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Protein

50S ribosomal protein L24

Gene

rplX

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.By similarity
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L24
Gene namesi
Name:rplX
Ordered Locus Names:TTHA1681
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11011050S ribosomal protein L24PRO_0000130741Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Protein-protein interaction databases

STRINGi300852.TTHA1681.

Structurei

Secondary structure

1
110
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 113Combined sources
Beta strandi12 – 154Combined sources
Turni19 – 224Combined sources
Beta strandi24 – 318Combined sources
Helixi32 – 343Combined sources
Beta strandi36 – 394Combined sources
Beta strandi43 – 486Combined sources
Beta strandi50 – 523Combined sources
Beta strandi53 – 553Combined sources
Beta strandi60 – 645Combined sources
Beta strandi66 – 683Combined sources
Helixi69 – 713Combined sources
Beta strandi72 – 754Combined sources
Turni77 – 793Combined sources
Beta strandi85 – 895Combined sources
Beta strandi91 – 933Combined sources
Beta strandi95 – 1028Combined sources
Beta strandi105 – 1073Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VVJX-ray3.44RY/YY1-110[»]
1VY4X-ray2.60BY/DY1-110[»]
1VY5X-ray2.55BY/DY1-110[»]
1VY6X-ray2.90BY/DY1-110[»]
1VY7X-ray2.80BY/DY1-110[»]
4L47X-ray3.22RY/YY1-110[»]
4L71X-ray3.90RY/YY1-110[»]
4LELX-ray3.90RY/YY1-110[»]
4LFZX-ray3.92RY/YY1-110[»]
4LNTX-ray2.94RY/YY1-110[»]
4LSKX-ray3.48RY/YY1-110[»]
4LT8X-ray3.14RY/YY1-110[»]
4P6FX-ray3.60RY/YY1-110[»]
4P70X-ray3.68RY/YY1-110[»]
4V42X-ray5.50BU1-110[»]
4V4PX-ray5.50U65-68[»]
4V4XX-ray5.00BX1-110[»]
4V4YX-ray5.50BX1-110[»]
4V4ZX-ray4.51BX1-110[»]
4V51X-ray2.80BY/DY1-110[»]
4V5AX-ray3.50BY/DY1-110[»]
4V5CX-ray3.30BY/DY1-110[»]
4V5DX-ray3.50BY/DY1-110[»]
4V5EX-ray3.45BY/DY1-110[»]
4V5FX-ray3.60BY/DY1-110[»]
4V5GX-ray3.60BY/DY1-110[»]
4V5JX-ray3.10BY/DY1-110[»]
4V5KX-ray3.20BY/DY1-110[»]
4V5LX-ray3.10BY1-110[»]
4V5Melectron microscopy7.80BY1-110[»]
4V5Nelectron microscopy7.60BY1-110[»]
4V5PX-ray3.10BY/DY1-110[»]
4V5QX-ray3.10BY/DY1-110[»]
4V5RX-ray3.10BY/DY1-110[»]
4V5SX-ray3.10BY/DY1-110[»]
4V68electron microscopy6.40BY2-102[»]
4V6AX-ray3.10BY/DY1-110[»]
4V6FX-ray3.10AU/DU1-110[»]
4V6GX-ray3.50BU/DU1-110[»]
4V7JX-ray3.30AY/BY1-110[»]
4V7KX-ray3.60AY/BY1-110[»]
4V7LX-ray3.00BY/DY1-110[»]
4V7MX-ray3.45BY/DY1-110[»]
4V7WX-ray3.00BY/DY1-110[»]
4V7XX-ray3.00BY/DY1-110[»]
4V7YX-ray3.00BY/DY1-110[»]
4V7ZX-ray3.10BY/DY1-110[»]
4V87X-ray3.10AU/DU2-103[»]
4V8AX-ray3.20AY/BY1-110[»]
4V8BX-ray3.00BU/DU1-110[»]
4V8CX-ray3.30AU/BU1-110[»]
4V8DX-ray3.00BU/DU1-110[»]
4V8EX-ray3.30AU/CU1-110[»]
4V8FX-ray3.30AU/DU1-110[»]
4V8GX-ray3.00BY/DY1-110[»]
4V8HX-ray3.10BY/DY1-110[»]
4V8IX-ray2.70BY/DY1-110[»]
4V8JX-ray3.90BY/DY1-110[»]
4V8NX-ray3.10BY/DY1-110[»]
4V8OX-ray3.80BY1-110[»]
4V8QX-ray3.10AY1-110[»]
4V8UX-ray3.70BY/DY1-110[»]
4V8XX-ray3.35BY/DY1-110[»]
4V90X-ray2.95BY2-110[»]
4V95X-ray3.20BY/DY1-110[»]
4V97X-ray3.52BY/DY1-110[»]
4V9AX-ray3.30BU/DU1-110[»]
4V9BX-ray3.10BU/DU1-110[»]
4V9HX-ray2.86BY1-110[»]
4V9IX-ray3.30BY/DY2-101[»]
4V9RX-ray3.00BY/DY1-110[»]
4V9SX-ray3.10BY/DY1-110[»]
4W2EX-ray2.90Y1-110[»]
4W2FX-ray2.40BY/DY1-110[»]
4W2GX-ray2.55BY/DY1-110[»]
4W2HX-ray2.70BY/DY1-110[»]
4W2IX-ray2.70BY/DY1-110[»]
ProteinModelPortaliQ5SHP9.
SMRiQ5SHP9. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHP9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

