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Protein

50S ribosomal protein L22

Gene

rplV

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).By similarity
The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1693-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L22
Gene namesi
Name:rplV
Ordered Locus Names:TTHA1687
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001252491 – 11350S ribosomal protein L22Add BLAST113

Proteomic databases

PRIDEiQ5SHP3

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Protein-protein interaction databases

STRINGi300852.TTHA1687

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 24Combined sources11
Helixi29 – 38Combined sources10
Helixi43 – 62Combined sources20
Helixi66 – 68Combined sources3
Beta strandi69 – 78Combined sources10
Beta strandi82 – 86Combined sources5
Turni89 – 91Combined sources3
Beta strandi94 – 98Combined sources5
Beta strandi101 – 109Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ML5electron microscopy14.00s1-113[»]
1VVJX-ray3.44RW/YW1-113[»]
1VY4X-ray2.60BW/DW1-113[»]
1VY5X-ray2.55BW/DW1-113[»]
1VY6X-ray2.90BW/DW1-113[»]
1VY7X-ray2.80BW/DW1-113[»]
4L47X-ray3.22RW/YW1-113[»]
4L71X-ray3.90RW/YW1-113[»]
4LELX-ray3.90RW/YW1-113[»]
4LFZX-ray3.92RW/YW1-113[»]
4LNTX-ray2.94RW/YW1-113[»]
4LSKX-ray3.48RW/YW1-113[»]
4LT8X-ray3.14RW/YW1-113[»]
4P6FX-ray3.60RW/YW1-113[»]
4P70X-ray3.68RW/YW1-113[»]
4TUAX-ray3.60RW/YW1-113[»]
4TUBX-ray3.60RW/YW1-113[»]
4TUCX-ray3.60RW/YW1-113[»]
4TUDX-ray3.60RW/YW1-113[»]
4TUEX-ray3.50RW/YW1-113[»]
4V42X-ray5.50BS1-113[»]
4V4PX-ray5.50AS1-113[»]
4V4RX-ray5.90BW1-113[»]
4V4SX-ray6.76BW1-113[»]
4V4TX-ray6.46BW1-113[»]
4V4XX-ray5.00BV1-113[»]
4V4YX-ray5.50BV1-113[»]
4V4ZX-ray4.51BV1-113[»]
4V51X-ray2.80BW/DW1-113[»]
4V5AX-ray3.50BW/DW1-113[»]
4V5CX-ray3.30BW/DW1-113[»]
4V5DX-ray3.50BW/DW1-113[»]
4V5EX-ray3.45BW/DW1-113[»]
4V5FX-ray3.60BW/DW1-113[»]
4V5GX-ray3.60BW/DW1-113[»]
4V5JX-ray3.10BW/DW1-113[»]
4V5KX-ray3.20BW/DW1-113[»]
4V5LX-ray3.10BW1-113[»]
4V5Melectron microscopy7.80BW1-113[»]
4V5Nelectron microscopy7.60BW1-113[»]
4V5PX-ray3.10BW/DW1-113[»]
4V5QX-ray3.10BW/DW1-113[»]
4V5RX-ray3.10BW/DW1-113[»]
4V5SX-ray3.10BW/DW1-113[»]
4V68electron microscopy6.40BW1-113[»]
4V6AX-ray3.10BW/DW1-113[»]
4V6FX-ray3.10AS/DS1-113[»]
4V6GX-ray3.50BS/DS1-113[»]
4V7JX-ray3.30AW/BW1-113[»]
4V7KX-ray3.60AW/BW1-113[»]
4V7LX-ray3.00BW/DW1-113[»]
4V7MX-ray3.45BW/DW1-113[»]
4V7WX-ray3.00BW/DW1-113[»]
4V7XX-ray3.00BW/DW1-113[»]
4V7YX-ray3.00BW/DW1-113[»]
4V7ZX-ray3.10BW/DW1-113[»]
4V87X-ray3.10AS/DS1-113[»]
4V8AX-ray3.20AW/BW1-113[»]
4V8BX-ray3.00BS/DS1-113[»]
4V8CX-ray3.30AS/BS1-113[»]
4V8DX-ray3.00BS/DS1-113[»]
4V8EX-ray3.30AS/CS1-113[»]
4V8FX-ray3.30AS/DS1-113[»]
4V8GX-ray3.00BW/DW1-113[»]
4V8HX-ray3.10BW/DW1-113[»]
4V8IX-ray2.70BW/DW1-113[»]
4V8JX-ray3.90BW/DW1-113[»]
4V8NX-ray3.10BW/DW1-113[»]
4V8OX-ray3.80BW1-113[»]
4V8QX-ray3.10AW1-113[»]
4V8UX-ray3.70BW/DW1-113[»]
4V8XX-ray3.35BW/DW1-113[»]
4V90X-ray2.95BW1-113[»]
4V95X-ray3.20BW/DW1-113[»]
4V97X-ray3.52BW/DW1-113[»]
4V9AX-ray3.30BS/DS1-113[»]
4V9BX-ray3.10BS/DS1-113[»]
4V9HX-ray2.86BW1-113[»]
4V9IX-ray3.30BW/DW1-112[»]
4V9RX-ray3.00BW/DW1-113[»]
4V9SX-ray3.10BW/DW1-113[»]
4W2EX-ray2.90W1-113[»]
4W2FX-ray2.40BW/DW1-113[»]
4W2GX-ray2.55BW/DW1-113[»]
4W2HX-ray2.70BW/DW1-113[»]
4W2IX-ray2.70BW/DW1-113[»]
4W4GX-ray3.30RW/YW1-113[»]
4WPOX-ray2.80AW/CW1-113[»]
4WQ1X-ray3.10A5/E81-113[»]
4WQFX-ray2.80AW/CW1-113[»]
4WQRX-ray3.15A5/E81-113[»]
4WQUX-ray2.80AW/CW1-113[»]
4WQYX-ray2.80AW/CW1-113[»]
4WR6X-ray3.05A5/E81-113[»]
4WRAX-ray3.05A5/E81-113[»]
4WROX-ray3.05E81-113[»]
4WSDX-ray2.95A5/E81-113[»]
4WSMX-ray3.30A5/E81-113[»]
4WT1X-ray3.05A5/E81-113[»]
4WT8X-ray3.40CW1-113[»]
DW1-112[»]
4WU1X-ray3.20A5/E81-113[»]
4WZDX-ray3.10A5/E81-113[»]
4WZOX-ray3.30A5/E81-113[»]
4Y4OX-ray2.301W/2W1-113[»]
4Y4PX-ray2.501W/2W1-113[»]
4YPBX-ray3.40RW/YW1-113[»]
4YZVX-ray3.10RW/YW1-113[»]
4Z3SX-ray2.651W/2W1-113[»]
4Z8CX-ray2.901W/2W1-113[»]
4ZERX-ray3.101W/2W1-112[»]
4ZSNX-ray3.60RW/YW1-113[»]
5A9Zelectron microscopy4.70AT1-110[»]
5AA0electron microscopy5.00AT1-110[»]
5CZPX-ray3.30RW/YW1-113[»]
5D8BX-ray3.63MB/Q1-113[»]
5DFEX-ray3.10RW/YW1-113[»]
5DOXX-ray3.101W/2W1-113[»]
5DOYX-ray2.601W/2W1-113[»]
5E7KX-ray3.20A5/E81-113[»]
5E81X-ray2.95A5/E81-113[»]
5EL4X-ray3.15A5/E81-113[»]
5EL5X-ray3.15A5/E81-113[»]
5EL6X-ray3.10A5/E81-113[»]
5EL7X-ray3.15A5/E81-113[»]
5F8KX-ray2.801W/2W1-112[»]
5FDUX-ray2.901W/2W1-112[»]
5FDVX-ray2.801W/2W1-112[»]
5HAUX-ray3.001U/2U1-113[»]
5HCPX-ray2.891W/2W1-113[»]
5HCQX-ray2.801W/2W1-113[»]
5HCRX-ray2.801W/2W1-113[»]
5HD1X-ray2.701W/2W1-113[»]
5IB7X-ray2.99A5/E81-113[»]
5IB8X-ray3.13A5/E81-113[»]
5IBBX-ray2.96A5/E81-113[»]
5IMQelectron microscopy3.80o1-113[»]
5IMRelectron microscopy-o1-113[»]
5J30X-ray3.20RW/YW1-113[»]
5J3CX-ray3.04RW/YW1-113[»]
5J4BX-ray2.601W/2W1-113[»]
5J4CX-ray2.801W/2W1-113[»]
5J8BX-ray2.60W1-113[»]
5NDKX-ray2.95A5/E81-113[»]
5OT7electron microscopy3.80x1-113[»]
5UQ7electron microscopy3.50W1-112[»]
5UQ8electron microscopy3.20W1-112[»]
5VP2X-ray2.801W/2W1-113[»]
5W4KX-ray2.701W/2W1-113[»]
5WISX-ray2.701W/2W1-113[»]
5WITX-ray2.601W/2W1-113[»]
6C5LX-ray3.20BW/DW1-113[»]
6CFJX-ray2.801W/2W1-113[»]
6CFKX-ray2.701W/2W1-113[»]
6CFLX-ray2.601W/2W1-113[»]
ProteinModelPortaliQ5SHP3
SMRiQ5SHP3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHP3

