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Q5SHQ4 (RL18_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L18
Alternative name(s):
TL24
Gene names
Name:rplR
Ordered Locus Names:TTHA1676
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is one of the proteins that binds and mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. HAMAP-Rule MF_01337_B

Subunit structure

Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and probably the 23S rRNA; has been isolated in a complex with the 5S rRNA and RL25 (Ref.2).

Sequence similarities

Belongs to the ribosomal protein L18P family.

Mass spectrometry

Molecular mass is 12481 Da from positions 2 - 112. Determined by MALDI. Ref.5

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2 Ref.3 Ref.4
Chain2 – 11211150S ribosomal protein L18 HAMAP-Rule MF_01337_B
PRO_0000131372

Secondary structure

.................... 112
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SHQ4 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: EA2AB016AEDB0638

FASTA11212,612
        10         20         30         40         50         60 
MARLTAYERR KFRVRNRIKR TGRLRLSVFR SLKHIYAQII DDEKGVTLVS ASSLALKLKG 

        70         80         90        100        110 
NKTEVARQVG RALAEKALAL GIKQVAFDRG PYKYHGRVKA LAEGAREGGL EF 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Identification, purification and partial sequence of four Thermus thermophilus 5S rRNA binding proteins."
Kim J.-S., Boysen R.I., Schroeder W., Erdmann V.A., Gessner R.V.
Endocyt. Cell Res. 11:177-194(1996)
Cited for: PROTEIN SEQUENCE OF 2-24, ISOLATION OF 5S RRNA-ASSOCIATED COMPLEXES.
[3]"The isolation and complete amino acid sequence of the ribosomal protein L36 from Thermus thermophilus and its zinc-binding motif."
Boysen R.I., Lorenz S., Kim J.S., Schroeder W.F.K.J., Erdmann V.A.
Endocyt. Cell Res. 11:41-58(1995)
Cited for: PROTEIN SEQUENCE OF 2-19.
[4]"Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-16.
[5]"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
[6]"The path of messenger RNA through the ribosome."
Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[7]"Crystal structure of the ribosome at 5.5 A resolution."
Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F.
Science 292:883-896(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD71499.1.
RefSeqYP_144942.1. NC_006461.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GIYX-ray5.50Q1-112[»]
1YL3X-ray5.50Q1-112[»]
2HGJX-ray5.00R1-112[»]
2HGQX-ray5.50R1-112[»]
2HGUX-ray4.51R1-112[»]
2J01X-ray2.80S2-112[»]
2J03X-ray2.80S2-112[»]
2V47X-ray3.50S2-112[»]
2V49X-ray3.50S2-112[»]
2WDIX-ray3.30S1-112[»]
2WDJX-ray3.30S1-112[»]
2WDLX-ray3.50S1-112[»]
2WDNX-ray3.50S1-112[»]
2WH2X-ray3.45S1-112[»]
2WH4X-ray3.45S1-112[»]
2WRJX-ray3.60S1-112[»]
