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Protein

[LysW]-aminoadipate kinase

Gene

lysZ

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of LysW-gamma-alpha-aminoadipate.UniRule annotation

Catalytic activityi

[LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate + ATP = [LysW]-C-terminal-L-glutamyl-gamma-L-2-aminoadipate 6-phosphate + ADP.UniRule annotation

Pathwayi: L-lysine biosynthesis via AAA pathway

This protein is involved in step 2 of the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route).UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Alpha-aminoadipate--LysW ligase LysX (lysX)
  2. [LysW]-aminoadipate kinase (lysZ)
  3. [LysW]-L-2-aminoadipate 6-phosphate reductase (lysY)
  4. [LysW]-aminoadipate semialdehyde transaminase (lysJ)
  5. [LysW]-lysine hydrolase (lysK)
This subpathway is part of the pathway L-lysine biosynthesis via AAA pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lysine from L-alpha-aminoadipate (Thermus route), the pathway L-lysine biosynthesis via AAA pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Transition state stabilizerUniRule annotation1
Binding sitei64SubstrateUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Sitei231Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Lysine biosynthesisUniRule annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-6801.
TTHE300852:GH8R-1892-MONOMER.
UniPathwayiUPA00033; UER00036.

Names & Taxonomyi

Protein namesi
Recommended name:
[LysW]-aminoadipate kinaseUniRule annotation (EC:2.7.2.-UniRule annotation)
Gene namesi
Name:lysZUniRule annotation
Ordered Locus Names:TTHA1903Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1903.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U6UX-ray1.92A/C1-269[»]
ProteinModelPortaliQ5SH27.
SMRiQ5SH27.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SH27.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249AA_kinaseInterPro annotationAdd BLAST249

Sequence similaritiesi

Belongs to the acetylglutamate kinase family. LysZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107U4Q. Bacteria.
COG0548. LUCA.
HOGENOMiHOG000233259.
KOiK05828.
OMAiEMVYCGK.
PhylomeDBiQ5SH27.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_02082. LysZ. 1 hit.
InterProiView protein in InterPro
IPR036393. AceGlu_kinase-like_sf.
IPR004662. AcgluKinase_fam.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR037529. LysZ.
PfamiView protein in Pfam
PF00696. AA_kinase. 1 hit.
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SH27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVKVGGAE GINYEAVAKD AASLWKEGVK LLLVHGGSAE TNKVAEALGH
60 70 80 90 100
PPRFLTHPGG QVSRLTDRKT LEIFEMVYCG LVNKRLVELL QKEGANAIGL
110 120 130 140 150
SGLDGRLFVG RRKTAVKYVE NGKVKVHRGD YTGTVEEVNK ALLDLLLQAG
160 170 180 190 200
YLPVLTPPAL SYENEAINTD GDQIAALLAT LYGAEALVYL SNVPGLLARY
210 220 230 240 250
PDEASLVREI PVERIEDPEY LALAQGRMKR KVMGAVEAVK GGVKRVVFAD
260
GRVENPIRRA LSGEGTVVR
Length:269
Mass (Da):29,054
Last modified:December 21, 2004 - v1
Checksum:i04F16090B98F5F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71726.1.
RefSeqiWP_011229000.1. NC_006461.1.
YP_145169.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71726; BAD71726; BAD71726.
GeneIDi3167977.
KEGGittj:TTHA1903.
PATRICifig|300852.9.peg.1871.

Similar proteinsi

Entry informationi

Entry nameiQ5SH27_THET8
AccessioniPrimary (citable) accession number: Q5SH27
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: January 31, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported