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Q5SHU0 (Q5SHU0_THET8) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
Short name=ADC HAMAP-Rule MF_01417
EC=4.1.1.19 HAMAP-Rule MF_01417
Gene names
Name:speA HAMAP-Rule MF_01417
Ordered Locus Names:TTHA1640 EMBL BAD71463.1
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP] EMBL BAD71463.1
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. RuleBase RU003740 HAMAP-Rule MF_01417 SAAS SAAS002985

Cofactor

Magnesium By similarity. RuleBase RU003740 HAMAP-Rule MF_01417 SAAS SAAS002985

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417 SAAS SAAS002985

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. HAMAP-Rule MF_01417

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01417

Sequences

Sequence LengthMass (Da)Tools
Q5SHU0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 565F8577FDF8D999

FASTA62870,241
        10         20         30         40         50         60 
MAKRFTLKDA EELYLVPHWS GGFFRVGEKG DLEVTPLGPK GPAASLLEIV EALRDEGRPL 

        70         80         90        100        110        120 
PLVLRFPQIL EARVRDLNEA FLEAMAKYGY QGTYRGVYPV KVNQRRLVLE TVARAGRPYH 

       130        140        150        160        170        180 
LGLEAGSKPE LALILAQDLS EEALITTNGF KDDDFVRLAL MGRKLGRNVV ITLEKFAELF 

       190        200        210        220        230        240 
RVLRLSKELG VKPLLGIRYK LKAKGAGQWE ASGGENAKFG LTTPEIVRAV EVLQEEGLLD 

       250        260        270        280        290        300 
ALVMLHAHIG SQVTDIRRIK AAVREAAQTY VQLRKLGAPL RYLNLGGGLA VDYDGSKTNF 

       310        320        330        340        350        360 
YASANYTLSE YAENLVYVTK EVVEAQGEPH PILVTESGRA ITAYHEVLVL QVIDVIAPPG 

       370        380        390        400        410        420 
EARPSPPPPE AHPLVKELWE SLQSLSPKNF QEVYHDAFAD KETLQTLYDL GLVSLRDRAL 

       430        440        450        460        470        480 
AEEIFYHIAR RVQTIAQNLP YVPDELEDLE KLLADKLVCN FSVFQSLPDA WAIHQLFPVV 

       490        500        510        520        530        540 
PLSRLLEPPT RRATLVDISC DSDGKMDRFI DLHDVRQTLP VHPVRPGEPY YLGVFLVGAY 

       550        560        570        580        590        600 
QDVLGSNHNL FGQVGEAHVR VEEEGFAIER FVGGETAERV IEKMGFTARE LMLGVERLVR 

       610        620 
QSRLSPVEKG AFLERYAREL QGYTYLED

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References

[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD71463.1.
RefSeqYP_144906.1. NC_006461.1.

3D structure databases

ProteinModelPortalQ5SHU0.
ModBaseSearch...

Protein-protein interaction databases

STRING300852.TTHA1640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD71463; BAD71463; BAD71463.
GeneID3169310.
KEGGttj:TTHA1640.
PATRIC23958235. VBITheThe93045_1610.

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1679-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PANTHERPTHR11482:SF3. PTHR11482:SF3. 1 hit.
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5SHU0_THET8
AccessionPrimary (citable) accession number: Q5SHU0
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: May 29, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info