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Q5SHQ4

- RL18_THET8

UniProt

Q5SHQ4 - RL18_THET8

Protein

50S ribosomal protein L18

Gene

rplR

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is one of the proteins that binds and mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1715-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L18
    Alternative name(s):
    TL24
    Gene namesi
    Name:rplR
    Ordered Locus Names:TTHA1676
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 11211150S ribosomal protein L18PRO_0000131372Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and probably the 23S rRNA; has been isolated in a complex with the 5S rRNA and RL25 (1 Publication).

    Protein-protein interaction databases

    STRINGi300852.TTHA1676.

    Structurei

    Secondary structure

    1
    112
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 2015
    Beta strandi25 – 306
    Beta strandi35 – 417
    Turni42 – 454
    Beta strandi46 – 527
    Turni53 – 575
    Helixi62 – 7817
    Turni79 – 813
    Beta strandi86 – 883
    Beta strandi94 – 974
    Helixi100 – 1078
    Beta strandi108 – 1103

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GIYX-ray5.50Q1-112[»]
    1YL3X-ray5.50Q1-112[»]
    2HGJX-ray5.00R1-112[»]
    2HGQX-ray5.50R1-112[»]
    2HGUX-ray4.51R1-112[»]
    2J01X-ray2.80S2-112[»]
    2J03X-ray2.80S2-112[»]
    2V47X-ray3.50S2-112[»]
    2V49X-ray3.50S2-112[»]
    2WDIX-ray3.30S1-112[»]
    2WDJX-ray3.30S1-112[»]
    2WDLX-ray3.50S1-112[»]
    2WDNX-ray3.50S1-112[»]
    2WH2X-ray3.45S1-112[»]
    2WH4X-ray3.45S1-112[»]
    2WRJX-ray3.60S1-112[»]
    2WRLX-ray3.60S1-112[»]
    2WROX-ray3.60S1-112[»]
    2WRRX-ray3.60S1-112[»]
    2X9SX-ray3.10S1-112[»]
    2X9UX-ray3.10S1-112[»]
    2XG0X-ray3.20S1-112[»]
    2XG2X-ray3.20S1-112[»]
    2XQEX-ray3.10S1-112[»]
    2XTGelectron microscopy7.80S1-112[»]
    2XUXelectron microscopy7.60S1-112[»]
    2Y0VX-ray3.10S1-112[»]
    2Y0XX-ray3.10S1-112[»]
    2Y0ZX-ray3.10S1-112[»]
    2Y11X-ray3.10S1-112[»]
    2Y13X-ray3.10S1-112[»]
    2Y15X-ray3.10S1-112[»]
    2Y17X-ray3.10S1-112[»]
    2Y19X-ray3.10S1-112[»]
    3FINelectron microscopy6.40S11-109[»]
    3HUXX-ray3.10S1-112[»]
    3HUZX-ray3.10S1-112[»]
    3I8FX-ray3.10Q1-112[»]
    3I8IX-ray3.10Q1-112[»]
    3I9CX-ray3.50Q1-112[»]
    3I9EX-ray3.50Q1-112[»]
    3KIRX-ray3.30S1-112[»]
    3KITX-ray3.30S1-112[»]
    3KIWX-ray3.60S1-112[»]
    3KIYX-ray3.60S1-112[»]
    3KNIX-ray3.00S1-112[»]
    3KNKX-ray3.00S1-112[»]
    3KNMX-ray3.45S1-112[»]
    3KNOX-ray3.45S1-112[»]
    3TVEX-ray3.10Q2-112[»]
    3TVHX-ray3.10Q2-112[»]
    3UXQX-ray3.20S1-112[»]
    3UXRX-ray3.20S1-112[»]
    3UYEX-ray3.00Q1-112[»]
    3UYGX-ray3.00Q1-112[»]
    3UZ1X-ray3.30Q1-112[»]
    3UZ2X-ray3.30Q1-112[»]
    3UZ8X-ray3.00Q1-112[»]
    3UZ9X-ray3.00Q1-112[»]
    3UZFX-ray3.30Q1-112[»]
    3UZHX-ray3.30Q1-112[»]
    3UZKX-ray3.30Q1-112[»]
    3UZNX-ray3.30Q1-112[»]
    3V23X-ray3.00S1-112[»]
    3V25X-ray3.00S1-112[»]
    3V27X-ray3.10S1-112[»]
    3V29X-ray3.10S1-112[»]
    3V2DX-ray2.70S1-112[»]
    3V2FX-ray2.70S1-112[»]
    3V6WX-ray3.90S1-112[»]
    3V6XX-ray3.90S1-112[»]
    3ZN9X-ray3.10S1-112[»]
    3ZNEX-ray3.10S1-112[»]
    3ZVPX-ray3.80S1-112[»]
    4ABSX-ray3.10S1-112[»]
    4B8GX-ray3.70S1-112[»]
    4B8IX-ray3.70S1-112[»]
    4BTDX-ray2.95S2-112[»]
    4BYCX-ray3.35S1-112[»]
    4BYEX-ray3.35S1-112[»]
    4DHAX-ray3.20S1-112[»]
    4DHCX-ray3.20S1-112[»]
    4EJBX-ray3.52S1-112[»]
    4EJCX-ray3.52S1-112[»]
    4G5LX-ray3.30Q1-112[»]
    4G5NX-ray3.30Q1-112[»]
    4G5UX-ray3.10Q1-112[»]
    4G5WX-ray3.10Q1-112[»]
    4JUXX-ray2.86S1-112[»]
    4K0MX-ray3.30S11-108[»]
    4K0QX-ray3.30S11-108[»]
    4NVVX-ray3.00S1-112[»]
    4NVXX-ray3.00S1-112[»]
    4NVZX-ray3.10S1-112[»]
    4NW1X-ray3.10S1-112[»]
    ProteinModelPortaliQ5SHQ4.
    SMRiQ5SHQ4. Positions 3-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SHQ4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L18P family.Curated

