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Protein

50S ribosomal protein L3

Gene

rplC

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1698-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L3
Gene namesi
Name:rplC
Ordered Locus Names:TTHA1692
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000771801 – 20650S ribosomal protein L3Add BLAST206

Post-translational modificationi

The mass differences between the observed and calculated masses are suggested to be due to methylation, which is known to occur in the E.coli and R.palustris orthologs.

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

Protein-protein interaction databases

STRINGi300852.TTHA1692

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 16Combined sources14
Beta strandi19 – 27Combined sources9
Beta strandi35 – 37Combined sources3
Turni39 – 42Combined sources4
Beta strandi46 – 48Combined sources3
Helixi61 – 63Combined sources3
Beta strandi87 – 89Combined sources3
Helixi93 – 95Combined sources3
Beta strandi101 – 107Combined sources7
Beta strandi110 – 114Combined sources5
Turni116 – 118Combined sources3
Beta strandi127 – 130Combined sources4
Beta strandi144 – 147Combined sources4
Beta strandi158 – 162Combined sources5
Beta strandi164 – 174Combined sources11
Turni177 – 180Combined sources4
Beta strandi181 – 186Combined sources6
Beta strandi195 – 200Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VVJX-ray3.44RE/YE1-206[»]
1VY4X-ray2.60BE/DE1-206[»]
1VY5X-ray2.55BE/DE1-206[»]
1VY6X-ray2.90BE/DE1-206[»]
1VY7X-ray2.80BE/DE1-206[»]
4L47X-ray3.22RE/YE1-206[»]
4L71X-ray3.90RE/YE1-206[»]
4LELX-ray3.90RE/YE1-206[»]
4LFZX-ray3.92RE/YE1-206[»]
4LNTX-ray2.94RE/YE1-206[»]
4LSKX-ray3.48RE/YE1-206[»]
4LT8X-ray3.14RE/YE1-206[»]
4P6FX-ray3.60RE/YE1-206[»]
4P70X-ray3.68RE/YE1-206[»]
4TUAX-ray3.60RE/YE1-206[»]
4TUBX-ray3.60RE/YE1-206[»]
4TUCX-ray3.60RE/YE1-206[»]
4TUDX-ray3.60RE/YE1-206[»]
4TUEX-ray3.50RE/YE1-206[»]
4V42X-ray5.50BE21-26[»]
4V4PX-ray5.50E21-26[»]
4V4XX-ray5.00E1-206[»]
4V4YX-ray5.50E1-206[»]
4V4ZX-ray4.51E1-206[»]
4V51X-ray2.80BE/DE1-206[»]
4V5AX-ray3.50BE/DE1-206[»]
4V5CX-ray3.30BE/DE1-206[»]
4V5DX-ray3.50BE/DE1-206[»]
4V5EX-ray3.45BE/DE1-206[»]
4V5FX-ray3.60BE/DE1-206[»]
4V5GX-ray3.60BE/DE1-206[»]
4V5JX-ray3.10BE/DE1-206[»]
4V5KX-ray3.20BE/DE1-206[»]
4V5LX-ray3.10BE1-206[»]
4V5Melectron microscopy7.80BE1-206[»]
4V5Nelectron microscopy7.60BE1-206[»]
4V5PX-ray3.10BE/DE1-206[»]
4V5QX-ray3.10BE/DE1-206[»]
4V5RX-ray3.10BE/DE1-206[»]
4V5SX-ray3.10BE/DE1-206[»]
4V68electron microscopy6.40BE1-205[»]
4V6AX-ray3.10BE/DE1-206[»]
4V6FX-ray3.10AE/DE1-206[»]
4V6GX-ray3.50BE/DE1-206[»]
4V7JX-ray3.30AE/BE1-206[»]
4V7KX-ray3.60AE/BE1-206[»]
4V7LX-ray3.00BE/DE1-206[»]
4V7MX-ray3.45BE/DE1-206[»]
4V7WX-ray3.00BE/DE1-206[»]
4V7XX-ray3.00BE/DE1-206[»]
4V7YX-ray3.00BE/DE1-206[»]
4V7ZX-ray3.10BE/DE1-206[»]
4V87X-ray3.10AE/DE1-205[»]
4V8AX-ray3.20AE/BE1-206[»]
4V8BX-ray3.00BE/DE1-206[»]
4V8CX-ray3.30AE/BE1-206[»]
4V8DX-ray3.00BE/DE1-206[»]
4V8EX-ray3.30AE/CE1-206[»]
4V8FX-ray3.30AE/DE1-206[»]
4V8GX-ray3.00BE/DE1-206[»]
4V8HX-ray3.10BE/DE1-206[»]
4V8IX-ray2.70BE/DE1-206[»]
4V8JX-ray3.90BE/DE1-206[»]
4V8NX-ray3.10BE/DE1-206[»]
4V8OX-ray3.80BE1-206[»]
4V8QX-ray3.10AE1-206[»]
4V8UX-ray3.70BE/DE1-206[»]
4V8XX-ray3.35BE/DE1-206[»]
4V90X-ray2.95BE1-206[»]
4V95X-ray3.20BE/DE1-206[»]
4V97X-ray3.52BE/DE1-206[»]
4V9AX-ray3.30BE/DE1-206[»]
4V9BX-ray3.10BE/DE1-206[»]
4V9HX-ray2.86BE1-206[»]
4V9IX-ray3.30BE/DE1-204[»]
4V9RX-ray3.00BE/DE1-206[»]
4V9SX-ray3.10BE/DE1-206[»]
4W2EX-ray2.90E1-206[»]
4W2FX-ray2.40BE/DE1-206[»]
4W2GX-ray2.55BE/DE1-206[»]
4W2HX-ray2.70BE/DE1-206[»]
4W2IX-ray2.70BE/DE1-206[»]
4W4GX-ray3.30RE/YE1-206[»]
4WPOX-ray2.80AE/CE1-206[»]
4WQ1X-ray3.1021/291-205[»]
4WQFX-ray2.80AE/CE1-206[»]
4WQRX-ray3.1521/291-206[»]
4WQUX-ray2.80AE/CE1-206[»]
4WQYX-ray2.80AE/CE1-206[»]
4WR6X-ray3.0521/291-206[»]
4WRAX-ray3.0521/291-206[»]
4WROX-ray3.05211-206[»]
4WSDX-ray2.9521/291-206[»]
4WSMX-ray3.3021/291-206[»]
4WT1X-ray3.0521/291-206[»]
4WT8X-ray3.40CC/DC1-204[»]
4WU1X-ray3.2021/291-206[»]
4WZDX-ray3.1021/291-206[»]
4WZOX-ray3.3021/291-206[»]
4Y4OX-ray2.301E/2E1-206[»]
4Y4PX-ray2.501E/2E1-206[»]
4YPBX-ray3.40RE/YE1-206[»]
4YZVX-ray3.10RE/YE1-206[»]
4Z3SX-ray2.651E/2E1-206[»]
4Z8CX-ray2.901E/2E1-206[»]
4ZERX-ray3.101E/2E1-204[»]
4ZSNX-ray3.60RE/YE1-206[»]
5A9Zelectron microscopy4.70AE1-206[»]
5AA0electron microscopy5.00AE1-206[»]
5CZPX-ray3.30RE/YE1-206[»]
5D8BX-ray3.63B/XA1-206[»]
5DFEX-ray3.10RE/YE1-206[»]
5DOXX-ray3.101E/2E1-206[»]
5DOYX-ray2.601E/2E1-206[»]
5E7KX-ray3.2021/291-206[»]
5E81X-ray2.9521/291-206[»]
5EL4X-ray3.1521/291-206[»]
5EL5X-ray3.1521/291-206[»]
5EL6X-ray3.1021/291-206[»]
5EL7X-ray3.1521/291-206[»]
5F8KX-ray2.801E/2E1-204[»]
5FDUX-ray2.901E/2E1-204[»]
5FDVX-ray2.801E/2E1-204[»]
5HAUX-ray3.001E/2E1-206[»]
5HCPX-ray2.891E/2E1-206[»]
5HCQX-ray2.801E/2E1-206[»]
5HCRX-ray2.801E/2E1-206[»]
5HD1X-ray2.701E/2E1-206[»]
5IB7X-ray2.9921/291-206[»]
5IB8X-ray3.1321/291-206[»]
5IBBX-ray2.9621/291-206[»]
5IMQelectron microscopy3.80b1-206[»]
5IMRelectron microscopy-b1-206[»]
5J30X-ray3.20RE/YE1-206[»]
5J3CX-ray3.04RE/YE1-206[»]
5J4BX-ray2.601E/2E1-206[»]
5J4CX-ray2.801E/2E1-206[»]
5J8BX-ray2.60E1-206[»]
5NDKX-ray2.9521/291-206[»]
5OT7electron microscopy3.80h1-205[»]
5UQ7electron microscopy3.50E1-204[»]
5UQ8electron microscopy3.20E1-204[»]
5VP2X-ray2.801E/2E1-206[»]
5W4KX-ray2.701E/2E1-206[»]
5WISX-ray2.701E/2E1-206[»]
5WITX-ray2.601E/2E1-206[»]
6C5LX-ray3.20BE/DE1-206[»]
6CFJX-ray2.801E/2E1-206[»]
6CFKX-ray2.701E/2E1-206[»]
6FKRX-ray3.201E/2E1-204[»]
ProteinModelPortaliQ5SHN8
SMRiQ5SHN8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHN8

