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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108ZincUniRule annotationCombined sources1
Metal bindingi111ZincUniRule annotation1
Metal bindingi111Zinc; via pros nitrogenCombined sources1
Metal bindingi179ZincUniRule annotationCombined sources1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

One-carbon metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Metal-bindingUniRule annotationCombined sourcesSAAS annotation, Nucleotide-binding, ZincUniRule annotationCombined sourcesSAAS annotation

Enzyme and pathway databases

BRENDAi3.5.4.16. 2305.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotationSAAS annotation (EC:3.5.4.16UniRule annotationSAAS annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:TTHA1878Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA1878.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WM9X-ray2.20A/B/C/D/E1-220[»]
1WUQX-ray2.00A/B/C/D/E1-220[»]
1WURX-ray1.82A/B/C/D/E1-220[»]
ProteinModelPortaliQ5SH52.
SMRiQ5SH52.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SH52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 215GTP_cyclohydroIInterPro annotationAdd BLAST174

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiNSAMITS.
PhylomeDBiQ5SH52.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SH52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGPQSGGQ ERGSMERKMV ELEDTGLTFA TEVDLERLQA LAAEWLQVIG
60 70 80 90 100
EDPGREGLLK TPERVAKAWA FLTRGYRQRL EEVVGGAVFP AEGSEMVVVK
110 120 130 140 150
GVEFYSMCEH HLLPFFGKVH IGYIPDGKIL GLSKFARIVD MFARRLQVQE
160 170 180 190 200
RLAVQIAEAI QEVLEPQGVG VVVEGVHLCM MMRGVEKQHS RTVTSAMLGV
210 220
FRENQKTREE FLSHLRDGTA
Length:220
Mass (Da):24,539
Last modified:December 21, 2004 - v1
Checksum:i81B31AAFD1709A71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71701.1.
RefSeqiWP_011228980.1. NC_006461.1.
YP_145144.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71701; BAD71701; BAD71701.
GeneIDi3168138.
KEGGittj:TTHA1878.
PATRICi23958717. VBITheThe93045_1845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71701.1.
RefSeqiWP_011228980.1. NC_006461.1.
YP_145144.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WM9X-ray2.20A/B/C/D/E1-220[»]
1WUQX-ray2.00A/B/C/D/E1-220[»]
1WURX-ray1.82A/B/C/D/E1-220[»]
ProteinModelPortaliQ5SH52.
SMRiQ5SH52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71701; BAD71701; BAD71701.
GeneIDi3168138.
KEGGittj:TTHA1878.
PATRICi23958717. VBITheThe93045_1845.

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiNSAMITS.
PhylomeDBiQ5SH52.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BRENDAi3.5.4.16. 2305.

Miscellaneous databases

EvolutionaryTraceiQ5SH52.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SH52_THET8
AccessioniPrimary (citable) accession number: Q5SH52
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.