eggNOGiCOG0198.
HOGENOMiHOG000039891.
KOiK02895.
OMAiKVMLYCN.
OrthoDBiEOG6FFSDM.
PhylomeDBiQ5SHP9.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_B. Ribosomal_L24_B.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR12903. PTHR12903. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKMHVKKG DTVLVASGKY KGRVGKVKEV LPKKYAVIVE GVNIVKKAVR
60 70 80 90 100
VSPKYPQGGF IEKEAPLHAS KVRPICPACG KPTRVRKKFL ENGKKIRVCA
110
KCGGALDTEE
Length:110
Mass (Da):12,057
Last modified:December 21, 2004 - v1
Checksum:iA9E773D9A86B819A
GO

Mass spectrometryi

Molecular mass is 12057 Da from positions 1 - 110. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71504.1.
RefSeqiYP_144947.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71504; BAD71504; BAD71504.
GeneIDi3169836.
KEGGittj:TTHA1681.
PATRICi23958317. VBITheThe93045_1651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71504.1.
RefSeqiYP_144947.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VVJX-ray3.44RY/YY1-110[»]
1VY4X-ray2.60BY/DY1-110[»]
1VY5X-ray2.55BY/DY1-110[»]
1VY6X-ray2.90BY/DY1-110[»]
1VY7X-ray2.80BY/DY1-110[»]
4L47X-ray3.22RY/YY1-110[»]
4L71X-ray3.90RY/YY1-110[»]
4LELX-ray3.90RY/YY1-110[»]
4LFZX-ray3.92RY/YY1-110[»]
4LNTX-ray2.94RY/YY1-110[»]
4LSKX-ray3.48RY/YY1-110[»]
4LT8X-ray3.14RY/YY1-110[»]
4P6FX-ray3.60RY/YY1-110[»]
4P70X-ray3.68RY/YY1-110[»]
4V42X-ray5.50BU1-110[»]
4V4PX-ray5.50U65-68[»]
4V4XX-ray5.00BX1-110[»]
4V4YX-ray5.50BX1-110[»]
4V4ZX-ray4.51BX1-110[»]
4V51X-ray2.80BY/DY1-110[»]
4V5AX-ray3.50BY/DY1-110[»]
4V5CX-ray3.30BY/DY1-110[»]
4V5DX-ray3.50BY/DY1-110[»]
4V5EX-ray3.45BY/DY1-110[»]
4V5FX-ray3.60BY/DY1-110[»]
4V5GX-ray3.60BY/DY1-110[»]
4V5JX-ray3.10BY/DY1-110[»]
4V5KX-ray3.20BY/DY1-110[»]
4V5LX-ray3.10BY1-110[»]
4V5Melectron microscopy7.80BY1-110[»]
4V5Nelectron microscopy7.60BY1-110[»]
4V5PX-ray3.10BY/DY1-110[»]
4V5QX-ray3.10BY/DY1-110[»]
4V5RX-ray3.10BY/DY1-110[»]
4V5SX-ray3.10BY/DY1-110[»]
4V68electron microscopy6.40BY2-102[»]
4V6AX-ray3.10BY/DY1-110[»]
4V6FX-ray3.10AU/DU1-110[»]
4V6GX-ray3.50BU/DU1-110[»]
4V7JX-ray3.30AY/BY1-110[»]
4V7KX-ray3.60AY/BY1-110[»]
4V7LX-ray3.00BY/DY1-110[»]
4V7MX-ray3.45BY/DY1-110[»]
4V7WX-ray3.00BY/DY1-110[»]
4V7XX-ray3.00BY/DY1-110[»]
4V7YX-ray3.00BY/DY1-110[»]
4V7ZX-ray3.10BY/DY1-110[»]
4V87X-ray3.10AU/DU2-103[»]
4V8AX-ray3.20AY/BY1-110[»]
4V8BX-ray3.00BU/DU1-110[»]
4V8CX-ray3.30AU/BU1-110[»]
4V8DX-ray3.00BU/DU1-110[»]
