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Q5SGE0

- LPPRC_RAT

UniProt

Q5SGE0 - LPPRC_RAT

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Protein

Leucine-rich PPR motif-containing protein, mitochondrial

Gene

Lrpprc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity).By similarity

GO - Molecular functioni

  1. beta-tubulin binding Source: HGNC
  2. DNA binding Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA transport Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transcription, Transcription regulation, Transport

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich PPR motif-containing protein, mitochondrial
Alternative name(s):
130 kDa leucine-rich protein
Short name:
LRP 130
Leucine rich protein 157
Short name:
rLRP157
Gene namesi
Name:Lrpprc
Synonyms:Lrp157
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306575. Lrpprc.

Subcellular locationi

Mitochondrion 1 Publication. Nucleus 1 Publication. Nucleusnucleoplasm By similarity. Nucleus inner membrane By similarity. Nucleus outer membrane By similarity

GO - Cellular componenti

  1. condensed nuclear chromosome Source: HGNC
  2. cytoskeleton Source: HGNC
  3. membrane Source: UniProtKB-KW
  4. mitochondrion Source: UniProtKB-KW
  5. nucleus Source: HGNC
  6. perinuclear region of cytoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7777MitochondrionSequence AnalysisAdd
BLAST
Chaini78 – 13921315Leucine-rich PPR motif-containing protein, mitochondrialPRO_0000295547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511N6-acetyllysineBy similarity
Modified residuei186 – 1861N6-acetyllysineBy similarity
Modified residuei291 – 2911N6-acetyllysineBy similarity
Modified residuei462 – 4621N6-acetyllysineBy similarity
Modified residuei749 – 7491N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5SGE0.
PRIDEiQ5SGE0.

2D gel databases

World-2DPAGE0004:Q5SGE0.

PTM databases

PhosphoSiteiQ5SGE0.

Expressioni

Tissue specificityi

Widely expressed. Expressed in liver, brain and a subset of small diameter sensory neurons in the dorsal root ganglion (at protein level).1 Publication

Inductioni

Induced by NGF in nociceptors.1 Publication

Gene expression databases

GenevestigatoriQ5SGE0.

Interactioni

Subunit structurei

Interacts with CECR2, HEBP2, MAP1S, UXT, PPARGC1A and FOXO1. Component of mRNP complexes associated with HNRPA1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008200.

Structurei

3D structure databases

ProteinModelPortaliQ5SGE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 15935PPR 1Add
BLAST
Repeati160 – 19435PPR 2Add
BLAST
Repeati195 – 22935PPR 3Add
BLAST
Repeati230 – 26435PPR 4Add
BLAST
Repeati265 – 29935PPR 5Add
BLAST
Repeati300 – 33435PPR 6Add
BLAST
Repeati402 – 43635PPR 7Add
BLAST
Repeati437 – 47135PPR 8Add
BLAST
Repeati677 – 70832PPR 9Add
BLAST
Repeati709 – 74537PPR 10Add
BLAST
Repeati746 – 78338PPR 11Add
BLAST
Repeati784 – 82037PPR 12Add
BLAST
Repeati821 – 85636PPR 13Add
BLAST
Repeati953 – 98735PPR 14Add
BLAST
Repeati1030 – 106435PPR 15Add
BLAST
Repeati1065 – 110137PPR 16Add
BLAST
Repeati1102 – 113635PPR 17Add
BLAST
Repeati1137 – 117337PPR 18Add
BLAST
Repeati1174 – 120835PPR 19Add
BLAST
Repeati1315 – 134935PPR 20Add
BLAST

