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Q5SHU0

- Q5SHU0_THET8

UniProt

Q5SHU0 - Q5SHU0_THET8

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Protein

Biosynthetic arginine decarboxylase

Gene
speA, TTHA1640
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations
Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1679-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:TTHA1640Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1640.

Structurei

3D structure databases

ProteinModelPortaliQ5SHU0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.
PhylomeDBiQ5SHU0.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHU0-1 [UniParc]FASTAAdd to Basket

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MAKRFTLKDA EELYLVPHWS GGFFRVGEKG DLEVTPLGPK GPAASLLEIV    50
EALRDEGRPL PLVLRFPQIL EARVRDLNEA FLEAMAKYGY QGTYRGVYPV 100
KVNQRRLVLE TVARAGRPYH LGLEAGSKPE LALILAQDLS EEALITTNGF 150
KDDDFVRLAL MGRKLGRNVV ITLEKFAELF RVLRLSKELG VKPLLGIRYK 200
LKAKGAGQWE ASGGENAKFG LTTPEIVRAV EVLQEEGLLD ALVMLHAHIG 250
SQVTDIRRIK AAVREAAQTY VQLRKLGAPL RYLNLGGGLA VDYDGSKTNF 300
YASANYTLSE YAENLVYVTK EVVEAQGEPH PILVTESGRA ITAYHEVLVL 350
QVIDVIAPPG EARPSPPPPE AHPLVKELWE SLQSLSPKNF QEVYHDAFAD 400
KETLQTLYDL GLVSLRDRAL AEEIFYHIAR RVQTIAQNLP YVPDELEDLE 450
KLLADKLVCN FSVFQSLPDA WAIHQLFPVV PLSRLLEPPT RRATLVDISC 500
DSDGKMDRFI DLHDVRQTLP VHPVRPGEPY YLGVFLVGAY QDVLGSNHNL 550
FGQVGEAHVR VEEEGFAIER FVGGETAERV IEKMGFTARE LMLGVERLVR 600
QSRLSPVEKG AFLERYAREL QGYTYLED 628
Length:628
Mass (Da):70,241
Last modified:December 21, 2004 - v1
Checksum:i565F8577FDF8D999
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71463.1.
RefSeqiWP_011228825.1. NC_006461.1.
YP_144906.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71463; BAD71463; BAD71463.
GeneIDi3169310.
KEGGittj:TTHA1640.
PATRICi23958235. VBITheThe93045_1610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71463.1 .
RefSeqi WP_011228825.1. NC_006461.1.
YP_144906.1. NC_006461.1.

3D structure databases

ProteinModelPortali Q5SHU0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71463 ; BAD71463 ; BAD71463 .
GeneIDi 3169310.
KEGGi ttj:TTHA1640.
PATRICi 23958235. VBITheThe93045_1610.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.
PhylomeDBi Q5SHU0.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci TTHE300852:GH8R-1679-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiQ5SHU0_THET8
AccessioniPrimary (citable) accession number: Q5SHU0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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