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Protein

Leucine-rich PPR motif-containing protein, mitochondrial

Gene

Lrpprc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transcription, Transcription regulation, Transport

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich PPR motif-containing protein, mitochondrial
Alternative name(s):
130 kDa leucine-rich protein
Short name:
LRP 130
Leucine rich protein 157
Short name:
rLRP157
Gene namesi
Name:Lrpprc
Synonyms:Lrp157
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306575. Lrpprc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 77MitochondrionSequence analysisAdd BLAST77
ChainiPRO_000029554778 – 1392Leucine-rich PPR motif-containing protein, mitochondrialAdd BLAST1315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151N6-acetyllysineBy similarity1
Modified residuei186N6-acetyllysineBy similarity1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei462N6-acetyllysineBy similarity1
Modified residuei749N6-acetyllysineBy similarity1
Modified residuei1025PhosphoserineBy similarity1
Modified residuei1026PhosphoserineCombined sources1
Modified residuei1028PhosphoserineBy similarity1
Modified residuei1137PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5SGE0.
PRIDEiQ5SGE0.

2D gel databases

World-2DPAGE0004:Q5SGE0.

PTM databases

iPTMnetiQ5SGE0.
PhosphoSitePlusiQ5SGE0.

Expressioni

Tissue specificityi

Widely expressed. Expressed in liver, brain and a subset of small diameter sensory neurons in the dorsal root ganglion (at protein level).1 Publication

Inductioni

Induced by NGF in nociceptors.1 Publication

Interactioni

Subunit structurei

Interacts with CECR2, HEBP2, MAP1S, UXT, PPARGC1A and FOXO1. Component of mRNP complexes associated with HNRPA1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008200.

Structurei

3D structure databases

ProteinModelPortaliQ5SGE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati125 – 159PPR 1Add BLAST35
Repeati160 – 194PPR 2Add BLAST35
Repeati195 – 229PPR 3Add BLAST35
Repeati230 – 264PPR 4Add BLAST35
Repeati265 – 299PPR 5Add BLAST35
Repeati300 – 334PPR 6Add BLAST35
Repeati402 – 436PPR 7Add BLAST35
Repeati437 – 471PPR 8Add BLAST35
Repeati677 – 708PPR 9Add BLAST32
Repeati709 – 745PPR 10Add BLAST37
Repeati746 – 783PPR 11Add BLAST38
Repeati784 – 820PPR 12Add BLAST37
Repeati821 – 856PPR 13Add BLAST36
Repeati953 – 987PPR 14Add BLAST35
Repeati1030 – 1064PPR 15Add BLAST35
Repeati1065 – 1101PPR 16Add BLAST37
Repeati1102 – 1136PPR 17Add BLAST35
Repeati1137 – 1173PPR 18Add BLAST37
Repeati1174 – 1208PPR 19Add BLAST35
Repeati1315 – 1349PPR 20Add BLAST35