Sequence similaritiesi

Contains 20 PPR (pentatricopeptide) repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiNOG238430.
HOGENOMiHOG000113350.
HOVERGENiHBG097314.
InParanoidiQ5SGE0.
KOiK17964.
PhylomeDBiQ5SGE0.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002885. Pentatricopeptide_repeat.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF01535. PPR. 5 hits.
PF13812. PPR_3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 2 hits.
PROSITEiPS51375. PPR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SGE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSALLRPARW LLGAAAVPRL PLSLRLPAGG PGRLPSVVRV AAAGGRPAAG
60 70 80 90 100
ELLSQARLYA IVAEKKDLPE EPAPVRRSGS QFDWALMRLD NSVRRTGRIT
110 120 130 140 150
KGLLQKVFES TCRSGSPGSN QALLLLRSCG SLLPELSLAE RTEFAHKIWD
160 170 180 190 200
KLQQLGTVYD VSHYNALLKV YLQNEYRFSP TDFLAKMEGA NIQPNRVTYQ
210 220 230 240 250
RLIAAYCSVG DIEGASKILG FMKTRDLPIT EAVFSALVTG HARAGDMESA
260 270 280 290 300
ENILTVMKQA GIEPGPDTYL ALLNAHAEKG DIDHVKQILE KVEKSDHYFM
310 320 330 340 350
DRDFLQIIVS FSKAGYPQYV SEILEKITYE RRSIPDAMNL ILLLVTEKLE
360 370 380 390 400
DTAFQVLLAL PLARDETSSS FGSFFLRHCV TMDTPAEKLI DYCKRLRDAK
410 420 430 440 450
VHSSSLQFTL HCALQANKTA LAKAVMEALR DEGFPIRTHY FWPLLVGHQK
460 470 480 490 500
TKNVQGIIDI LKIMKEMGVD PDQETYINYV FPCFGSVQSA RAALQENKCL
510 520 530 540 550
PKSTTFAQAE VRNEAINGNL QNILSFLESN ALPFSFNSLR GSLILGFRRS
560 570 580 590 600
MNIDLWSKIT ELLYKDDRYC QKPPGPTEAV GYFLYNLIDS MSDSEVQAKE
610 620 630 640 650
ERLRQYFHQL REMNVKVSEN IYKGICNLLD NYHVPELIKD VKVLVDREKI
660 670 680 690 700
DSRKTSQFTS SDLESTLEKL KAEGHPVGDP LKQLILLLCS EENMQKALEV
710 720 730 740 750
KAKYESDMVI GGYAALINLC CRHDNAEDAL NLKQEFDRLD PSAVLDTAKY
760 770 780 790 800
VALVKVLGKH GRVQDAINIL KEMKEKDVVI KDAAVLSFFH ILNGAALRGE
810 820 830 840 850
IETVKQLHEA IVTLGLAKPS SNISFPLVTV HLEKDDLPAA LEASIACHEK
860 870 880 890 900
YKVLPRIHDV LCKLIEKGET DLIQKAMDFV SQEQGEMSML YDLFFAFLQT
910 920 930 940 950
GNYKEAKKII ETPGIRARPT RLQWFCDRCI ANNQVETLEK LVELTEKLFE
960 970 980 990 1000
CDRDQMYYNL LKLYKISGDW QRADAVWNKM QEENLIPRER TLRLLAGILK
1010 1020 1030 1040 1050
TSNQEVPFDV PELWFGDDRS SLSSSSPSAG DTVTEKMLLS DCRLKKSKDA
1060 1070 1080 1090 1100
YNIFLKAEKQ DVVFSSEAYS TLVGLLLSKD DFTRAMHVKD FAETHIKGFT
1110 1120 1130 1140 1150
LNGAASSLLI IAQVRRDYLK VALETLKAAL DLEQVPSELA VTRLIQALAL
1160 1170 1180 1190 1200
QGDVKSIETI QKMVKGLDAI ELSRMVFINN IALAQMKNNE IDAAIENIEH
1210 1220 1230 1240 1250
MLASENQTVE HQYFGLSYLF RKVIEEQMEP ALEKLSIMSE RLANQFALYK
1260 1270 1280 1290 1300
PVTDLFLQLV DSGKVDEARA LLERCGAIAE QTSILSVFCL RTSQKPKKAP
1310 1320 1330 1340 1350
VLKTLLELIP ELRENDRVYS CSMKSYVADK DVASAKALYE HLTAKNMKLD
1360 1370 1380 1390
DLFLKRYASL LKDVGEPVPF TEPPESFGFY IKQLKEAREN PS
Length:1,392
Mass (Da):156,653
Last modified:December 21, 2004 - v1
Checksum:i80D6040F4671D097
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY293808 mRNA. Translation: AAQ74626.1.
RefSeqiNP_001008519.1. NM_001008519.1.
UniGeneiRn.92051.

Genome annotation databases

GeneIDi313867.
KEGGirno:313867.
UCSCiRGD:1306575. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY293808 mRNA. Translation: AAQ74626.1 .
RefSeqi NP_001008519.1. NM_001008519.1.
UniGenei Rn.92051.

3D structure databases

ProteinModelPortali Q5SGE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008200.

PTM databases

PhosphoSitei Q5SGE0.

2D gel databases

World-2DPAGE 0004:Q5SGE0.

Proteomic databases

PaxDbi Q5SGE0.
PRIDEi Q5SGE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 313867.
KEGGi rno:313867.
UCSCi RGD:1306575. rat.

Organism-specific databases

CTDi 10128.
RGDi 1306575. Lrpprc.

Phylogenomic databases

eggNOGi NOG238430.
HOGENOMi HOG000113350.
HOVERGENi HBG097314.
InParanoidi Q5SGE0.
KOi K17964.
PhylomeDBi Q5SGE0.

Miscellaneous databases

NextBioi 666938.
PROi Q5SGE0.

Gene expression databases

Genevestigatori Q5SGE0.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR002885. Pentatricopeptide_repeat.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF01535. PPR. 5 hits.
PF13812. PPR_3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00756. PPR. 2 hits.
PROSITEi PS51375. PPR. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of an mRNA binding protein homologue that is expressed in nociceptors."
    Eilers H., Trilk S.L., Lee S.Y., Xue Q., Jong B.E., Moff I., Levine J.D., Schumacher M.A.
    Eur. J. Neurosci. 20:2283-2293(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiLPPRC_RAT
AccessioniPrimary (citable) accession number: Q5SGE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3