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Protein

GTPase Obg

Gene

obg

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi171MagnesiumUniRule annotation1
Metal bindingi191MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi164 – 171GTPUniRule annotation8
Nucleotide bindingi189 – 193GTPUniRule annotation5
Nucleotide bindingi211 – 214GTPUniRule annotation4
Nucleotide bindingi277 – 280GTPUniRule annotation4
Nucleotide bindingi305 – 307GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ObgUniRule annotation (EC:3.6.5.-UniRule annotation)
Alternative name(s):
GTP-binding protein ObgUniRule annotation
TT1381
Gene namesi
Name:obgUniRule annotation
Ordered Locus Names:TTHA1781
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003863611 – 416GTPase ObgAdd BLAST416

Interactioni

Subunit structurei

Monomer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA1781.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 11Combined sources8
Beta strandi44 – 48Combined sources5
Turni73 – 75Combined sources3
Beta strandi84 – 88Combined sources5
Beta strandi90 – 96Combined sources7
Turni97 – 99Combined sources3
Beta strandi102 – 106Combined sources5
Beta strandi112 – 116Combined sources5
Helixi125 – 128Combined sources4
Beta strandi138 – 140Combined sources3
Beta strandi147 – 154Combined sources8
Beta strandi159 – 163Combined sources5
Helixi166 – 168Combined sources3
Helixi170 – 177Combined sources8
Beta strandi195 – 200Combined sources6
Beta strandi202 – 204Combined sources3
Beta strandi206 – 211Combined sources6
Helixi219 – 221Combined sources3
Helixi227 – 233Combined sources7
Beta strandi235 – 244Combined sources10
Helixi249 – 263Combined sources15
Helixi265 – 269Combined sources5
Beta strandi272 – 277Combined sources6
Helixi284 – 295Combined sources12
Turni296 – 298Combined sources3
Beta strandi301 – 303Combined sources3
Turni306 – 308Combined sources3
Helixi312 – 324Combined sources13
Beta strandi345 – 350Combined sources6
Beta strandi353 – 357Combined sources5
Helixi359 – 365Combined sources7
Beta strandi368 – 370Combined sources3
Helixi373 – 375Combined sources3
Helixi376 – 385Combined sources10
Helixi388 – 393Combined sources6
Turni394 – 396Combined sources3
Beta strandi402 – 405Combined sources4
Beta strandi408 – 411Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UDXX-ray2.07A1-416[»]
ProteinModelPortaliQ5SHE9.
SMRiQ5SHE9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHE9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 324OBG-type GUniRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.UniRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiLVDFRYK.
PhylomeDBiQ5SHE9.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 2 hits.
PfamiPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SHE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQDVLVITV AAGRGGDGAV SFRREKFVPK GGPDGGDGGR GGSVYLRARG
60 70 80 90 100
SVDSLSRLSK RTYKAEDGEH GRGSQQHGRG GEDLVIEVPR GTRVFDADTG
110 120 130 140 150
ELLADLTEEG QTVLVARGGA GGRGNMHFVS PTRQAPRFAE AGEEGEKRRL
160 170 180 190 200
RLELMLIADV GLVGYPNAGK SSLLAAMTRA HPKIAPYPFT TLSPNLGVVE
210 220 230 240 250
VSEEERFTLA DIPGIIEGAS EGKGLGLEFL RHIARTRVLL YVLDAADEPL
260 270 280 290 300
KTLETLRKEV GAYDPALLRR PSLVALNKVD LLEEEAVKAL ADALAREGLA
310 320 330 340 350
VLPVSALTGA GLPALKEALH ALVRSTPPPE MPKPVPRKEV QAGVEVVPVA
360 370 380 390 400
EGVYEVRAPE VERYLARIKG DLMEAAGYLQ EVFRRQGVEA ALRAKGVRAG
410
DLVRIGGLEF EYIPEV
Length:416
Mass (Da):44,498
Last modified:December 21, 2004 - v1
Checksum:i10969D7E66C4E21E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110607 Genomic DNA. Translation: BAC76805.2.
AP008226 Genomic DNA. Translation: BAD71604.1.
RefSeqiWP_011228913.1. NC_006461.1.
YP_145047.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71604; BAD71604; BAD71604.
GeneIDi3169474.
KEGGittj:TTHA1781.
PATRICi23958523. VBITheThe93045_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB110607 Genomic DNA. Translation: BAC76805.2.
AP008226 Genomic DNA. Translation: BAD71604.1.
RefSeqiWP_011228913.1. NC_006461.1.
YP_145047.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UDXX-ray2.07A1-416[»]
ProteinModelPortaliQ5SHE9.
SMRiQ5SHE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71604; BAD71604; BAD71604.
GeneIDi3169474.
KEGGittj:TTHA1781.
PATRICi23958523. VBITheThe93045_1751.

Phylogenomic databases

eggNOGiENOG4105C9R. Bacteria.
COG0536. LUCA.
HOGENOMiHOG000019083.
KOiK03979.
OMAiLVDFRYK.
PhylomeDBiQ5SHE9.

Miscellaneous databases

EvolutionaryTraceiQ5SHE9.

Family and domain databases

Gene3Di2.70.210.12. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01454. GTPase_Obg. 1 hit.
InterProiIPR031167. G_OBG.
IPR014100. GTP-bd_Obg/CgtA.
IPR015349. GTP-bd_prot_GTP1/OBG_C.
IPR006074. GTP1-OBG_CS.
IPR006169. GTP1_OBG_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PANTHERiPTHR11702:SF3. PTHR11702:SF3. 2 hits.
PfamiPF09269. DUF1967. 1 hit.
PF01018. GTP1_OBG. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF102741. SSF102741. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF82051. SSF82051. 1 hit.
TIGRFAMsiTIGR02729. Obg_CgtA. 1 hit.
TIGR03595. Obg_CgtA_exten. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOBG_THET8
AccessioniPrimary (citable) accession number: Q5SHE9
Secondary accession number(s): Q7X493
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.