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Protein

GTPase Obg

Gene

obg

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi171 – 1711MagnesiumUniRule annotation
Metal bindingi191 – 1911MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1718GTPUniRule annotation
Nucleotide bindingi189 – 1935GTPUniRule annotation
Nucleotide bindingi211 – 2144GTPUniRule annotation
Nucleotide bindingi277 – 2804GTPUniRule annotation
Nucleotide bindingi305 – 3073GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
TT1381
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:TTHA1781
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416GTPase ObgPRO_0000386361Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA1781.

Structurei

Secondary structure

1
416
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 118Combined sources
Beta strandi44 – 485Combined sources
Turni73 – 753Combined sources
Beta strandi84 – 885Combined sources
Beta strandi90 – 967Combined sources
Turni97 – 993Combined sources
Beta strandi102 – 1065Combined sources
Beta strandi112 – 1165Combined sources
Helixi125 – 1284Combined sources
Beta strandi138 – 1403Combined sources
Beta strandi147 – 1548Combined sources
Beta strandi159 – 1635Combined sources
Helixi166 – 1683Combined sources
Helixi170 – 1778Combined sources
Beta strandi195 – 2006Combined sources
Beta strandi202 – 2043Combined sources
Beta strandi206 – 2116Combined sources
Helixi219 – 2213Combined sources
Helixi227 – 2337Combined sources
Beta strandi235 – 24410Combined sources
Helixi249 – 26315Combined sources
Helixi265 – 2695Combined sources
Beta strandi272 – 2776Combined sources
Helixi284 – 29512Combined sources
Turni296 – 2983Combined sources
Beta strandi301 – 3033Combined sources
Turni306 – 3083Combined sources
Helixi312 – 32413Combined sources
Beta strandi345 – 3506Combined sources
Beta strandi353 – 3575Combined sources
Helixi359 – 3657Combined sources
Beta strandi368 – 3703Combined sources
Helixi373 – 3753Combined sources
Helixi376 – 38510Combined sources
Helixi388 – 3936Combined sources
Turni394 – 3963Combined sources
Beta strandi402 – 4054Combined sources
Beta strandi408 – 4114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UDXX-ray2.07A1-416[»]
ProteinModelPortaliQ5SHE9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHE9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 324167OBG-type GUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiLVDFRYK.
OrthoDBiEOG6H1Q1M.
PhylomeDBiQ5SHE9.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 2 hits.
PfamiPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQDVLVITV AAGRGGDGAV SFRREKFVPK GGPDGGDGGR GGSVYLRARG
60 70 80 90 100
SVDSLSRLSK RTYKAEDGEH GRGSQQHGRG GEDLVIEVPR GTRVFDADTG
110 120 130 140 150
ELLADLTEEG QTVLVARGGA GGRGNMHFVS PTRQAPRFAE AGEEGEKRRL
160 170 180 190 200
RLELMLIADV GLVGYPNAGK SSLLAAMTRA HPKIAPYPFT TLSPNLGVVE
210 220 230 240 250
VSEEERFTLA DIPGIIEGAS EGKGLGLEFL RHIARTRVLL YVLDAADEPL
260 270 280 290 300
KTLETLRKEV GAYDPALLRR PSLVALNKVD LLEEEAVKAL ADALAREGLA
310 320 330 340 350
VLPVSALTGA GLPALKEALH ALVRSTPPPE MPKPVPRKEV QAGVEVVPVA
360 370 380 390 400
EGVYEVRAPE VERYLARIKG DLMEAAGYLQ EVFRRQGVEA ALRAKGVRAG
410
DLVRIGGLEF EYIPEV
Length:416
Mass (Da):44,498
Last modified:December 21, 2004 - v1
Checksum:i10969D7E66C4E21E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110607 Genomic DNA. Translation: BAC76805.2.
AP008226 Genomic DNA. Translation: BAD71604.1.
RefSeqiWP_011228913.1. NC_006461.1.
YP_145047.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71604; BAD71604; BAD71604.
GeneIDi3169474.
KEGGittj:TTHA1781.
PATRICi23958523. VBITheThe93045_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110607 Genomic DNA. Translation: BAC76805.2.
AP008226 Genomic DNA. Translation: BAD71604.1.
RefSeqiWP_011228913.1. NC_006461.1.
YP_145047.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UDXX-ray2.07A1-416[»]
ProteinModelPortaliQ5SHE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71604; BAD71604; BAD71604.
GeneIDi3169474.
KEGGittj:TTHA1781.
PATRICi23958523. VBITheThe93045_1751.

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiLVDFRYK.
OrthoDBiEOG6H1Q1M.
PhylomeDBiQ5SHE9.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1823-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SHE9.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 2 hits.
PfamiPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Crystal structure of the conserved protein TT1381 from Thermus thermophilus HB8."
    Kukimoto-Niino M., Murayama K., Terada T., Kuramitsu S., Shirouzu M., Yokoyama S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  3. "Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8."
    Kukimoto-Niino M., Murayama K., Inoue M., Terada T., Tame J.R., Kuramitsu S., Shirouzu M., Yokoyama S.
    J. Mol. Biol. 337:761-770(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiOBG_THET8
AccessioniPrimary (citable) accession number: Q5SHE9
Secondary accession number(s): Q7X493
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 21, 2004
Last modified: December 9, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.