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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Gene namesi
Name:secY
Ordered Locus Names:TTHA1672
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicAdd
BLAST
Transmembranei19 – 3416Helical; Name=1Add
BLAST
Topological domaini35 – 5622PeriplasmicAdd
BLAST
Transmembranei57 – 8731Discontinuously helical; Name=2Add
BLAST
Intramembranei57 – 6711Helical; Name=Helix 2AAdd
BLAST
Intramembranei68 – 714
Intramembranei72 – 8716Helical; Name=Helix 2BAdd
BLAST
Topological domaini88 – 11427CytoplasmicAdd
BLAST
Transmembranei115 – 13016Helical; Name=3Add
BLAST
Topological domaini131 – 15727PeriplasmicAdd
BLAST
Transmembranei158 – 17518Helical; Name=4Add
BLAST
Topological domaini176 – 1827Cytoplasmic
Transmembranei183 – 20119Helical; Name=5Add
BLAST
Topological domaini202 – 21413PeriplasmicAdd
BLAST
Transmembranei215 – 23117Helical; Name=6Add
BLAST
Topological domaini232 – 27140CytoplasmicAdd
BLAST
Transmembranei272 – 28817Helical; Name=7Add
BLAST
Topological domaini289 – 30315PeriplasmicAdd
BLAST
Transmembranei304 – 32320Helical; Name=8Add
BLAST
Topological domaini324 – 37249CytoplasmicAdd
BLAST
Transmembranei373 – 38917Helical; Name=9Add
BLAST
Topological domaini390 – 3923Periplasmic
Transmembranei393 – 40816Helical; Name=10Add
BLAST
Topological domaini409 – 43830CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Protein translocase subunit SecYPRO_0000414214Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA1672.

Structurei

Secondary structure

1
438
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 109Combined sources
Helixi12 – 3120Combined sources
Helixi41 – 488Combined sources
Helixi53 – 564Combined sources
Helixi57 – 615Combined sources
Turni62 – 643Combined sources
Helixi66 – 694Combined sources
Turni72 – 776Combined sources
Helixi78 – 9316Combined sources
Helixi95 – 1017Combined sources
Turni105 – 1073Combined sources
Helixi108 – 13326Combined sources
Helixi137 – 1404Combined sources
Helixi151 – 17828Combined sources
Beta strandi179 – 1813Combined sources
Helixi183 – 19311Combined sources
Helixi196 – 20914Combined sources
Helixi214 – 23623Combined sources
Beta strandi238 – 2447Combined sources
Beta strandi248 – 2503Combined sources
Beta strandi253 – 2553Combined sources
Beta strandi257 – 26711Combined sources
Helixi272 – 28817Combined sources
Helixi295 – 3039Combined sources
Beta strandi306 – 3083Combined sources
Helixi309 – 33022Combined sources
Helixi333 – 34210Combined sources
Helixi354 – 38936Combined sources
Helixi394 – 3963Combined sources
Helixi398 – 42326Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20Y3-434[»]
2ZQPX-ray6.00Y3-434[»]
5AWWX-ray2.72Y1-438[»]
5CH4X-ray3.64Y1-435[»]
ProteinModelPortaliQ5SHQ8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHQ8.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiQ5SHQ8.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAFWSALQ IPELRQRVLF TLLVLAAYRL GAFIPTPGVD LDKIQEFLRT
60 70 80 90 100
AQGGVFGIIN LFSGGNFERF SIFALGIMPY ITAAIIMQIL VTVVPALEKL
110 120 130 140 150
SKEGEEGRRI INQYTRIGGI ALGAFQGFFL ATAFLGAEGG RFLLPGWSPG
160 170 180 190 200
PFFWFVVVVT QVAGIALLLW MAERITEYGI GNGTSLIIFA GIVVEWLPQI
210 220 230 240 250
LRTIGLIRTG EVNLVAFLFF LAFIVLAFAG MAAVQQAERR IPVQYARKVV
260 270 280 290 300
GRRVYGGQAT YIPIKLNAAG VIPIIFAAAI LQIPIFLAAP FQDNPVLQGI
310 320 330 340 350
ANFFNPTRPS GLFIEVLLVI LFTYVYTAVQ FDPKRIAESL REYGGFIPGI
360 370 380 390 400
RPGEPTVKFL EHIVSRLTLW GALFLGLVTL LPQIIQNLTG IHSIAFSGIG
410 420 430
LLIVVGVALD TLRQVESQLM LRSYEGFLSR GRLRGRNR
Length:438
Mass (Da):48,204
Last modified:December 21, 2004 - v1
Checksum:i71BBEF926123A69E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71495.1.
RefSeqiWP_011228842.1. NC_006461.1.
YP_144938.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71495; BAD71495; BAD71495.
GeneIDi3169829.
KEGGittj:TTHA1672.
PATRICi23958299. VBITheThe93045_1642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71495.1.
RefSeqiWP_011228842.1. NC_006461.1.
YP_144938.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20Y3-434[»]
2ZQPX-ray6.00Y3-434[»]
5AWWX-ray2.72Y1-438[»]
5CH4X-ray3.64Y1-435[»]
ProteinModelPortaliQ5SHQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71495; BAD71495; BAD71495.
GeneIDi3169829.
KEGGittj:TTHA1672.
PATRICi23958299. VBITheThe93045_1642.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiQ5SHQ8.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1711-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SHQ8.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_THET8
AccessioniPrimary (citable) accession number: Q5SHQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 21, 2004
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.