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Q5SHQ4

- RL18_THET8

UniProt

Q5SHQ4 - RL18_THET8

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Protein

50S ribosomal protein L18

Gene

rplR

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is one of the proteins that binds and mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L18
Alternative name(s):
TL24
Gene namesi
Name:rplR
Ordered Locus Names:TTHA1676
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 11211150S ribosomal protein L18PRO_0000131372Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and probably the 23S rRNA; has been isolated in a complex with the 5S rRNA and RL25 (1 Publication).

Protein-protein interaction databases

STRINGi300852.TTHA1676.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2015
Beta strandi25 – 306
Beta strandi35 – 417
Turni42 – 454
Beta strandi46 – 527
Turni53 – 575
Helixi62 – 7817
Turni79 – 813
Beta strandi86 – 883
Beta strandi94 – 974
Helixi100 – 1078
Beta strandi108 – 1103

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GIYX-ray5.50Q1-112[»]
1VVMX-ray3.22S1-112[»]
1VVOX-ray3.22S1-112[»]
1VVQX-ray3.90S1-112[»]
1VVSX-ray3.90S1-112[»]
1VVUX-ray3.90S1-112[»]
1VVWX-ray3.90S1-112[»]
1VVYX-ray3.92S1-112[»]
1VW0X-ray3.92S1-112[»]
1VX9X-ray2.94S1-112[»]
1VXJX-ray2.94S1-112[»]
1VXLX-ray3.48S1-112[»]
1VXNX-ray3.48S1-112[»]
1VXQX-ray3.14S1-112[»]
1VXTX-ray3.14S1-112[»]
1VY1X-ray3.68S1-112[»]
1VY3X-ray3.68S1-112[»]
1YL3X-ray5.50Q1-112[»]
2HGJX-ray5.00R1-112[»]
2HGQX-ray5.50R1-112[»]
2HGUX-ray4.51R1-112[»]
2J01X-ray2.80S2-112[»]
2J03X-ray2.80S2-112[»]
2V47X-ray3.50S2-112[»]
2V49X-ray3.50S2-112[»]
2WDIX-ray3.30S1-112[»]
2WDJX-ray3.30S1-112[»]
2WDLX-ray3.50S1-112[»]
2WDNX-ray3.50S1-112[»]
2WH2X-ray3.45S1-112[»]
2WH4X-ray3.45S1-112[»]
2WRJX-ray3.60S1-112[»]
2WRLX-ray3.60S1-112[»]
2WROX-ray3.60S1-112[»]
2WRRX-ray3.60S1-112[»]
2X9SX-ray3.10S1-112[»]
2X9UX-ray3.10S1-112[»]
2XG0X-ray3.20S1-112[»]
2XG2X-ray3.20S1-112[»]
2XQEX-ray3.10S1-112[»]
2XTGelectron microscopy7.80S1-112[»]
2XUXelectron microscopy7.60S1-112[»]
2Y0VX-ray3.10S1-112[»]
2Y0XX-ray3.10S1-112[»]
2Y0ZX-ray3.10S1-112[»]
2Y11X-ray3.10S1-112[»]
2Y13X-ray3.10S1-112[»]
2Y15X-ray3.10S1-112[»]
2Y17X-ray3.10S1-112[»]
2Y19X-ray3.10S1-112[»]
3FINelectron microscopy6.40S11-109[»]
3HUXX-ray3.10S1-112[»]
3HUZX-ray3.10S1-112[»]
3I8FX-ray3.10Q1-112[»]
3I8IX-ray3.10Q1-112[»]
3I9CX-ray3.50Q1-112[»]
3I9EX-ray3.50Q1-112[»]
3KIRX-ray3.30S1-112[»]
3KITX-ray3.30S1-112[»]
3KIWX-ray3.60S1-112[»]
3KIYX-ray3.60S1-112[»]
3KNIX-ray3.00S1-112[»]
3KNKX-ray3.00S1-112[»]
3KNMX-ray3.45S1-112[»]
3KNOX-ray3.45S1-112[»]
3TVEX-ray3.10Q2-112[»]
3TVHX-ray3.10Q2-112[»]
3UXQX-ray3.20S1-112[»]
3UXRX-ray3.20S1-112[»]
3UYEX-ray3.00Q1-112[»]
3UYGX-ray3.00Q1-112[»]
3UZ1X-ray3.30Q1-112[»]
3UZ2X-ray3.30Q1-112[»]
3UZ8X-ray3.00Q1-112[»]
3UZ9X-ray3.00Q1-112[»]
3UZFX-ray3.30Q1-112[»]
3UZHX-ray3.30Q1-112[»]
3UZKX-ray3.30Q1-112[»]
3UZNX-ray3.30Q1-112[»]
3V23X-ray3.00S1-112[»]
3V25X-ray3.00S1-112[»]
3V27X-ray3.10S1-112[»]
3V29X-ray3.10S1-112[»]
3V2DX-ray2.70S1-112[»]
3V2FX-ray2.70S1-112[»]
3V6WX-ray3.90S1-112[»]
3V6XX-ray3.90S1-112[»]
3ZN9X-ray3.10S1-112[»]
3ZNEX-ray3.10S1-112[»]
3ZVPX-ray3.80S1-112[»]
4ABSX-ray3.10S1-112[»]
4B8GX-ray3.70S1-112[»]
4B8IX-ray3.70S1-112[»]
4BTDX-ray2.95S2-112[»]
4BYCX-ray3.35S1-112[»]
4BYEX-ray3.35S1-112[»]
4DHAX-ray3.20S1-112[»]
4DHCX-ray3.20S1-112[»]
4EJBX-ray3.52S1-112[»]
4EJCX-ray3.52S1-112[»]
4G5LX-ray3.30Q1-112[»]
4G5NX-ray3.30Q1-112[»]
4G5UX-ray3.10Q1-112[»]
4G5WX-ray3.10Q1-112[»]
4JUXX-ray2.86S1-112[»]
4K0MX-ray3.30S11-108[»]
4K0QX-ray3.30S11-108[»]
4KX0X-ray3.44S1-112[»]
4KX2X-ray3.44S1-112[»]
4NVVX-ray3.00S1-112[»]
4NVXX-ray3.00S1-112[»]
4NVZX-ray3.10S1-112[»]
4NW1X-ray3.10S1-112[»]
4QCNX-ray2.60S1-112[»]
4QCPX-ray2.60S1-112[»]
4QCRX-ray2.55S1-112[»]
4QCTX-ray2.55S1-112[»]
4QCVX-ray2.90S1-112[»]
4QCXX-ray2.90S1-112[»]
4QCZX-ray2.80S1-112[»]
4QD1X-ray2.80S1-112[»]
ProteinModelPortaliQ5SHQ4.
SMRiQ5SHQ4. Positions 3-112.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHQ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L18P family.Curated