4V8EX-ray3.30AU/CU1-110[»]
4V8FX-ray3.30AU/DU1-110[»]
4V8GX-ray3.00BY/DY1-110[»]
4V8HX-ray3.10BY/DY1-110[»]
4V8IX-ray2.70BY/DY1-110[»]
4V8JX-ray3.90BY/DY1-110[»]
4V8NX-ray3.10BY/DY1-110[»]
4V8OX-ray3.80BY1-110[»]
4V8QX-ray3.10AY1-110[»]
4V8UX-ray3.70BY/DY1-110[»]
4V8XX-ray3.35BY/DY1-110[»]
4V90X-ray2.95BY2-110[»]
4V95X-ray3.20BY/DY1-110[»]
4V97X-ray3.52BY/DY1-110[»]
4V9AX-ray3.30BU/DU1-110[»]
4V9BX-ray3.10BU/DU1-110[»]
4V9HX-ray2.86BY1-110[»]
4V9IX-ray3.30BY/DY2-101[»]
4V9RX-ray3.00BY/DY1-110[»]
4V9SX-ray3.10BY/DY1-110[»]
4W2EX-ray2.90Y1-110[»]
4W2FX-ray2.40BY/DY1-110[»]
4W2GX-ray2.55BY/DY1-110[»]
4W2HX-ray2.70BY/DY1-110[»]
4W2IX-ray2.70BY/DY1-110[»]
ProteinModelPortaliQ5SHP9.
SMRiQ5SHP9. Positions 1-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71504; BAD71504; BAD71504.
GeneIDi3169836.
KEGGittj:TTHA1681.
PATRICi23958317. VBITheThe93045_1651.

Phylogenomic databases

eggNOGiCOG0198.
HOGENOMiHOG000039891.
KOiK02895.
OMAiKVMLYCN.
OrthoDBiEOG6FFSDM.
PhylomeDBiQ5SHP9.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1720-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SHP9.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_B. Ribosomal_L24_B.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR12903. PTHR12903. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "The isolation and complete amino acid sequence of the ribosomal protein L36 from Thermus thermophilus and its zinc-binding motif."
    Boysen R.I., Lorenz S., Kim J.S., Schroeder W.F.K.J., Erdmann V.A.
    Endocyt. Cell Res. 11:41-58(1994)
    Cited for: PROTEIN SEQUENCE OF 1-44.
  3. "Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
    Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
    Biol. Chem. 381:1079-1087(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-24.
  4. "Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
    Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
    Proteomics 5:4818-4831(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
  5. "The path of messenger RNA through the ribosome."
    Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
    Cell 106:233-241(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.

Entry informationi

Entry nameiRL24_THET8
AccessioniPrimary (citable) accession number: Q5SHP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: April 1, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.