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EEE Bacteria
COG0087 LUCA
HOGENOMiHOG000100368
KOiK02906
OMAiKGMRMAG
PhylomeDBiQ5SHN8

Family and domain databases

HAMAPiMF_01325_B Ribosomal_L3_B, 1 hit
InterProiView protein in InterPro
IPR000597 Ribosomal_L3
IPR019927 Ribosomal_L3_bac/org-type
IPR019926 Ribosomal_L3_CS
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR11229 PTHR11229, 1 hit
PfamiView protein in Pfam
PF00297 Ribosomal_L3, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
TIGRFAMsiTIGR03625 L3_bact, 1 hit
PROSITEiView protein in PROSITE
PS00474 RIBOSOMAL_L3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SHN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGILGVKVG MTRIFRDDRA VPVTVILAGP CPVVQRRTPE KDGYTAVQLG
60 70 80 90 100
FLPQNPKRVN RPLKGHFAKA GVEPVRILRE IRDFNPEGDT VTVEIFKPGE
110 120 130 140 150
RVDVTGTSKG RGFAGVMKRW NFAGGPDSHG AHKIHRHPGS IGNRKTPGRV
160 170 180 190 200
YKGKKMAGHY GAERVTVMNL EVVDVIPEEN LLLVKGAVPG PNGGLVIVRE

TKKAAK
Length:206
Mass (Da):22,408
Last modified:December 21, 2004 - v1
Checksum:iA920741478CB6028
GO

Mass spectrometryi

Molecular mass is 22437 Da from positions 1 - 206. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71515.1
RefSeqiWP_011173714.1, NC_006461.1
YP_144958.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71515; BAD71515; BAD71515
GeneIDi3167929
KEGGittj:TTHA1692
PATRICifig|300852.9.peg.1662

Similar proteinsi

Entry informationi

Entry nameiRL3_THET8
AccessioniPrimary (citable) accession number: Q5SHN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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