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Protein

GTPase Obg

Gene

obg

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi171MagnesiumUniRule annotation1
Metal bindingi191MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi164 – 171GTPUniRule annotation8
Nucleotide bindingi189 – 193GTPUniRule annotation5
Nucleotide bindingi211 – 214GTPUniRule annotation4
Nucleotide bindingi277 – 280GTPUniRule annotation4
Nucleotide bindingi305 – 307GTPUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1788-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
TT1381
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:TTHA1781
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003863611 – 416GTPase ObgAdd BLAST416

Interactioni

Subunit structurei

Monomer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA1781

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi44 – 48Combined sources5
Turni73 – 75Combined sources3
Beta strandi84 – 88Combined sources5
Beta strandi90 – 96Combined sources7
Turni97 – 99Combined sources3
Beta strandi102 – 106Combined sources5
Beta strandi112 – 116Combined sources5
Helixi125 – 128Combined sources4
Beta strandi138 – 140Combined sources3
Beta strandi147 – 154Combined sources8
Beta strandi159 – 163Combined sources5
Helixi166 – 168Combined sources3
Helixi170 – 177Combined sources8
Beta strandi195 – 200Combined sources6
Beta strandi202 – 204Combined sources3
Beta strandi206 – 211Combined sources6
Helixi219 – 221Combined sources3
Helixi227 – 233Combined sources7
Beta strandi235 – 244Combined sources10
Helixi249 – 263Combined sources15
Helixi265 – 269Combined sources5
Beta strandi272 – 277Combined sources6
Helixi284 – 295Combined sources12
Turni296 – 298Combined sources3
Beta strandi301 – 303Combined sources3
Turni306 – 308Combined sources3
Helixi312 – 324Combined sources13
Beta strandi345 – 350Combined sources6
Beta strandi353 – 357Combined sources5
Helixi359 – 365Combined sources7
Beta strandi368 – 370Combined sources3
Helixi373 – 375Combined sources3
Helixi376 – 385Combined sources10
Helixi388 – 393Combined sources6
Turni394 – 396Combined sources3
Beta strandi402 – 405Combined sources4
Beta strandi408 – 411Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UDXX-ray2.07A1-416[»]
ProteinModelPortaliQ5SHE9
SMRiQ5SHE9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHE9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 324OBG-type GUniRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R Bacteria
COG0536 LUCA
HOGENOMiHOG000019083
KOiK03979
OMAiPHVGIVH
PhylomeDBiQ5SHE9

Family and domain databases

CDDicd01898 Obg, 1 hit
Gene3Di2.40.240.60, 1 hit
2.70.210.12, 1 hit
HAMAPiMF_01454 GTPase_Obg, 1 hit
InterProiView protein in InterPro
IPR031167 G_OBG
IPR035101 GTP-bd_Obg
IPR014100 GTP-bd_Obg/CgtA
IPR015349 GTP-bd_prot_GTP1/OBG_C
IPR036346 GTP-bd_prot_GTP1/OBG_C_sf
IPR006074 GTP1-OBG_CS
IPR006169 GTP1_OBG_dom
IPR036726 GTP1_OBG_dom_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PfamiView protein in Pfam
PF09269 DUF1967, 1 hit
PF01018 GTP1_OBG, 1 hit
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF002401 GTP_bd_Obg/CgtA, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF102741 SSF102741, 1 hit
SSF52540 SSF52540, 1 hit
SSF82051 SSF82051, 1 hit
TIGRFAMsiTIGR02729 Obg_CgtA, 1 hit
TIGR03595 Obg_CgtA_exten, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SHE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQDVLVITV AAGRGGDGAV SFRREKFVPK GGPDGGDGGR GGSVYLRARG
60 70 80 90 100
SVDSLSRLSK RTYKAEDGEH GRGSQQHGRG GEDLVIEVPR GTRVFDADTG
110 120 130 140 150
ELLADLTEEG QTVLVARGGA GGRGNMHFVS PTRQAPRFAE AGEEGEKRRL
160 170 180 190 200
RLELMLIADV GLVGYPNAGK SSLLAAMTRA HPKIAPYPFT TLSPNLGVVE
210 220 230 240 250
VSEEERFTLA DIPGIIEGAS EGKGLGLEFL RHIARTRVLL YVLDAADEPL
260 270 280 290 300
KTLETLRKEV GAYDPALLRR PSLVALNKVD LLEEEAVKAL ADALAREGLA
310 320 330 340 350
VLPVSALTGA GLPALKEALH ALVRSTPPPE MPKPVPRKEV QAGVEVVPVA
360 370 380 390 400
EGVYEVRAPE VERYLARIKG DLMEAAGYLQ EVFRRQGVEA ALRAKGVRAG
410
DLVRIGGLEF EYIPEV
Length:416
Mass (Da):44,498
Last modified:December 21, 2004 - v1
Checksum:i10969D7E66C4E21E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110607 Genomic DNA Translation: BAC76805.2
AP008226 Genomic DNA Translation: BAD71604.1
RefSeqiWP_011228913.1, NC_006461.1
YP_145047.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71604; BAD71604; BAD71604
GeneIDi3169474
KEGGittj:TTHA1781
PATRICifig|300852.9.peg.1751

Similar proteinsi

Entry informationi

Entry nameiOBG_THET8
AccessioniPrimary (citable) accession number: Q5SHE9
Secondary accession number(s): Q7X493
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health