2WRLX-ray3.60S1-112[»]
2WROX-ray3.60S1-112[»]
2WRRX-ray3.60S1-112[»]
2X9SX-ray3.10S1-112[»]
2X9UX-ray3.10S1-112[»]
2XG0X-ray3.20S1-112[»]
2XG2X-ray3.20S1-112[»]
2XQEX-ray3.10S1-112[»]
2XTGelectron microscopy7.80S1-112[»]
2XUXelectron microscopy7.60S1-112[»]
2Y0VX-ray3.10S1-112[»]
2Y0XX-ray3.10S1-112[»]
2Y0ZX-ray3.10S1-112[»]
2Y11X-ray3.10S1-112[»]
2Y13X-ray3.10S1-112[»]
2Y15X-ray3.10S1-112[»]
2Y17X-ray3.10S1-112[»]
2Y19X-ray3.10S1-112[»]
3FINelectron microscopy6.40S11-109[»]
3HUXX-ray3.10S1-112[»]
3HUZX-ray3.10S1-112[»]
3I8FX-ray3.10Q1-112[»]
3I8IX-ray3.10Q1-112[»]
3I9CX-ray3.50Q1-112[»]
3I9EX-ray3.50Q1-112[»]
3KIRX-ray3.30S1-112[»]
3KITX-ray3.30S1-112[»]
3KIWX-ray3.60S1-112[»]
3KIYX-ray3.60S1-112[»]
3KNIX-ray3.00S1-112[»]
3KNKX-ray3.00S1-112[»]
3KNMX-ray3.45S1-112[»]
3KNOX-ray3.45S1-112[»]
3TVEX-ray3.10Q2-112[»]
3TVHX-ray3.10Q2-112[»]
3UXQX-ray3.20S1-112[»]
3UXRX-ray3.20S1-112[»]
3UYEX-ray3.00Q1-112[»]
3UYGX-ray3.00Q1-112[»]
3UZ1X-ray3.30Q1-112[»]
3UZ2X-ray3.30Q1-112[»]
3UZ8X-ray3.00Q1-112[»]
3UZ9X-ray3.00Q1-112[»]
3UZFX-ray3.30Q1-112[»]
3UZHX-ray3.30Q1-112[»]
3UZKX-ray3.30Q1-112[»]
3UZNX-ray3.30Q1-112[»]
3V23X-ray3.00S1-112[»]
3V25X-ray3.00S1-112[»]
3V27X-ray3.10S1-112[»]
3V29X-ray3.10S1-112[»]
3V2DX-ray2.70S1-112[»]
3V2FX-ray2.70S1-112[»]
3V6WX-ray3.90S1-112[»]
3V6XX-ray3.90S1-112[»]
3ZN9X-ray3.10S1-112[»]
3ZNEX-ray3.10S1-112[»]
3ZVPX-ray3.80S1-112[»]
4ABSX-ray3.10S1-112[»]
4B8GX-ray3.70S1-112[»]
4B8IX-ray3.70S1-112[»]
4BTDX-ray2.95S2-112[»]
4BYCX-ray3.35S1-112[»]
4BYEX-ray3.35S1-112[»]
4DHAX-ray3.20S1-112[»]
4DHCX-ray3.20S1-112[»]
4EJBX-ray3.52S1-112[»]
4EJCX-ray3.52S1-112[»]
4G5LX-ray3.30Q1-112[»]
4G5NX-ray3.30Q1-112[»]
4G5UX-ray3.10Q1-112[»]
4G5WX-ray3.10Q1-112[»]
4JUXX-ray2.86S1-112[»]
4K0MX-ray3.30S11-108[»]
4K0QX-ray3.30S11-108[»]
4NVVX-ray3.00S1-112[»]
4NVXX-ray3.00S1-112[»]
4NVZX-ray3.10S1-112[»]
4NW1X-ray3.10S1-112[»]
ProteinModelPortalQ5SHQ4.
SMRQ5SHQ4. Positions 3-112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA1676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD71499; BAD71499; BAD71499.
GeneID3169978.
KEGGttj:TTHA1676.
PATRIC23958307. VBITheThe93045_1646.

Phylogenomic databases

eggNOGCOG0256.
HOGENOMHOG000248742.
KOK02881.
OMARTNCHIY.
OrthoDBEOG64NB48.
PhylomeDBQ5SHQ4.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1715-MONOMER.

Family and domain databases

HAMAPMF_01337_B. Ribosomal_L18_B.
InterProIPR005484. Ribosomal_L18/L5.
IPR004389. Ribosomal_L18_bac-type.
[Graphical view]
PfamPF00861. Ribosomal_L18p. 1 hit.
[Graphical view]
TIGRFAMsTIGR00060. L18_bact. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ5SHQ4.

Entry information

Entry nameRL18_THET8
AccessionPrimary (citable) accession number: Q5SHQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references