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Q5SHP3 (RL22_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L22
Gene names
Name:rplV
Ordered Locus Names:TTHA1687
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus ›

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. HAMAP-Rule MF_01331_B

The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel. HAMAP-Rule MF_01331_B

Subunit structure

Part of the 50S ribosomal subunit.

Sequence similarities

Belongs to the ribosomal protein L22P family.

Mass spectrometry

Molecular mass is 12781 Da from positions 1 - 113. Determined by MALDI. Ref.3

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11311350S ribosomal protein L22 HAMAP-Rule MF_01331_B
PRO_0000125249

Secondary structure

1 ................ 113
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q5SHP3 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 11814D2DE644AF1F

FASTA11312,780
        10         20         30         40         50         60 
MEAKAIARYV RISPRKVRLV VDLIRGKSLE EARNILRYTN KRGAYFVAKV LESAAANAVN 

        70         80         90        100        110 
NHDMLEDRLY VKAAYVDEGP ALKRVLPRAR GRADIIKKRT SHITVILGEK HGK

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[2]"Identification of the 50S ribosomal proteins from the eubacterium Thermus thermophilus."
Katsani K.R., Tsiboli P., Anagnostopoulos K., Urlaub H., Choli-Papadopoulou T.
Biol. Chem. 381:1079-1087(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-20.
[3]"Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry."
Suh M.-J., Hamburg D.M., Gregory S.T., Dahlberg A.E., Limbach P.A.
Proteomics 5:4818-4831(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
[4]"The path of messenger RNA through the ribosome."
Yusupova G.Z., Yusupov M.M., Cate J.H.D., Noller H.F.
Cell 106:233-241(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS) OF THE RIBOSOME.
[5]"Crystal structure of the ribosome at 5.5 A resolution."
Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H.D., Noller H.F.
Science 292:883-896(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (5.5 ANGSTROMS) OF THE RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP008226 Genomic DNA. Translation: BAD71510.1.
RefSeqYP_144953.1. NC_006461.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GIYX-ray5.50S1-113[»]
1YL3X-ray5.50S1-113[»]
2B66X-ray5.90W1-113[»]
2B9NX-ray6.76W1-113[»]
2B9PX-ray6.46W1-113[»]
2HGJX-ray5.00V1-113[»]
2HGQX-ray5.50V1-113[»]
2HGUX-ray4.51V1-113[»]
2J01X-ray2.80W1-113[»]
2J03X-ray2.80W1-113[»]
2V47X-ray3.80W1-113[»]
2V49X-ray3.80W1-113[»]
2WDIX-ray3.30W1-113[»]
2WDJX-ray3.30W1-113[»]
2WDLX-ray3.50W1-113[»]
2WDNX-ray3.50W1-113[»]
2WH2X-ray3.45W1-113[»]
2WH4X-ray3.45W1-113[»]
2WRJX-ray3.60W1-113[»]
2WRLX-ray3.60W1-113[»]
2WROX-ray3.60W1-113[»]
2WRRX-ray3.60W1-113[»]
2X9SX-ray3.10W1-113[»]
2X9UX-ray3.10W1-113[»]
2XG0X-ray3.20W1-113[»]
2XG2X-ray3.20W1-113[»]
2XQEX-ray3.10W1-113[»]
2XTGelectron microscopy7.80W1-113[»]
2XUXelectron microscopy7.60W1-113[»]
2Y0VX-ray3.10W1-113[»]
2Y0XX-ray3.10W1-113[»]
2Y0ZX-ray3.10W1-113[»]
2Y11X-ray3.10W1-113[»]
2Y13X-ray3.10W1-113[»]
2Y15X-ray3.10W1-113[»]
2Y17X-ray3.10W1-113[»]
2Y19X-ray3.10W1-113[»]
3FINelectron microscopy6.40W1-113[»]
3HUXX-ray3.10W1-113[»]
3HUZX-ray3.10W1-113[»]
3I8FX-ray3.10S1-113[»]
3I8IX-ray3.10S1-113[»]
3I9CX-ray3.50S1-113[»]
3I9EX-ray3.50S1-113[»]
3KIRX-ray3.30W1-113[»]
3KITX-ray3.30W1-113[»]
3KIWX-ray3.60W1-113[»]
3KIYX-ray3.60W1-113[»]
3KNIX-ray3.00W1-113[»]
3KNKX-ray3.00W1-113[»]
3KNMX-ray3.45W1-113[»]
3KNOX-ray3.45W1-113[»]
3TVEX-ray3.10S1-113[»]
3TVHX-ray3.10S1-113[»]
3UXQX-ray3.20W1-113[»]
3UXRX-ray3.20W1-113[»]
3UYEX-ray3.00S1-113[»]
3UYGX-ray3.00S1-113[»]
3UZ1X-ray3.30S1-113[»]
3UZ2X-ray3.30S1-113[»]
3UZ8X-ray3.00S1-113[»]
3UZ9X-ray3.00S1-113[»]
3UZFX-ray3.30S1-113[»]
3UZHX-ray3.30S1-113[»]
3UZKX-ray3.30S1-113[»]
3UZNX-ray3.30S1-113[»]
3V23X-ray3.00W1-113[»]
3V25X-ray3.00W1-113[»]
3V27X-ray3.10W1-113[»]
3V29X-ray3.10W1-113[»]
3V2DX-ray2.70W1-113[»]
3V2FX-ray2.70W1-113[»]
3ZN9X-ray3.10W1-113[»]
3ZNEX-ray3.10W1-113[»]
3ZVPX-ray3.80W1-113[»]
4ABSX-ray3.10W1-113[»]
4B8GX-ray3.70W1-113[»]
4B8IX-ray3.70W1-113[»]
4DHAX-ray3.20W1-113[»]
4DHCX-ray3.20W1-113[»]
4G5LX-ray3.30S1-113[»]
4G5NX-ray3.30S1-113[»]
4G5UX-ray3.10S1-113[»]
4G5WX-ray3.10S1-113[»]
ProteinModelPortalQ5SHP3.
SMRQ5SHP3. Positions 1-113.
ModBaseSearch...

Protein-protein interaction databases

STRING300852.TTHA1687.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD71510; BAD71510; BAD71510.
GeneID3169835.
KEGGttj:TTHA1687.
PATRIC23958329. VBITheThe93045_1657.

Phylogenomic databases

eggNOGCOG0091.
HOGENOMHOG000205046.
KOK02890.
OMAASRINKR.
ProtClustDBPRK00565.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1726-MONOMER.

Family and domain databases

Gene3D3.90.470.10. 1 hit.
HAMAPMF_01331_B. Ribosomal_L22_B.
InterProIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERPTHR13501. PTHR13501. 1 hit.
PfamPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMSSF54843. Ribosomal_L22. 1 hit.
TIGRFAMsTIGR01044. rplV_bact. 1 hit.
PROSITEPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5SHP3.

Entry information

Entry nameRL22_THET8
AccessionPrimary (citable) accession number: Q5SHP3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents