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Q5SHP7 (RS17_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
30S ribosomal protein S17
Gene names
Name:rpsQ
Ordered Locus Names:TTHA1683
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform and body of the 30S subunit by bringing together and stabilizing interactions between several different RNA helices. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. HAMAP-Rule MF_01345

Deletion of the protein leads to an increased generation time and a temperature-sensitive phenotype. HAMAP-Rule MF_01345

Subunit structure

Part of the 30S ribosomal subunit. Contacts protein S12. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.12 Ref.13 Ref.15 Ref.16

Sequence similarities

Belongs to the ribosomal protein S17P family.

Mass spectrometry

Molecular mass is 12167 Da from positions 2 - 105. Determined by MALDI. Ref.5

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 10510430S ribosomal protein S17 HAMAP-Rule MF_01345
PRO_0000128492

Experimental info

Sequence conflict501K → R in CAA39893. Ref.1
Sequence conflict531L → V in CAA39893. Ref.1
Sequence conflict621S → A in CAA39893. Ref.1
Sequence conflict791S → E in CAA39893. Ref.1
Sequence conflict821M → L in CAA39893. Ref.1
Sequence conflict901I → V in CAA39893. Ref.1
Sequence conflict961E → A in CAA39893. Ref.1

Secondary structure

....................... 105
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SHP7 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 60981D6D57478FBD

FASTA10512,298
        10         20         30         40         50         60 
MPKKVLTGVV VSDKMQKTVT VLVERQFPHP LYGKVIKRSK KYLAHDPEEK YKLGDVVEII 

