Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylglutamate kinase

Gene

TTHA1903

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.SAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.SAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (TTHA1903), Acetylglutamate/acetylaminoadipate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase (argC)
  4. Acetylornithine/acetyl-lysine aminotransferase (argD), Acetylornithine/acetyl-lysine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-6801.
TTHE300852:GH8R-1949-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinaseSAAS annotation (EC:2.7.2.-SAAS annotation, EC:2.7.2.8SAAS annotation)
Gene namesi
Ordered Locus Names:TTHA1903Imported
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Imported
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi300852.TTHA1903.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U6UX-ray1.92A/C1-269[»]
ProteinModelPortaliQ5SH27.
SMRiQ5SH27. Positions 1-269.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5SH27.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 249249AA_kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acetylglutamate kinase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107U4Q. Bacteria.
COG0548. LUCA.
HOGENOMiHOG000233259.
KOiK05828.
OMAiAEGFMTK.
OrthoDBiEOG6T1WVF.
PhylomeDBiQ5SH27.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5SH27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVKVGGAE GINYEAVAKD AASLWKEGVK LLLVHGGSAE TNKVAEALGH
60 70 80 90 100
PPRFLTHPGG QVSRLTDRKT LEIFEMVYCG LVNKRLVELL QKEGANAIGL
110 120 130 140 150
SGLDGRLFVG RRKTAVKYVE NGKVKVHRGD YTGTVEEVNK ALLDLLLQAG
160 170 180 190 200
YLPVLTPPAL SYENEAINTD GDQIAALLAT LYGAEALVYL SNVPGLLARY
210 220 230 240 250
PDEASLVREI PVERIEDPEY LALAQGRMKR KVMGAVEAVK GGVKRVVFAD
260
GRVENPIRRA LSGEGTVVR
Length:269
Mass (Da):29,054
Last modified:December 21, 2004 - v1
Checksum:i04F16090B98F5F5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71726.1.
RefSeqiWP_011229000.1. NC_006461.1.
YP_145169.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71726; BAD71726; BAD71726.
GeneIDi3167977.
KEGGittj:TTHA1903.
PATRICi23958771. VBITheThe93045_1871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71726.1.
RefSeqiWP_011229000.1. NC_006461.1.
YP_145169.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3U6UX-ray1.92A/C1-269[»]
ProteinModelPortaliQ5SH27.
SMRiQ5SH27. Positions 1-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71726; BAD71726; BAD71726.
GeneIDi3167977.
KEGGittj:TTHA1903.
PATRICi23958771. VBITheThe93045_1871.

Phylogenomic databases

eggNOGiENOG4107U4Q. Bacteria.
COG0548. LUCA.
HOGENOMiHOG000233259.
KOiK05828.
OMAiAEGFMTK.
OrthoDBiEOG6T1WVF.
PhylomeDBiQ5SH27.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00107.
BioCyciMetaCyc:MONOMER-6801.
TTHE300852:GH8R-1949-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5SH27.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579Imported.
  2. "The structure of first dimeric archaeal N-acetyl glutamate kinase reveals an intermediate conformation of the enzyme in the catalytic cycle."
    Ramya S., Preethi R., Kuramitsu S., Yokoyama S., Kumarevel T.S., Karthe P.
    Submitted (OCT-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS).

Entry informationi

Entry nameiQ5SH27_THET8
AccessioniPrimary (citable) accession number: Q5SH27
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.