Phylogenomic databases

eggNOGiCOG0256.
HOGENOMiHOG000248742.
KOiK02881.
OMAiRTNCHIY.
OrthoDBiEOG64NB48.
PhylomeDBiQ5SHQ4.

Family and domain databases

HAMAPiMF_01337_B. Ribosomal_L18_B.
InterProiIPR005484. Ribosomal_L18/L5.
IPR004389. Ribosomal_L18_bac-type.
[Graphical view]
PfamiPF00861. Ribosomal_L18p. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00060. L18_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SHQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLTAYERR KFRVRNRIKR TGRLRLSVFR SLKHIYAQII DDEKGVTLVS
60 70 80 90 100
ASSLALKLKG NKTEVARQVG RALAEKALAL GIKQVAFDRG PYKYHGRVKA
110
LAEGAREGGL EF
Length:112
Mass (Da):12,612
Last modified:January 23, 2007 - v3
Checksum:iEA2AB016AEDB0638
GO

Mass spectrometryi

Molecular mass is 12481 Da from positions 2 - 112. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71499.1.
RefSeqiYP_144942.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71499; BAD71499; BAD71499.
GeneIDi3169978.
KEGGittj:TTHA1676.
PATRICi23958307. VBITheThe93045_1646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71499.1 .
RefSeqi YP_144942.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GIY X-ray 5.50 Q 1-112 [» ]
1VVM X-ray 3.22 S 1-112 [» ]
1VVO X-ray 3.22 S 1-112 [» ]
1VVQ X-ray 3.90 S 1-112 [» ]
1VVS X-ray 3.90 S 1-112 [» ]
1VVU X-ray 3.90 S 1-112 [» ]
1VVW X-ray 3.90 S 1-112 [» ]
1VVY X-ray 3.92 S 1-112 [» ]
1VW0 X-ray 3.92 S 1-112 [» ]
1VX9 X-ray 2.94 S 1-112 [» ]
1VXJ X-ray 2.94 S 1-112 [» ]
1VXL X-ray 3.48 S 1-112 [» ]
1VXN X-ray 3.48 S 1-112 [» ]
1VXQ X-ray 3.14 S 1-112 [» ]
1VXT X-ray 3.14 S 1-112 [» ]
1VY1 X-ray 3.68 S 1-112 [» ]
1VY3 X-ray 3.68 S 1-112 [» ]
1YL3 X-ray 5.50 Q 1-112 [» ]
2HGJ X-ray 5.00 R 1-112 [» ]
2HGQ X-ray 5.50 R 1-112 [» ]
2HGU X-ray 4.51 R 1-112 [» ]
2J01 X-ray 2.80 S 2-112 [» ]
2J03 X-ray 2.80 S 2-112 [» ]
2V47 X-ray 3.50 S 2-112 [» ]
2V49 X-ray 3.50 S 2-112 [» ]
2WDI X-ray 3.30 S 1-112 [» ]
2WDJ X-ray 3.30 S 1-112 [» ]
2WDL X-ray 3.50 S 1-112 [» ]
2WDN X-ray 3.50 S 1-112 [» ]
2WH2 X-ray 3.45 S 1-112 [» ]
2WH4 X-ray 3.45 S 1-112 [» ]
2WRJ X-ray 3.60 S 1-112 [» ]
2WRL X-ray 3.60 S 1-112 [» ]
2WRO X-ray 3.60 S 1-112 [» ]
2WRR X-ray 3.60 S 1-112 [» ]
2X9S X-ray 3.10 S 1-112 [» ]
2X9U X-ray 3.10 S 1-112 [» ]
2XG0 X-ray 3.20 S 1-112 [» ]
2XG2 X-ray 3.20 S 1-112 [» ]
2XQE X-ray 3.10 S 1-112 [» ]
2XTG electron microscopy 7.80 S 1-112 [» ]
2XUX electron microscopy 7.60 S 1-112 [» ]
2Y0V X-ray 3.10 S 1-112 [» ]
2Y0X X-ray 3.10 S 1-112 [» ]
