50S ribosomal protein L18 - Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

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Reviewed, UniProtKB/Swiss-Prot Q5SHQ4 (RL18_THET8)

Last modified November 3, 2009. Version 43. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
50S ribosomal protein L18
Alternative name(s):
TL24

Gene names

Name:	rplR
Ordered Locus Names:	TTHA1676

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This is one of the proteins that binds and mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. HAMAP MF_01337
Subunit structure	Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and probably the 23S rRNA; has been isolated in a complex with the 5S rRNA and RL25 (Ref.4). HAMAP MF_01337
Sequence similarities	Belongs to the ribosomal protein L18P family.
Mass spectrometry	Molecular mass is 12481 Da from positions 2 - 112. Determined by MALDI. Ref.5

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed Ref.2 Ref.3 Ref.4

Chain

111

50S ribosomal protein L18 HAMAP MF_01337

PRO_0000131372

Secondary structure

1

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112

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q5SHQ4-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: EA2AB016AEDB0638
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112

12,612

        10         20         30         40         50         60 
MARLTAYERR KFRVRNRIKR TGRLRLSVFR SLKHIYAQII DDEKGVTLVS ASSLALKLKG 

        70         80         90        100        110 
NKTEVARQVG RALAEKALAL GIKQVAFDRG PYKYHGRVKA LAEGAREGGL EF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Boysen R.I., Schroeder W., Erdmann V.A. Submitted (FEB-1994) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-19.
[3]	"Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus." Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T. Biol. Chem. 381:1079-1087(2000) [PubMed: 11154066] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-16.
[4]	"Identification, purification and partial sequence of four Thermus thermophilus 5S rRNA binding proteins." Kim J.-S., Boysen R.I., Schroeder W., Erdmann V.A., Gessner R.V. Endocyt. Cell Res. 11:177-194(1996) Cited for: PROTEIN SEQUENCE OF 2-24, ISOLATION OF 5S RRNA-ASSOCIATED COMPLEXES.
[5]	"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry." Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A. Proteomics 5:4818-4831(2005) [PubMed: 16287167] [Abstract] Cited for: MASS SPECTROMETRY.
[6]	"The path of messenger RNA through the ribosome." Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F. Cell 106:233-241(2001) [PubMed: 11511350] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[7]	"Crystal structure of the ribosome at 5.5 A resolution." Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F. Science 292:883-896(2001) [PubMed: 11283358] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
+	Additional computationally mapped references.

Cross-references

Sequence databases

AP008226 Genomic DNA. Translation: BAD71499.1.

RefSeq

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GIY	X-ray	5.50	Q	-	[»]
1YL3	X-ray	5.50	Q	23-26	[»]
2HGJ	X-ray	5.00	R	-	[»]
2HGQ	X-ray	5.50	R	1-112	[»]
2HGU	X-ray	4.51	R	-	[»]
2J01	X-ray	2.80	S	2-111	[»]
2J03	X-ray	2.80	S	2-111	[»]
2V47	X-ray	3.80	S	2-111	[»]
2V49	X-ray	3.80	S	2-111	[»]
2WDI	X-ray	3.30	S	1-112	[»]
2WDJ	X-ray	3.30	S	1-112	[»]
2WDL	X-ray	3.50	S	1-112	[»]
2WDN	X-ray	3.50	S	1-112	[»]
2WH2	X-ray	3.45	S	1-112	[»]
2WH4	X-ray	3.45	S	1-112	[»]
3FIN	electron microscopy	6.40	S	11-109	[»]

ModBase

Protein-protein interaction databases

STRING

Genome annotation databases

GeneID

GenomeReviews

Gene locus TTHA1676 in contig AP008226_GR.

KEGG

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

OMA

Enzyme and pathway databases

BioCyc

TTHE300852:TTHA1676-MON.

Family and domain databases

HAMAP

MF_01337.
[Tree]

InterPro

IPR005484. Ribosomal_L18/L5.
IPR004389. Ribosomal_L18_bac.
[Graphical view]

Pfam

PF00861. Ribosomal_L18p. 1 hit.
[Graphical view]

ProDom

PD001394. Ribosomal_L18p. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR00060. L18_bact. 1 hit.

ProtoNet

Entry information

Entry name

RL18_THET8

Accession

Primary (citable) accession number: Q5SHQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 43 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Ribosomal proteins

Ribosomal proteins families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents