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Q5SHQ3

- RL6_THET8

UniProt

Q5SHQ3 - RL6_THET8

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Protein

50S ribosomal protein L6

Gene
rplF, TTHA1677
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1716-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L6
Gene namesi
Name:rplF
Ordered Locus Names:TTHA1677
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 18017950S ribosomal protein L6UniRule annotationPRO_0000131072Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Protein-protein interaction databases

STRINGi300852.TTHA1677.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 63
Beta strandi13 – 153
Beta strandi16 – 205
Beta strandi23 – 275
Beta strandi28 – 314
Beta strandi32 – 365
Beta strandi41 – 466
Beta strandi49 – 535
Helixi59 – 8022
Beta strandi83 – 919
Beta strandi95 – 995
Beta strandi102 – 1065
Beta strandi108 – 1114
Beta strandi113 – 1153
Beta strandi119 – 1213
Beta strandi122 – 1243
Beta strandi126 – 1294
Beta strandi130 – 1367
Helixi138 – 15114
Beta strandi156 – 1594
Beta strandi161 – 1644

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GIYX-ray5.50H26-177[»]
1YL3X-ray5.50H24-177[»]
2HGJX-ray5.00H1-180[»]
2HGQX-ray5.50H1-180[»]
2HGUX-ray4.51H1-180[»]
2J01X-ray2.80H2-180[»]
2J03X-ray2.80H2-180[»]
2V47X-ray3.50H2-180[»]
2V49X-ray3.50H2-180[»]
2WDIX-ray3.30H1-180[»]
2WDJX-ray3.30H1-180[»]
2WDLX-ray3.50H1-180[»]
2WDNX-ray3.50H1-180[»]
2WH2X-ray3.45H1-180[»]
2WH4X-ray3.45H1-180[»]
2WRJX-ray3.60H1-180[»]
2WRLX-ray3.60H1-180[»]
2WROX-ray3.60H1-180[»]
2WRRX-ray3.60H1-180[»]
2X9SX-ray3.10H1-180[»]
2X9UX-ray3.10H1-180[»]
2XG0X-ray3.20H1-180[»]
2XG2X-ray3.20H1-180[»]
2XQEX-ray3.10H1-180[»]
2XTGelectron microscopy7.80H1-180[»]
2XUXelectron microscopy7.60H1-180[»]
2Y0VX-ray3.10H1-180[»]
2Y0XX-ray3.10H1-180[»]
2Y0ZX-ray3.10H1-180[»]
2Y11X-ray3.10H1-180[»]
2Y13X-ray3.10H1-180[»]
2Y15X-ray3.10H1-180[»]
2Y17X-ray3.10H1-180[»]
2Y19X-ray3.10H1-180[»]
3FINelectron microscopy6.40H12-171[»]
3HUXX-ray3.10H1-180[»]
3HUZX-ray3.10H1-180[»]
3I8FX-ray3.10H1-180[»]
3I8IX-ray3.10H1-180[»]
3I9CX-ray3.50H1-180[»]
3I9EX-ray3.50H1-180[»]
3KIRX-ray3.30H1-180[»]
3KITX-ray3.30H1-180[»]
3KIWX-ray3.60H1-180[»]
3KIYX-ray3.60H1-180[»]
3KNIX-ray3.00H1-180[»]
3KNKX-ray3.00H1-180[»]
3KNMX-ray3.45H1-180[»]
3KNOX-ray3.45H1-180[»]
3TVEX-ray3.10H2-171[»]
3TVHX-ray3.10H2-171[»]
3UXQX-ray3.20H1-180[»]
3UXRX-ray3.20H1-180[»]
3UYEX-ray3.00H1-180[»]
3UYGX-ray3.00H1-180[»]
3UZ1X-ray3.30H1-180[»]
3UZ2X-ray3.30H1-180[»]
3UZ8X-ray3.00H1-180[»]
3UZ9X-ray3.00H1-180[»]
3UZFX-ray3.30H1-180[»]
3UZHX-ray3.30H1-180[»]
3UZKX-ray3.30H1-180[»]
3UZNX-ray3.30H1-180[»]
3V23X-ray3.00H1-180[»]
3V25X-ray3.00H1-180[»]
3V27X-ray3.10H1-180[»]
3V29X-ray3.10H1-180[»]
3V2DX-ray2.70H1-180[»]
3V2FX-ray2.70H1-180[»]
3V6WX-ray3.90H1-180[»]
3V6XX-ray3.90H1-180[»]
3ZN9X-ray3.10H1-180[»]
3ZNEX-ray3.10H1-180[»]
3ZVPX-ray3.80H1-180[»]
4ABSX-ray3.10H1-180[»]
4B8GX-ray3.70H1-180[»]
4B8IX-ray3.70H1-180[»]
4BTDX-ray2.95H1-180[»]
4BYCX-ray3.35H1-180[»]
4BYEX-ray3.35H1-180[»]
4DHAX-ray3.20H1-180[»]
4DHCX-ray3.20H1-180[»]
4EJBX-ray3.52H1-180[»]
4EJCX-ray3.52H1-180[»]
4G5LX-ray3.30H1-180[»]
4G5NX-ray3.30H1-180[»]
4G5UX-ray3.10H1-180[»]
4G5WX-ray3.10H1-180[»]
4JUXX-ray2.86H1-180[»]
4K0MX-ray3.30H12-170[»]
4K0QX-ray3.30H12-170[»]
4NVVX-ray3.00H1-180[»]
4NVXX-ray3.00H1-180[»]
4NVZX-ray3.10H1-180[»]
4NW1X-ray3.10H1-180[»]
ProteinModelPortaliQ5SHQ3.
SMRiQ5SHQ3. Positions 4-177.

