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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9SubstrateUniRule annotation1
Binding sitei13SubstrateUniRule annotation1
Active sitei61Proton donor/acceptorUniRule annotation1
Binding sitei88SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1803-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:TTHA1794
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000178301 – 126Methylglyoxal synthaseAdd BLAST126

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1794

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi10 – 12Combined sources3
Helixi13 – 22Combined sources10
Helixi24 – 27Combined sources4
Beta strandi32 – 34Combined sources3
Helixi36 – 46Combined sources11
Turni56 – 59Combined sources4
Helixi60 – 69Combined sources10
Beta strandi73 – 79Combined sources7
Helixi89 – 101Combined sources13
Helixi110 – 122Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WO8X-ray1.70A/B/C/D/E/F1-126[»]
ProteinModelPortaliQ5SHD6
SMRiQ5SHD6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SHD6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 126MGS-likeUniRule annotationAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 38Substrate bindingUniRule annotation4
Regioni55 – 56Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiRACDVHN
PhylomeDBiQ5SHD6

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SHD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALALIAHD AKKDEMVAFC LRHKDVLARY PLLATGTTGA RIQEATGLAV
60 70 80 90 100
ERVLSGPLGG DLQIGARVAE GKVLAVVFLQ DPLTAKPHEP DVQALMRVCN
110 120
VHGVPLATNL VAAEALIAWI RKGTPQ
Length:126
Mass (Da):13,380
Last modified:December 21, 2004 - v1
Checksum:iC13C4F5DAD5F6156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71617.1
RefSeqiWP_011228922.1, NC_006461.1
YP_145060.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71617; BAD71617; BAD71617
GeneIDi3168681
KEGGittj:TTHA1794
PATRICifig|300852.9.peg.1765

Similar proteinsi

Entry informationi

Entry nameiMGSA_THET8
AccessioniPrimary (citable) accession number: Q5SHD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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