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Q5SHF5

- PANC_THET8

UniProt

Q5SHF5 - PANC_THET8

Protein

Pantothenate synthetase

Gene

panC

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei32 – 321Proton donorUniRule annotation
    Binding sitei56 – 561Beta-alanineUniRule annotation
    Binding sitei56 – 561PantoateUniRule annotation
    Binding sitei149 – 1491PantoateUniRule annotation
    Binding sitei172 – 1721ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi25 – 328ATPUniRule annotation
    Nucleotide bindingi143 – 1464ATPUniRule annotation
    Nucleotide bindingi180 – 1834ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1817-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:TTHA1775
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Pantothenate synthetasePRO_0000128283Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi300852.TTHA1775.

    Structurei

    Secondary structure

    1
    276
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Helixi7 – 137
    Beta strandi19 – 246
    Helixi30 – 4213
    Beta strandi44 – 507
    Helixi54 – 563
    Turni63 – 653
    Helixi70 – 7910
    Beta strandi83 – 864
    Helixi90 – 934
    Beta strandi100 – 1045
    Helixi107 – 1104
    Helixi113 – 1164
    Helixi120 – 13516
    Beta strandi138 – 1436
    Helixi144 – 1463
    Helixi147 – 16014
    Beta strandi165 – 1695
    Helixi182 – 1865
    Helixi189 – 1946
    Helixi197 – 21014
    Helixi215 – 22612
    Beta strandi233 – 2408
    Turni242 – 2443
    Beta strandi256 – 2638
    Beta strandi266 – 2738

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UFVX-ray2.05A/B1-276[»]
    1V8FX-ray1.90A/B1-276[»]
    ProteinModelPortaliQ5SHF5.
    SMRiQ5SHF5. Positions 1-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5SHF5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiIVRDSDH.
    OrthoDBiEOG6Z6FZ4.
    PhylomeDBiQ5SHF5.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5SHF5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTVSTVAEL RAALPREGVG FVPTMGYLHR GHLALVERAR RENPFVVVSV    50
    FVNPLQFGPG EDYHRYPRDL ERDRALLQEA GVDLLFAPGV EEMYPEGFAT 100
    RVQVEGPLTA LWEGAVRPGH FQGVATVVAR LFLLVQPQRA YFGEKDYQQL 150
    LVVRRMVRDL GFPVEVVGVP TVREEDGLAL SSRNVYLSPE TRKKAPVLYR 200
    ALLAMREVAG QGGSVAEALR AGEEALRAVP EFRKDYLAIV HPETLLPLSD 250
    WVAGARGIVA GRFPEARLID NLEVYP 276
    Length:276
    Mass (Da):30,695
    Last modified:December 21, 2004 - v1
    Checksum:i975B6B82D162AE40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71598.1.
    RefSeqiWP_011173797.1. NC_006461.1.
    YP_145041.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD71598; BAD71598; BAD71598.
    GeneIDi3169469.
    KEGGittj:TTHA1775.
    PATRICi23958511. VBITheThe93045_1745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD71598.1 .
    RefSeqi WP_011173797.1. NC_006461.1.
    YP_145041.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UFV X-ray 2.05 A/B 1-276 [» ]
    1V8F X-ray 1.90 A/B 1-276 [» ]
    ProteinModelPortali Q5SHF5.
    SMRi Q5SHF5. Positions 1-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 300852.TTHA1775.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD71598 ; BAD71598 ; BAD71598 .
    GeneIDi 3169469.
    KEGGi ttj:TTHA1775.
    PATRICi 23958511. VBITheThe93045_1745.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi IVRDSDH.
    OrthoDBi EOG6Z6FZ4.
    PhylomeDBi Q5SHF5.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci TTHE300852:GH8R-1817-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5SHF5.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    2. "Crystal structure of pantothenate synthetase from Thermus thermophilus HB8."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2003) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiPANC_THET8
    AccessioniPrimary (citable) accession number: Q5SHF5
    Secondary accession number(s): P83701
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation
    PDB 1UFV apparently has a Val-49-Ala mutation.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3