Miscellaneous databases

EvolutionaryTraceiQ5SHQ3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0097.
HOGENOMiHOG000039903.
KOiK02933.
OMAiAANKNAR.
OrthoDBiEOG67DPRD.
PhylomeDBiQ5SHQ3.

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
HAMAPiMF_01365_B. Ribosomal_L6_B.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSiPR00059. RIBOSOMALL6.
SUPFAMiSSF56053. SSF56053. 2 hits.
TIGRFAMsiTIGR03654. L6_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SHQ3-1 [UniParc]FASTAAdd to Basket

« Hide

MSRIGRLPIP VPKGVSVEVA PGRVKVKGPK GELEVPVSPE MRVVVEEGVV    50
RVERPSDERR HKSLHGLTRT LIANAVKGVS EGYSKELLIK GIGYRARLVG 100
RALELTVGFS HPVVVEPPEG ITFEVPEPTR VRVSGIDKQK VGQVAANIRA 150
IRKPSAYHEK GIYYAGEPVR LKPGKAGAKK 180
Length:180
Mass (Da):19,532
Last modified:January 23, 2007 - v3
Checksum:i1913833C0C30E95D
GO

Mass spectrometryi

Molecular mass is 19401 Da from positions 2 - 180. Determined by MALDI. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161S → Q1 Publication
Sequence conflicti18 – 181E → Q1 Publication
Sequence conflicti19 – 202VA → AV AA sequence 1 Publication
Sequence conflicti20 – 201A → S1 Publication
Sequence conflicti23 – 231R → L1 Publication
Sequence conflicti25 – 251K → L AA sequence 1 Publication
Sequence conflicti27 – 271K → Y AA sequence 1 Publication
Sequence conflicti34 – 341E → S in CAA39899. 1 Publication
Sequence conflicti41 – 422MR → LK in CAA39899. 1 Publication
Sequence conflicti48 – 481G → N in CAA39899. 1 Publication
Sequence conflicti62 – 621K → R in CAA39899. 1 Publication
Sequence conflicti84 – 841S → V in CAA39899. 1 Publication
Sequence conflicti102 – 1032AL → SI in CAA39899. 1 Publication
Sequence conflicti131 – 1311V → I in CAA39899. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71500.1.
X56552 Genomic DNA. Translation: CAA39899.1.
PIRiS15442.
RefSeqiWP_011173704.1. NC_006461.1.
YP_144943.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71500; BAD71500; BAD71500.
GeneIDi3169807.
KEGGittj:TTHA1677.
PATRICi23958309. VBITheThe93045_1647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD71500.1 .
X56552 Genomic DNA. Translation: CAA39899.1 .
PIRi S15442.
RefSeqi WP_011173704.1. NC_006461.1.
YP_144943.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GIY X-ray 5.50 H 26-177 [» ]
1YL3 X-ray 5.50 H 24-177 [» ]
2HGJ X-ray 5.00 H 1-180 [» ]