    Phylogenomic databases

    eggNOGiCOG0256.
    HOGENOMiHOG000248742.
    KOiK02881.
    OMAiRTNCHIY.
    OrthoDBiEOG64NB48.
    PhylomeDBiQ5SHQ4.

    Family and domain databases

    HAMAPiMF_01337_B. Ribosomal_L18_B.
    InterProiIPR005484. Ribosomal_L18/L5.
    IPR004389. Ribosomal_L18_bac-type.
    [Graphical view]
    PfamiPF00861. Ribosomal_L18p. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00060. L18_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5SHQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLTAYERR KFRVRNRIKR TGRLRLSVFR SLKHIYAQII DDEKGVTLVS    50
    ASSLALKLKG NKTEVARQVG RALAEKALAL GIKQVAFDRG PYKYHGRVKA 100
    LAEGAREGGL EF 112
    Length:112
    Mass (Da):12,612
    Last modified:January 23, 2007 - v3
    Checksum:iEA2AB016AEDB0638
    GO

    Mass spectrometryi

    Molecular mass is 12481 Da from positions 2 - 112. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71499.1.
    RefSeqiYP_144942.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD71499; BAD71499; BAD71499.
    GeneIDi3169978.
    KEGGittj:TTHA1676.
    PATRICi23958307. VBITheThe93045_1646.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71499.1 .
    RefSeqi YP_144942.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GIY X-ray 5.50 Q 1-112 [» ]
    1YL3 X-ray 5.50 Q 1-112 [» ]
    2HGJ X-ray 5.00 R 1-112 [» ]
    2HGQ X-ray 5.50 R 1-112 [» ]
    2HGU X-ray 4.51 R 1-112 [» ]
    2J01 X-ray 2.80 S 2-112 [» ]
    2J03 X-ray 2.80 S 2-112 [» ]
    2V47 X-ray 3.50 S 2-112 [» ]
    2V49 X-ray 3.50 S 2-112 [» ]
    2WDI X-ray 3.30 S 1-112 [» ]
    2WDJ X-ray 3.30 S 1-112 [» ]
    2WDL X-ray 3.50 S 1-112 [» ]
    2WDN X-ray 3.50 S 1-112 [» ]
    2WH2 X-ray 3.45 S 1-112 [» ]
    2WH4 X-ray 3.45 S 1-112 [» ]
    2WRJ X-ray 3.60 S 1-112 [» ]
    2WRL X-ray 3.60 S 1-112 [» ]
    2WRO X-ray 3.60 S 1-112 [» ]
    2WRR X-ray 3.60 S 1-112 [» ]
    2X9S X-ray 3.10 S 1-112 [» ]
    2X9U X-ray 3.10 S 1-112 [» ]
    2XG0 X-ray 3.20 S 1-112 [» ]
    2XG2 X-ray 3.20 S 1-112 [» ]
    2XQE X-ray 3.10 S 1-112 [» ]
    2XTG electron microscopy 7.80 S 1-112 [» ]
    2XUX electron microscopy 7.60 S 1-112 [» ]
    2Y0V X-ray 3.10 S 1-112 [» ]
    2Y0X X-ray 3.10 S 1-112 [» ]
    2Y0Z X-ray 3.10 S 1-112 [» ]
    2Y11 X-ray 3.10 S 1-112 [» ]
    2Y13 X-ray 3.10 S 1-112 [» ]
    2Y15 X-ray 3.10 S 1-112 [» ]
    2Y17 X-ray 3.10 S 1-112 [» ]
    2Y19 X-ray 3.10 S 1-112 [» ]
    3FIN electron microscopy 6.40 S 11-109 [» ]
    3HUX X-ray 3.10 S 1-112 [» ]
    3HUZ X-ray 3.10 S 1-112 [» ]
    3I8F X-ray 3.10 Q 1-112 [» ]
    3I8I X-ray 3.10 Q 1-112 [» ]
    3I9C X-ray 3.50 Q 1-112 [» ]
    3I9E X-ray 3.50 Q 1-112 [» ]
    3KIR X-ray 3.30 S 1-112 [» ]
    3KIT X-ray 3.30 S 1-112 [» ]
    3KIW X-ray 3.60 S 1-112 [» ]
    3KIY X-ray 3.60 S 1-112 [» ]
    3KNI X-ray 3.00 S 1-112 [» ]
    3KNK X-ray 3.00 S 1-112 [» ]
    3KNM X-ray 3.45 S 1-112 [» ]
    3KNO X-ray 3.45 S 1-112 [» ]
    3TVE X-ray 3.10 Q 2-112 [» ]
    3TVH X-ray 3.10 Q 2-112 [» ]
    3UXQ X-ray 3.20 S 1-112 [» ]
    3UXR X-ray 3.20 S 1-112 [» ]
    3UYE X-ray 3.00 Q 1-112 [» ]
    3UYG X-ray 3.00 Q 1-112 [» ]
    3UZ1 X-ray 3.30 Q 1-112 [» ]
    3UZ2 X-ray 3.30 Q 1-112 [» ]
    3UZ8 X-ray 3.00 Q 1-112 [» ]
    3UZ9 X-ray 3.00 Q 1-112 [» ]
    3UZF X-ray 3.30 Q 1-112 [» ]
    3UZH X-ray 3.30 Q 1-112 [» ]