        70         80         90        100 
ESRPISKRKR FRVLRLVESG RMDLVEKYLI RRQNYESLSK RGGKA 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the spc ribosomal protein operon of Thermus aquaticus."
Jahn O., Hartmann R.K., Erdmann V.A.
Eur. J. Biochem. 197:733-740(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[3]"Purification and characterization of the 30S ribosomal proteins from the bacterium Thermus thermophilus."
Tsiboli P., Herfurth E., Choli T.
Eur. J. Biochem. 226:169-177(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-14.
[4]"Ribosomal gene disruption in the extreme thermophile Thermus thermophilus HB8. Generation of a mutant lacking ribosomal protein S17."
Simitsopoulou M., Avila H., Franceschi F.
Eur. J. Biochem. 266:524-532(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: DELETION OF THE GENE.
[5]"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
[6]"Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution."
Clemons W.M. Jr., May J.L.C., Wimberly B.T., McCutcheon J.P., Capel M.S., Ramakrishnan V.
Nature 400:833-840(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE 30S SUBUNIT.
[7]"Structure of the 30S ribosomal subunit."
Wimberly B.T., Brodersen D.E., Clemons W.M. Jr., Morgan-Warren R.J., Carter A.P., Vonrhein C., Hartsch T., Ramakrishnan V.
Nature 407:327-339(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
[8]"Structure of functionally activated small ribosomal subunit at 3.3 A resolution."
Schluenzen F., Tocilj A., Zarivach R., Harms J., Gluehmann M., Janell D., Bashan A., Bartels H., Agmon I., Franceschi F., Yonath A.
Cell 102:615-623(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[9]"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit."
Brodersen D.E., Clemons W.M. Jr., Carter A.P., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V.
Cell 103:1143-1154(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 30S SUBUNIT.
[10]"Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics."
Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V.
Nature 407:340-348(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 30S SUBUNIT.
[11]"The path of messenger RNA through the ribosome."
Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[12]"Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3."
Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H., Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A., Franceschi F.
EMBO J. 20:1829-1839(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[13]"Crystal structure of an initiation factor bound to the 30S ribosomal subunit."
Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., Ramakrishnan V.
Science 291:498-501(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF THE 30S SUBUNIT.
[14]"Crystal structure of the ribosome at 5.5 A resolution."
Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F.
Science 292:883-896(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
[15]"Recognition of cognate transfer RNA by the 30S ribosomal subunit."
Ogle J.M., Brodersen D.E., Clemons W.M. Jr., Tarry M.J., Carter A.P., Ramakrishnan V.
Science 292:897-902(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.11 ANGSTROMS) OF THE 30S SUBUNIT.
[16]"Crystal structure of the 30S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16S RNA."
Brodersen D.E., Clemons W.M. Jr., Carter A.P., Wimberly B.T., Ramakrishnan V.
J. Mol. Biol. 316:725-768(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF THE 30S SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56552 Genomic DNA. Translation: CAA39893.1.
AP008226 Genomic DNA. Translation: BAD71506.1.
RefSeqYP_144949.1. NC_006461.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FJGX-ray3.00Q1-105[»]
1GIXX-ray5.50T1-105[»]
1HNWX-ray3.40Q1-105[»]
1HNXX-ray3.40Q1-105[»]
1HNZX-ray3.30Q1-105[»]
1HR0X-ray3.20Q1-105[»]
1I94X-ray3.20Q2-105[»]
1I95X-ray4.50Q2-105[»]
1I96X-ray4.20Q2-105[»]
1I97X-ray4.50Q2-105[»]
1IBKX-ray3.31Q1-105[»]
1IBLX-ray3.11Q1-105[»]
1IBMX-ray3.31Q1-105[»]
1J5EX-ray3.05Q2-105[»]
1JGOX-ray5.60T1-105[»]
1JGPX-ray7.00T1-105[»]
1JGQX-ray5.00T1-105[»]
1L1Umodel-Q1-105[»]
1ML5electron microscopy14.00T1-105[»]
1N32X-ray3.00Q2-105[»]
1N33X-ray3.35Q2-105[»]
1N34X-ray3.80Q2-105[»]
1N36X-ray3.65Q2-105[»]
1PNSX-ray8.70Q2-105[»]
1PNXX-ray9.50Q2-105[»]
1VOQX-ray11.50Q2-105[»]
1VOSX-ray11.50Q2-105[»]
1VOVX-ray11.50Q2-105[»]
1XMOX-ray3.25Q1-105[»]
1XMQX-ray3.00Q1-105[»]
1XNQX-ray3.05Q1-105[»]
1XNRX-ray3.10Q1-105[»]
1YL4X-ray5.50T1-105[»]
2B64X-ray5.90Q1-105[»]
2B9MX-ray6.76Q1-105[»]
2B9OX-ray6.46Q1-105[»]
2E5LX-ray3.30Q2-105[»]
2F4VX-ray3.80Q1-105[»]
2HGIX-ray5.00T1-105[»]
2HGPX-ray5.50T1-105[»]
2HGRX-ray4.51T1-105[»]
