Q5SHT7 (MURI_THET8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate racemase
EC=5.1.1.3

Gene names

Name:	murI
Ordered Locus Names:	TTHA1643

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the (R)-glutamate required for cell wall biosynthesis By similarity. HAMAP MF_00258
Catalytic activity	L-glutamate = D-glutamate. HAMAP MF_00258
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00258
Sequence similarities	Belongs to the aspartate/glutamate racemases family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Glutamate racemase HAMAP MF_00258		PRO_1000078584

Sequences

	Sequence		Length	Mass (Da)
	Q5SHT7 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 048F2B8DE59669B1	FASTA	257	27,656
	10 20 30 40 50 60 MKDPKAPIGV FDSGVGGLTV LKALRRLLPR EEFLYFGDTA RVPYGGKPLA MVRRFAWEIA 70 80 90 100 110 120 GFLLRQGVKA IVVACNTASS AALPDLAEDL SVPVFGVVEP AARAARGFRK VGLIGTQATV 130 140 150 160 170 180 ESGAYPRYVD LAWAKACPLF VPLVEEGLWD DPVALLVARH YLEDAPKDLE ALILGCTHYP 190 200 210 220 230 240 FLKGAIGAVL PGVALLDSAE LTAQEVARAL EAEGLLNPEG RGRTFHLVTG DPEAYRALAE 250 RLGERVEAVR RVSLEEL

References

[1]

"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008226 Genomic DNA. Translation: BAD71466.1.
RefSeq	YP_144909.1. NC_006461.1.
3D structure databases
HSSP	HSSP built from PDB template 1B74 based on UniProtKB P56868.
ProteinModelPortal	Q5SHT7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5SHT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3169688.
GenomeReviews	Gene locus TTHA1643 in contig AP008226_GR.
KEGG	ttj:TTHA1643.
NMPDR	fig|300852.3.peg.1955.
PATRIC	23958241. VBITheThe93045_1613.
Phylogenomic databases
eggNOG	COG0796.
HOGENOM	HBG645102.
OMA	PQEDTIY.
ProtClustDB	CLSK738787.
Enzyme and pathway databases
BioCyc	TTHE300852:TTHA1643-MONOMER.
Family and domain databases
HAMAP	MF_00258. Glu_racemase. [Tree]
InterPro	IPR015942. Asp/Glu/hydantoin_racemase. IPR001920. Asp/Glu_race. IPR018187. Asp/Glu_racemase_AS. IPR004391. Glu_race. [Graphical view]
Gene3D	G3DSA:3.40.50.1860. Asp/Glu_race. 2 hits.
KO	K01776.
PANTHER	PTHR21198. PTHR21198. 1 hit.
Pfam	PF01177. Asp_Glu_race. 1 hit. [Graphical view]
SUPFAM	SSF53681. Asp/Glu_race. 2 hits.
TIGRFAMs	TIGR00067. Glut_race. 1 hit.
PROSITE	PS00923. ASP_GLU_RACEMASE_1. 1 hit. PS00924. ASP_GLU_RACEMASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURI_THET8

Accession

Primary (citable) accession number: Q5SHT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program