    3UZK X-ray 3.30 Q 1-112 [» ]
    3UZN X-ray 3.30 Q 1-112 [» ]
    3V23 X-ray 3.00 S 1-112 [» ]
    3V25 X-ray 3.00 S 1-112 [» ]
    3V27 X-ray 3.10 S 1-112 [» ]
    3V29 X-ray 3.10 S 1-112 [» ]
    3V2D X-ray 2.70 S 1-112 [» ]
    3V2F X-ray 2.70 S 1-112 [» ]
    3V6W X-ray 3.90 S 1-112 [» ]
    3V6X X-ray 3.90 S 1-112 [» ]
    3ZN9 X-ray 3.10 S 1-112 [» ]
    3ZNE X-ray 3.10 S 1-112 [» ]
    3ZVP X-ray 3.80 S 1-112 [» ]
    4ABS X-ray 3.10 S 1-112 [» ]
    4B8G X-ray 3.70 S 1-112 [» ]
    4B8I X-ray 3.70 S 1-112 [» ]
    4BTD X-ray 2.95 S 2-112 [» ]
    4BYC X-ray 3.35 S 1-112 [» ]
    4BYE X-ray 3.35 S 1-112 [» ]
    4DHA X-ray 3.20 S 1-112 [» ]
    4DHC X-ray 3.20 S 1-112 [» ]
    4EJB X-ray 3.52 S 1-112 [» ]
    4EJC X-ray 3.52 S 1-112 [» ]
    4G5L X-ray 3.30 Q 1-112 [» ]
    4G5N X-ray 3.30 Q 1-112 [» ]
    4G5U X-ray 3.10 Q 1-112 [» ]
    4G5W X-ray 3.10 Q 1-112 [» ]
    4JUX X-ray 2.86 S 1-112 [» ]
    4K0M X-ray 3.30 S 11-108 [» ]
    4K0Q X-ray 3.30 S 11-108 [» ]
    4NVV X-ray 3.00 S 1-112 [» ]
    4NVX X-ray 3.00 S 1-112 [» ]
    4NVZ X-ray 3.10 S 1-112 [» ]
    4NW1 X-ray 3.10 S 1-112 [» ]
    ProteinModelPortali Q5SHQ4.
    SMRi Q5SHQ4. Positions 3-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD71499 ; BAD71499 ; BAD71499 .
    GeneIDi 3169978.
    KEGGi ttj:TTHA1676.
    PATRICi 23958307. VBITheThe93045_1646.

    Phylogenomic databases

    eggNOGi COG0256.
    HOGENOMi HOG000248742.
    KOi K02881.
    OMAi RTNCHIY.
    OrthoDBi EOG64NB48.
    PhylomeDBi Q5SHQ4.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-1715-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SHQ4.

    Family and domain databases

    HAMAPi MF_01337_B. Ribosomal_L18_B.
    InterProi IPR005484. Ribosomal_L18/L5.
    IPR004389. Ribosomal_L18_bac-type.
    [Graphical view ]
    Pfami PF00861. Ribosomal_L18p. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00060. L18_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    2. "Identification, purification and partial sequence of four Thermus thermophilus 5S rRNA binding proteins."
      Kim J.-S., Boysen R.I., Schroeder W., Erdmann V.A., Gessner R.V.
      Endocyt. Cell Res. 11:177-194(1996)
      Cited for: PROTEIN SEQUENCE OF 2-24, ISOLATION OF 5S RRNA-ASSOCIATED COMPLEXES.
    3. "The isolation and complete amino acid sequence of the ribosomal protein L36 from Thermus thermophilus and its zinc-binding motif."
      Boysen R.I., Lorenz S., Kim J.S., Schroeder W.F.K.J., Erdmann V.A.
      Endocyt. Cell Res. 11:41-58(1995)
      Cited for: PROTEIN SEQUENCE OF 2-19.
    4. "Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
      Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
      Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16.
    5. "Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
      Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
      Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
    6. "The path of messenger RNA through the ribosome."
      Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
      Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.

    Entry informationi

    Entry nameiRL18_THET8
    AccessioniPrimary (citable) accession number: Q5SHQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3