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Q5SGE0

- LPPRC_RAT

UniProt

Q5SGE0 - LPPRC_RAT

Protein

Leucine-rich PPR motif-containing protein, mitochondrial

Gene

Lrpprc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA By similarity.By similarity

    GO - Molecular functioni

    1. beta-tubulin binding Source: HGNC
    2. DNA binding Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA transport Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA transport, Transcription, Transcription regulation, Transport

    Keywords - Ligandi

    DNA-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich PPR motif-containing protein, mitochondrial
    Alternative name(s):
    130 kDa leucine-rich protein
    Short name:
    LRP 130
    Leucine rich protein 157
    Short name:
    rLRP157
    Gene namesi
    Name:Lrpprc
    Synonyms:Lrp157
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306575. Lrpprc.

    Subcellular locationi

    Mitochondrion 1 Publication. Nucleus 1 Publication. Nucleusnucleoplasm By similarity. Nucleus inner membrane By similarity. Nucleus outer membrane By similarity

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: HGNC
    2. cytoskeleton Source: HGNC
    3. mitochondrion Source: UniProtKB-SubCell
    4. nuclear inner membrane Source: UniProtKB-SubCell
    5. nuclear outer membrane Source: UniProtKB-SubCell
    6. nucleoplasm Source: UniProtKB-SubCell
    7. nucleus Source: HGNC
    8. perinuclear region of cytoplasm Source: HGNC

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 7777MitochondrionSequence AnalysisAdd
    BLAST
    Chaini78 – 13921315Leucine-rich PPR motif-containing protein, mitochondrialPRO_0000295547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511N6-acetyllysineBy similarity
    Modified residuei186 – 1861N6-acetyllysineBy similarity
    Modified residuei291 – 2911N6-acetyllysineBy similarity
    Modified residuei462 – 4621N6-acetyllysineBy similarity
    Modified residuei749 – 7491N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5SGE0.
    PRIDEiQ5SGE0.

    2D gel databases

    World-2DPAGE0004:Q5SGE0.

    PTM databases

    PhosphoSiteiQ5SGE0.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in liver, brain and a subset of small diameter sensory neurons in the dorsal root ganglion (at protein level).1 Publication

    Inductioni

    Induced by NGF in nociceptors.1 Publication

    Gene expression databases

    GenevestigatoriQ5SGE0.

    Interactioni

    Subunit structurei

    Interacts with CECR2, HEBP2, MAP1S, UXT, PPARGC1A and FOXO1. Component of mRNP complexes associated with HNRPA1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008200.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SGE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati125 – 15935PPR 1Add
    BLAST
    Repeati160 – 19435PPR 2Add
    BLAST
    Repeati195 – 22935PPR 3Add
    BLAST
    Repeati230 – 26435PPR 4Add
    BLAST
    Repeati265 – 29935PPR 5Add
    BLAST
    Repeati300 – 33435PPR 6Add
    BLAST
    Repeati402 – 43635PPR 7Add
    BLAST
    Repeati437 – 47135PPR 8Add
    BLAST
    Repeati677 – 70832PPR 9Add
    BLAST
    Repeati709 – 74537PPR 10Add
    BLAST
    Repeati746 – 78338PPR 11Add
    BLAST
    Repeati784 – 82037PPR 12Add
    BLAST
    Repeati821 – 85636PPR 13Add
    BLAST
    Repeati953 – 98735PPR 14Add
    BLAST
    Repeati1030 – 106435PPR 15Add
    BLAST
    Repeati1065 – 110137PPR 16Add
    BLAST
    Repeati1102 – 113635PPR 17Add
    BLAST
    Repeati1137 – 117337PPR 18Add
    BLAST
    Repeati1174 – 120835PPR 19Add
    BLAST
    Repeati1315 – 134935PPR 20Add
    BLAST