2Y0Z X-ray 3.10 S 1-112 [» ]
2Y11 X-ray 3.10 S 1-112 [» ]
2Y13 X-ray 3.10 S 1-112 [» ]
2Y15 X-ray 3.10 S 1-112 [» ]
2Y17 X-ray 3.10 S 1-112 [» ]
2Y19 X-ray 3.10 S 1-112 [» ]
3FIN electron microscopy 6.40 S 11-109 [» ]
3HUX X-ray 3.10 S 1-112 [» ]
3HUZ X-ray 3.10 S 1-112 [» ]
3I8F X-ray 3.10 Q 1-112 [» ]
3I8I X-ray 3.10 Q 1-112 [» ]
3I9C X-ray 3.50 Q 1-112 [» ]
3I9E X-ray 3.50 Q 1-112 [» ]
3KIR X-ray 3.30 S 1-112 [» ]
3KIT X-ray 3.30 S 1-112 [» ]
3KIW X-ray 3.60 S 1-112 [» ]
3KIY X-ray 3.60 S 1-112 [» ]
3KNI X-ray 3.00 S 1-112 [» ]
3KNK X-ray 3.00 S 1-112 [» ]
3KNM X-ray 3.45 S 1-112 [» ]
3KNO X-ray 3.45 S 1-112 [» ]
3TVE X-ray 3.10 Q 2-112 [» ]
3TVH X-ray 3.10 Q 2-112 [» ]
3UXQ X-ray 3.20 S 1-112 [» ]
3UXR X-ray 3.20 S 1-112 [» ]
3UYE X-ray 3.00 Q 1-112 [» ]
3UYG X-ray 3.00 Q 1-112 [» ]
3UZ1 X-ray 3.30 Q 1-112 [» ]
3UZ2 X-ray 3.30 Q 1-112 [» ]
3UZ8 X-ray 3.00 Q 1-112 [» ]
3UZ9 X-ray 3.00 Q 1-112 [» ]
3UZF X-ray 3.30 Q 1-112 [» ]
3UZH X-ray 3.30 Q 1-112 [» ]
3UZK X-ray 3.30 Q 1-112 [» ]
3UZN X-ray 3.30 Q 1-112 [» ]
3V23 X-ray 3.00 S 1-112 [» ]
3V25 X-ray 3.00 S 1-112 [» ]
3V27 X-ray 3.10 S 1-112 [» ]
3V29 X-ray 3.10 S 1-112 [» ]
3V2D X-ray 2.70 S 1-112 [» ]
3V2F X-ray 2.70 S 1-112 [» ]
3V6W X-ray 3.90 S 1-112 [» ]
3V6X X-ray 3.90 S 1-112 [» ]
3ZN9 X-ray 3.10 S 1-112 [» ]
3ZNE X-ray 3.10 S 1-112 [» ]
3ZVP X-ray 3.80 S 1-112 [» ]
4ABS X-ray 3.10 S 1-112 [» ]
4B8G X-ray 3.70 S 1-112 [» ]
4B8I X-ray 3.70 S 1-112 [» ]
4BTD X-ray 2.95 S 2-112 [» ]
4BYC X-ray 3.35 S 1-112 [» ]
4BYE X-ray 3.35 S 1-112 [» ]
4DHA X-ray 3.20 S 1-112 [» ]
4DHC X-ray 3.20 S 1-112 [» ]
4EJB X-ray 3.52 S 1-112 [» ]
4EJC X-ray 3.52 S 1-112 [» ]
4G5L X-ray 3.30 Q 1-112 [» ]
4G5N X-ray 3.30 Q 1-112 [» ]
4G5U X-ray 3.10 Q 1-112 [» ]
4G5W X-ray 3.10 Q 1-112 [» ]
4JUX X-ray 2.86 S 1-112 [» ]
4K0M X-ray 3.30 S 11-108 [» ]
4K0Q X-ray 3.30 S 11-108 [» ]
4KX0 X-ray 3.44 S 1-112 [» ]
4KX2 X-ray 3.44 S 1-112 [» ]
4NVV X-ray 3.00 S 1-112 [» ]
4NVX X-ray 3.00 S 1-112 [» ]
4NVZ X-ray 3.10 S 1-112 [» ]
4NW1 X-ray 3.10 S 1-112 [» ]
4QCN X-ray 2.60 S 1-112 [» ]
4QCP X-ray 2.60 S 1-112 [» ]
4QCR X-ray 2.55 S 1-112 [» ]
4QCT X-ray 2.55 S 1-112 [» ]
4QCV X-ray 2.90 S 1-112 [» ]
4QCX X-ray 2.90 S 1-112 [» ]
4QCZ X-ray 2.80 S 1-112 [» ]
4QD1 X-ray 2.80 S 1-112 [» ]
ProteinModelPortali Q5SHQ4.
SMRi Q5SHQ4. Positions 3-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71499 ; BAD71499 ; BAD71499 .
GeneIDi 3169978.
KEGGi ttj:TTHA1676.
PATRICi 23958307. VBITheThe93045_1646.

