccessioniPrimary (citable) accession number: Q5SHW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3