2HGQ X-ray 5.50 H 1-180 [» ]
2HGU X-ray 4.51 H 1-180 [» ]
2J01 X-ray 2.80 H 2-180 [» ]
2J03 X-ray 2.80 H 2-180 [» ]
2V47 X-ray 3.50 H 2-180 [» ]
2V49 X-ray 3.50 H 2-180 [» ]
2WDI X-ray 3.30 H 1-180 [» ]
2WDJ X-ray 3.30 H 1-180 [» ]
2WDL X-ray 3.50 H 1-180 [» ]
2WDN X-ray 3.50 H 1-180 [» ]
2WH2 X-ray 3.45 H 1-180 [» ]
2WH4 X-ray 3.45 H 1-180 [» ]
2WRJ X-ray 3.60 H 1-180 [» ]
2WRL X-ray 3.60 H 1-180 [» ]
2WRO X-ray 3.60 H 1-180 [» ]
2WRR X-ray 3.60 H 1-180 [» ]
2X9S X-ray 3.10 H 1-180 [» ]
2X9U X-ray 3.10 H 1-180 [» ]
2XG0 X-ray 3.20 H 1-180 [» ]
2XG2 X-ray 3.20 H 1-180 [» ]
2XQE X-ray 3.10 H 1-180 [» ]
2XTG electron microscopy 7.80 H 1-180 [» ]
2XUX electron microscopy 7.60 H 1-180 [» ]
2Y0V X-ray 3.10 H 1-180 [» ]
2Y0X X-ray 3.10 H 1-180 [» ]
2Y0Z X-ray 3.10 H 1-180 [» ]
2Y11 X-ray 3.10 H 1-180 [» ]
2Y13 X-ray 3.10 H 1-180 [» ]
2Y15 X-ray 3.10 H 1-180 [» ]
2Y17 X-ray 3.10 H 1-180 [» ]
2Y19 X-ray 3.10 H 1-180 [» ]
3FIN electron microscopy 6.40 H 12-171 [» ]
3HUX X-ray 3.10 H 1-180 [» ]
3HUZ X-ray 3.10 H 1-180 [» ]
3I8F X-ray 3.10 H 1-180 [» ]
3I8I X-ray 3.10 H 1-180 [» ]
3I9C X-ray 3.50 H 1-180 [» ]
3I9E X-ray 3.50 H 1-180 [» ]
3KIR X-ray 3.30 H 1-180 [» ]
3KIT X-ray 3.30 H 1-180 [» ]
3KIW X-ray 3.60 H 1-180 [» ]
3KIY X-ray 3.60 H 1-180 [» ]
3KNI X-ray 3.00 H 1-180 [» ]
3KNK X-ray 3.00 H 1-180 [» ]
3KNM X-ray 3.45 H 1-180 [» ]
3KNO X-ray 3.45 H 1-180 [» ]
3TVE X-ray 3.10 H 2-171 [» ]
3TVH X-ray 3.10 H 2-171 [» ]
3UXQ X-ray 3.20 H 1-180 [» ]
3UXR X-ray 3.20 H 1-180 [» ]
3UYE X-ray 3.00 H 1-180 [» ]
3UYG X-ray 3.00 H 1-180 [» ]
3UZ1 X-ray 3.30 H 1-180 [» ]
3UZ2 X-ray 3.30 H 1-180 [» ]
3UZ8 X-ray 3.00 H 1-180 [» ]
3UZ9 X-ray 3.00 H 1-180 [» ]
3UZF X-ray 3.30 H 1-180 [» ]
3UZH X-ray 3.30 H 1-180 [» ]
3UZK X-ray 3.30 H 1-180 [» ]
3UZN X-ray 3.30 H 1-180 [» ]
3V23 X-ray 3.00 H 1-180 [» ]
3V25 X-ray 3.00 H 1-180 [» ]
3V27 X-ray 3.10 H 1-180 [» ]
3V29 X-ray 3.10 H 1-180 [» ]
3V2D X-ray 2.70 H 1-180 [» ]
3V2F X-ray 2.70 H 1-180 [» ]
3V6W X-ray 3.90 H 1-180 [» ]
3V6X X-ray 3.90 H 1-180 [» ]
3ZN9 X-ray 3.10 H 1-180 [» ]
3ZNE X-ray 3.10 H 1-180 [» ]
3ZVP X-ray 3.80 H 1-180 [» ]
4ABS X-ray 3.10 H 1-180 [» ]
4B8G X-ray 3.70 H 1-180 [» ]
4B8I X-ray 3.70 H 1-180 [» ]
4BTD X-ray 2.95 H 1-180 [» ]
4BYC X-ray 3.35 H 1-180 [» ]
4BYE X-ray 3.35 H 1-180 [» ]
4DHA X-ray 3.20 H 1-180 [» ]