    Sequence similaritiesi

    Contains 20 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiNOG238430.
    HOGENOMiHOG000113350.
    HOVERGENiHBG097314.
    InParanoidiQ5SGE0.
    KOiK17964.
    PhylomeDBiQ5SGE0.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    InterProiIPR002885. Pentatricopeptide_repeat.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF01535. PPR. 5 hits.
    PF13812. PPR_3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00756. PPR. 2 hits.
    PROSITEiPS51375. PPR. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5SGE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSALLRPARW LLGAAAVPRL PLSLRLPAGG PGRLPSVVRV AAAGGRPAAG     50
    ELLSQARLYA IVAEKKDLPE EPAPVRRSGS QFDWALMRLD NSVRRTGRIT 100
    KGLLQKVFES TCRSGSPGSN QALLLLRSCG SLLPELSLAE RTEFAHKIWD 150
    KLQQLGTVYD VSHYNALLKV YLQNEYRFSP TDFLAKMEGA NIQPNRVTYQ 200
    RLIAAYCSVG DIEGASKILG FMKTRDLPIT EAVFSALVTG HARAGDMESA 250
    ENILTVMKQA GIEPGPDTYL ALLNAHAEKG DIDHVKQILE KVEKSDHYFM 300
    DRDFLQIIVS FSKAGYPQYV SEILEKITYE RRSIPDAMNL ILLLVTEKLE 350
    DTAFQVLLAL PLARDETSSS FGSFFLRHCV TMDTPAEKLI DYCKRLRDAK 400
    VHSSSLQFTL HCALQANKTA LAKAVMEALR DEGFPIRTHY FWPLLVGHQK 450
    TKNVQGIIDI LKIMKEMGVD PDQETYINYV FPCFGSVQSA RAALQENKCL 500
    PKSTTFAQAE VRNEAINGNL QNILSFLESN ALPFSFNSLR GSLILGFRRS 550
    MNIDLWSKIT ELLYKDDRYC QKPPGPTEAV GYFLYNLIDS MSDSEVQAKE 600
    ERLRQYFHQL REMNVKVSEN IYKGICNLLD NYHVPELIKD VKVLVDREKI 650
    DSRKTSQFTS SDLESTLEKL KAEGHPVGDP LKQLILLLCS EENMQKALEV 700
    KAKYESDMVI GGYAALINLC CRHDNAEDAL NLKQEFDRLD PSAVLDTAKY 750
    VALVKVLGKH GRVQDAINIL KEMKEKDVVI KDAAVLSFFH ILNGAALRGE 800
    IETVKQLHEA IVTLGLAKPS SNISFPLVTV HLEKDDLPAA LEASIACHEK 850
    YKVLPRIHDV LCKLIEKGET DLIQKAMDFV SQEQGEMSML YDLFFAFLQT 900
    GNYKEAKKII ETPGIRARPT RLQWFCDRCI ANNQVETLEK LVELTEKLFE 950
    CDRDQMYYNL LKLYKISGDW QRADAVWNKM QEENLIPRER TLRLLAGILK 1000
    TSNQEVPFDV PELWFGDDRS SLSSSSPSAG DTVTEKMLLS DCRLKKSKDA 1050
    YNIFLKAEKQ DVVFSSEAYS TLVGLLLSKD DFTRAMHVKD FAETHIKGFT 1100
    LNGAASSLLI IAQVRRDYLK VALETLKAAL DLEQVPSELA VTRLIQALAL 1150
    QGDVKSIETI QKMVKGLDAI ELSRMVFINN IALAQMKNNE IDAAIENIEH 1200
    MLASENQTVE HQYFGLSYLF RKVIEEQMEP ALEKLSIMSE RLANQFALYK 1250
    PVTDLFLQLV DSGKVDEARA LLERCGAIAE QTSILSVFCL RTSQKPKKAP 1300
    VLKTLLELIP ELRENDRVYS CSMKSYVADK DVASAKALYE HLTAKNMKLD 1350
    DLFLKRYASL LKDVGEPVPF TEPPESFGFY IKQLKEAREN PS 1392
    Length:1,392
    Mass (Da):156,653
    Last modified:December 21, 2004 - v1
    Checksum:i80D6040F4671D097
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY293808 mRNA. Translation: AAQ74626.1.
    RefSeqiNP_001008519.1. NM_001008519.1.
    UniGeneiRn.92051.

    Genome annotation databases

    GeneIDi313867.
    KEGGirno:313867.
    UCSCiRGD:1306575. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY293808 mRNA. Translation: AAQ74626.1 .
    RefSeqi NP_001008519.1. NM_001008519.1.
    UniGenei Rn.92051.

    3D structure databases

    ProteinModelPortali Q5SGE0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008200.

    PTM databases

    PhosphoSitei Q5SGE0.

    2D gel databases

    World-2DPAGE 0004:Q5SGE0.

    Proteomic databases

    PaxDbi Q5SGE0.
    PRIDEi Q5SGE0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 313867.
    KEGGi rno:313867.
    UCSCi RGD:1306575. rat.

    Organism-specific databases

    CTDi 10128.
    RGDi 1306575. Lrpprc.

    Phylogenomic databases

    eggNOGi NOG238430.
    HOGENOMi HOG000113350.
    HOVERGENi HBG097314.
    InParanoidi Q5SGE0.
    KOi K17964.
    PhylomeDBi Q5SGE0.

    Miscellaneous databases

    NextBioi 666938.
    PROi Q5SGE0.

    Gene expression databases

    Genevestigatori Q5SGE0.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    InterProi IPR002885. Pentatricopeptide_repeat.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF01535. PPR. 5 hits.
    PF13812. PPR_3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00756. PPR. 2 hits.
    PROSITEi PS51375. PPR. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of an mRNA binding protein homologue that is expressed in nociceptors."
      Eilers H., Trilk S.L., Lee S.Y., Xue Q., Jong B.E., Moff I., Levine J.D., Schumacher M.A.
      Eur. J. Neurosci. 20:2283-2293(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiLPPRC_RAT
    AccessioniPrimary (citable) accession number: Q5SGE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3