2HHHX-ray3.35Q1-105[»]
2J00X-ray2.80Q2-105[»]
2J02X-ray2.80Q2-105[»]
2OW8X-ray3.71r1-105[»]
2UU9X-ray3.10Q2-105[»]
2UUAX-ray2.90Q2-105[»]
2UUBX-ray2.80Q2-105[»]
2UUCX-ray3.10Q2-105[»]
2UXBX-ray3.10Q2-105[»]
2UXCX-ray2.90Q2-105[»]
2UXDX-ray3.20Q2-105[»]
2V46X-ray3.50Q2-105[»]
2V48X-ray3.50Q2-105[»]
2WDGX-ray3.30Q1-105[»]
2WDHX-ray3.30Q1-105[»]
2WDKX-ray3.50Q1-105[»]
2WDMX-ray3.50Q1-105[»]
2WH1X-ray3.45Q1-105[»]
2WH3X-ray3.45Q1-105[»]
2WRIX-ray3.60Q1-105[»]
2WRKX-ray3.60Q1-105[»]
2WRNX-ray3.60Q1-105[»]
2WRQX-ray3.60Q1-105[»]
2X9RX-ray3.10Q1-105[»]
2X9TX-ray3.10Q1-105[»]
2XFZX-ray3.20Q1-105[»]
2XG1X-ray3.20Q1-105[»]
2XQDX-ray3.10Q1-105[»]
2XSYelectron microscopy7.80Q1-105[»]
2XUYelectron microscopy7.60Q1-105[»]
2Y0UX-ray3.10Q1-105[»]
2Y0WX-ray3.10Q1-105[»]
2Y0YX-ray3.10Q1-105[»]
2Y10X-ray3.10Q1-105[»]
2Y12X-ray3.10Q1-105[»]
2Y14X-ray3.10Q1-105[»]
2Y16X-ray3.10Q1-105[»]
2Y18X-ray3.10Q1-105[»]
2ZM6X-ray3.30Q2-105[»]
3FICelectron microscopy6.40Q2-101[»]
3HUWX-ray3.10Q1-105[»]
3HUYX-ray3.10Q1-105[»]
3I8GX-ray3.10T1-105[»]
3I8HX-ray3.10T1-105[»]
3I9BX-ray3.50T1-105[»]
3I9DX-ray3.50T1-105[»]
3KIQX-ray3.30q1-105[»]
3KISX-ray3.30q1-105[»]
3KIUX-ray3.60q1-105[»]
3KIXX-ray3.60q1-105[»]
3KNHX-ray3.00Q1-105[»]
3KNJX-ray3.15Q1-105[»]
3KNLX-ray3.45Q1-105[»]
3KNNX-ray3.45Q1-105[»]
3OGEX-ray3.00Q1-105[»]
3OGYX-ray3.00Q1-105[»]
3OHCX-ray3.00Q1-105[»]
3OHDX-ray3.00Q1-105[»]
3OHYX-ray3.00Q1-105[»]
3OI0X-ray3.00Q1-105[»]
3OI2X-ray3.10Q1-105[»]
3OI4X-ray3.10Q1-105[»]
3OTOX-ray3.69Q1-105[»]
3T1HX-ray3.11Q1-105[»]
3T1YX-ray2.80Q1-105[»]
3TVFX-ray3.10T1-105[»]
3TVGX-ray3.10T1-105[»]
3UXSX-ray3.20Q1-105[»]
3UXTX-ray3.20Q1-105[»]
3UYDX-ray3.00T1-105[»]
3UYFX-ray3.00T1-105[»]
3UZ3X-ray3.30T1-105[»]
3UZ4X-ray3.30T1-105[»]
3UZ6X-ray3.00T1-105[»]
3UZ7X-ray3.00T1-105[»]
3UZGX-ray3.30T1-105[»]
3UZIX-ray3.30T1-105[»]
3UZLX-ray3.30T1-105[»]
3UZMX-ray3.30T1-105[»]
3V22X-ray3.00Q1-105[»]
3V24X-ray3.00Q1-105[»]
3V26X-ray3.10Q1-105[»]
3V28X-ray3.10Q1-105[»]
3V2CX-ray2.70Q1-105[»]
3V2EX-ray2.70Q1-105[»]
3V6UX-ray3.90Q1-105[»]
3V6VX-ray3.90Q1-105[»]
3ZN7X-ray3.10Q1-105[»]
3ZNDX-ray3.10Q1-105[»]
3ZVOX-ray3.80Q1-105[»]
4ABRX-ray3.10Q1-105[»]
4AQYX-ray3.50Q2-105[»]
4B3MX-ray2.90Q2-105[»]
4B3RX-ray3.00Q2-105[»]
4B3SX-ray3.15Q2-105[»]
4B3TX-ray3.00Q2-105[»]
4B8FX-ray3.70Q1-105[»]
4B8HX-ray3.70Q1-105[»]
4BYBX-ray3.35Q1-105[»]
4BYDX-ray3.35Q1-105[»]
4CR1X-ray2.95Q1-105[»]
4DH9X-ray3.20Q1-105[»]
4DHBX-ray3.20Q1-105[»]
4DR1X-ray3.60Q1-105[»]
4DR2X-ray3.25Q1-105[»]
4DR3X-ray3.35Q1-105[»]
4DR4X-ray3.97Q1-105[»]
4DR5X-ray3.45Q1-105[»]
4DR6X-ray3.30Q1-105[»]
4DR7X-ray3.75Q1-105[»]
4DUYX-ray3.39Q1-105[»]
4DUZX-ray3.65Q1-105[»]
4DV0X-ray3.85Q1-105[»]
4DV1X-ray3.85Q1-105[»]
4DV2X-ray3.65Q1-105[»]
4DV3X-ray3.55Q1-105[»]
4DV4X-ray3.65Q1-105[»]
4DV5X-ray3.68Q1-105[»]
4DV6X-ray3.30Q1-105[»]
4DV7X-ray3.29Q1-105[»]
4EJ9X-ray3.52Q1-105[»]
4EJAX-ray3.52Q1-105[»]
4G5KX-ray3.30T1-105[»]
4G5MX-ray3.30T1-105[»]
4G5TX-ray3.10T1-105[»]
4G5VX-ray3.10T1-105[»]
4GKJX-ray3.30Q2-105[»]
4GKKX-ray3.20Q2-105[»]
4JI0X-ray3.49Q1-105[»]
4JI1X-ray3.14Q1-105[»]
4JI2X-ray3.64Q1-105[»]
4JI3X-ray3.35Q1-105[»]
4JI4X-ray3.69Q1-105[»]
4JI5X-ray3.85Q1-105[»]
4JI6X-ray3.55Q1-105[»]
4JI7X-ray3.50Q1-105[»]
4JI8X-ray3.74Q1-105[»]
4JUWX-ray2.86Q2-100[»]
4JV5X-ray3.16Q2-100[»]
4JYAX-ray3.10Q2-100[»]
4K0KX-ray3.40Q2-101[»]
4K0LX-ray3.30Q2-100[»]
4K0PX-ray3.30Q2-100[»]
4KHPX-ray3.10Q2-100[»]
4NVUX-ray3.00Q1-105[»]
4NVWX-ray3.00Q1-105[»]
4NVYX-ray3.10Q1-105[»]
4NW0X-ray3.10Q1-105[»]
4NXMX-ray3.65Q1-105[»]
4NXNX-ray3.54Q1-105[»]
4OX9X-ray3.80Q2-105[»]
ProteinModelPortalQ5SHP7.
SMRQ5SHP7. Positions 2-105.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING300852.TTHA1683.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD71506; BAD71506; BAD71506.
GeneID3169831.
KEGGttj:TTHA1683.
PATRIC23958321. VBITheThe93045_1653.

Phylogenomic databases

eggNOGCOG0186.
HOGENOMHOG000231339.
KOK02961.
OMAHDEKNET.
OrthoDBEOG63JRH2.
PhylomeDBQ5SHP7.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1722-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_01345_B. Ribosomal_S17_B.
InterProIPR012340. NA-bd_OB-fold.
IPR000266. Ribosomal_S17.
IPR019984. Ribosomal_S17_bac-type.
IPR019979. Ribosomal_S17_CS.
[Graphical view]
PANTHERPTHR10744. PTHR10744. 1 hit.
PfamPF00366. Ribosomal_S17. 1 hit.
[Graphical view]
PRINTSPR00973. RIBOSOMALS17.
ProDomPD001295. Ribosomal_S17. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR03635. S17_bact. 1 hit.
PROSITEPS00056. RIBOSOMAL_S17. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5SHP7.

Entry information

Entry nameRS17_THET8
AccessionPrimary (citable) accession number: Q5SHP7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references