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KAP Bacteria
COG0091 LUCA
HOGENOMiHOG000205046
KOiK02890
OMAiPQGRAHR
PhylomeDBiQ5SHP3

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
HAMAPiMF_01331_B Ribosomal_L22_B, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR018260 Ribosomal_L22/L17_CS
IPR036394 Ribosomal_L22/L17_sf
IPR005727 Ribosomal_L22_bac/chlpt-type
PANTHERiPTHR13501 PTHR13501, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
TIGRFAMsiTIGR01044 rplV_bact, 1 hit
PROSITEiView protein in PROSITE
PS00464 RIBOSOMAL_L22, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SHP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKAIARYV RISPRKVRLV VDLIRGKSLE EARNILRYTN KRGAYFVAKV
60 70 80 90 100
LESAAANAVN NHDMLEDRLY VKAAYVDEGP ALKRVLPRAR GRADIIKKRT
110
SHITVILGEK HGK
Length:113
Mass (Da):12,780
Last modified:December 21, 2004 - v1
Checksum:i11814D2DE644AF1F
GO

Mass spectrometryi

Molecular mass is 12781 Da from positions 1 - 113. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71510.1
RefSeqiWP_011173710.1, NC_006461.1
YP_144953.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71510; BAD71510; BAD71510
GeneIDi3169835
KEGGittj:TTHA1687
PATRICifig|300852.9.peg.1657

Similar proteinsi

Entry informationi

Entry nameiRL22_THET8
AccessioniPrimary (citable) accession number: Q5SHP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health