Phylogenomic databases

eggNOGi COG0256.
HOGENOMi HOG000248742.
KOi K02881.
OMAi RTNCHIY.
OrthoDBi EOG64NB48.
PhylomeDBi Q5SHQ4.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1715-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SHQ4.

Family and domain databases

HAMAPi MF_01337_B. Ribosomal_L18_B.
InterProi IPR005484. Ribosomal_L18/L5.
IPR004389. Ribosomal_L18_bac-type.
[Graphical view ]
Pfami PF00861. Ribosomal_L18p. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00060. L18_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Identification, purification and partial sequence of four Thermus thermophilus 5S rRNA binding proteins."
    Kim J.-S., Boysen R.I., Schroeder W., Erdmann V.A., Gessner R.V.
    Endocyt. Cell Res. 11:177-194(1996)
    Cited for: PROTEIN SEQUENCE OF 2-24, ISOLATION OF 5S RRNA-ASSOCIATED COMPLEXES.
  3. "The isolation and complete amino acid sequence of the ribosomal protein L36 from Thermus thermophilus and its zinc-binding motif."
    Boysen R.I., Lorenz S., Kim J.S., Schroeder W.F.K.J., Erdmann V.A.
    Endocyt. Cell Res. 11:41-58(1995)
    Cited for: PROTEIN SEQUENCE OF 2-19.
  4. "Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
    Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
    Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16.
  5. "Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
    Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
    Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
  6. "The path of messenger RNA through the ribosome."
    Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
    Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.

Entry informationi

Entry nameiRL18_THET8
AccessioniPrimary (citable) accession number: Q5SHQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3