Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5SGE0 (LPPRC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich PPR motif-containing protein, mitochondrial
Alternative name(s):
130 kDa leucine-rich protein
Short name=LRP 130
Leucine rich protein 157
Short name=rLRP157
Gene names
Name:Lrpprc
Synonyms:Lrp157
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1392 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA By similarity.

Subunit structure

Interacts with CECR2, HEBP2, MAP1S, UXT, PPARGC1A and FOXO1 By similarity. Component of mRNP complexes associated with HNRPA1 By similarity.

Subcellular location

Mitochondrion. Nucleus. Nucleusnucleoplasm By similarity. Nucleus inner membrane By similarity. Nucleus outer membrane By similarity Ref.1.

Tissue specificity

Widely expressed. Expressed in liver, brain and a subset of small diameter sensory neurons in the dorsal root ganglion (at protein level). Ref.1

Induction

Induced by NGF in nociceptors. Ref.1

Sequence similarities

Contains 20 PPR (pentatricopeptide) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 7777Mitochondrion Potential
Chain78 – 13921315Leucine-rich PPR motif-containing protein, mitochondrial
PRO_0000295547

Regions

Repeat125 – 15935PPR 1
Repeat160 – 19435PPR 2
Repeat195 – 22935PPR 3
Repeat230 – 26435PPR 4
Repeat265 – 29935PPR 5
Repeat300 – 33435PPR 6
Repeat402 – 43635PPR 7
Repeat437 – 47135PPR 8
Repeat677 – 70832PPR 9
Repeat709 – 74537PPR 10
Repeat746 – 78338PPR 11
Repeat784 – 82037PPR 12
Repeat821 – 85636PPR 13
Repeat953 – 98735PPR 14
Repeat1030 – 106435PPR 15
Repeat1065 – 110137PPR 16
Repeat1102 – 113635PPR 17
Repeat1137 – 117337PPR 18
Repeat1174 – 120835PPR 19
Repeat1315 – 134935PPR 20

Amino acid modifications

Modified residue1511N6-acetyllysine By similarity
Modified residue1861N6-acetyllysine By similarity
Modified residue2911N6-acetyllysine By similarity
Modified residue4621N6-acetyllysine By similarity
Modified residue7491N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5SGE0 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 80D6040F4671D097

FASTA1,392156,653
        10         20         30         40         50         60 
MSALLRPARW LLGAAAVPRL PLSLRLPAGG PGRLPSVVRV AAAGGRPAAG ELLSQARLYA 

        70         80         90        100        110        120 
IVAEKKDLPE EPAPVRRSGS QFDWALMRLD NSVRRTGRIT KGLLQKVFES TCRSGSPGSN 

       130        140        150        160        170        180 
QALLLLRSCG SLLPELSLAE RTEFAHKIWD KLQQLGTVYD VSHYNALLKV YLQNEYRFSP 

       190        200        210        220        230        240 
TDFLAKMEGA NIQPNRVTYQ RLIAAYCSVG DIEGASKILG FMKTRDLPIT EAVFSALVTG 

       250        260        270        280        290        300 
HARAGDMESA ENILTVMKQA GIEPGPDTYL ALLNAHAEKG DIDHVKQILE KVEKSDHYFM 

       310        320        330        340        350        360 
DRDFLQIIVS FSKAGYPQYV SEILEKITYE RRSIPDAMNL ILLLVTEKLE DTAFQVLLAL 

       370        380        390        400        410        420 
PLARDETSSS FGSFFLRHCV TMDTPAEKLI DYCKRLRDAK VHSSSLQFTL HCALQANKTA 

       430        440        450        460        470        480 
LAKAVMEALR DEGFPIRTHY FWPLLVGHQK TKNVQGIIDI LKIMKEMGVD PDQETYINYV 

       490        500        510        520        530        540 
FPCFGSVQSA RAALQENKCL PKSTTFAQAE VRNEAINGNL QNILSFLESN ALPFSFNSLR 

       550        560        570        580        590        600 
GSLILGFRRS MNIDLWSKIT ELLYKDDRYC QKPPGPTEAV GYFLYNLIDS MSDSEVQAKE 

