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Protein

Isoprenyl transferase

Gene

uppS

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381UniRule annotation
Metal bindingi38 – 381MagnesiumUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Active sitei86 – 861Proton acceptorUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei212 – 2121SubstrateUniRule annotation
Metal bindingi231 – 2311MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1961-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:TTHA1915
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Isoprenyl transferasePRO_0000123703Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi300852.TTHA1915.

Structurei

3D structure databases

ProteinModelPortaliQ5SH15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 424Substrate bindingUniRule annotation
Regioni83 – 853Substrate bindingUniRule annotation
Regioni218 – 2203Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK12503.
OMAiWAKLKNK.
OrthoDBiEOG68H89T.
PhylomeDBiQ5SH15.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5SH15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRLLALSR PLYWLYEKRL LREVKRGPMP RHLGLILDGN RRYARALGLS
60 70 80 90 100
PTKGHEFGVQ KAYEVLEWCL EMGIKTVTVW VFSTDNFKRP PEEVETLMNL
110 120 130 140 150
FLREAERMAE DHRILEHQVR VRFIGRREGF SPEVVRAIER LERRTEGHRG
160 170 180 190 200
MFLNIAMGYG GREEIVDAVK RLLLEAEARG LSPKEVAEGL TPEDIARHLY
210 220 230 240 250
TAGLPDPDFI IRTSGEIRLS GFLLWQSAYS EFYFADVLWP EFRKIDFLRA
260
LRSYQARERR FGR
Length:263
Mass (Da):30,893
Last modified:December 21, 2004 - v1
Checksum:i686E5F50E3B3079A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71738.1.
RefSeqiWP_011229011.1. NC_006461.1.
YP_145181.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD71738; BAD71738; BAD71738.
GeneIDi3170150.
KEGGittj:TTHA1915.
PATRICi23958795. VBITheThe93045_1883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA. Translation: BAD71738.1.
RefSeqiWP_011229011.1. NC_006461.1.
YP_145181.1. NC_006461.1.

3D structure databases

ProteinModelPortaliQ5SH15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA1915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD71738; BAD71738; BAD71738.
GeneIDi3170150.
KEGGittj:TTHA1915.
PATRICi23958795. VBITheThe93045_1883.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK12503.
OMAiWAKLKNK.
OrthoDBiEOG68H89T.
PhylomeDBiQ5SH15.

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1961-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.

Entry informationi

Entry nameiISPT_THET8
AccessioniPrimary (citable) accession number: Q5SH15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.