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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Gene namesi
Name:secY
Ordered Locus Names:TTHA1672
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicAdd BLAST18
Transmembranei19 – 34Helical; Name=1Add BLAST16
Topological domaini35 – 56PeriplasmicAdd BLAST22
Transmembranei57 – 87Discontinuously helical; Name=2Add BLAST31
Intramembranei57 – 67Helical; Name=Helix 2AAdd BLAST11
Intramembranei68 – 714
Intramembranei72 – 87Helical; Name=Helix 2BAdd BLAST16
Topological domaini88 – 114CytoplasmicAdd BLAST27
Transmembranei115 – 130Helical; Name=3Add BLAST16
Topological domaini131 – 157PeriplasmicAdd BLAST27
Transmembranei158 – 175Helical; Name=4Add BLAST18
Topological domaini176 – 182Cytoplasmic7
Transmembranei183 – 201Helical; Name=5Add BLAST19
Topological domaini202 – 214PeriplasmicAdd BLAST13
Transmembranei215 – 231Helical; Name=6Add BLAST17
Topological domaini232 – 271CytoplasmicAdd BLAST40
Transmembranei272 – 288Helical; Name=7Add BLAST17
Topological domaini289 – 303PeriplasmicAdd BLAST15
Transmembranei304 – 323Helical; Name=8Add BLAST20
Topological domaini324 – 372CytoplasmicAdd BLAST49
Transmembranei373 – 389Helical; Name=9Add BLAST17
Topological domaini390 – 392Periplasmic3
Transmembranei393 – 408Helical; Name=10Add BLAST16
Topological domaini409 – 438CytoplasmicCuratedAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004142141 – 438Protein translocase subunit SecYAdd BLAST438

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA1672.

Structurei

Secondary structure

1438
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 10Combined sources9
Helixi12 – 31Combined sources20
Helixi41 – 48Combined sources8
Helixi53 – 56Combined sources4
Helixi57 – 61Combined sources5
Turni62 – 64Combined sources3
Helixi66 – 69Combined sources4
Turni72 – 77Combined sources6
Helixi78 – 93Combined sources16
Helixi95 – 101Combined sources7
Turni105 – 107Combined sources3
Helixi108 – 133Combined sources26
Helixi137 – 140Combined sources4
Helixi151 – 178Combined sources28
Beta strandi179 – 181Combined sources3
Helixi183 – 193Combined sources11
Helixi196 – 209Combined sources14
Helixi214 – 236Combined sources23
Beta strandi238 – 244Combined sources7
Beta strandi248 – 250Combined sources3
Beta strandi253 – 255Combined sources3
Beta strandi257 – 267Combined sources11
Helixi272 – 288Combined sources17
Helixi295 – 303Combined sources9
Beta strandi306 – 308Combined sources3
Helixi309 – 330Combined sources22
Helixi333 – 342Combined sources10
Helixi354 – 389Combined sources36
Helixi394 – 396Combined sources3
Helixi398 – 423Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20Y3-434[»]
2ZQPX-ray6.00Y3-434[»]
5AWWX-ray2.72Y1-438[»]
5CH4X-ray3.64Y1-435[»]
ProteinModelPortaliQ5SHQ8.
SMRiQ5SHQ8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHQ8.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiQ5SHQ8.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKAFWSALQ IPELRQRVLF TLLVLAAYRL GAFIPTPGVD LDKIQEFLRT
60 70 80 90 100
AQGGVFGIIN LFSGGNFERF SIFALGIMPY ITAAIIMQIL VTVVPALEKL
110 120 130 140 150
SKEGEEGRRI INQYTRIGGI ALGAFQGFFL ATAFLGAEGG RFLLPGWSPG
160 170 180 190 200
PFFWFVVVVT QVAGIALLLW MAERITEYGI GNGTSLIIFA GIVVEWLPQI
210 220 230 240 250
LRTIGLIRTG EVNLVAFLFF LAFIVLAFAG MAAVQQAERR IPVQYARKVV
260 270 280 290 300
GRRVYGGQAT YIPIKLNAAG VIPIIFAAAI LQIPIFLAAP FQDNPVLQGI
310 320 330 340 350
ANFFNPTRPS GLFIEVLLVI LFTYVYTAVQ FDPKRIAESL REYGGFIPGI
360 370 380 390 400
RPGEPTVKFL EHIVSRLTLW GALFLGLVTL LPQIIQNLTG IHSIAFSGIG
410 420 430
LLIVVGVALD TLRQVESQLM LRSYEGFLSR GRLRGRNR
Length:438
Mass (Da):48,204
Last modified:December 21, 2004 - v1
Checksum:i71BBEF926123A69E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71495.1.
RefSeqiWP_011228842.1. NC_006461.1.
YP_144938.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71495; BAD71495; BAD71495.
GeneIDi3169829.
KEGGittj:TTHA1672.
PATRICi23958299. VBITheThe93045_1642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71495.1.
RefSeqiWP_011228842.1. NC_006461.1.
YP_144938.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20Y3-434[»]
2ZQPX-ray6.00Y3-434[»]
5AWWX-ray2.72Y1-438[»]
5CH4X-ray3.64Y1-435[»]
ProteinModelPortaliQ5SHQ8.
SMRiQ5SHQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71495; BAD71495; BAD71495.
GeneIDi3169829.
KEGGittj:TTHA1672.
PATRICi23958299. VBITheThe93045_1642.

Phylogenomic databases

eggNOGiENOG4105CGG. Bacteria.
COG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
PhylomeDBiQ5SHQ8.

Miscellaneous databases

EvolutionaryTraceiQ5SHQ8.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_THET8
AccessioniPrimary (citable) accession number: Q5SHQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.