       610        620        630        640        650        660 
ERLRQYFHQL REMNVKVSEN IYKGICNLLD NYHVPELIKD VKVLVDREKI DSRKTSQFTS 

       670        680        690        700        710        720 
SDLESTLEKL KAEGHPVGDP LKQLILLLCS EENMQKALEV KAKYESDMVI GGYAALINLC 

       730        740        750        760        770        780 
CRHDNAEDAL NLKQEFDRLD PSAVLDTAKY VALVKVLGKH GRVQDAINIL KEMKEKDVVI 

       790        800        810        820        830        840 
KDAAVLSFFH ILNGAALRGE IETVKQLHEA IVTLGLAKPS SNISFPLVTV HLEKDDLPAA 

       850        860        870        880        890        900 
LEASIACHEK YKVLPRIHDV LCKLIEKGET DLIQKAMDFV SQEQGEMSML YDLFFAFLQT 

       910        920        930        940        950        960 
GNYKEAKKII ETPGIRARPT RLQWFCDRCI ANNQVETLEK LVELTEKLFE CDRDQMYYNL 

       970        980        990       1000       1010       1020 
LKLYKISGDW QRADAVWNKM QEENLIPRER TLRLLAGILK TSNQEVPFDV PELWFGDDRS 

      1030       1040       1050       1060       1070       1080 
SLSSSSPSAG DTVTEKMLLS DCRLKKSKDA YNIFLKAEKQ DVVFSSEAYS TLVGLLLSKD 

      1090       1100       1110       1120       1130       1140 
DFTRAMHVKD FAETHIKGFT LNGAASSLLI IAQVRRDYLK VALETLKAAL DLEQVPSELA 

      1150       1160       1170       1180       1190       1200 
VTRLIQALAL QGDVKSIETI QKMVKGLDAI ELSRMVFINN IALAQMKNNE IDAAIENIEH 

      1210       1220       1230       1240       1250       1260 
MLASENQTVE HQYFGLSYLF RKVIEEQMEP ALEKLSIMSE RLANQFALYK PVTDLFLQLV 

      1270       1280       1290       1300       1310       1320 
DSGKVDEARA LLERCGAIAE QTSILSVFCL RTSQKPKKAP VLKTLLELIP ELRENDRVYS 

      1330       1340       1350       1360       1370       1380 
CSMKSYVADK DVASAKALYE HLTAKNMKLD DLFLKRYASL LKDVGEPVPF TEPPESFGFY 

      1390 
IKQLKEAREN PS 

« Hide

References

[1]"Isolation of an mRNA binding protein homologue that is expressed in nociceptors."
Eilers H., Trilk S.L., Lee S.Y., Xue Q., Jong B.E., Moff I., Levine J.D., Schumacher M.A.
Eur. J. Neurosci. 20:2283-2293(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY293808 mRNA. Translation: AAQ74626.1.
RefSeqNP_001008519.1. NM_001008519.1.
UniGeneRn.92051.

3D structure databases

ProteinModelPortalQ5SGE0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008200.

PTM databases

PhosphoSiteQ5SGE0.

2D gel databases

World-2DPAGE0004:Q5SGE0.

Proteomic databases

PaxDbQ5SGE0.
PRIDEQ5SGE0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID313867.
KEGGrno:313867.
UCSCRGD:1306575. rat.

Organism-specific databases

CTD10128.
RGD1306575. Lrpprc.

Phylogenomic databases

eggNOGNOG238430.
HOGENOMHOG000113350.
HOVERGENHBG097314.
InParanoidQ5SGE0.

Gene expression databases

GenevestigatorQ5SGE0.

Family and domain databases

Gene3D1.25.40.10. 3 hits.
InterProIPR002885. Pentatricopeptide_repeat.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF01535. PPR. 5 hits.
PF13812. PPR_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00756. PPR. 2 hits.
PROSITEPS51375. PPR. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio666938.
PROQ5SGE0.

Entry information

Entry nameLPPRC_RAT
AccessionPrimary (citable) accession number: Q5SGE0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families