4DHC X-ray 3.20 H 1-180 [» ]
4EJB X-ray 3.52 H 1-180 [» ]
4EJC X-ray 3.52 H 1-180 [» ]
4G5L X-ray 3.30 H 1-180 [» ]
4G5N X-ray 3.30 H 1-180 [» ]
4G5U X-ray 3.10 H 1-180 [» ]
4G5W X-ray 3.10 H 1-180 [» ]
4JUX X-ray 2.86 H 1-180 [» ]
4K0M X-ray 3.30 H 12-170 [» ]
4K0Q X-ray 3.30 H 12-170 [» ]
4NVV X-ray 3.00 H 1-180 [» ]
4NVX X-ray 3.00 H 1-180 [» ]
4NVZ X-ray 3.10 H 1-180 [» ]
4NW1 X-ray 3.10 H 1-180 [» ]
ProteinModelPortali Q5SHQ3.
SMRi Q5SHQ3. Positions 4-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 300852.TTHA1677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD71500 ; BAD71500 ; BAD71500 .
GeneIDi 3169807.
KEGGi ttj:TTHA1677.
PATRICi 23958309. VBITheThe93045_1647.

Phylogenomic databases

eggNOGi COG0097.
HOGENOMi HOG000039903.
KOi K02933.
OMAi AANKNAR.
OrthoDBi EOG67DPRD.
PhylomeDBi Q5SHQ3.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1716-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5SHQ3.

Family and domain databases

Gene3Di 3.90.930.12. 2 hits.
HAMAPi MF_01365_B. Ribosomal_L6_B.
InterProi IPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
[Graphical view ]
PANTHERi PTHR11655. PTHR11655. 1 hit.
Pfami PF00347. Ribosomal_L6. 2 hits.
[Graphical view ]
PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
PRINTSi PR00059. RIBOSOMALL6.
SUPFAMi SSF56053. SSF56053. 2 hits.
TIGRFAMsi TIGR03654. L6_bact. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Analysis of the spc ribosomal protein operon of Thermus aquaticus."
    Jahn O., Hartmann R.K., Erdmann V.A.
    Eur. J. Biochem. 197:733-740(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-131.
  3. "Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
    Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
    Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-29.
  4. "Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
    Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
    Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
  5. "The path of messenger RNA through the ribosome."
    Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
    Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.

Entry informationi

Entry nameiRL6_THET8
AccessioniPrimary (citable) accession number: Q5SHQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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