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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotationSAAS annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi108ZincUniRule annotationCombined sources1
Metal bindingi111ZincUniRule annotation1
Metal bindingi111Zinc; via pros nitrogenCombined sources1
Metal bindingi179ZincUniRule annotationCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processOne-carbon metabolismUniRule annotationSAAS annotation
LigandGTP-bindingUniRule annotation, Metal-bindingUniRule annotationCombined sourcesSAAS annotation, Nucleotide-binding, ZincUniRule annotationCombined sourcesSAAS annotation

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1884-MONOMER
BRENDAi3.5.4.16 2305
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:TTHA1878Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Homopolymer.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA1878

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WM9X-ray2.20A/B/C/D/E1-220[»]
1WUQX-ray2.00A/B/C/D/E1-220[»]
1WURX-ray1.82A/B/C/D/E1-220[»]
ProteinModelPortaliQ5SH52
SMRiQ5SH52
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SH52

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 215GTP_cyclohydroIInterPro annotationAdd BLAST174

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EUJ Bacteria
COG0302 LUCA
HOGENOMiHOG000221222
KOiK01495
OMAiIVVVECE
PhylomeDBiQ5SH52

Family and domain databases

HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SH52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGPQSGGQ ERGSMERKMV ELEDTGLTFA TEVDLERLQA LAAEWLQVIG
60 70 80 90 100
EDPGREGLLK TPERVAKAWA FLTRGYRQRL EEVVGGAVFP AEGSEMVVVK
110 120 130 140 150
GVEFYSMCEH HLLPFFGKVH IGYIPDGKIL GLSKFARIVD MFARRLQVQE
160 170 180 190 200
RLAVQIAEAI QEVLEPQGVG VVVEGVHLCM MMRGVEKQHS RTVTSAMLGV
210 220
FRENQKTREE FLSHLRDGTA
Length:220
Mass (Da):24,539
Last modified:December 21, 2004 - v1
Checksum:i81B31AAFD1709A71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71701.1
RefSeqiWP_011228980.1, NC_006461.1
YP_145144.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71701; BAD71701; BAD71701
GeneIDi3168138
KEGGittj:TTHA1878
PATRICifig|300852.9.peg.1845

Similar proteinsi

Entry informationi

Entry nameiQ5SH52_THET8
AccessioniPrimary (citable) accession number: Q5SH52
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: February 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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