Sequence similaritiesi

Contains 20 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4318. Eukaryota.
ENOG410XSG9. LUCA.
HOGENOMiHOG000113350.
HOVERGENiHBG097314.
InParanoidiQ5SGE0.
KOiK17964.
PhylomeDBiQ5SGE0.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR033490. LRP130.
IPR002885. Pentatricopeptide_repeat.
IPR033443. PPR_long.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR24015:SF187. PTHR24015:SF187. 8 hits.
PfamiPF01535. PPR. 3 hits.
PF13812. PPR_3. 1 hit.
PF17177. PPR_long. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
TIGRFAMsiTIGR00756. PPR. 2 hits.
PROSITEiPS51375. PPR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SGE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLRPARW LLGAAAVPRL PLSLRLPAGG PGRLPSVVRV AAAGGRPAAG
60 70 80 90 100
ELLSQARLYA IVAEKKDLPE EPAPVRRSGS QFDWALMRLD NSVRRTGRIT
110 120 130 140 150
KGLLQKVFES TCRSGSPGSN QALLLLRSCG SLLPELSLAE RTEFAHKIWD
160 170 180 190 200
KLQQLGTVYD VSHYNALLKV YLQNEYRFSP TDFLAKMEGA NIQPNRVTYQ
210 220 230 240 250
RLIAAYCSVG DIEGASKILG FMKTRDLPIT EAVFSALVTG HARAGDMESA
260 270 280 290 300
ENILTVMKQA GIEPGPDTYL ALLNAHAEKG DIDHVKQILE KVEKSDHYFM
310 320 330 340 350
DRDFLQIIVS FSKAGYPQYV SEILEKITYE RRSIPDAMNL ILLLVTEKLE
360 370 380 390 400
DTAFQVLLAL PLARDETSSS FGSFFLRHCV TMDTPAEKLI DYCKRLRDAK
410 420 430 440 450
VHSSSLQFTL HCALQANKTA LAKAVMEALR DEGFPIRTHY FWPLLVGHQK
460 470 480 490 500
TKNVQGIIDI LKIMKEMGVD PDQETYINYV FPCFGSVQSA RAALQENKCL
510 520 530 540 550
PKSTTFAQAE VRNEAINGNL QNILSFLESN ALPFSFNSLR GSLILGFRRS
560 570 580 590 600
MNIDLWSKIT ELLYKDDRYC QKPPGPTEAV GYFLYNLIDS MSDSEVQAKE
610 620 630 640 650
ERLRQYFHQL REMNVKVSEN IYKGICNLLD NYHVPELIKD VKVLVDREKI
660 670 680 690 700
DSRKTSQFTS SDLESTLEKL KAEGHPVGDP LKQLILLLCS EENMQKALEV
710 720 730 740 750
KAKYESDMVI GGYAALINLC CRHDNAEDAL NLKQEFDRLD PSAVLDTAKY
760 770 780 790 800
VALVKVLGKH GRVQDAINIL KEMKEKDVVI KDAAVLSFFH ILNGAALRGE
810 820 830 840 850
IETVKQLHEA IVTLGLAKPS SNISFPLVTV HLEKDDLPAA LEASIACHEK
860 870 880 890 900
YKVLPRIHDV LCKLIEKGET DLIQKAMDFV SQEQGEMSML YDLFFAFLQT
910 920 930 940 950
GNYKEAKKII ETPGIRARPT RLQWFCDRCI ANNQVETLEK LVELTEKLFE
960 970 980 990 1000
CDRDQMYYNL LKLYKISGDW QRADAVWNKM QEENLIPRER TLRLLAGILK
1010 1020 1030 1040 1050
TSNQEVPFDV PELWFGDDRS SLSSSSPSAG DTVTEKMLLS DCRLKKSKDA
1060 1070 1080 1090 1100
YNIFLKAEKQ DVVFSSEAYS TLVGLLLSKD DFTRAMHVKD FAETHIKGFT
1110 1120 1130 1140 1150
LNGAASSLLI IAQVRRDYLK VALETLKAAL DLEQVPSELA VTRLIQALAL
1160 1170 1180 1190 1200
QGDVKSIETI QKMVKGLDAI ELSRMVFINN IALAQMKNNE IDAAIENIEH
1210 1220 1230 1240 1250
MLASENQTVE HQYFGLSYLF RKVIEEQMEP ALEKLSIMSE RLANQFALYK
1260 1270 1280 1290 1300
PVTDLFLQLV DSGKVDEARA LLERCGAIAE QTSILSVFCL RTSQKPKKAP
1310 1320 1330 1340 1350
VLKTLLELIP ELRENDRVYS CSMKSYVADK DVASAKALYE HLTAKNMKLD
1360 1370 1380 1390
DLFLKRYASL LKDVGEPVPF TEPPESFGFY IKQLKEAREN PS
Length:1,392
Mass (Da):156,653
Last modified:December 21, 2004 - v1
Checksum:i80D6040F4671D097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY293808 mRNA. Translation: AAQ74626.1.
RefSeqiNP_001008519.1. NM_001008519.1.
UniGeneiRn.92051.

Genome annotation databases

GeneIDi313867.
KEGGirno:313867.
UCSCiRGD:1306575. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY293808 mRNA. Translation: AAQ74626.1.
RefSeqiNP_001008519.1. NM_001008519.1.
UniGeneiRn.92051.

3D structure databases

ProteinModelPortaliQ5SGE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008200.

PTM databases

iPTMnetiQ5SGE0.
PhosphoSitePlusiQ5SGE0.

2D gel databases

World-2DPAGE0004:Q5SGE0.

Proteomic databases

PaxDbiQ5SGE0.
PRIDEiQ5SGE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi313867.
KEGGirno:313867.
UCSCiRGD:1306575. rat.

Organism-specific databases

CTDi10128.
RGDi1306575. Lrpprc.

Phylogenomic databases

eggNOGiKOG4318. Eukaryota.
ENOG410XSG9. LUCA.
HOGENOMiHOG000113350.
HOVERGENiHBG097314.
InParanoidiQ5SGE0.
KOiK17964.
PhylomeDBiQ5SGE0.

Miscellaneous databases

PROiQ5SGE0.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR033490. LRP130.
IPR002885. Pentatricopeptide_repeat.
IPR033443. PPR_long.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR24015:SF187. PTHR24015:SF187. 8 hits.
PfamiPF01535. PPR. 3 hits.
PF13812. PPR_3. 1 hit.
PF17177. PPR_long. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
TIGRFAMsiTIGR00756. PPR. 2 hits.
PROSITEiPS51375. PPR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPPRC_RAT
AccessioniPrimary (citable) accession number: Q5SGE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.